• 정신신체의학
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• 제12권2호
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• pp.122-134
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• 2004

연구목적 : 본 연구의 목적은 분노반응 척도를 개발하고 임상에 적용하고자 하는 데 있다. 방법: 성인 정상인 123명을 대상으로 분노반응 척도 예비설문을 시행하여 16개 문항을 추출하였다. 그 다음에 이 문항들이 포함된 설문을 정상인 258명을 대상으로 실시하였다. 상기 척도의 임상적 적용은 환자군 189명(불안장애 59명, 우울장애 72명, 신체형장애 58명)을 대상으로 하였다. 결과: 이 자료들을 요인분석한 결과 4개의 하위요인 즉 공격성반응, 짜증반응, 도피반응, 분노억압반응이 추출되었다. 상기 척도의 신뢰도는 정상인 53명에게 2주 간격으로 검사-재검사를 시행, 분석한 결과 4개 하위척도 점수와 척도 전체 점수간의 상관계수가 .53-.71로 모두 유의한 상관성을 보였다. 한편 내적 일치도는 4개 하위척도의 Cronbach's ${\alpha}$가 .62-.72, 척도 전체의 Cronbach's ${\alpha}$가 .76로 유의한 수준을 보였다. 공존 타당도의 평가는 공격성질문지 (Aggression Questionnaire) 총점, 상태-특성분노표출척도(State-Trait Anger Expression Inventory), 스트레스반응척도(Stress Response Inventory)의 분노 및 공격성 하위척도, Symptom Checklist-90-Revised (SCL-90-R)의 적대감 하위척도를 사용하였다. 환자군과 정상군 간에 척도의 전체 점수와 하위척도 점수를 비교한 결과 도피반응과 분노억압반응 하위척도에서만 각각 유의한 차이를 보였고 공격성 및 짜증반응, 척도 전체 점수에서는 유의한 차이를 보이지 않았다. 도피반응 하위척도 점수에서 우울장애군과 신체형장애군은 각각 정상군보다 유의하게 더 높았다. 결론: 이상의 결과들은 분노반응 척도가 신뢰도 및 타당도가 모두 유의한 수준의 도구이고, 특히 도피반응은 우울장애군 및 신체형장애군의 특징적인 분노반응일 가능성을 시사해 준다.

• 종양간호연구
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• 제5권1호
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• pp.22-30
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• 2005

Purpose: The aim of this study was to investigate the differences in emotional response and coping pattern by age among cancer patients. Method: As descriptive research, from November 2000 to April 2001, data was collected with semi-structured questionnaire to 90 adult cancer patients, and analyzed using quantitative analysis. Result: Most emotional response at the time of diagnosis of cancer is despair in 20-39years & more than 60 years, and Impact in 40-59years. In emotional response during treatment by age, there were most much hope in 20-39 years, fear in 40-59years, and acceptance in more than 60years. In difficulties by age during treatment, there were most much mental burden in 20-29years, problems about occupation/finance in 40-59years, and physical discomfort related to treatment in more than 60 years. Resolution of difficulties of treatment shows avoidance in 20-39years, active participation in 40-59years and compliance in more than 60 years. Coping pattern during treatment was positive thinking in 20-39years, refreshment in 40-59years, and despair/avoidance in more than 60 years. Coping with treatment & progress shows in 20-39years maintenance of current health, 40-59years impossible to recover, more than 60year health recovery. Conclusion: Nursing could be considered emotional response and coping pattern according to age.

• 대한불안의학회지
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• 제4권1호
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• pp.49-54
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• 2008

Objective : This article is a part of the Korean Medication Algorithm Project for Panic Disorder, which aims to build consensus regarding the diagnosis, treatment response and achievement of clinical remission for patients with panic disorder in Korea. Methods : The questionnaire used in this article had parts : 1) diagnosis, 2) treatment response, and 3) remission for patients with panic disorder. The questionnaire was completed by each of 54 Korean psychiatrists who had much experience in treating patients with panic disorder. We classified the experts' opinions into 3 categories (first-line, second-line, and third-line) using the ${\chi}^2$-test. Results : Five factors were considered in this research : panic attack, anticipatory anxiety, phobic avoidance, severity of illness, and psychosocial disability. Most reviewers agreed that the presence of a panic attack was the most important factor in the diagnosis of patients with panic disorder. Phobic avoidance was included in the first-line category, whereas the severity of illness and psychosocial disability were included in the second-line category. Most reviewers also agreed that the presence of a panic attack was the most important factor in determining the appropriate treatment response, and it was included in the first-line category along with several other items. To determine remission status, the patients' scores on tests pertaining to the severity of panic attack, anticipatory anxiety, phobic avoidance, severity of illness and psychosocial disability should be less than 3.0-3.3 on a 9-point Likert scale. Conclusion : We suggest useful information for making a diagnosisof panic disorder, determining the appropriate treatment response and identifying remission in panic disorder patients on the basis of the results of a nationwide survey of experts in Korea.

• 치위생과학회지
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• 제7권3호
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• pp.193-196
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• 2007

본 연구는 부산시내에 소재하는 치과의원 3곳을 임의 선정하여 2007년 4월 9일부터 5월 4일까지 치과에 내원한 20세 이상의 성인 178명을 대상으로 치과치료에 대한 공포감에 관련된 요인을 조사하고자 하였다. 일반적 특성 4개 문항과 20개 문항의 DFS를 이용하여 치과 치료에 대한 공포감의 정도를 자기기입방식으로 설문조사한 후 얻어진 자료를 분석한 결과는 다음과 같다. 1. 각 세부요인별 내적 일치도는 Cronbach의 신뢰도 계수가 0.662~0.921로 모든 요인의 신뢰도 계수가 0.6이상으로 나타나 Dental Fear Survey Scale(DFS)의 신뢰성을 알 수 있었다. 2. 세부요인 3가지 중 치료자극 반응요인이 다른 2가지의 요인보다 높은 공포감을 나타냈으며 일반적 특성에 따른 결과로는 여성이 남성보다, 연령이 높을수록, 교육수준이 높을수록, 그리고 월평균수입이 많을수록 치과 공포가 높게 나타났다. 3. 치과치료에 대한 전체적인 공포 정도에 영향을 미치는 요인으로는 치료자극 반응요인, 치과진료 회피요인, 생리적 반응요인이 유의한 변수로 작용하였고, 이 요인들에 의한 설명력은 66.1%였다.

• The Korean Journal of Physiology
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• 제2권1호
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• pp.1-8
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• 1968

유두체의 기능을 탐색하기 위하여 외과 수술에 의하여 유두체를 떼어버린 개를 마련하고 수술전에서부터 수술후에 걸쳐 다음의 세가지 실험을 실시하여 그 성적을 비교하였다. 첫째 실험에서는 먹이 먹는 개의 혀에 전기 충격을 가한다음 이어서 동물이 다시 먹이 그릇에 접근하기까지의 시간을 측정하여 동물이 무서움을 타는정도를 짐작하였으며, 둘째 실험에서는 높은 소리 (12,000 cps, 100 db)를 한 시간 동안 동물에게 들려 스트레스로 삼고 혈액 호산구 수의 변동을 추적하여 스트레스에 대한 반응의 지표로 삼았다. 셋째 실험에서는 아침과 저녁 일정한 시간에 항문 온도를 반복 측정하였다. 실험 결과는 다음과 같다. 1. 유두체 제거후의 동물이 유두체 제거전 보다 무서움을 더 혹은 덜 탄다는 증거는 없었다(제 1 표). 2. 유두체가 제거된 후에도 스트레스에 대한 반응은 유두체 제거전과 같은 정도로 현저히 나타나나 스트레스에서의 회복과정은 유두체 제거전에 비하여 유두체 제거후에 유의하게 지연되었다(제 1 도). 3. 유두체가 제거된 동물의 체온은 유두체 제거전에 비하여 떨어지는데 그 정도는 미약하나 통계적으로 유의한 차이를 나타내었다(제 2 표).

• 사상체질의학회지
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• 제26권2호
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• pp.133-145
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• 2014

Objectives In this study, we tried to examine that Sasang Constitutional differences affect the direction of the treatment of anger by comparing the effect of mindfulness meditation for anger scale in accordance with the difference of the constitution. Methods We analysed 105 college student's Constitution by Questionnaire for the Sasang Constitution Classification II and the effect of mindfulness meditation for anger by State-Trait Anger Expression Inventory Korean version(STAXI-K), Korean Version of the Behavioral Anger Response Questionnaire(K-BARQ). Volunteers who participated in this study were 105 people, except for person that did not properly entered the anger scale and Questionnaire for the Sasang Constitution Classification II, the subjects of analysis for State-Trait Anger Expression Inventory Scale were 45 and for the Behavioral Anger Scale were 49. Results & Conclusions The result of the effects of mindfulness meditation according to Sasang Constitution was as follows. The tendency to try to disperse and avoid the anger was increased through meditation for all subjects. The diffusion of male subjects and the avoidance of female subjects was increased. The effect of meditation on anger did not differ according to Sasang Constitution, constitutional differences did not affect the effects of meditation. The tendency of avoidance of anger was increased in Soyangin, Anger-out was decreased and the tendency of avoidance and diffusion of anger were decreased in Taeeumin through meditation.

• Natural Product Sciences
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• 제19권4호
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• pp.324-328
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• 2013

Soy (Glycine max, family Leguminosae) contains isoflavones and saponins as main constituents. In our preliminary study, soybean ethanol extract (SE) ameliorated scopolamine-induced memory impairment in mice in the passive avoidance task. Therefore, to confirm its ameliorating effect for memory impairments, we measured its effect in scopolamine-induced memory-impaired mice in Morris water maze task. SE significantly prevented scopolamine-induced memory impairment in the Morris water maze task. SE also increased the swimming time within quadrant section of the platform on the day after the final training session test. SE protected the reduction of brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation in the hippocampi of scopolamine-treated mice. However, SE did not inhibit acetylcholinesterase. To understand the possible role of soysaponins in memory impairments, we prepared soyasaponins-rich (butanol) fraction of soybean (SRF) and investigated its protective effect against in the passive avoidance and Morris water maze tasks. SRF ameliorated scopolamine-induced memory impairment in mice. The memory impairment-ameliorating effect of SRF was more effective than that of SE. Based on these findings, soybean may improve memory impairment by regulating CREB phosphorylation and BDNF expression.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.467-473
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• 2014

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.

• 생약학회지
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• 제5권3호
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• pp.159-166
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• 1974

The Yellow needle crystal was isolated from Atractylis Rhizoma, having mp $124{\sim}126^{\circ}C$(decomp.), the chemical composition $C_{16}H_{21}N_{3}O_{6}$, and its m.w. 251. The pharmacological actions of this alkaloid were studied by various psycopharmacological experiments. 1) In order to see the effect of this Atractylis(=At.) alkaloid on gross general behaviors in mice, a behavioral analysis experiment was adapted. The occurrence number of sleep and lying in At. alkaloidal animals with the doses 10mg/kg or 20mg/kg was increased but the number of jumping, exploration, rearing and defecation was significantly decreased than those of placebo. 2) The effect of the At. alkaloid on unlearned emotional behaviors of mice was studied with an open-field method. The At. alkaloidal groups with the doses 20mg/kg or 30mg/kg showed less often the frequency of locomotion than that of placebo. 3) To know the effect of the At. alkaloid on the learning, a standard water maze experiment and conditioned avoidance response were conducted. As compared to placebo control, the aquisition rate of the maze learning in the alkaloidal mice with the dose of 10mg/kg or 20mg/kg was significantly impaired and the speed of swimming was also signficantly delayed. In the conditioned avoidance response, the extinction performances of the alkaloidal rats with doses of 20mg/kg or 30mg/kg did not differ significantly than that of placebo.

• 제어로봇시스템학회논문지
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• 제6권7호
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• pp.537-543
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• 2000

mathematical models for a hydraulic brake actuator and a brake control law for vehicle collision warning/collision avoidance (CW/CA) systems will be presented in this paper. The control law have been designed for optimzied safety and comfort. A solenoid-valve-controlled hydraulic brake actuator system for the CW/CA systems has been investigated, A nonlinear computer model and a linear model of the hydraulic brake actuator system have been developed. Both models were found to represent the actual system with good accuracy. Uncertainties in the brake actuator model have been considered in the design of the control law for the roubustness of the controller. The effects of brake control on CW/CA vehicle response has been investigated via simulations. The simulations were performed using the hydraulic brake system model and a complete nonlinear vehicle model. The results indicate that the proposed brake control law can provide the CW/CA vehicles with an opimized compromise between safety and comfort.