• 한국소음진동공학회논문집
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• 제27권2호
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• pp.221-233
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• 2017

The array equations are commonly used for analysis and conceptual design of active sonar projector arrays. Calculation of the radiation impedance matrix poses a major computational bottleneck for the solution of the array equations, which leads to a dramatic increase in computational load as the number of constituent transducers increases. Here, we propose an iteration-based solution method that does not require the calculation of the radiation impedance matrix, as a computationally efficient alternative to the status quo. The validity of the iteration-based analysis is judged against the full finite-element analysis that includes the entire array as well as the medium. The array equations for the 1/3-sector of a cylindrical array comprised of 48 Tonpilz transducers are augmented by the lumped element models, and are solved iteratively for the acoustic and electro-mechanical characteristics. The iteration-based analysis exhibits rapid convergence and accuracy comparable with the FE analysis. Simulations also reveal that the acoustic coupling between transducers has more pronounced effects on the electro-mechanical characteristics of individual transducers than the acoustic performance of the array.

• Journal of Ginseng Research
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• 제42권2호
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• pp.218-224
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• 2018

Background: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed. Results: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factors-filaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2-were augmented by CK and were modulated through the inhibitor of ${\kappa}B{\alpha}$, c-Jun N-terminal kinase, or extracellular signal-regulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed. Conclusion: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level.

• Journal of Periodontal and Implant Science
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• 제47권4호
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• pp.194-210
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• 2017

Purpose: The aim of the present study was to evaluate the healing of post-extraction sockets following alveolar ridge preservation clinically, radiologically, and histologically. Methods: Overall, 7 extraction sockets in 7 patients were grafted with demineralised bovine bone mineral and covered with a porcine-derived non-crosslinked collagen matrix (CM). Soft tissue healing was clinically evaluated on the basis of a specific healing index. Horizontal and vertical ridge dimensional changes were assessed clinically and radiographically at baseline and 6 months after implant placement. For histological and histomorphometric analysis, bone biopsies were harvested from the augmented sites during implant surgery 6 months after the socket preservation procedure. Results: Clinically, healing proceeded uneventfully in all the sockets. A trend towards reduced horizontal and vertical socket dimensions was observed from baseline to the final examination. The mean width and height of resorption were 1.21 mm (P=0.005) and 0.46 mm (P=0.004), respectively. Histologically, residual xenograft particles ($31.97%{\pm}3.52%$) were surrounded by either newly formed bone ($16.02%{\pm}7.06%$) or connective tissue ($50.67%{\pm}8.42%$) without fibrous encapsulation. The CM underwent a physiological substitution process in favour of well-vascularised collagen-rich connective tissue. Conclusions: Socket preservation using demineralised bovine bone mineral in combination with CM provided stable dimensional changes of the alveolar ridge associated with good reepithelialisation of the soft tissues during a 6-month healing period.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.781-791
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• 2018

BACKGROUND: Glucosamine hydrochloride (GlcN HCl) has been shown to inhibit cell growth and matrix synthesis, but not with N-acetyl-glucosamine (GlcNAc) supplementation. This effect might be related to an inhibition of critical growth factors (GF), or to a different metabolization of the two glucosamine derivatives. The aim of the present study was to evaluate the synergy between GlcN HCl, GlcNAc, and GF on proliferation and cartilage matrix synthesis. METHOD: Bovine chondrocytes were cultivated in monolayers for 48 h and in three-dimensional (3D) chitosan scaffolds for 30 days in perfusion bioreactors. Serum-free (SF) medium was supplemented with either growth factors (GF) $TGF-{\beta}$ ($5ng\;mL^{-1}$) and IGF-I ($10ng\;mL^{-1}$), GlcN HCl or GlcNAc at 1mM each or both. Six groups were compared according to medium supplementation: (a) SF control; (b) SF + GlcN HCl; (c) SF + GlcNAc; (d) SF + GF; (e) SF + GF + GlcN HCl; and (f) SF + GF + GlcNAc. Cell proliferation, proteoglycan, collagen I (COL1), and collagen II (COL2) synthesis were evaluated. RESULTS: The two glucosamines showed opposite effects in monolayer culture: GlcN HCl significantly reduced proliferation and GlcNAc significantly augmented cellular metabolism. In the 30 days 3D culture, the GlcN HCl added to GF stimulated cell proliferation more than when compared to GF only, but the proteoglycan synthesis was smaller than GF. However, GlcNAc added to GF improved the cell proliferation and proteoglycan synthesis more than when compared to GF and GF/GlcN HCl. The synthesis of COL1 and COL2 was observed in all groups containing GF. CONCLUSION: GlcN HCl and GlcNAc increased cell growth and stimulated COL2 synthesis in long-time 3D culture. However, only GlcNAc added to GF improved proteoglycan synthesis.

• The Journal of Asian Finance, Economics and Business
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• 제7권12호
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• pp.677-682
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• 2020

To investigate the nexus between urban population, gross capital formation, and economic growth in the Kingdom of Saudi Arabia, yearly data was collected from the World Bank for the period 1974- 2018. Basic statistics test and correlation matrix was used to investigate the causal effect among the tested parameters, followed by Augmented Dickey-Fuller (ADF) stationary test, co-integration analysis by Johansen test after that Vector Auto-Correction Model for both short-run and long-run and finally the Granger-Causality tests. Result of unit root test analysis shows that the urban population became stationary at I (0) level while economic growth and gross capital formation became stationary at I (1). Johansen co-integration analysis indicates that there is presence of both long-run and short-run relationship between the three variables in the Kingdom of Saudi Arabia. The result of the VECM Model reflects that both economic growth and gross capital formation have a negative impact on urban population in the short run. According to the Granger-Causality tests, there is unidirectional causality with the urban population by both gross capital formation and economic growth. Also, the result of the Granger Causality tests show that there is unidirectional causality between economic growth and gross capital formations.

• 한국자동차공학회논문집
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• 제4권5호
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• pp.16-25
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• 1996

In the present work a rigid-plastic finite element formulation using dynamic explicit time integration scheme is proposed for numerical analysis of auto-body panel stamping processes. The rigid-plastic finite element method based on membrane elements has long been employed as a useful numerical technique for the analysis of sheet metal forming because of its time effectiveness. A damping scheme is proposed in order to achieve a stable solution procedure in dynamic sheet forming problems. In order to improve the drawbacks of the conventional membrane elements, BEAM(abbreviated from Bending Energy Augmented Membrane) elements are employed. Rotational damping and spring about the drilling direction are introduced to prevent a zero energy mode. The lumping scheme is employed for the diagonal mass matrix and linearizing dynamic formulation. A contact scheme is developed by combining the skew boundary condition and the direct trial-and-error method. Computations are carried out for analysis of complicated auto-body panel stamping processes such as forming of an oilpan, a fuel tank and a front fender. The numerical results of explicit analysis are compared with the implicit results with good agreements and it is shown that the explicit scheme requires much shorter computational time, especially when the problem becomes more complicated. It is thus shown that the proposed dynamic explicit rigid-plastic finite element method enables an effective computation for complicated autobody panel stamping processes.

• Journal of Electrical Engineering and Technology
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• 제11권1호
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• pp.200-214
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• 2016

This paper investigates the problem of stability analysis and robust H_∞ controller for time-delayed systems with parameter uncertainties and stochastic disturbances. It is assumed parameter uncertainties are norm bounded and mean and variance for disturbances of them are known. Firstly, by constructing a newly augmented Lyapunov-Krasovskii functional, a stability criterion for nominal systems with time-varying delays is derived in terms of linear matrix inequalities (LMIs). Secondly, based on the result of stability analysis, a new controller design method is proposed for the nominal form of the systems. Finally, the proposed method is extended to the problem of robust H_∞ controller design for a time-delayed system with parameter uncertainties and stochastic disturbances. To show the validity and effectiveness of the presented criteria, three examples are included.

• 대한전기학회논문지:전력기술부문A
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• 제49권5호
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• pp.233-241
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• 2000

This paper presents a systematic design procedure of $H_{\infty}$ controller of TCSC for damping low frequency inter-area oscillations in large power systems. Sensitivities of the inter-area mode for changes in line susceptance are computed using the eigen-sensitivity theory of augmented system matrix and TCSC locations are selected using the line sensitivities. The reduced model required for designing a manageable-size $H_{\infty}$ controller is obtained using the reduced frequency domain system identification method and the various weighting functions are tuned systematically to provide a robust performance. The proposed $H_{\infty}$ controller proved to be very effective for damping the inter-area mode of the large KEPCO power system.

• 대한기계학회논문집
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• 제19권3호
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• pp.639-646
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• 1995

The objective of this study is to minimize the weight of a damped anisotropic roto-bearing system considering whirl natural frequency and stability. The system is modeled as an assemblage of rigid disks, flexible shafts and discrete bearings. The system design variables are the crosssectional areas of shaft elements and the properties of bearings. To analyze the system, the polynomial method which is derived by rearranging the calculations performed by a transfer matrix method is adopted. For the optimization, the optimization software IDOL (Integrated Design Optimization Library) which is based on the Augmented Lagrange Multiplier (ALM) method is employed. Also, an analytical design sensitivity analysis of the system is used for high accuracy and efficiency. To demonstrate the usefulness of the proposed optimal design program incorporating analysis, design sensitivity analysis, and optimization modules, a damped anisotropic rotor-bearing system is optimized to obtain 34$ weight reduction.

• 전자공학회논문지A
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• 제33A권6호
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• pp.81-89
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• 1996

Quantum RF impedance of SIS (superconductor insulator superconductor) junction has been analyzed by using through on tucker's quantum mixer theory in the frequency range form 80 GHz to 120 GHz. The embedding impedance of waveguide-type mixer mount and its equivalent circuit have been evaluated. From these evaluated results, the impedance matching efficiency between mixer mount embedding impedance and mixer port impedance of upper-side band and IF which were determined by augmented admittance matrix with given backshort position has been discussed in detail. It is found that the mixer with fixed backshort mount ahs a impedance matching efficiency about 80% at each port of mixer within 85GHz to 115GHz, which implys a conversion los of mixer would be good enough to be operated such a wide band frequency range. Therefore, the theoretical evaluated results show that our method can be used ot design the mixer mount without any mechanical tuning elements such a backshort or an E-plane tunners for wide band operation.