• Title/Summary/Keyword: asymmetric changes

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Design of MAHA Supercomputing System for Human Genome Analysis (대용량 유전체 분석을 위한 고성능 컴퓨팅 시스템 MAHA)

  • Kim, Young Woo;Kim, Hong-Yeon;Bae, Seungjo;Kim, Hag-Young;Woo, Young-Choon;Park, Soo-Jun;Choi, Wan
    • KIPS Transactions on Software and Data Engineering
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    • v.2 no.2
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    • pp.81-90
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    • 2013
  • During the past decade, many changes and attempts have been tried and are continued developing new technologies in the computing area. The brick wall in computing area, especially power wall, changes computing paradigm from computing hardwares including processor and system architecture to programming environment and application usage. The high performance computing (HPC) area, especially, has been experienced catastrophic changes, and it is now considered as a key to the national competitiveness. In the late 2000's, many leading countries rushed to develop Exascale supercomputing systems, and as a results tens of PetaFLOPS system are prevalent now. In Korea, ICT is well developed and Korea is considered as a one of leading countries in the world, but not for supercomputing area. In this paper, we describe architecture design of MAHA supercomputing system which is aimed to develop 300 TeraFLOPS system for bio-informatics applications like human genome analysis and protein-protein docking. MAHA supercomputing system is consists of four major parts - computing hardware, file system, system software and bio-applications. MAHA supercomputing system is designed to utilize heterogeneous computing accelerators (co-processors like GPGPUs and MICs) to get more performance/$, performance/area, and performance/power. To provide high speed data movement and large capacity, MAHA file system is designed to have asymmetric cluster architecture, and consists of metadata server, data server, and client file system on top of SSD and MAID storage servers. MAHA system softwares are designed to provide user-friendliness and easy-to-use based on integrated system management component - like Bio Workflow management, Integrated Cluster management and Heterogeneous Resource management. MAHA supercomputing system was first installed in Dec., 2011. The theoretical performance of MAHA system was 50 TeraFLOPS and measured performance of 30.3 TeraFLOPS with 32 computing nodes. MAHA system will be upgraded to have 100 TeraFLOPS performance at Jan., 2013.

Debt Issuance and Capacity of Korean Retail Firms (유통 상장기업들의 부채변화에 관한 연구)

  • Lee, Jeong-Hwan;Son, Sam-Ho
    • Journal of Distribution Science
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    • v.13 no.9
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    • pp.47-57
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    • 2015
  • Purpose - The aim of this paper is to investigate the explanatory power of the Pecking-order theory (the cost of financing increases with asymmetric information) among Korean retail firms from the perspective of debt capacity. According to the Pecking-order theory, a firm's first preference is to use internal funds for its capital needs, its next preference is the issuance of debt, and its last preference is the issuance of equity; this is due to the information asymmetry problem between existing shareholders and investors. However, prior empirical studies, such as Lemmon and Zender (2010), argue that the entire sample test for the Pecking-order theory could be misleading due to the different levels of debt issuance capability of each of the individual firms; in fact, they confirm that the explanatory power of the Pecking-order theory improves after taking into account the differences in debt capacity of the U.S. firms they examined. This paper implements a case study approach among Korean retail firms to examine the relationship between debt capacity and the explanatory power of the Pecking-order theory in Korea. Research design, data, and methodology - This study uses the sample of public retail firms on the Korea Composite Stock Price Index (KOSPI) from the time period of 1990 to 2013. We gather related financial and accounting statements from the financial information firm WISEfn. Credit rating information is provided by the Korea Investor Service. We employ the models of Lemmon and Zender (2010) and Son and Kim (2013) to measure a firm's debt capacity. Their logit models use the rating dummy variable as a dependent variable and incorporate other firm characteristics as independent variables to estimate debt capacity. To test the Pecking-order theory, we adopt variants of the financing deficit model of Shyam-Sunder and Myers (1999). In the test of the Pecking-order theory, we consider all of the changes in total debt obligations, current debt obligations, and long-term debt obligations. Results - Our main contribution to the literature is our confirmation of the predicted relationship between debt capacity and the explanatory power of the Pecking-order theory among Korean retail firms. The coefficients on financing deficits become greater as a firm's debt capacity improves. This is consistent with the results of Lemmon and Zender (2010). The coefficients on the square of the financing deficits are also negative for the firms in the largest debt capacity group, which is also consistent with the predictions in prior literature. Conclusions - This study takes a case study approach by examining Korean retail firms. We confirm that the Pecking-order theory explains the capital structure of retail firms more appropriately, after taking into account the debt capacity of each firm. This result suggests the importance of debt capacity consideration in the testing of the Pecking-order theory. Our result also implies that there has been a potential underestimation of the explanatory power of the Pecking-order theory in existing studies.

FACIAL ASYMMETRY OF UNILATERAL CLEFT LIP AND PALATE PATIENTS (편측성 순구개열자의 안면비대칭에 관한 연구)

  • Son, Woo-Sung;Kim, Mi-Kyung
    • The korean journal of orthodontics
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    • v.25 no.1 s.48
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    • pp.13-18
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    • 1995
  • Craniofacial asymmetry was analyzed in 39 patients with complete unilateral cleft lip and palate(UCLP). The samples are devided into three groups nine below 9 years, twenty three from 9 years 1 month to 14 years and seven over 14 years group. Seventeen measurements were obtained from the tracing of PA X-ray cephalometric headfilms to evaluate the asymmetric characteristics and changes accdording to aging in UCLP. The obtained results were as follows. 1. Facial asymmetry in UCLP is variable(1.22-3.47 $mm/^{\circ}$) and the length from midsagitta1 reference line to maxillary 1st molar, to upper central incisor and the length of mandibular ramus showed significant asymmetry 2. Nasal septum and anterior nasal spine were deviated In the cleft side and the lower border of nasal cavity was 1ower in cleft side. 3. The deviation of nasal septum was continued significantly till after 14 years old.

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An Analysis of Near-infrared Light Curves of δ Scuti Variable BO Lyn (δ Scuti형 변광성 BO Lyn의 근적외선 광도곡선 분석)

  • Lim, Ji-Hye;Sohn, Jungjoo
    • Journal of the Korean earth science society
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    • v.37 no.7
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    • pp.389-397
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    • 2016
  • In order to investigate the light curve difference in visual and infrared wavelength of ${\delta}$ Scuti variable Bo Lyn, observations were performed using BOAO 1.8m reflecting telescope and an infrared detector, KASINICS, with J, H, and Ks filters. Infrared light curves of total 7 nights were obtained between March and April in 2011, and those were compared to the V-filter light curve to examine the differences in period, time of maximum light, amplitude, and shape. From the periodic analysis of infrared light curve, a single frequency of $f_1=10.712cycle/day$, $P=0.09335{\pm}0.00002days$ was obtained, and there was no difference in the period along different wavelengths. In the infrared light curve, a frequency of $2f_1$ was detected. This frequency well explains the asymmetric shape of light curve, one of the characteristics of high-amplitude ${\delta}$ Scuti variables. We compared the locations of the measured infrared maxima and the predicted maxima of V-filter, finding that the times of maxima were delayed about 0.3 phase at infrared wavelengths. Amplitude ratios were adopted to be ${\Delta}J/{\Delta}V=0.328$, ${\Delta}H/{\Delta}V=0.216$, and ${\Delta}Ks/{\Delta}V=0.211$, with the range of variation being smaller at longer wavelengths. It seems that the differences in the times of maxima and amplitude occurred because the changes in brightness of a pulsating variable star are mainly caused by the change in temperature.

A Study on Price Asymmetries in Local Petroleum Markets (석유제품의 가격 비대칭성에 관한 연구)

  • Kim, Jin Hyung
    • Environmental and Resource Economics Review
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    • v.16 no.4
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    • pp.833-854
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    • 2007
  • Output prices tend to respond faster to input price increases than to decreases. The 'rockets and feathers' hypothesis of asymmetric price behavior in petroleum market is tested by a full adjustment error correction model. Using monthly data for the period January 1977 to June 2006, evidence is found that there is a significant degree of asymmetry in the adjustment of wholesale prices to increases and to decreases in crude oil price. A similar hypothesis in regard to the exchange rate is also rejected by the data. Using weekly data over the period examined, evidence of asymmetry for gasoline, diesel and heating oil is also found in the transmission of price changes from wholesale to retail: retail prices increase more quickly in response to the wholesale price increases than to wholesale price decreases.

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Study on the Direction of Korea's National Defense Strategy Focused on the Hegemony Strategy of U.S.A. (미국의 패권전략과 한국 군사전략 발전방향)

  • Kim, Sung-Woo
    • Journal of National Security and Military Science
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    • s.8
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    • pp.239-270
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    • 2010
  • This thesis is to make an appropriate national defense policy of Republic of Korea through studying the Hegemony Strategy of United States. I searched the theory of hegemony. The hegemony was differently defined by the point of time and region. The strong power nations with the hegemony have been making efforts to maintain their hegemony everytime. I have conclusion that the presence of hegemony once emerged, it brought regional stability in place whether it is coercive or beneficial. The stability and instability of international order IS not exclusively dependent on hegemony. Even if the safety of hegemony cannot guarantee absolute stability of international order, there IS on doubt that the hegemony has enormous impact on that. According to the hegemonic theory, the history of mankind equals to the history of rising and falling hegemony. The international order was changed as the hegemony changes. The United States has been making efforts to maintain her global hegemony during the post cold-war era as well. Taking all these into consideration, relevant military strategy direction able to pursue national interest is that to make up for the relative weakness in the strategic environment. South Korea have to prepare security policy response as following. First, South Korea should build the military force equipped with advanced weapons in military technology sector and solidify military diplomatic relation able to form cooperative relation in wartime. Second, South Korea should make solid Alliance of Korea and U.S. Third, develop and maintain multilateral security cooperation of East Asia. Forth, we could realize that there are means that can neutralize opponent's strong point by seeking one or two and more asymmetry in the aspect of strategy, tactics, and means through asymmetric strategy. Than the military force of South Korea should develop into a force that is able to overcome to the traditional North Korea's threat and new type of conflicts. And the force should have sufficient strength and be deployed to effectively defend the Korean Peninsula. So, we need to establish a denial and defense system against any hostile neighboring country. Therefore, ROK military forces preparing for the future should try to construct a future military power to gradually establish enough strength for self-defense to prepare for a uncertain security environment and when the Korean Peninsula is unified in a future.

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The Change of Facial Contouring after Unilateral Injection of Botulinum Toxin in Unilateral Masseter Hypertrophy Patients (편측성 교근비대 환자에서 편측 보툴리눔 독소 주사 후 안모의 변화)

  • Cha, Yu-Rim;Kim, Young-Gun;Kim, Ji-Hyun;Shim, Young-Joo;Kim, Seong-Taek
    • Journal of Dental Rehabilitation and Applied Science
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    • v.27 no.2
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    • pp.247-251
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    • 2011
  • Botulinum toxin type A (BoNT-A) is used for treating bilateral masseter hypertrophy since 1994. Recently there have been more clinical studies in this area, with some authors reporting that BoNT-A can reduce the size of the masseter muscle, as documented by photography, ultrasonography, computed tomography, and 3D(three dimensional) laser scan. However, earlier studies were only for bilateral masseter hypertrophy cases, not for unilateral masseter hypertrophy cases. The aim of this study was to use 3D laser scanning to evaluate changes in the external facial contour induced by unilateral BoNT-A injection. BoNT-A was injected into hypertrophic masseter muscle unilaterally in 10 patients with asymmetric masseter hypertrophy. The clinical effects of unilaterally injected BoNT-A were evaluated before the injection and 4, 8, and 12weeks after the injection using 3D laser scan. And the mean values of both sides (injection and non-injection sides) were compared with. At injection side, mean values of the volume and the bulkiest height at each time point diminished significantly between pre-injection and 4, 8, and 12weeks post-injection. At non-injection side, in contrast, mean values of the volume and the bulkiest height diminished also but less than that of injected side, and there was no statistical significance. In this limited study, we concluded that the unilaterally BoNT-A injection side showed greater mean values of the reduction of muscle volume than non-injection side at 4, 8, and 12 weeks after the injection.

The Effect of Lidocaine.HCl on the Fluidity of Native and Model Membrane Lipid Bilayers

  • Park, Jun-Seop;Jung, Tae-Sang;Noh, Yang-Ho;Kim, Woo-Sung;Park, Won-Ick;Kim, Young-Soo;Chung, In-Kyo;Sohn, Uy Dong;Bae, Soo-Kyung;Bae, Moon-Kyoung;Jang, Hye-Ock;Yun, Il
    • The Korean Journal of Physiology and Pharmacology
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    • v.16 no.6
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    • pp.413-422
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    • 2012
  • The purpose of this study is to investigated the mechanism of pharmacological action of local anesthetic and provide the basic information about the development of new effective local anesthetics. Fluorescent probe techniques were used to evaluate the effect of lidocaine HCl on the physical properties (transbilayer asymmetric lateral and rotational mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex, and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Lidocaine HCl increased the bulk lateral and rotational mobility of neuronal and model membrane lipid bilayes, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. Lidocaine HCl increased annular lipid fluidity in SPMV lipid bilayers. It also caused membrane proteins to cluster. The most important finding of this study is that there is far greater increase in annular lipid fluidity than that in lateral and rotational mobilities by lidocaine HCl. Lidocaine HCl alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data suggest that lidocaine, in addition to its direct interaction with proteins, concurrently interacts with membrane lipids, fluidizing the membrane, and thus inducing conformational changes of proteins known to be intimately associated with membrane lipid.

Arm Swing Asymmetry and Effect of Auditory Cues on Amplitude in the Patients with Parkinson's Disease (파킨슨병 환자의 상지 스윙의 비대칭과 청각신호에 따른 보행 시 진폭에 미치는 영향)

  • Son, Ho-Hee;Kim, Eun-Jung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.1
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    • pp.344-350
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    • 2013
  • A recent study reporting significantly reduced symmetry in arm swing amplitude in early Parkinson's disease (PD), as measured during gait by auditory cues velocity, led to this investigation of arm swing symmetry and amplitude in PD. The subjects were 14 elderly patients diagnosed with PD. Patients were measured of three conditions performed in random order: slow, general, fast. The auditory cue velocity consisted of a metronome beat ${\pm}20%$ than the subject's general gait speed. Using a motion analysis measurement system, changes in kinematic variables were compared to arm swing analysis. PD groups showed a highly significant reduction of the arm swing amplitude on the more affected body side(MAS)(p<.05). Comparison between the auditory cues velocity, there was a significant increase arm swing amplitude in fast velocity gait than slow and general velocity gait(p<.05). We conclude that motion analysis during gait by auditory cues velocity allows reliable investigation of asymmetric arm movements in early PD patients which attenuate with ongoing disease. The measurement of limb kinematics during gait by auditory cues velocity can broaden our methodological line-up for the analysis of complex motor programs in movement disorders.

A Comparative Study of Contents on Children's Rights between South and North Korea through the UN Convention on the Rights of the Child (유엔아동권리협약 국가보고서를 통해 본 남북한 아동권리 내용 비교)

  • Kim, Seok Hyang;Chung, Ick Joong;Kim, Mi Ju;Oh, Eun Chan
    • Journal of the Korean Society of Child Welfare
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    • no.54
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    • pp.1-44
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    • 2016
  • Using the United Nations Convention on the Rights of the Child(UNCRC) as a frame of reference, this study examined South and North Korean children's rights as reported in the UNCRC and the pattern of changes in the reports depending on the period in which the reports were written. For this purpose, we reviewed Article 1 of the Convention to see what age range the South and North Korean governments, respectively, specify to define a child. We also analyzed the method and attitude of how each Korean government acknowledges the rights of children in the four general principles of the Convention("non-discrimination", "the best interests of the child", "the right to life, survival, and development" and "respect for the views of the child"). The results showed that there was asymmetric content between South and North Korea in the four general principles of the Convention. Both South and North Korea lack a sense of respect for the views of children. There were also differences in the rights of children depending on the distinct characteristics of each Korea. In South Korea, it is important to guarantee the rights of multicultural children and provide a plan for child safety. On the other hand, North Korea has emphasized that they provide the necessities of life and free education to children. Both Koreas have continuously submitted their reports and showed improvement in understanding the rights of children in each report. We conclude that it is essential for South and North Korea to build common ground in their respective contents on children and to establish a foundation of normative standards in the path to prepare for reunification. Moreover, we also conclude that South and North Korea should work collaboratively to reach mutual consent to achieve these goals.