• Journal of Periodontal and Implant Science
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• v.42 no.5
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• pp.151-157
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• 2012

Purpose: Cyclooxygenase (COX) enzyme catalyzes the production of prostaglandins, which are important mediators of tissue destruction in periodontitis. Single nucleotide polymorphisms of $COX_2$ enzyme have been associated with increasing susceptibility to inflammatory diseases. The present study evaluates the association of two single nucleotide polymorphisms in $COX_2$ gene (-1195G>A and $8_{473}$C>T) with chronic periodontitis in North Indians. Methods: Both SNPs and their haplotypes were used to explore the associations between $COX_2$ polymorphisms and chronic periodontitis in 56 patients and 60 controls. Genotyping was done by polymerase chain reaction followed by restriction fragment length polymorphism. Chi-square test and logistic regression analysis were performed for association analysis. Results: By the individual genotype analysis, mutant genotypes (GA and AA) of $COX_2$-1195 showed more than a two fold risk (odds ratio [OR]>2) and $COX_2$ $8_{473}$ (TC and CC) showed a reduced risk for the disease, but the findings were not statistically significant. Haplotype analysis showed that the frequency of the haplotype AT was higher in the case group and a significant association was found for haplotype AT (OR, 1.79; 95% confidence interval, 1.03 to 3.11; P=0.0370) indicating an association between the AT haplotype of $COX_2$ gene SNPs and chronic periodontitis. Conclusions: Individual genotypes of both the SNPs were not associated while haplotype AT was found to be associated with chronic periodontitis in North Indians.

• English & American cultural studies
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• v.14 no.1
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• pp.73-94
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• 2014

Accounts from therapeutic culture seem often to associate the selfish, or at least self-centered quest for self-fulfillment with individual choice or satisfaction, self-expression, expressive individualism, and emotionalism. These associations point to the downside of therapy as they present it as constituting a culture of narcissism, selfishness, or irresponsibility. While some of these characterizations contain useful insights, they overlook what are maybe some of the most important features of a therapeutic outlook. This paper aims to reveal that the therapeutic imperative is not so much geared towards the realization of self-fulfillment, as it is the promotion of self-limitation. Therapeutic culture tends to posit the self in a fragile and feeble form and insist that the management of life requires the continuous intervention of therapeutic expertise. Because of this, the elevated concern with the self is underpinned by anxiety, pain, suffering, and survival, rather than seen as a positive vision of realizing the human potential. Therapeutic culture has in this way helped to construct a diminished sense of self by which one is seen as suffering from an emotional deficit and vulnerability. This paper demonstrates this downside of therapeutic culture concerning self-limitation and the sense of a diminished self by examining popular "misery memoirs." Misery memoirs are widely consumed by the general public, therefore tend to be treated by contemporary therapeutic culture as a gospel on the therapeutic ideal for self-fulfillment and self-discovery. This is, despite the existence of hidden evidence to the contrary, because of their redemptive, happy endings that show individuals overcoming difficult trials such as child abuse, incestuous rape, and domestic violence. Individual self-fulfillment and self-discovery in such stories are not achieved through the active agency of the subject but through the passive endurance of pathological symptoms and with the aid of expertise and outside support. Therefore, such stories put victims in the limited position.

• Journal of The Korean Astronomical Society
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• v.38 no.2
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• pp.241-244
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• 2005

We have analysed near-infrared JHKL observations of the members of the $\approx$9 Myr-old $\eta$ Chamaeleontis cluster. Using (J - H)/(K - L) and (H - K)/(K - L) IR colour-colour diagrams for the brightest 15 members of the cluster, we find the fraction of stellar systems with near-IR excess emission was 0.60 $\pm$ 0.13 (2$\sigma$). For the CTT and WTT star population, we also find a strong correlation between the IR excess and Ha emission which is also known as an accretion indicator. The (K - L) excess of these stars appears to indicate a wide range of star-disk activity; from a CTT star with high levels of accretion, to CTT - WTT transitional objects with evidence for some on-going accretion, and WTT stars with weak or absent IR excesses. Among the brightest 15 members, four stars (RECX 5, 9, 11 and ECHA J0843.3-7905) with IR excesses ${\Delta}$(K - L) > 0.4 mag and strong or variable optical emission were identified as likely experiencing on-going mass accretion from their circumstellar disks which we confirmed their accretion disks from the optical high-resolution echelle spectroscopic study. The result-ing accretion fraction of 0.27 $\pm$ 0.13 (2$\sigma$) suggests that the accretion phase, in addition to the disks themselves, can endure for at least ${\~}$10 Myr.

• Genomics & Informatics
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• v.2 no.3
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• pp.131-133
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• 2004

MediScore is an information retrieval system, which helps to search for the set of genes associated with a specific disease or the set of diseases associated with a specific gene. Despite recent improvement of natural language processing (NLP) and other text mining approaches to search for disease associated genes, many false positive results come out due to diversity of exceptional cases as well as ambiguities in gene names. In order to overcome the weak points of current text mining approaches, MediScore introduces statistical normalization based on binomial to normal distribution approximation which corrects inaccurate scores caused by common words not representing genes and interactive rescoring by the user to remove the false positive results. Interactive rescoring includes individual alias scoring for each gene to remove false gene synonyms, referring MEDLINE abstracts, and cross referencing between OMIM and other related information.

• Journal of The Korean Astronomical Society
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• v.44 no.2
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• pp.39-48
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• 2011

UBV I CCD photometry of NGC 2353 is performed as a part of the "Sejong Open cluster Survey" (SOS). Using photometric membership criteria we select probable members of the cluster. We derive the reddening and distance to the cluster, i.e., E(B - V ) = 0.10 ${\pm}$ 0.02 mag and 1.17 ${\pm}$ 0.04 kpc, respectively. We find that the projected distribution of the probable members on the sky is elliptical in shape rather than circular. The age of the cluster is estimated to be log(age)=8.1 ${\pm}$ 0.1 in years, older than what was found in previous studies. The minimum value of binary fraction is estimated to be about 48 ${\pm}$ 5 percent from a Gaussian function fit to the distribution of the distance moduli of the photometric members. Finally, we also obtain the luminosity function and the initial mass function (IMF) of the probable cluster members. The slope of the IMF is ${\Gamma}=-1.3{\pm}0.2$.

• Journal of Families and Better Life
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• v.11 no.1
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• pp.134-148
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• 1993

The study was designed to examine the present state of the provider-role consciousness of married working women in Korea and to identify five variable-clusters which were drawn from the theoretical perspectives. The subjects of this study were 573 married working women whose husbands also had their work. The statistical methods adopted for data analyses were frequencies. oneway ANOVA. Scheffe-test t-test, and multiple regression analysis. The major findings of this study can be summarized as follows; 1) The level of the provider-role consciousness of married working women was slightly high. 2) As for the aspects of the individual attribute variables. educational level job income age native area motive of work. and sex-role identity significantly influenced the provider-role consciousness of married working women. 3) Concerning the family background variables marriage duration number of children mother's experience of employment father's educational level and husbands's income were significantly related to the provider-role consciousness of married working women, 4) As for the social relationship variables. degree of participation in social associations significant others' attitudes toward housewife's work degree of domestic role sharing with husband and wife/husband income ration significantly affected the provider-role conscious-ness of married working women. Based on these findings it came to be revealed that multidirectional perspecitves were useful to identify variables which could predict the provider-role consciousness of married working women, Also it was revealed that the significant others' approvals for women's work were necessary to the establishment of the provider-role consciousness of married working women.

• Journal of The Korean Astronomical Society
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• v.41 no.6
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• pp.147-155
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• 2008

We present UBV I photometry of the old open cluster NGC 1193. Color-magnitude diagrams (CMDs) of this cluster show a well defined main sequence and a sparse red giant branch. For the inner region of r < 50", three blue straggler candidates are newly found in addition to the objects Kaluzny (1988) already found. The color-color diagrams show that the reddening value toward NGC 1193 is E(B - V ) = $0.19{\pm}0.04$. From the ultraviolet excess measurement, we derived the metallicity to be [Fe/H]= $-0.45{\pm}0.12$. A distance modulus of ${(m\;-\;M)}_0$ = $13.3{\pm}0.15$ is obtained from zero age main sequence fitting with the empirically calibrated Hyades isochrone of Pinsonneault et al. (2004). CMD comparison with the Padova isochrones by Bertelli et al. (1994) gives an age of log t = $9.7{\pm}0.1$.

• International Journal of Human Ecology
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• v.13 no.1
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• pp.39-56
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• 2012

This study aims at exploring Korean mothers' beliefs on the development of emotion of their children. In specific, sensitivity and maternal reactions to their children's both negative and positive emotion expressions were explored. Further, associations among maternal sensitivity, maternal reactions and child emotion regulation were examined. A total of 100 Korean mothers whose children were between 6 and 7 years old participated in the study. In order to assess mothers' beliefs about sensitivity, vignettes in a forced-choice format were presented through individual interviews. Mothers' self reported reactions to their children's negative emotions and positive emotions and mothers' perceptions of children's emotion regulation were assessed using questionnaires. Results revealed that Korean mothers endorsed both proactive and reactive sensitivity. However, their sensitivity differed depending on the situation. Mothers tended to endorse either Emotion Focused or Problem Focused reactions to their children's negative emotions. Mothers reported that they were most likely to restrict their child positive emotional expression with explanation in supportive way followed by invalidating through reprimanding it. Mothers' reported Distress Reactions and Punitive Reactions to children's expression of negative emotion were associated with children's liability whereas Emotion-Focused Reaction and Problem-Focused Reaction were associated with children's functional emotion regulation. The results are discussed within a theoretical framework of socialization of emotions.

• Journal of The Korean Astronomical Society
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• v.42 no.6
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• pp.135-144
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• 2009

We present JHK near-infrared photometric study for the old open cluster (OC) Trumpler 5 (Tr 5), based on the 2MASS data. From the color-magnitude diagrams of Tr 5, we have located the position of the red giant clump (RGC) stars, and used the mean magnitude of the RGC stars in K-band to estimate the distance to Tr 5, d = $3.1{\pm}0.1$ kpc ($(m-M)_0$ = $12.46{\pm}0.04$). From fitting the theoretical isochrones of Padova group, we have estimated the reddening, metallicity, and age : E(B-V) = $0.64{\pm}0:05$, [Fe/H] = $-0.4{\pm}0.1$ dex, and t = $2.8{\pm}0.2$ Gyr (log t = $9.45{\pm}0.04$), respectively. These parameters generally agree well with those obtained from the previous studies on Tr 5 and confirms that this cluster is an old OC with metallicity being metal-poorer than solar abundance, located in the anti-Galactic center region.

• Safety and Health at Work
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• v.8 no.2
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• pp.206-211
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• 2017

Background: Self-reported low back pain (LBP) has been evaluated in relation to material handling lifting tasks, but little research has focused on relating quantifiable stressors to LBP at the individual level. The National Institute for Occupational Safety and Health (NIOSH) Composite Lifting Index (CLI) has been used to quantify stressors for lifting tasks. A chemical exposure can be readily used as an exposure metric or stressor for chemical risk assessment (RA). Defining and quantifying lifting nonchemical stressors and related adverse responses is more difficult. Stressor-response models appropriate for CLI and LBP associations do not easily fit in common chemical RA modeling techniques (e.g., Benchmark Dose methods), so different approaches were tried. Methods: This work used prospective data from 138 manufacturing workers to consider the linkage of the occupational stressor of material lifting to LBP. The final model used a Bayesian random threshold approach to estimate the probability of an increase in LBP as a threshold step function. Results: Using maximal and mean CLI values, a significant increase in the probability of LBP for values above 1.5 was found. Conclusion: A risk of LBP associated with CLI values > 1.5 existed in this worker population. The relevance for other populations requires further study.