• Biomedical Science Letters
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• v.13 no.3
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• pp.213-221
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• 2007

This study was designed to investigate the correlation between the expression rate of p53 and p21 proteins, c-erbB-2 oncoprotein and $TGF-{\beta}1$ and tumor prognostic factors in colon cancer including the tumor size, histological differentiation and Dukes' stage. The expression rate of p53 protein was 11.4% (4 cases) at well differentiation, 48.6% (17 cases) at moderately differentiation, and 17.1% (6 cases) at poorly differentiation. In other words, the poorer differentiation, the higher the expression rate of p53 protein (P<0.05). The expression rate of p21 protein was 17.1% (6 cases) at well differentiation, 40.0% (14 cases) at moderately differentiation, and 8.6% (3 cases) at poorly differentiation, indicating that, as the histological malignant degeneration progressed, the expression rate of p21 protein decreased distinctively (P<0.05). However, the correlation of the above mentioned proteins with tumor size and Dukes' stage was not recognized. The expression rate of c-cerbB-2 oncoprotein was 11.4% (4 cases) at well differentiation, 54.3% (19 cases) at moderately differentiation, and 17.1% (6 cases) at poorly differentiation, indicating that the poorer differentiation, the higher expression rate of c-erbB-2 oncoprotein (P<0.05). The expression rate of $TGF-{\beta}1$ was 17.1% (6 cases) at well differentiation, 48.6% (17 cases) at moderately differentiation, and 11.4% (4 cases) at poorly differentiation. As Dukes' stage progressed, the expression rate of $TGF-{\beta}1$ was 8.6% (3 cases) in stage A, 20.0% (7 cases) in stage B, 37.1 % (13 cases) in stage C, and 11.4% (4 cases) in stage D. There was a difference in expression rates between Dukes' stages (P<0.05). In 10 cases, p53 protein was positive while p21 protein was negative, and in 6 cases, p53 protein was negative whereas p21 was positive (P<0.05). Therefore, a statistically significant inverse correlation between the expression rate of p53 protein and that of p21 protein was observed. In conclusion, since there was a signigicant correlation between histological differentiation of colon cancer and the expressions of p53 and p21 proteins and c-erbB-2 oncoprotein, and between Dukes' stage and the expression of $TGF-{\beta}1$, it was conformed that the overexpression of p53 and p21 proteins, c-erbB-2 oncoprotein, and $TGF-{\beta}1$ is closely associated with the occurrence of colon cancer and its progress. Accordingly, this study may be greatly beneficial to the presumption of diagnosis, treatment and prognosis of colon cancer patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.153-162
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• 2017

Weapon systems have been developed with high technology electronic equipment due to technology growth. In addition, the capital, operational and maintenance costs of weapon systems have all increased. However, cost of operation and maintenance for weapon systems has been decreased relatively compared to the increased capital cost of weapon systems. Therefore, the defense industry needs to research the life cycle cost of weapon systems that have high operational and maintenance costs. This paper focuses on maintenance equipment for the operation and maintenance of weapon systems. Recently, it seems that the weapon systems that have periodic calibration with maintenance equipment are valid. The equipment requires periodic calibration by the manufacturer to check its own validation. Basically, customers demand high reliability devices from foreign companies that have qualified in the global market. Therefore, the tools need to be calibrated overseas. In other words, weapon systems are not available when the equipment has to be calibrated overseas because the systems require validation with valid maintenance equipment. A purpose of this paper is to compare the loss costs that arise from the calibration of the equipment overseas and the purchasing cost of the tools. Finally, the research shows the number of equipment that customers need to minimize the cost. This research will help to improve the efficiency of operation of weapon systems and solve the problems associated with the need for maintenance overseas.

• Korean Journal of Cognitive Science
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• v.4 no.1
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• pp.213-242
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• 1993

During the past decades,several automatic indexing systems have been developed such as single term indexing.phrase indexing and thesaurus basedidndexing systems.Among these systems,single term indexing has been known as superior to others despte its simpicity of extracting meaningful terms.On the other hand,thesaurus based one has been conceived as producing low retrival rate ,mainly because thesauri do not usually have enough index terms.so that much of text data fail to be indexed if they do not match with any of index terms in thesauri.This paper develops a thesaurus based indexing system THINS that yields higher retrieval rate than other systems.by doing syntactic analysis of text data and matching them with index terms in thesauri partially.First,the system analyzes the input text syntactically by using the machine translation suystem MATES/EK and extracts noun phrases.After deleting stop words from noun phrases and stemming the remaining ones.it tries to index these with similar index terms in the thesaurus as much as possible. We conduct an experiment with CACM data set that measures the retrieval effectiveness with CACM data set that measures the retrieval effectuvenss of THINS with single term based one under HYKIS-a thesaurus based information retrieval system.It turns out that THINS yields about 10 percent higher precision than single term based one.while shows 8to9 percent lower recall.This retrieval rate shows that THINS improves much better than privious ones that only yields 25 or 30 percent lower precision than single term based one.We also argue that the relatively lower recall is cause by that CRCS-the thesaurus included in CACM datea set is very incomplete one,having only more than one thousand terms,thus THINS is expected to produce much higher rate if it is associated with currently available large thesaurus.

• The Journal of the Acoustical Society of Korea
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• v.35 no.1
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• pp.74-82
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• 2016

In this paper, a new automatic speech recognition (ASR) was proposed where ultrasonic doppler signals were used, instead of conventional speech signals. The proposed method has the advantages over the conventional speech/non-speech-based ASR including robustness against acoustic noises and user comfortability associated with usage of the non-contact sensor. In the method proposed herein, 40 kHz ultrasonic signal was radiated toward to the mouth and the reflected ultrasonic signals were then received. Frequency shift caused by the doppler effects was used to implement ASR. The proposed method employed multi-channel ultrasonic signals acquired from the various locations, which is different from the previous method where single channel ultrasonic signal was employed. The PCA(Principal Component Analysis) coefficients were used as the features of ASR in which hidden markov model (HMM) with left-right model was adopted. To verify the feasibility of the proposed ASR, the speech recognition experiment was carried out the 60 Korean isolated words obtained from the six speakers. Moreover, the experiment results showed that the overall word recognition rates were comparable with the conventional speech-based ASR methods and the performance of the proposed method was superior to the conventional signal channel ASR method. Especially, the average recognition rate of 90 % was maintained under the noise environments.

• Journal of Distribution Science
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• v.14 no.6
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• pp.65-73
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• 2016

Purpose - Recently, the management conditions of small independent retailers are getting worse everyday as large-scale marts and franchised convenience stores are increasing. The objective of this research is to find out the antecedents and consequences of cooperation in voluntary chain in order to enhance small independent retailer's competitiveness. Voluntary chains, also called affiliation or symbol groups, or allied group represent a high market shared in some European countries like Italy, France, and Germany. Nevertheless, there are still limitations in this research from academic fields. Drawing from network theory, the author investigates the relationship between antecedent factors in voluntary chain cooperation, such as participation benefits, justice of compensation, and autonomy in voluntary chain, and relationship specific asset. The author also attempts to examine the relationship between the relationship specific asset and cooperation of voluntary chain member shop and cooperation and consequence factors of voluntary chain cooperation, such as efficiency, group cohesiveness, and long-term relationship. Research design, data, and methodology - The author presented conceptual framework integrating the major antecedents and consequences of voluntary chain cooperation. The data were collected from 174 independent small retailers who joined K-voluntary chain. K-voluntary chain consists of small independent retailers. In accordance with their status, each entrepreneur associated with the voluntary group can own one or more outlets and can be a part of the life and the decision-making process of the group. This participation is not based on company turnover or on the number of outlets, but based on a one member, one vote system. To verify the research model and test hypotheses, the author carefully investigated the reliability, content validity, convergent validity, and discriminant validity of the proposed model. The data were analyzed by using SPSS 18.0 and AMOS structural equation modeling program. Results - The results of this study are as follows. First, as antecedent variables, participation benefits and justice of compensation have positive effect on the relationship specific assets of voluntary chain members. Second, voluntary chain members' relationship specific asset also directly related to the level of its cooperation to chain headquarter. Third, cooperation of voluntary chain member shop facilitates efficiency, group cohesiveness, and long-term relationship. Unexpectedly, there are no effect autonomy in voluntary chain to relationship specific asset. Conclusions - This research shows several theoretical and practical implications to both marketing scholars and marketers. In terms of theoretical implications, this study applies to network theory and network theory variables to explain the antecedent and consequence factors of cooperation in voluntary chain. From the point of view from business management, most of all, this study shows the way how to reinforce competitiveness of voluntary chain. Specifically, it is necessary for voluntary chain headquarter to give higher level of participation benefit and justice of compensation to its members. Second, the results also indicate what the consequence factors of cooperation in voluntary chain. In other words, to increase the level of marketing efficiency, group cohesiveness, long-term orientation in retail voluntary chain, and chain headquarter need to facilitate participants' cooperation.

• Journal of the Korean Geographical Society
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• v.46 no.4
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• pp.501-517
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• 2011

This research investigates a geographical issue as to which factor discovered in the only Japanese telemedicine with regard to social and medical circumstances performs a role as a determinant in regionalization, especially, local areas in Japan. According to the results, strong human networks based on regionalism are mirrored in regionalization and are associated with not only the development and management of telemedicine operations, but also the choice of telemedicine users concretely. In other words, all processes from the suggestion stage of telemedicine to the practical usage or application stage of telemedicine are involved in the existing human networks within one prefecture (the third diagnostic area); further, personal stakes are transferred to public health care services (telemedicine) and their relationships have been formulated by the telemedicine council including local government, medical association, region-rooted companies, core health centers and universities, etc. Accordingly, the telemedicine council responses to the need of telemedicine users immediately and contributes to develop regional health care. Also, telemedicine users have been connected with each other closely before operating telemedicine; accordingly, the human relationships between doctors and patients or among doctors influence the choice of telemedicine serving sites and their behaviors comes down to regional-based diagnosis via the telemedicine system.

• Journal of Labour Economics
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• v.24 no.1
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• pp.97-124
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• 2001

Co-residence is a type of intergenerational private transfers of resources: money, time and space. Adult daughters and their elderly parents decide to co-reside, depending on their utility levels before and after co-residence that mainly depend on the health status of the elderly. Therefore, co-residence implies positive net benefits to both parties in the sense that, when they co-reside, elderly parents share childcare and adult daughter provide elderly care. In other words, formal (paid) care can be substituted with informal (unpaid) one. Both marriage and giving births are considered as the major obstacles to labor market attachment of women who bear burdens of home production and childcare. Co-residence can be a solution for married women to avoid career interruption by sharing burdens with their elderly parents. However, most previous studies using the U.S. data on intergenerational private transfers focused on elderly care and have concluded that they reduce government expenditures associated with public subsidies to the elderly. This study focuses on adult daughters and it examines effects of co-residence on labor supply of married women in Korea, who face limited formal childcare programs in terms of both quantity and quality. It applies the Tobit model of married women's labor supply to the data from the Second Wave of the Korean Labor and Income Panel Survey( 1999), in order to investigate effects of co-residence and the work and health status of the co-residing elderly as well as their own health status. Four specifications of the empirical model are tested that each includes co-residence with elderly parents, their gender, or their work and health status. Estimation results show that co-residence, co-residence with female elderly, and co-residence with not-working female elderly have significant positive effects on labor supply of married women while poor health status of co-residing female elderly does not bring about any negative effects. However, co-residence with male elderly, regardless of their work and health status, has no significant effect The results indicate that co-residence is closely related to sharing of home production among female elderly and adult daughters who are married and, through intergenerational private transfers of resources in terms of time, it helps women avoid career interruption.

• Science of Emotion and Sensibility
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• v.10 no.3
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• pp.463-470
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• 2007

There have been many studies on patients who suffer from anxiety disorders. However, there is been not enough attention on the difference in the level of between the two populations with and without anxiety disorders. This study was performed to investigate the difference in the ANS responses induced by fear in children. Experimental procedures were as follow: All subjects were in upper grade levels in elementary school. ANX(anxiety) scales of PIC(Personality Inventory for Children) were used to measure fear anxiety. Audio-visual clips were used as stimulus to provoke fear emotion. Baseline of physiological signals, ECG, PPG, EDA, and SKT, were measured for 30 seconds before the fear stimulus. Physiological signals were then recorded for 2 minutes while fear is evoked. Psychological and physiological responses were analyzed. All the children reacted to the fear stimulus with high intensity of fear. Physiological responses showed that SKT, SCR, NSCR, HR, RSA, RESP, HF were increased, while R-R was significantly decreased, respectively, during the period of fear induction. Analysis of the level of anxiety and the physiological responses produced by the experience of fear revealed a statistically significant positive correlation in SKT, HR, and RSA. In other words, the higher the level of anxiety, the higher the levels of SKT, HR, and RSA when children experienced fear in conclusion, it is confirmed through this research that physiological responses to fear is associated with the level of anxiety each individual.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.2
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• pp.128-135
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• 2007

This study was designed to investigate the correlation between the expression rate of p53 and p21 proteins by immunohistochemical staining and tumor prognostic factors including the tumor size, histological differentiation and Dukes' stage of tumor prognostic factors in colon cancer, and to acquire necessary data for the presumption of diagnosis, treatment and prognosis of colon cancer patients. From January 2000 to January 2003 at Hanyang University Guri Hospital, the paraffin blocks of 35 patients diagnosed with colon cancer whose pathologic reports were possible to review were selected. Harris hematoxylin & eosin (H&E) staining and immunohistochemical staining by ABC (Avidin Biotin Conjugate) method were performed. The histological differentiation grade and stage were classified according to the classification of the World Health Organization (WHO) and modified Dukes's stage from H&E staining. The expression rate of p53 and p21 proteins were analyzed by immunohistochemical staining. The results was analyzed statistically by SPSS (Windows version 8.0). As a result, the expression rate of p53 protein was 11.4% (4 cases) in clear differentiation, 48.6% (17 cases) in moderate differentiation, and 17.1% (6 cases) in poor differentiation. In other words, the poorer the differentiation, the higher the expression rate of p53 protein (p<0.05). The expression rate of p21 was 17.1% (6 cases) in clear differentiation, 40.0%(14 cases) in moderate differentiation, and 8.6% (3 cases) in poor differentiation, According to the progression of histological malignant degeneration, the expression rate of p21 protein decreased distinctively (p<0.05). However, the correlation between the two above mentioned proteins and the tumor-size and Dukes' stage was not of statistical significance. In the comparison of the expression rate of p53 protein with that of p21 protein, in 10 cases, p53 protein expression was positive while p21 protein expression was negative, and in 6 cases, p53 protein expression was negative whereas p21 protein expression was positive. Consequently a statistically significant inverse correlation between the expression rate of p53 protein and that of p21 protein was observed (p<0.05). In conclusion, we found a significant correlation between histological differentiation and the expression rate of p53 and p21 proteins (p<0.05), and a significant inverse correlation between the expression rate of p53 protein and that of p21 protein (p<0.05). Also, it could be confirmed that the over expression of p53 and p21 proteins is closely associated with the occurrence of colon cancer and its progress. Therefore, it is thought that this study may be greatly beneficial to the presumption of diagnosis, treatment and prognosis of colon cancer patients.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.52 no.3
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• pp.241-247
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• 2016

The trawl fishery is an important fishery accounting for around 30.0% of adjacent water fishery production in Korea, and the commercial fishing is associated with high rate of fatal and non-fatal occupational injury. The hazard analysis for the fishermen's safety of offshore trawler was conducted to serve as basic data for improving the healthy and safe working environment of fishermen using fishermen's occupational accidents of the national federation of fisheries cooperatives (NFFC) from 2012 to 2014 (n=464). As a result, the occupational accident occurrence rate of large powered trawl fishery was 241.4‰ in east sea trawl fishery, 6.9 times the rate of that. In addition, death and missing rate was found to have very serious level management to 97.7‱ in east sea trawl fishery of death at 6.2 times. The accident occurred in 91.7 to 100.0% was happened at sea. The slipping, others and struck by object and son on occurred more frequently in order in the frequency of accident occurrence pattern. However, the occurrence rate of death and missing did not match the frequency of accident pattern. In other words, slipping occurred more frequently while death and missing risk was not high. The fall in the waters was low while death and missing risk was high. The results are expected to help identify and assess safety hazard occurred in offshore trawlers.