• BMB Reports
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• v.40 no.1
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• pp.15-21
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• 2007

Breast cancer is the most common malignancy among women, and mutations in the BRCA1 gene produce increased susceptibility to these malignancies in certain families. In this study, the forward 1-13 exons of breast cancer associated gene BRCA1 were cloned from breast cancer cell line ZR-75-30 by RT-PCR method. Sequence analysis showed that nine BRCA1 splice forms were isolated and characterized, compared with wild-type BRCA1 gene, five splice forms of which were novel. These splice isoforms were produced from the molecular mechanism of 5' and 3' alternative splicing. All these splice forms deleting exon 11b and the locations of alternative splicing were focused on two parts:one was exons 2 and 3, and the other was exons 9 and 10. These splice forms accorded with GT-AG rule. Most these BRCA1 splice variants still kept the original reading frame. Western blot analysis indicated that some BRCA1 splice variants were expressed in ZR-75-30 cell line at the protein level. In addition, we confirmed the presence of these new transcripts of BRCA1 gene in MDA-MB-435S, K562, Hela, HLA, HIC, H9, Jurkat and human fetus samples by RT-PCR analysis. These results suggested that breast cancer associated gene BRCA1 may have unexpectedly a large number of splice variants. We hypothesized that alternative splicing of BRCA1 possibly plays a major role in the tumorigenesis of breast and/or ovarian cancer. Thus, the identification of cancer-specific splice forms will provide a novel source for the discovery of diagnostic or prognostic biomarkers and tumor antigens suitable as targets for therapeutic intervention.

• Journal of the Korean Mathematical Society
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• v.33 no.4
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• pp.823-855
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• 1996

We study Dirichlet forms and the associated diffusion processes for the Gibbs measures related to the quantum unbounded spin systems (lattice boson systems) interacting via superstable and regular potentials. This work is a continuation of the author's previous study on the classical systems [LPY] to the quantum cases. In [LPY], we constructed Dirichlet forms and the associated diffusion processes for the Gibbs measures of classical unbounded spin systems. Furthermore, we also showed the essential self-adjointness of the Dirichlet operator and the log-Sobolev inequality for any Gibbs measure under appropriate conditions on the potentials. In this atudy we try to extend the results of the classical systems to the quantum cases. Because of some technical difficulties, we are only able to construct a Dirichlet form and the associated diffusion process for any Gibbs measure of the quantum systems. We utilize the general scheme of the previous work on the theory in infinite dimensional spaces [AH-K1-2, AKR, AR1-2, Kus, MR, Ro, Sch] and the ideas we employed in our study of the calssical systems ]LPY].

• Journal of the Chungcheong Mathematical Society
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• v.8 no.1
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• pp.119-130
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• 1995

I study the extension of the definition of the analytic operator-valued Feynman integral to potentials given by a class of signed measures described in terms of additive functionals associated with regular Dirichlet forms.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• v.2 no.1
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• pp.69-78
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• 1998

Contents of heavy metals (Cr, Cu, Zn, Cd, and Pb) in the sediments of Ulsan Bay were investigated by the sequential extraction methods that classifies heavy metals into five types of chemical forms: exchangeable, bound to carbonates, bound to Fe-Mn oxides, bound to organic matter and residual. The analytes were determined by using an ICP-MS. Total Cr concentrations in the sediments were in the range of 41.6-96.4, Cu 60.7-680, Zn 189-1954, Cd 33.1-83.4, and Pb 138-567 mg/kg. Results of sequential fractionation indicates that relatively high proportion $(\~44\%)$ of Cu is associated with organic matter A large proportion of Pb is associated with three types of chemical forms: Fe-Mn oxides, organic matter, and residual. There were significant correlation in concentrations between the exchangeable components and total organic carbons. The heavy metals in the residual phase cannot be easily released to the environment since these are bound to the crystal lattice. But, reducible and organic Phases cfn a significant amount of most heavy metals. Therefore. there is potential danger of a substantial amount of metals becoming chemically mobile with environmental changes.

• Journal of Environmental Science International
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• v.2 no.1
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• pp.69-78
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• 1993

Contents of heavy metals (Cr, Cu, Zn, Cd, and Pb) in the sediments of Ulsan Bay were investigated by the sequential extraction methods that classifies heavy metals into five types of chemical forms: exchangeable, bound to carbonates, bound to Fe-Mn oxides, bound to organic matter and residual. The analyses were determined by using an ICP-MS. Total Cr concentrations in the sediments were in the range of 41.6-96.4, Cu 60.7-680, Zn 189-1954, Cd 33.1-83.4, and Pb 138-567 mg/kg. Results of sequential fractionation indicates that relatively high proportion ( ~44%) of Cu is associated with organic matter. A large proportion of Pb is associated with three types of chemical forms: Fe-Mn oxides, organic matter, and residual. There were significant correlation in concentrations between the exchangeable components and total organic carbons. The heavy metals In the residual phase cannot be easily released to the environment since these are bound to the crystal lattice. But, reducible and organic Phases con a significant amount of most heavy metals. Therefore, there is Potential dancer of a substantial amount of metals becoming chemically mobile with environmental changes.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.63.2-63.2
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• 2015

Solar flare is one of the energetic phenomena observed on the Sun, and it is often accompanied with eruptions such as global-scale eruption of a flux rope (filament/prominence eruption) and small-scale eruption of a plasmoid. A flare itself is a dissipative phenomenon where accumulated electric current representing free magnetic energy is dissipated quickly at a special location called a current sheet formed in a generally highly conductive solar corona. Previous studies have demonstrated how a solar magnetic field placed on the Sun forms a current sheet when magnetic shear is added to the field. Our study is focused on a self-consistent process of how a subsurface magnetic field emerges into the solar atmosphere and forms a current sheet in the corona. This study also gives light to a relation among a flare and two types of flare-associated eruptions; flux-rope eruption and plasmoid eruption.

• Honam Mathematical Journal
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• v.35 no.1
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• pp.73-82
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• 2013

There are some identities between the representations of Hecke operators defined on a subspace of modular forms associated with orders of a Quaternion algebra. In this paper, we find the identities between the zeta functions attached to these representations.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.10
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• pp.1638-1641
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• 2005

In order to develop novel food products or additives using transglutaminase (TGase), some physicochemical and morphological understandings are needed. Raw skim milk was adjusted to pH 5.5, 7.0, and 8.5, and each was treated with microbial TGase for 0, 1, 2, 4, and 8 hours, for the protein structure observation using scanning electron microscope (SEM), The particles of untreated raw skim milk were small and evenly associated. After adjustment of pH to 5.5 and treatment of TGase for 1-hour, the protein particles aggregated widely in a bigger form than that of control. Under the same condition for 2 hours, the particles associated and clustered. The particles gathered widely and became a number of small spherical forms after 4 hours. After 8 hours, they made larger forms than the result of 1-hour treatment, and the aggregation broadened. Under the pH 7.0 and 8.5 conditions with TGase-treatment, the protein Particles fractionated and associated into the bigger masses at 1 hour point, but each piece slowly became smaller and more fractionated until treated time reached 4 hours. After 8 hours, the fragmented protein particles aggregated into larger forms as those on the pH 5.5 condition. In general, the electron microscopical forms of the samples adjusted to pH 5.5 showed smaller than those of pH 7.0 or pH 8.5, It is suggested that the protein particles and textural behavior were influenced by pH, TGase, and reaction time.

• 한국신재생에너지학회:학술대회논문집
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• 2009.06a
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• pp.680-681
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• 2009

On the basis of seismic interpretation, seismic indicators of gas hydrate and associated gas such as bottom simulating reflector (BSR), acoustic blanking, column structure, gas seepage, enhanced reflection were identified in the Ulleung Basin. Fractures, faults, sandy layer could be the migration pathways transporting fluid and gas to stability zone. The formation of gas hydrate in the Ulleung Basin include: (1) nodules, veins, layers in muddy sediments and disseminated forms in sandy layer within localized column structure, (2) disseminated forms in sandy layer, and (3) disseminated forms in sandy layer just above BSR.

• Honam Mathematical Journal
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• v.40 no.3
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• pp.521-528
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• 2018

The object of the present paper is to study a decomposable $(APS)_n$ and hypersurfaces of $(APS)_n$. Also, the existence of a decomposable $(APS)_n$ is ensured by a proper example.