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Bone Age Assessment Using Artificial Intelligence in Korean Pediatric Population: A Comparison of Deep-Learning Models Trained With Healthy Chronological and Greulich-Pyle Ages as Labels

  • Pyeong Hwa Kim;Hee Mang Yoon;Jeong Rye Kim;Jae-Yeon Hwang;Jin-Ho Choi;Jisun Hwang;Jaewon Lee;Jinkyeong Sung;Kyu-Hwan Jung;Byeonguk Bae;Ah Young Jung;Young Ah Cho;Woo Hyun Shim;Boram Bak;Jin Seong Lee
    • Korean Journal of Radiology
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    • v.24 no.11
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    • pp.1151-1163
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    • 2023
  • Objective: To develop a deep-learning-based bone age prediction model optimized for Korean children and adolescents and evaluate its feasibility by comparing it with a Greulich-Pyle-based deep-learning model. Materials and Methods: A convolutional neural network was trained to predict age according to the bone development shown on a hand radiograph (bone age) using 21036 hand radiographs of Korean children and adolescents without known bone development-affecting diseases/conditions obtained between 1998 and 2019 (median age [interquartile range {IQR}], 9 [7-12] years; male:female, 11794:9242) and their chronological ages as labels (Korean model). We constructed 2 separate external datasets consisting of Korean children and adolescents with healthy bone development (Institution 1: n = 343; median age [IQR], 10 [4-15] years; male: female, 183:160; Institution 2: n = 321; median age [IQR], 9 [5-14] years; male: female, 164:157) to test the model performance. The mean absolute error (MAE), root mean square error (RMSE), and proportions of bone age predictions within 6, 12, 18, and 24 months of the reference age (chronological age) were compared between the Korean model and a commercial model (VUNO Med-BoneAge version 1.1; VUNO) trained with Greulich-Pyle-based age as the label (GP-based model). Results: Compared with the GP-based model, the Korean model showed a lower RMSE (11.2 vs. 13.8 months; P = 0.004) and MAE (8.2 vs. 10.5 months; P = 0.002), a higher proportion of bone age predictions within 18 months of chronological age (88.3% vs. 82.2%; P = 0.031) for Institution 1, and a lower MAE (9.5 vs. 11.0 months; P = 0.022) and higher proportion of bone age predictions within 6 months (44.5% vs. 36.4%; P = 0.044) for Institution 2. Conclusion: The Korean model trained using the chronological ages of Korean children and adolescents without known bone development-affecting diseases/conditions as labels performed better in bone age assessment than the GP-based model in the Korean pediatric population. Further validation is required to confirm its accuracy.

A Study on Analysis of Eco-space from a Standpoint of Poong-soo -On the Ground of Korean Traditional Poong-soo- (풍수지리관점(風水地理觀點)에서 본 생태공간해석(生態空間解析)에 관한 연구(硏究) -한국(韓國)의 전통적(傳統的) 풍수지리(風水地理)를 중심(中心)으로-)

  • Hyun, Young Jo;Lee, Dong Kun
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.5 no.6
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    • pp.49-63
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    • 2002
  • While the existing feng-shui is largely approached architecturally and geographically as positive place and negative place, the study is characterized by approaching and analyzing poong-soo environmentally. The theory of Eco-city as one of modern-city theories is worthy of studying by analyzing the merits and demerits of it and combining it with poong-soo and making a new alternative theory. Theory of Natural Energy and principle of Natural Balance. Thus, poong-soo ideas can be an important view of nature in analyzing the theory of Eco-city which is coming to the front these days. In particular, we try to make use of poong-soo as a basic theory for a city planning and design by studying and analyzing and combining the merits and demerits of Eco-city with poong-soo and presenting a new alternative method of a stable and balanced "refined city development". On the other hand, we connect 'theory with practice(or experience)' by covering all spaces variably from minimum unit space to city-space from the standpoint of poong-soo. But, problem of the Theory of Eco-city from the view of poong-soo are too artificial and theoretical, even if ideal. Conversely, from the view of Eco-city, the possibility of the practicability of Korean poong-soo is judged to be high. we can tell that among capital cities applied by poong-soo, historical cities like Beijing in China, Seoul in Korea and Tokyo in Japan are poong-soo cities in accordance with the requirements of Eco-city.

Mutual comparison of Two Frequency Modulation System (두가지 주파소변조방식의 상호비교)

  • 정만영;김영웅
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.11 no.6
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    • pp.44-49
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    • 1974
  • reactance modulator composed of multi-stage phase modulator utilizing VVC diodes as variable reactance elements and an oscillartor-modulator, utilizing a VVC diode as a tuning element, coupled to a crystal resonator through an artificial λ/4 network are introduced and their characteristics as FM modulator are compared mutually from the practical view points. especially, to get high modulation sensitivity of reactance modulators using VVC diodes, making a multi-stage modulation distortion characteristics of multi-stage modulator was necessary. The harmonic moj\dulationdistorion characteristics of multi-stage reactance modulator is analized in detall. Multi-stage reachance modulator is preferable to maintain sufficiently stable carrier frequency over the wide range of temperature and a mobile-transceiver was made through this method. On the other hand, FM-Quartz oscillator using a VVc diode is suitavle for handy-talkies of good quality were made through this method.

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A Study on the Evaluation of Pro-environmental Potential of Streams in Sunchon City (중.소도시 하천의 친환경적 활용 잠재력 평가에 관한 연구 -전남 순천시 하천을 사례로-)

  • 정정채;이상석
    • Journal of the Korean Institute of Landscape Architecture
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    • v.26 no.1
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    • pp.96-112
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    • 1998
  • This study aims to evaluate the potential of pro-environmental application(PEP) in streams conceptualized ecological conservation and recreational use to be in harmony with. The main content of research are to clarify the PEP, to establish the evaluation model, and to evaluate 3 streams(Dongchon, Seokhyunchon, Okchon) in Sunchon city. Researchers introduced 12 evaluation items(water quality, water quantity, vegetation-water area, vegetation conservation, streamscape, neighborhood landscape, stream width, optimum area, nearby landuse, facility in stream, distance from user, obstacle to acces) by 5 scales to evaluate the characteristics of natural and artificial factors in stream area and nearby area. Also to decide the weight of items, researchers surveyed the opinion of 22 landscape architects experienced stream-plan through delphi method. Lastly the pro-environmental potential on streams were calculated by the ecological potential and recreational potential indices to be standardized and indicidual sections in streams were divided 5 grades on the basis of PEP. The result of this study are as follows; 1) The evaluation model of PEP was constructed by 4 steps, such as the decision of weight, the measurement of scale, the calculation of potential indices, the gradation of individual sections in streams. 2) The ecological potential were highly influenced by natural factor such as water quality, vegetation conservation, vegetation-water area, but on the other hand the recreational potential were influenced by optimum area, distance from user, water quantity, obstacle to access. 3) The factors such as vegetation conservation, optimum area, nearby landuse, distance from user were function as discernment factors to evaluate relatively ecological and recreational potential. and water quality, water quantity, vegetation -water area, neighborhood landscape were acted as important items to decide PEP.

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A Study on the New Partial Discharge Pattern Analysis System used by PA Map (Pulse Analysis Map) (PA Map(Pulse Analysis Map)을 이용한 새로운 부분방전 패턴인식에 관한 연구)

  • Kim, Ji-Hong;Kim, Jeung-Tae;Kim, Jin-Gi;Koo, Ja-Yoon
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.56 no.6
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    • pp.1092-1098
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    • 2007
  • Since one decade, the detection of HFPD (High frequency Partial Discharge) has been proposed as one of the effective method for the diagnosis of the power component under service in power grids. As a tool for HFPD detection, Metal Foil sensor based on the embedded technology has been commercialized for mainly power cable due to its advantages. Recently, for the on-site noise discrimination, several PA (Pulse analysis) methods have been reported and the related software, such as Neural Network and Fuzzy, have been proposed to separate the PD (Partial Discharge) signals from the noises since their wave shapes are completely different from each other. On the other hand, the relevant fundamental investigation has not yet clearly made while it is reported that the effectiveness of the current methods based on PA is dependant on the types of sensors. Moreover, regarding the identification of the vital defects introducible into the Power Cable, the direct identification of the nature of defects from the PD signals through Metal Foil coupler has not yet been realized. As a trial for solving above shortcomings, different types of software have been proposed and employed without any convincing probability of identification. In this regards, our novel algorithm 'PA Map' based on the pulse analysis is suggested to identify directly the defects inside the power cable from the HFPD signals which is output of the HFCT and metal foil sensors. This method enables to discriminate the noise and then to make the data analysis related to the PD signals. For the purpose, the HFPD detection and PA (Pulse Analysis) system have been developed and then the effect of noise discrimination has been investigated by use of the artificial defects using real scale mockup. Throughout these works, our system is proved to be capable of separating the small void discharges among the very large noises such as big air corona and ground floating discharges at the on-site as well as of identifying the concerned defects.

Experiments on the Detection of Delamination in FRP Reinforced Concrete (탄소섬유 보강 콘크리트의 박리 탐사 실험)

  • Rhim, Hong-Chul;Jung, Hang-Chul;Woo, Sang-Kyun;Song, Young-Chul
    • Journal of the Korea Concrete Institute
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    • v.19 no.1
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    • pp.3-9
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    • 2007
  • With a growing concern about the state of infrastructure worldwide, the demand for the development of reliable nondestructive testing techniques (NDT) is ever increasing. Among possible NDT techniques, microwave method is proven to be effective in fast and non-contact inspection of concrete structures and inclusions inside concrete. It is also found that the microwave method has a potential in detecting the delamination between fiber reinforced polymers (FRP) plate and concrete. On the other hand, ultrasonic method can be another way to find the delamination. In this paper, the research work needed for the development of a reliable microwave method and ultrasonic method is studied in the measurements of concrete specimens reinforced with FRP. Concrete specimens are made with FRP and artificial delamination inside. A microwave measurement system with hom antennas with high center frequency and broad frequency bandwidth are used to image inside concrete specimens for the detection of debonding between concrete and FRP. Also, ultrasonic method is used for the same condition. Both results are compared with each other.

Cultivation of Nostoc flagelliforme on Solid Medium

  • Su Jianyu;Jia Shiru;Qiao Changsheng;Kim Jung-Gyu;Hong Wan-Hae;Cho Ki-An;Choi DuBok
    • Korean Journal of Environmental Biology
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    • v.23 no.2 s.58
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    • pp.135-140
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    • 2005
  • In order to construct an artificial cultivation of Nostoc flagelliforme on solid medium, we attempted to assess the viability of approaches, which utilized either BG-11 agar or sand medium using both sterile and non-sterile algal segments. In the trial in which the BG -11 agar medium was inoculated with the non-sterile algal segments, the algae exhibited the rapid growth in the initial 4 days of cultivation. However, after 4 days of cultivation, the growth rate of the algae slowed, and the algal growth was completely stopped by 7 days of cultivation. When the BG -11 medium was inoculated with the sterile algal segments, the algae exhibited the rapid growth for a longer period of 8 days, reaching a length of 24.9 mm. The growth rate during this period was measured to be $24.5\%$. After the 8 days of cultivation, the algal growth rate began to slow and had almost stopped by the 13 days of cultivation. On the other hand, when the sterile algal segments were inoculated onto a sand plate, the algal segments decomposed, reaching total decomposition after 11 days of cultivation. By way of contrast, the desiccation treatment samples continued to grow for 14 days of cultivation. After 14 days of cultivation, the algae achieved a length of 26.1 mm, with a growth rate of $30.6\%$. Our results indicate that periodic desiccation may constitute an effective strategy for the prevention of algal decomposition.

Physiological Responses and Subjective Sensation of Human Body Wearing OnMapsi in Heating Environment (난방환경에서 온(溫)맵시 착용에 따른 생리적 반응 및 주관적 감각)

  • Na, Young-Joo;Lee, Ji-Yun
    • Journal of the Korean Society of Clothing and Textiles
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    • v.35 no.1
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    • pp.1-12
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    • 2011
  • This study tests the performance of the recommended winter dress OnMapsi for an office worker through the analysis of skin temperature changes according to the heating environment. We tested and compared the effects of with/without undergarments for 4 male subjects in an artificial-climate chamber with two air temperatures of $19^{\circ}C$ and $22^{\circ}C$, $50{\pm}10%$ R.H. During the 60 minute experiment that simulated office work, the subjective feelings (that included thermal, humidity and comfort sensation, and skin temperature) were measured at equal intervals. The results show that the forehead and chest skin temperatures were not affected by air temperature or clothing type, while the hand and foot skin temperatures were affected at $0.3-0.9^{\circ}C$ depending on clothing type and $1.9-2.2^{\circ}C$ depending on air temperature. The mean skin temperature was decreased by the experimental time pass more with regular formal wear than with OnMapsi. The second experiment located the ambient temperature in which subjects wearing OnMapsi show equal skin temperaturesto those without undergarments at $22^{\circ}C$. Therefore it is possible to decrease heating temperatures to $18-21^{\circ}C$ in the office for winter OnMapsi wear that produces a skin temperature and thermal sensation that is the same as those at $22^{\circ}C$.

Effect of $Y_2O_3$ Nanoparticles on Critical Current Density of $YBa_2Cu_3O_{7-x}$ Thin Films ($Y_2O_3$ 나노입자가 $YBa_2Cu_3O_{7-x}$ 박막의 임계전류밀도에 미치는 영향)

  • Tran, H.D.;Reddy, D.Sreekantha;Wie, C.H.;Kang, B.;Oh, Sang-Jun;Lee, Sung-Ik
    • Progress in Superconductivity
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    • v.11 no.1
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    • pp.62-66
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    • 2009
  • Introduction of proper impurity into $YBa_2Cu_3O_{7-x}$ (YBCO) thin films is an effective way to enhance its flux-pinning properties. We investigate effect of $Y_2O_3$ nanoparticles on the critical current density $J_c$ of the YBCO thin films. The $Y_2O_3$ nanoparticles were created perpendicular to the film surface (parallel with the c-axis) either between YBCO and substrate or on top of YBCO, YBCO/$Y_2O_3$/LAO or $Y_2O_3$/YBCO/STO, by pulsed laser deposition. The deposition temperature of the YBCO films were varied ($780^{\circ}C$ and $800^{\circ}C$) to modify surface morphology of the YBCO films. Surface morphology characterization revealed that the lower deposition temperature of $780^{\circ}C$ created nano-sized holes on the YBCO film surface which may behave as intrinsic pinning centers, while the higher deposition temperature produced much denser and smoother surface. $J_c$ values of the YBCO films with $Y_2O_3$ particles were either remained nearly the same or decreased for the samples in which YBCO is grown at $780^{\circ}C$. On the other hand, $J_c$ values were enhanced for the samples in which YBCO is grown at higher temperature of $800^{\circ}C$. The difference in the effect of $Y_2O_3$ can be explained by the fact that the higher deposition temperature of $800^{\circ}C$ reduces intrinsic pinning centers and $J_c$ is enhanced by introduction of artificial pinning centers in the form of $Y_2O_3$ nanoparticles.

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The Inter- and Intra-specific Comparison of Stereotyped Songs in Sympatric Gray-headed Bunting (Emberiza fucata) and Siberian-Meadow Bunting (Emberiza cioides) (동소성 붉은 뺨멧새 ( Emberiza fucata ) 와 멧새 ( Emberiza cioides ) 의 Stereotyped Song 의 비교)

  • Kim, Kil-Won;Shi-Ryong Park
    • The Korean Journal of Ecology
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    • v.16 no.3
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    • pp.317-327
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    • 1993
  • Stands profiles, yearly changes in growth of annual rings, age and diameter structure, and spatial distribution pattern of individuals in the Pinus densiflora stands around the Yeocheon industrial complex were investigated. Growth of annual ring in Pinus densiflora, which survived when vegetation of this area was damaged by air pollutants, was suppressed for about 10 years since 1974 when factories in this area began to operate, but since then such suppressed growth tended to be recovered. It was supposed that the suppresed growth was originated from air pollution and that improvement of growth since the suppressed period was due to the release from competition with them by death of neighbouring trees and the resuction of the amount of air pollutants. Physiognomy of Pinus densiflora stands showed mosaic pattern composed of different patches. Spatial distribution pattern of individuals an stand profiles were similar to those of Pinus densiflora stands regenerated after natural and artificial disturbances. In an age distribution diagram, age of Pinus densiflora population ranged from 1 to 33 years, Among these individuals were recrited corresponded to the suppresed period of growth of annual ring in Pinus densiflora survived when the vegetation was damaged by air pollution. On the other hand, from the result of analysis of frequency distribution diagram of diameter, it was postulated that even if whis Pinus densiflora community can be maintained as it is for the time being, it might be changed to Quercus community with the lapse of time. Regeneration; Pinus densiflora; Air pollution; Annual ring; Age structure; Diameter structure; Quercus spp. In these analyses, factors for individual recognition and species recognition were suggested.

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