• Journal of Korean Neurosurgical Society
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• 제67권1호
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• pp.103-114
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• 2024

Objective : Decompressive craniectomy (DC) with duroplasty is one of the common surgical treatments for life-threatening increased intracranial pressure (ICP). Once ICP is controlled, cranioplasty (CP) with reinsertion of the cryopreserved autologous bone flap or a synthetic implant is considered for protection and esthetics. Although with the risk of autologous bone flap resorption (BFR), cryopreserved autologous bone flap for CP is one of the important material due to its cost effectiveness. In this article, we performed conventional statistical analysis and the machine learning technique understand the risk factors for BFR. Methods : Patients aged >18 years who underwent autologous bone CP between January 2015 and December 2021 were reviewed. Demographic data, medical records, and volumetric measurements of the autologous bone flap volume from 94 patients were collected. BFR was defined with absolute quantitative method (BFR-A) and relative quantitative method (BFR%). Conventional statistical analysis and random forest with hyper-ensemble approach (RF with HEA) was performed. And overlapped partial dependence plots (PDP) were generated. Results : Conventional statistical analysis showed that only the initial autologous bone flap volume was statistically significant on BFR-A. RF with HEA showed that the initial autologous bone flap volume, interval between DC and CP, and bone quality were the factors with most contribution to BFR-A, while, trauma, bone quality, and initial autologous bone flap volume were the factors with most contribution to BFR%. Overlapped PDPs of the initial autologous bone flap volume on the BRF-A crossed at approximately 60 mL, and a relatively clear separation was found between the non-BFR and BFR groups. Therefore, the initial autologous bone flap of over 60 mL could be a possible risk factor for BFR. Conclusion : From the present study, BFR in patients who underwent CP with autologous bone flap might be inevitable. However, the degree of BFR may differ from one to another. Therefore, considering artificial bone flaps as implants for patients with large DC could be reasonable. Still, the risk factors for BFR are not clearly understood. Therefore, chronological analysis and pathophysiologic studies are needed.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집C
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• pp.482-484
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• 2001

In orthopedics, hip arthroplasty is the operation that replaces damaged hip joint to artificial joint. In hip arthroplasty, quite better result can be achieved if robot is applied to machine cavity in bone, especially when cementless stem is used. So several kinds of robots were introduced for hip arthroplasty, but they used MRI, CT Scan, vision analysis and real time tracking of bone position for registration of robot. To overcome shortage of conventional robot surgery, gauge based registration method was proposed and small robot was designed. In this method, small robot is mounted on femur, and its position is determined by gauge registration method. Operation procedure was performed on model femur and result was analyzed. This robotic hip surgery system is expected to more adaptable in operation room.

• 대한소아치과학회지
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• 제50권1호
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• pp.89-103
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• 2023

이 연구의 목적은 Greulich-Pyle (GP)방법을 기반으로 한 인공지능 프로그램을 이용해 골령을 측정하고 경추골 성숙도(Cervical vertebral maturation, CVM)와 중지 중절골 성숙도(Middle phalanx of the third finger, MP3) 각 단계에 해당하는 골령을 파악하는 것이다. 연구는 2013년부터 2021년까지 경희대학교와 부산대학교 치과병원 소아치과에 내원한 총 3,118명을 대상으로 하였다. CVM은 Baccetti 분류에 따라 5단계로 나누었고, MP3는 Hägg와 Taranger 의 방법에 따라 5단계로 나누었다. 골령은 GP 방법 기반의 인공지능 프로그램을 통해 평가하였다. 최대 성장기의 CVM 단계는 II, III로 CVM II의 평균 골령은 남자 11.00 ± 1.81세, 여자 10.00 ± 1.49세였고, III는 남자 13.00 ± 1.46세, 여자 12.00 ± 1.44세였다(p < 0.0001). MP3 최대 성장기는 G 단계로 평균 골령은 남자 13.14 ± 1.07세, 여자 11.40 ± 1.09세였다(p < 0.0001). 인공지능을 통한 골령 평가는 임상적 활용 가치가 있으며 신속하고 정확한 진단이 가능할 것으로 예상된다.

• 대한치과보철학회:학술대회논문집
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• 대한치과보철학회 2002년도 추계학술대회
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• pp.117-118
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• 2002

• Macromolecular Research
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• 제13권2호
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• pp.120-127
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• 2005

Conventional poly(methyl methacrylate) (PMMA) bone cement has been widely used as an useful biopolymeric material to fix bone using artificial prostheses. However, many patients had to be reoperated, due to the poor mechanical and thermal properties of conventional PMMA bone cement, which are derived from the presence of unreacted MMA liquid, the shrinkage and bubble formation that occur during the curing process of the bone cement, and the high curing temperature ($above 100^{\circ}C$) which has to be used. In the present study, a composite PMMA bone cement was prepared by impregnating conventional PMMA bone cement with ultra high molecular weight polyethylene (UHMWPE) powder, in order to improve its mechanical and thermal properties. The UHMWPE powder has poor adhesion with other biopolymeric materials due to the inertness of the powder surface. Therefore, the surface of the UHMWPE powder was modified with two kinds of silane coupling agent containing amino groups (3-amino propyltriethoxysilane ($TSL 8331^{R}$) and N-(2-aminoethyl)-3-(amino propyltrimethoxysilane) ($TSL 8340^{R}$)), in order to improve its bonding strength with the conventional PMMA bone cement. The tensile strengths of the composite PMMA bone cements containing $3 wt\%$ of the UHMWPE powder surface-modified with various ratios of $TSL 8331^{R}$ and $TSL 8340^{R}$ were similar or a little higher than that of the conventional PMMA bone cement. However, no significant difference in the tensile strengths between the conventional PMMA bone cement and the composite PMMA bone cements could be found. However, the curing temperatures of the composite PMMA bone cements were significantly decreased.

• 대한치과보철학회지
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• 제34권4호
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• pp.722-745
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• 1996

The purpose of this study is to investigate the effect of constant direct current electrical stimulation in healing the bone defects and surrounding tissues of the endo-oseous(TPS-IMZ) implants. Implants were inserted in the femur of adult dogs. Then a constrant direct current of approximately $10{\mu}A$ was applied. Artificial bone defects were prepared on one side of the implant site. Experimental groups were divided into 4 : control group : bone defect without treatment group I : bone defect filled with hydroxyapatite powders group II : bone defect, in which a negative and positive electrodes were inserted 5mm apart from both sides of the implant group III : bone defect, in which negative current was directly connected to the IMZ implant and a positive electrode was placed 10mm apart from the implant The animals were sacrificed in the 1st, 2nd, 4th and 8th week after implantation for the light microscopic examination. The results obtained were as follows : 1. In electrically stimulated experimental groups, new bone formation and osseointegration around implants were accelerated. 2. Group III showed the greatest activity in new bone formation. Osteoconductivity around HA particles was observed in group 1. 3. The defect area of the control group was healed by forming new bone, which grew from the underlying cancellous bone. The defect areas of the electrically stimulated experimental groups were healed by newly formed bone, which grew upward from the cancellous bone and downward from the periosteum. 4. 8 weeks after implantation, all the groups showed good osseointegration between the surrounding bone and implants.

• Imaging Science in Dentistry
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• 제53권3호
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• pp.199-207
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• 2023

Purpose: The objective of this study was to evaluate the accuracy and effectiveness of an artificial intelligence (AI) program in identifying dental conditions using panoramic radiographs(PRs), as well as to assess the appropriateness of its treatment recommendations. Materials and Methods: PRs from 100 patients(representing 4497 teeth) with known clinical examination findings were randomly selected from a university database. Three dentomaxillofacial radiologists and the Diagnocat AI software evaluated these PRs. The evaluations were focused on various dental conditions and treatments, including canal filling, caries, cast post and core, dental calculus, fillings, furcation lesions, implants, lack of interproximal tooth contact, open margins, overhangs, periapical lesions, periodontal bone loss, short fillings, voids in root fillings, overfillings, pontics, root fragments, impacted teeth, artificial crowns, missing teeth, and healthy teeth. Results: The AI demonstrated almost perfect agreement (exceeding 0.81) in most of the assessments when compared to the ground truth. The sensitivity was very high (above 0.8) for the evaluation of healthy teeth, artificial crowns, dental calculus, missing teeth, fillings, lack of interproximal contact, periodontal bone loss, and implants. However, the sensitivity was low for the assessment of caries, periapical lesions, pontic voids in the root canal, and overhangs. Conclusion: Despite the limitations of this study, the synthesized data suggest that AI-based decision support systems can serve as a valuable tool in detecting dental conditions, when used with PR for clinical dental applications.

• 한국CDE학회논문집
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• 제22권2호
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• pp.172-180
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• 2017

The fractal structures, which include Sierpinski and Pascal triangular fractals, have provided many mathematical interests. In this study, the hydrodynamic and mechanical properties of the triangular fractals were investigated, and their application to the design of various artificial bone scaffolds has been implemented via CAD modeling, computational analysis and mechanical testing. The study proved that the Sierpinski and Pascal triangular fractal structures could effectively be applied to bone scaffold design and manufacturing regarding permeability and mechanical stiffness.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권1호
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• pp.9-14
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• 2001

With the object of providing a temporary artificial periodonal ligament-like membrane around the dental implant, 10 Branemark type implants were coated with commercially available chitosan(Fluka Co., Buchs, Switzerland) which has a molecular weight of 70,000 and 80% deacetylation degree. Once this bioactive hydrophillic polymer(chitosan) contacts with blood or wound fluids, it becomes swollen and penetrates into the adjacent cancellous bone. Thus the interface between implant and surrounding bone is completely filled with chitosan. This tight junction in early healing phase enhances primary stability. The chitosan coated dental implants were implanted into the fresh patella bones from porcine knees, since the thickness of cortical bone is relatively even and their cancellous structure is homogenous. To test the shock absorbing effect, 1mm delta-rogette strain gage was installed behind the implant. The results showed 1. The principal strain peak value directed to the impact of coated implant was 0.064 0.018(p<0.05) and that of uncoated implant was 0.095(0.032 p<0.05). 2. The peak time delay of coated implant was 0.056sec(0.011 p<0.05) and that of uncoated implant was 0.024sec(0.009 p<0.05). It can be reasoned from this results that the chitosan coating has a shock absorbing effect comparable with a temporary artificial periodontal ligament.

• 대한의용생체공학회:의공학회지
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• 제9권2호
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• pp.251-252
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• 1988

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength.