• 대한약침학회지
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• 제22권4호
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• pp.210-224
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• 2019

Rheumatoid arthritis is a severe autoimmune disorder, related to joints. It is associated with serious cartilage destruction. This causes disability and reduces the excellence of life. Numerous treatments are existed to combat this disease, however, they are not very efficient and possess severe side effects, higher doses, and frequent administration. Therefore, newer therapies are developed to overcome all these limitations. These include different monoclonal antibodies, immunoglobulins, small molecules used for immunotherapy and transgenes for gene therapy. One of the main goals of these new generation therapeutics is to address the underlying distressing biological processes by specifically targeting the causative agents with fewer systemic side effects and greater patient console. It is very fortuitous that loads of progressive investigations are going on in this field and many of them have entered into the successful clinical trial. But till date, a limited molecule has got FDA clearance and entered the market for treating this devastating disease. This review highlights the overview of conventional therapy and advancements in newer therapeutics including immunotherapy and gene therapy for rheumatoid arthritis. Further, different novel techniques for the delivery of these therapeutics of active and passive targeting are also described.

• 성인간호학회지
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• 제15권3호
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• pp.393-401
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• 2003

Purpose: The purpose of this study was to examine the effects of a six week self-help empowerment strategy program on the empowerment status, pain intensity, physical function, joint flexibility and depression status in rheumatoid arthritis patients. Method: The subjects of the study consisted of a convenience sample thirteen rheumatoid arthritis patients. Data was collected from July to November, 2001. All patient received a self-help empowerment strategy program, once a week for six weeks. Result: After receiving the self-help empowerment strategy program, the empowerment status increased significantly, the pain intensity and the depression score decreased significantly and the level of physical function significantly improved but the flexibilities of shoulders, knees and ankles were not significantly changed. Conclusion: Further studies need to be done to determine the feasibility of implementing empowerment strategy and its possibility as an effective intervention program for decreasing pain intensity and depression score and improving the physical function.

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.130-133
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• 2016

Rheumatoid arthritis (RA) is a connective tissue disease involving the larynx in 30 % of the patients. Foreign body sensation, hoarseness, and cough are common symptoms in laryngeal involvement. An urgent tracheostomy is required when acute airway obstruction occurs in case of bilateral vocal fold paralysis. The most common cause of bilateral vocal fold paralysis in RA patients is a cricoarytenoid joint arthritis. Laryngeal nerve degeneration is rare cause of bilateral vocal fold paralysis in RA patients. In this case report, an emergent tracheostomy was performed on a 64-years-old male patient with acute dyspnea, and concurrent involvement of RA on laryngeal nerve and cricoarytenoid joint was revealed by laryngeal electromyography and histopathology. The vocal fold mobility was restored after 3-months medical treatment.

• 대한간호학회지
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• 제17권3호
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• pp.218-226
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• 1987

This descriptive-correlational study was undertaken in order to examine if there were relationships between family support, compliance and life satisfaction in chronic arthritis patients. The sampling method was a non-probability, purposive sampling technique. The participants of this study were 92 volunteer adults. 1) who have been diagnosed as having chronic arthritis and 2) who were at the medical out patient clinic of one university hospital in Seoul between April 27th to May 12th 1987. The instruments used for this study were the Family Support Scale developed by Kang Hyun Sook, a Compilance Scale developed by the researcher and the Life-Satisfaction Index-Z developed by Wood et.al. Analysis of data was done using t-test, ANOVA, Pearson Correlation Coefficient and Stepwise Multiple Regression Analysis. The results of study were as follows; Hypothesis I; “The higher the family support, the higher the compliance” was accepted. (r＝.2604, p＜.01) Hypothesis II; “The higher the compliance, the higher the life satisfaction,” was rejected. (r＝.1663, p＞0.5) Hypothesis III; “The higher the family support, the higher the life satisfaction” was accepted. (r＝.3914, p＜.01) In addition, by using Stepwise Multiple Regression Analysis it was determined that the main influencing factors on the life satisfaction were family support, the number of inflammatory joints, compliance and pain level. These 4 main variables made it possible to explain 30.8% of the variance in life satisfaction. In conclusion, this study revealed that family support is an important factor that can improve compliance and life satisfaction in chronic arthritis patients.

• Journal of Pharmaceutical Investigation
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• 제26권4호
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• pp.273-280
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• 1996

Chondroitin sulfate/gelatin microspheres containing dexamethasone 21-acetate were prepared by complex coacervation method and their release patterns were examined in vitro. Microspheres prepared with a small amount of crosslinking agent had smooth surface and few pores, but those with a large amount of crosslinking agent were more porous and less spherical. In vitro release patterns were varied by changing polymer/drug weight ratio and amount of crosslinking agent. The release rate of dexamethasone 21-acetate in the presence of collagenase was faster than that in the absence of collagenase. Anti-inflammatory effect of dexamethasone 21-acetate microspheres was more efficient than that of dexamethasone 21-acetate solution in carrageenan-induced arthritis in the rat. On the basis of the above results, we might expect the degradation and drug release rate of these microspheres to be regulated by the degree of crosslinking and the level of enzymes. In patients with severe rheumatoid arthritis who have high concentration of collagenase, more drug would be released from the microspheres. An intra-articular injection therapy of rheumatoid arthritis with desired release kinetics could be developed to enhance patient compliance and therapeutic index.

• 한방재활의학과학회지
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• 제32권3호
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• pp.161-169
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• 2022

A 50-year-old Korean male tour guide without any medical or family history complained of left knee pain. After receiving umbilical cord blood injection treatment, the pain gradually worsened. After being diagnosed with septic arthritis in the left knee, arthroscopic lavage, debridement, antibiotic treatment, and routine rehabilitation therapy were performed, but the symptoms persisted. In the hospital, acupuncture, pharmacopuncture, acupotomy, Chuna manual therapy, and cupping therapy were performed in addition to the usual treatment for 59 days. To evaluate the patient's improvement, the numeric rating scale, EuroQol 5-dimension, pain disability index, and Lysholm knee scoring system were used. After treatment, the symptoms improved in all assessment tools, swelling, and range of motion of the joint. Through this study, it was found that complex Korean medical therapies may be effective for postoperative ankylosis in septic arthritis of the knee, and further studies are needed to clarify the therapeutic effect.

• Hip & pelvis
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• 제34권3호
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• pp.185-190
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• 2022

Septic arthritis (SA) is a joint inflammation that develops secondary to infectious causes. SA in children is associated with a high rate of morbidity and mortality; therefore, it is regarded as an orthopedic emergency. Because SA of the hip joint usually mimics other musculoskeletal diseases, diagnosis remains challenging. Although this lesion usually shows a good outcome, treatment at an inappropriate time, neglect, or inadequate treatment could lead to poor outcomes. We report on the case of a healthy adolescent who complained of episodes of fever and chills, weight loss, pain in his left hip, and limping. After performing necessary workups, two differential diagnoses of tumor and SA were made. The results of Gram stain and culture of the synovial fluid after surgical excision showed Klebsiella pneumoniae and Enterobacter cloacae complex. To the best of our knowledge, this is the first report of SA due to co-infection with K. pneumoniae and E. cloacae in a healthy patient.

• 한국방사선학회논문지
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• 제12권3호
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• pp.397-402
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• 2018

본 연구는 엉치엉덩관절의 골절, 탈구, 엉치엉덩 퇴행성관절염 진단을 위한 가장 좋은 영상을 얻기 위해 골반 팬톰과 엑스선관을 각도 변화를 주어 엉치엉덩관절의 Joint space 가장 잘 나타내는 영상을 얻어 방사선사에게 주관적 평가를 받아 보았다. 평가 결과 결론으로 엉치엉덩관절염과 퇴행성 관절염 발견을 위한 단순촬영에서는 엎드린상태에서 촬영은 검사반대쪽 엉덩이를 $25^{\circ}{\sim}30^{\circ}$ 들어올리고 엑스선관을 앞엉덩뼈가 시에서 2.5 cm 안쪽을 지나는 시상면에 대해 수직촬영 하고 누운자세에서는 검사쪽 엉덩이를 $25^{\circ}{\sim}30^{\circ}$ 들어 올리고 위앞엉덩뼈가시가 중앙에서 위앞엉덩뼈가시가 중앙에 대해 엑스선관 각도를 발쪽으로 $5^{\circ}$ 촬영 하며 반드시 양쪽 엉치엉덩관절후전사방향(RAO,LAO) 및 전후사방향(RPO, LPO) 모두 촬영을 하게 되면 관절염 진단을 내리는데 있어 많은 도움이 되리라 본다.

• 대한족부족관절학회지
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• 제9권1호
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• pp.47-51
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• 2005

중등도 이상의 변형을 가진 족근 관절 관절염에 대해 관혈적 관절 고정술은 양호한 결과를 보였으며 경비골 도달법에 의한 관절 고정술이 이상적인 족근 관절의 고정 위치를 얻는데 보다 용이하였다.

• 대한물리의학회지
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• 제6권1호
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• pp.39-49
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• 2011

Purpose : The purpose of this study was to investigate the effectiveness of pain release through the four weeks aquatic exercise among the female subjects aged above 50 and who suffered from arthritis. Methods : The assessment was validated by blood analysis which measured the fluctuations of Erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and Rheumatoid factor(RF). Among the 50 subjects of this experiment, the control group has only taken a regular treatment from the clinic and the other experimental group has done aquatic exercise. The experimental group has practiced the aquatic exercise 50 minutes a day for one month excluding the weekends. Results : Blood analysis revealed that ESR was decreased in both the control group and the experimental group and the major effect of CRP was diminished only in the experimental group. No significance of RF was found in both the control group and the experimental group. Conclusion : These results indicate that the aquatic exercise is an effective treatment for arthritis that is compatible with the similar results from the previous studies. In line with this, the aquatic exercise program can provide an effective treatment and control of the disease with the arthritis patient. Accordingly, the regular basis aquatic exercise proved to be quite satisfactory treatment in this regard and we contend that it is vital for the arthritis patients.