• Title/Summary/Keyword: anti-skin wrinkle effect

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Development of Anti-aging from Natural Materials by Inhibition of UV Stimulating (자외선 자극에 의한 피부노화 억제 천연물 소재 개발)

  • Dang, Su-Min
    • Journal of the Korea Convergence Society
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    • v.12 no.1
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    • pp.251-257
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    • 2021
  • ln this study, natural extracts extracted from cypress sapiens, a natural material, were investigated as materials that could protect skin aging caused by ultraviolet rays, and experiments were conducted on the synthesis of filaggrins that make up the natural moisturizing factor of the skin, the synthesis of pro-colagen, a fibrous protein, which plays an important role in moisturizing the dermis, and elastin, which is an enzyme that decomposes collagen. As a result, cypress ethanol extract (COE) was a dependent inhibitor to collagenase and elastase, inhibiting the synthesis of filaggrin and the expression of MMP-1 for exfoliated cells damaged by ultraviolet rays. Therefore, it is estimated that ethanol extract will have the effect of delaying wrinkles and as a functional cosmetic material that inhibits skin aging convergence. Based on this study, we would like to further study the mechanism of the synthesis of filaggrin on the suppression of expression of MMP, which is the anti-wrinkle effect.

Study on Photo-aging Inhibition Effect of Microalgae-derived Oil for Cosmetic Material Development (화장품 소재 개발을 위한 미세조류 유래 오일의 광노화 억제 효과 연구)

  • Park, Eun-Kyung;Park, Sang-Hee;Yoon, Sang-A;Kim, You Sun;Lee, Woo-Ram;Kim, Woo-Jung
    • Journal of Marine Bioscience and Biotechnology
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    • v.10 no.2
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    • pp.83-90
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    • 2018
  • Ultraviolet (UV) radiation causes inflammation and matrix metalloproteinase (MMP) over-expression and extra cellular matrix depletion, leading to skin photo-aging such as wrinkle formation, dryness, and sagging. In this study, we demonstrated that pretreatment with the hexane extract of microalgae protects UVB mediated cell damages. The results of clinical study showed that Microalgal Oil treated group reduced wrinkle and improve elasticity. All these results suggest Microalgal Oil may be useful as new photo-aging cosmetics for protection against UV induced activity.

Anti-wrinkle Effect of Safflower (Carthamus tinctorius L.) Seed Extract (II) (홍화씨추출물의 피부 주름개선 효과(II))

  • Kim Mi Jin;Kim Ja Young;Choi Sang-Won;Hong Jin Tae;Yoon Kyung-Sup
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.4 s.48
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    • pp.449-456
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    • 2004
  • Phytoestrogens derived from plants and foods, which are diphenolic compounds with structural similarities to natural and synthetic estrogens, have been shown to estrogenic and antiestrogenic actions. Particularly, recent study revealed that phenolic compounds in safflower seed, such as serotonin derivatives, lignans and flavonoids, could be acted as phytoestrogens. Safflower (Carthamus tinctorius L.) seed extract (SID C.SE), therefore, are receiving a renewed interest as potential therapeutic source against skin wrinkles induced by estrogen deficiency. This study was conducted to investigate the anti-wrinkle effect of SID C.SE on normal human fibroblasts through the expression of type I procollagen and UVA-induced MMP-1 in vitro. The SID C.SE increased the type I procollagen expression, comparable to trans-retinol and reduced UVA-induced MMP-1 expression in a dose-dependent manner. The clinical study indicated that cream group treated with $0.1\%$ SID C.SE significantly reduced a skin wrinkles, as compared with a control (non-treated cream group) (p<0.05). These results suggest that the safflower seed extract may be useful as potential source of anti-wrinkle cosmetics.

The Research of the development of oriental cosmetics (한방화장품의 개발현황)

  • Park, Chang-Eun;Lim, Hee-Sun;Lee, Eun-Mi
    • Korean Journal of Korean Medical Institute of Dermatology and Aesthetics
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    • v.1 no.1
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    • pp.198-228
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    • 2005
  • Oriental cosmetics make the skin radiant by supplement and circulate qihyul(氣血). Oriental cosmetics aim at the radiant skin based on inner health. It accords the new trend of 21th century, well-being and naturalism. Recently a lot of new oriental cosmetics have been developed and enjoyed great popularity. The research of oriental cosmetics elucidated the active compounds having whitening effect and wrinkle cure effect. And the anti-acne and anti-atopy cosmetics have been researched. The development of oriental cosmetics should be based on oriental medical theory.

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Fructose-1,6-diphosphate : The new anti-aging material.

  • Ahn, Soo-Mi;Kim, Ji-Hyun;Lee, Jong-Chan;Lee, Byeong-Gon;Lee, Soo-Hwan;Jung, Jin-Ho;Chang, Ih-Seoup
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.13-34
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    • 2003
  • Fructose-1, 6-diphosphate (FOP), a glycolytic metabolite is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FOP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart. In this study, we examined whether FDP has protective effects on UV-induced oxidative damage in skin cell culture system and human skin in vivo. FDP had a protective role in UVB-induced LDH release and ROS accumulation in HaCaT although it did not show direct radical scavenging effect in the experiment using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). FDP also preserved cellular GSH content after UV irradiation in HaCaT and normal human fibroblast culture system. Cellular oxidative stress induces multiple downstream signaling pathways that regulate expression of multiple gene including MMP-1 and collagen, we examined the effects of FDP on UV-induced alteration of these protein expression in fibroblast culture and human skin in vivo. The increased MMP-1 expression in fibroblast and human skin by UV irradiation was significantly decreased by FDP. FDP also prevented the UV-induced decrease of collagen expression in fibroblast and human skin. Moreover, the decreasing the intracellular levels of reducing equivalents in human fibroblast by glutathione (GSH) depletion lowered the UVA dose threshold for reduction of procollagen expression, indicating that the differences of glutathione contents define the susceptibility of fibroblasts towards UV-induced reduction of procollagen expression. FDP also preserved cellular GSH content after UV irradiation, indicating that FDP has protective effects on UV-induced reduction of procollagen expression, which are possibly through maintaining intracellular reducing equivalent. Based on these premises, we examined the effect of daily use of a moisturizer containing FDP on facial wrinkle in comparison with vehicle moisturizer lacking FDP. In the clinical study, FDP significantly decreased facial wrinkle compared with vehicle alone after 6 months of use. Our results suggest that FDP has anti-aging effects in skin by increasing cellular antioxidant system and preventing oxidative signal and inflammatory reaction. Therefore FDP may be useful anti-aging agent for cosmetic purpose.

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Anti-aging Effect of Amino Acid Complex on the Skin (Amino Acid Complex의 항노화 작용)

  • Kim, Ki-Ho;Kim, Ki-Soo;Kim, Young-Heui;Ko, Kang-Il;Park, Sun-Hee;Kim, Jin-Guk;Chio, Hyun-Jin;Ko, Su-Yeon;Bae, Yoon-Joo;Kim, Yong-Min
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.32 no.2 s.57
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    • pp.81-88
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    • 2006
  • Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.

Development of Multifunctional Natural Sunscreen (BHC-S) Having Sunscreening and Anti-wrinkle (주름개선 자외선 차단효과를 갖는 다기능성 천연 자외선 차단제(BHC-S) 개발)

  • Kim, Chul;Jeong, Sae Byeol;Im, Gyeong Hyeon;Gang, Myeong Hwan;An, Jun Hyuk;Kim, Jin Hee;Lee, Ho
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.43 no.4
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    • pp.321-327
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    • 2017
  • This study was carried out to develop a stable plant-derived natural sunscreen (BHC-S) that replaces the artificially synthesized organic sunscreen agents. The natural sunscreen (BHC-S), which is composed of peanut extract, Centella asiatica extract, and Ecklonia stolonifera extract, has the same level of ultraviolet shielding effect as PARSOL MCX-XR (OMC), which is a synthetic sunscreen. and has safety against skin. MultiFunctional effect such as and anti-wrinkle improvement. Thus, it can be used as raw material for natural cosmetics for ultraviolet ray blocking, and anti-aging.

Whitening and Anti-wrinkle Effects of Prunus persica Flos (도화(桃花, Prunus persica Flos)의 미백 및 주름개선 효과)

  • Lee, Jin-Young;An, Bong-Jeun
    • Journal of Applied Biological Chemistry
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    • v.53 no.3
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    • pp.154-161
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    • 2010
  • The solvent extracts of Prunus persica Flos were investigated for the activities of whitening and anti-wrinkle effects to apply as a functional ingredient for cosmetic products. The tyrosinase inhibitory effect, which is related to skin-whitening, was 54.0, 58.3% in P. persica Flos (PPW, PPE) at 1,000 ppm. In addition, the ethanol extract of P. persica Flos (PPE) showed a potent tyrosinase inhibitory activity in the test using melanoma cell lines resulting in 40.0% inhibition at 100ppm. Furthermore, the aqueous acetone extract from the flower of P. persica Flos was found to inhibit elastase, which was more effective than ascorbic acid at 1,000 ppm. The inhibition of melanin synthesis by P. persica Flos extract (PPE) was about 56.5% at 100 ppm concentration. When compared to other extraction methods, the ethanol extract showed more potent whitening activity. For anti-wrinkle effect, the elastase inhibition activity of P. persica Flos extract (PPA) was 57.0% and higher than that of ascorbic acid at 1,000 ppm. The collagenase inhibition activity of P. persica Flos extract (PPA) was about 48.0% at 1,000 ppm. Collagen synthesis in fibroblast cell by P. persica Flos extracts (PPA) was about 41.0% at 100 ppm and its acetone extract was the best showing antiwrinkle activities. All these findings suggested that P. persica Flos has a great potential as a cosmeceutical ingredient with a whitening and anti-wrinkle effect.

The Suppressive Effect of Pueraria lobata Root Extract and Its Biotransformed Preparation against Skin Wrinkle Formation

  • Koo, Hyun Jung;Lee, SungRyul;Kang, Se Chan;Kwon, Jung Eun;Lee, Da Eun;Choung, Eui-Su;Lee, Jong-Sub;Lee, Jin Woo;Park, Yuna;Sim, Dong Soo;Sohn, Eun-Hwa
    • Korean Journal of Plant Resources
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    • v.30 no.3
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    • pp.272-279
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    • 2017
  • EP was obtained through 20% ethanol extraction of Pueraria lobata root, and the fermented form of EP, FEP, was prepared from the EP after incubating with Lactobacillus rhamnosus vitaP1. There was no significant toxicity by EP and FEP up to $1000{\mu}g/ml$ in NIH-3T3, HaCaT, and B16F10 cells. In addition to antioxidant potentials of EP and FEP determined by DPPH and ABST assays, we confirmed increase of procollagen type I and elastin synthesis by supplementation of the EP and FEP at the concentration of $50{\mu}g/ml$ using ELISA kits. The protein expression levels of matrix metalloprotease (MMP)-1, -3, and -9, those are involved in the degradation of collagen or other skin matrix proteins, were remarkably suppressed while their inhibitory protein metallopeptidase inhibitor 1 (TIMP-1) was greatly up-regulated by supplementation of the EP and FEP at a concentration of $50{\mu}g/ml$. Taken together, both EP and FEP supplementation could be involved in the suppression of the skin wrinkle formation through inhibiting degradation of collagen and stimulating the synthesis of collagen and elastin. The results showed that the anti-wrinkle potential of the EP and FEP will be a promising candidate for developing cosmeceutical compounds or products.

Anti Photoaging Effects of Hyaluronic Acid following Oral Administration in SKH-1 Hairless Mice (SKH-1 Hairless Mice에서의 히알루론산 경구 투여를 통한 피부 광노화 개선 효과)

  • Lee, Sung-jin;Seo, YoonHee;Yun, Min-kyu;Yu, Heui-jong;Choe, Soo-Young
    • The Korean Journal of Food And Nutrition
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    • v.28 no.6
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    • pp.941-946
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    • 2015
  • Photoaging is the main extrinsic aging factor that is induced due to UVB. Many studies have revealed that application of hyaluronic acid to the skin is effective in healing photoaging. However, the effect of hyaluronic acid through oral administration is unclear. The aim of this research was to investigate the effect on skin photoaging after oral administration of hyaluronic acid. During a ten week study, hyaluronic acid was fed to hairless mice, which were illuminated by UV radiation. After ten weeks, wrinkle indicator and histological changes were determined. Compared with the control group, the sample group had a decrease in wrinkle depth, thickness, and number. Especially, the HA 160 mg/kg group had a similar value of wrinkle depth ($19.44{\pm}0.75{\mu}m$), number ($654.00{\pm}98.34$), and thickness ($1.35{\pm}0.08mm$), when compared with the RA (retinoic acid) group ($19.28{\pm}0.95{\mu}m$, $653.57{\pm}83.54$, and $1.34{\pm}0.07mm$ respectively). Also, the treated group showed improved elastosis and decreased collagen degradation resulting from UV irradiation. Thus, we can conclude that hyaluronic acid has a positive effect in improving skin photoaging induced by UV radiation. Hyaluronic acid therefore has the potential to be an ingredient in skin health function foods.