• 한국유체기계학회 논문집
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• 제19권6호
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• pp.19-25
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• 2016

Anti-icing is important in gas turbines because ice formation on compressor inlet components, especially inlet guide vane, can cause performance degradation and mechanical damages. In general, the compressor bleeding anti-icing system that supplies hot air extracted from the compressor discharge to the engine intake has been used. However, this scheme causes considerable performance drop of gas turbines. A new method is proposed in this study for the anti-icing in combined cycle power plants(CCPP). It is a heat exchange heating method, which utilizes heat sources from the heat recovery steam generator(HRSG). We selected several options for the heat sources such as steam, hot water and exhaust gas. Performance reductions of the CCPP by the various options as well as the usual compressor bleeding method were comparatively analyzed. The results show that the heat exchange heating system would cause a lower performance decrease than the compressor bleeding anti-icing system. Especially, the option of using low pressure hot water is expected to provide the lowest performance reduction.

• 대한한방부인과학회지
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• 제18권4호
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• pp.242-252
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• 2005

Purpose : Dysfunctional uterine bleeding is an abnormal uterine bleeding without an organic disease. A hormone therapy or anti-depressant medicine is chosen to treat dysfunctional uterine bleeding. However sometimes it didn't work. Hysterectomy is recommended to stop bleeding but a lot of women are afraid of it. The purpose of this study is to show the possibility of oriental medical treatment for dysfunctional uterine bleeding in this case report. Methods : The 30-year-old female patient who had suffering from uterine bleeding was treated with hormone therapy and anti-depressant medicine. However she was bleeding again. She had no organic disease in some medical examination, finally she was recommended a hysterectomy. But she didn't want the operation. In addition, she started acute abdominal pain. She wanted a oriental medical treatment and we treated her from the May 14th 2005 to the June 4th 2005 in admission. We used Yikweseungyangtang(益胃升陽湯), Ojuksan(五積散), Kwibitang hap Gyoesamultang(歸婢湯合膠艾四物湯) for herb-medication. In acupuncture therapy,　ST36(Chok-Samni 足三里) SP1(Eunbek, 隱白) SP6(Samumgyo, 三陰交) SP10(Hyulhae, 血海) Liv1(Daedon, 大敦) Liv3(Taechung, 太衝) LI4(Hapgok, 合谷) was selected. In moxa therapy CV4(Kwanwon, 關元), CV6(Kihae, 氣海), CVl2(Chung-wan, 中脘) was used.　Results : After oriental medical treatment for 22 days, she stopped uterine bleeding　and recovered her health．　Conclusion ：　Oriental medical treatment is expected to have an effect on　dysfuctional uterine bleeding with abdominal pain.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권6호
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• pp.426-430
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• 2009

Purpose: Many patients in anti-platelet therapy have been consulted for bleeding risks before minor oral surgery. However, there has not been an established pretreatment protocol for treating these patients. The purpose of this study is to make a protocol for the preoperative management for patients in anti-platelet therapy. Patients and Methods: The existed consultation pattern of patients was examined in the Department of Oral and Maxillofacial Surgery, Yonsei Dental Hospital. Based on the observation, a protocol including classification of medical status of patients and the type of oral surgery in need was introduced. This protocol had been performed for 6 months. Result: Following this protocol, the frequency of consultation for bleeding risk was decreased. The number of minor oral surgeries with concurrent anti-platelet therapy was increased. There was no severe bleeding event observed among minor oral surgeries that were performed while maintaining anti-platelet therapy. Conclusion: This protocol can be used as a guideline for clinical practice of patients in anti-platelet therapy requiring minor oral surgery.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권2호
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• pp.105-110
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• 2012

Gastric ulcers are rare in children and are typically seen in cases of Helicobacter pylori (H. pylori) infection, non-steroidal anti-inflammatory drugs (NSAIDs) use, and critical illnesses such as sepsis. The risk of a bleeding ulcer due to use of NSAIDs is dependent on the dose, duration, and the individual NSAIDs, but the bleeding may occur soon after the initiation of NSAID therapy. An experience is described of a 16-month-old infant with a bleeding gastric ulcer after taking the usual dosage of ibuprofen for 3 days. The infant was also successfully treated with endoscopic hemostasis. Even a small amount of ibuprofen may be associated with bleeding gastric ulcers in infant.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.71-71
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• 2003

Methanol extract of Loranthus yadoriki showed the prolongation effect of bleeding time in vivo using mice in dose dependent manner. From the MeOH extract of Loranthus yadoriki, compound-A was isolated by the activity guided isolation method using silicagel column chromatography. The anti-coagulant activity was evaluated by the bleeding time test in vivo and plasma recalcification time test in vitro. Compound A showed moderate anti -coagulant activity on plasma recalcification time in vitro.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권5호
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• pp.383-389
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• 2002

This is a retrospective study on emergency patients with active oral bleeding. The study was based on a series of 135 patients treated as emergency patients at Wonju Christian Hospital, from Jan. 1, 1997, to Dec. 31, 2001. The postoperative bleeding was the most frequent cause of active oral bleeding in emergency room and bleeding from trauma and medically compromised (bleeding disorders) patients were next in order of frequency. In the injury of maxillofacial vessels, peak incidence was occurred in the inferior alveolar vessel (42.9%), followed by the submucosal vessel of lip & cheek, the superior alveolar vessel, and sublingual vessels. The most common disease of bleeding disorders was vascular wall alteration (infection, etc), followed by liver disease, thrombocytopenic purpura, anti-coagulation drugs in order. In the characteristics of dental diseases on bleeding disorders, periodontal disease and alveolar osteitis (osteomyelitis) were more common. The hemostasis was most obtained by use of wound suture, simple pressure dressing, drainage for infection control and primary interdental wiring of fracture. In the complication group, the infrequent incidence was showed in vomiting, hypovolemic shock, syncope, recurred bleeding & aspiration pneumonia. In the uncontrolled oral bleeding, the injured vessels were suspected as skull base & ethmoidal vessels. In this study, authors found that the close cooperation between the dentistry (Oral and maxillofacial surgery) and the medicine (emergency & internal medicine) was the most important for early proper control of active oral bleeding. And then post-operative wound closure, drainage for infection control and previous systemic evaluation of bleeding disorders were critical for the prevention of postoperative bleeding in the local dental clinic.

• Natural Product Sciences
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• 제6권2호
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• pp.53-55
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• 2000

In the course of continous work for the discovery of anti-thrombotic constituents from tubers of Gastrodia elata, citric acid 1,5-dimethyl ester was isolated from ethylacetate soluble fraction prepared from the methanol extract. The structure of the compound was determined by the spectroscopic data. The anti-thrombotic effect of this compound was observed with prolonging the bleeding time in thrombin-induced thrombosis model of mice.

• 대한상부위장관⦁헬리코박터학회지
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• 제18권4호
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• pp.219-224
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• 2018

New oral anticoagulants (NOACs) are now widely used for the prevention and treatment of venous thrombosis, and for the prevention of stroke and systemic embolism in patients with atrial fibrillation. As compared with warfarin, NOACs have the advantage of rapid onset of action and less drug interaction. However, they carry a higher risk of gastrointestinal (GI) bleeding than warfarin. The risk of GI bleeding in patients using NOACs varies according to the type and dose of the drug. By contrast, apixaban and edoxaban are reported to carry similar risks as warfarin, and the risks with dabigatran and rivaroxaban are higher than that with warfarin. In patients using NOACs, old age, impaired renal function, impaired liver function, concurrent use of antiplatelet agents, and nonsteroidal anti-inflammatory drugs are considered major risk factors of GI bleeding, and gastroprotective agents such as histamine-2 receptor antagonist and proton pump inhibitor have preventive effects. To prevent GI bleeding associated with NOACs, the characteristics of each NOAC and the risk factors of bleeding should be recognized.

• The Korean journal of internal medicine
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• 제39권2호
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• pp.261-271
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• 2024

Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper and lower GI tract in concomitant aspirin and acid suppressant users using the nationwide database of national claims data from the Korean National Health Insurance Service (NHIS). Methods: An aspirin cohort was constructed using the NHIS claims data from 2013 to 2020. Patients who manifested with hematemesis, melena, or hematochezia were considered to have GI bleeding. A Cox proportional hazards regression model was used to determine the risk factors for GI bleeding associated with the concomitant use of GI drugs and other covariates among aspirin users. Results: Overall, a total of 432,208 aspirin users were included. The concurrent use of an acid suppressant and eupatilin (hazard ratio [HR] = 0.85, p = 0.016, vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Moreover, a more than 3-month duration (HR = 0.88, p = 0.030) of acid suppressant and eupatilin prescription (vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Conclusions: Eupatilin administration for ≥ 3 months showed additional preventive effect on GI bleeding in concomitant aspirin and acid suppressant users. Thus, cotreatment with eupatilin with a duration of 3 months or longer is recommended for reducing GI bleeding among aspirin plus acid suppressant users.

• Archives of Pharmacal Research
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• 제23권2호
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• pp.116-120
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• 2000

Aspirin has been widely used as analgesic and anti-inflammatory drug. Recently, it was elucidated that aspirin have anti-coaggregatory effect in low dose. This study was carried out to investigate the synthesis of aspirin derivatives from aspirin and aromatic compound of antioxidant and its biological activities. Synthesis of aspirin derivatives was prepared by esterification in the presence of 1, 1-carbonyldiimidazole. Biological activities was examined using effect of anti-coagulant on bleeding time, effect of antioxidant and effect of anti-platelet aggregation. As a result, SJ-101 showed strong antioxidative activity and anti-coagulant activity among four compounds. Anti-platelet aggregation of SJ-101 was examined by collagen, ADP, PAF method. SJ-101 exhibited more stronger activity to aspirin at collagen aggregation reaction. These finding demonstrates that SJ-101 is usefull as care drug of aging and old-disease because of its has antioxidant activity, anti-coagulant activity and anti-platelet activity.