• Nutritional Sciences
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• v.9 no.1
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• pp.14-19
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• 2006

Breast cancer may be the consequence of free radical damage, which is partially caused by the excessive intake of dietary fat and imbalances in antioxidant scavenger system;. In this experiment, we examined! the effects of dietary peroxidizability index (PI) values on hepatic thiobmbituric acid reaction substances (TBARS) and antioxidant enzyme activities in rats treated with 7,12-dimethylbenz[$\alpha$]anthracene (DMBA). Female Sprague-Dawley rats were used and 7,12-DMBA (20 mg/kg body weight) was gastrically intubated at seven weeks of age in order to induce mammary tumors (MT). The levels of dietary PI were 36, 81, 126 and 217 (LPI, MLPI, MHPI and HPI), while dietary polyunsaturated/saturated fatty acids ratio was maintained at the same level (1.0). Fat used in the experiment was mixed with soybean oil, com oil, palm oil, perilla oil, sesame oil, fish oil, and beef tallow. Experimental diets were given for the following 20 weeks. We measured tumor numbers and weights, and then assayed the hepatic TBARS levels and antioxidant enzyme activities such as superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione-S-transferase (GST) and glutathione reductase (GR). The incidence of Mr was the lowest in the MHPI group. The hepatic TBARS level was significantly raised with increasing dietary PI value. The hepatic SOD and GR activities were differed significantly by dietary PI value. The hepatic SOD activity was negatively correlated with dietary PI value and GR activity was the highest in the rats fed the MHPI diet. When the dietary P/S ratio is kept at 1.0, adequate dietary PI value (PI value of 126) may reduce the incidence and growth of Mr, but this benefit may be lost with higher dietary PI value. These results suggest that the awareness of dietary PI values may help to decrease breast cancer incidence and growth.

• Resources Recycling
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• v.26 no.4
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• pp.56-61
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• 2017

This study investigated the feasibility of a statistical approach for soil recycling through the prediction of BaP, DahA and total PAH (${\Sigma}PAH$) concentrations from BaA concentration. As results of regression, excellent linear correlations ($R^2$ > 0.90) were observed between BaA and BaP (or DahA) concentrations. When a developed prediction equation was applied to other investigations as a validation study, good prediction results were obtained. The predictive model showed very good correlation between the measured and calculated BaP. From this equation, BaA was an apparently important hydrocarbon for the prediction of PAHs. This model might provide a potentially useful tool for the calculation of average BaP, DahA and ${\Sigma}PAH$ without additional tests.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.570-576
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• 2006

Phytoestrogen biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. This study examined the action of biochanin A with the carcinogen activation pathway that is mediated by the aryl hydrocarbon receptor (AhR) in MCF-7 breast carcinoma cells. Treating the cells with biochanin A alone caused the accumulation of CYP1A1 mRNA and an increase in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. A concomitant treatment with 7,12-dimethylbenz[a]anthracene (DMBA) and biochanin A markedly reduced the DMBA-inducible EROD activity and CYP1A1 mRNA level. In addition, the biochanin A treatment alone activated the DNA-binding capacity of the AhR for the dioxin-response element (DRE) of CYP1A1, as measured by the electrophoretic-mobility shift assay (EMSA). EMSA revealed that biochanin A reduced the level of the DMBA-inducible AhR-DRE binding complex. Furthermore, biochanin A competed with the prototypical AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), for binding to the AhR in an isolated rat cytosol. The biochanin A competitively inhibited the metabolic activation of DMBA, as measured by the formation of the DMBA-DNA adducts. These results suggest that biochanin A may thus be a natural ligand to bind on AhR. Therefore, biochanin A may be due to act an antagonist/agonist of the AhR pathway.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.4
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• pp.397-403
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• 2021

Polycyclic Aromatic Hydrocarbons (PAHs) were analyzed and safety evaluation was carried out in Korean coastal area. The target congeners were benzo[a]pyrene, benzo[a]anthracene, benzo[b]fluoranthene, and chrysene. The method of analysis was significant. The highest PAHs 4 congener concentrations (12.2 ㎍/kg) was found in the mussel of Gangwon area. Comparison among the average concentration of PAHs for each congener showed that, benzo[a] anthracene was found in mussel (0.276 ㎍/kg), oyster (0.463 ㎍/kg), ark shell clam (1.92 ㎍/kg), and chrysene was found in mussel (0.848 ㎍/kg), oyster (1.36 ㎍/kg), scallop (0.489 ㎍/kg), sea squirt (3.07 ㎍/kg), and ark shell clam (0.449 ㎍/kg). In addition, benzo[b]fluoranthene was found in mussel (0.253 ㎍/kg), scallop (0.244 ㎍/kg), and sea squirt (1.64 ㎍/kg). The most hazardous benzo[a]pyrene was found in mussel (0.147 ㎍/kg), and scallop (0.244 ㎍/kg), it was not detected in the other shellfishes. However, all the PAHs levels recorded in this study did not exceed international MRLs. There was no significant difference among the PAHs concentration in shellfish based on sampling area or species. Body exposure was calculated based on PAHs concentration and intake rate. The results of this study indicated that PAHs in shellfish were within acceptable safe levels.

• Analytical Science and Technology
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• v.21 no.5
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• pp.432-437
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• 2008

In this study, polysilanes were synthesized by electroreduction with different monomers such as $CH_3HSiCl_2$, $PhSiCl_3$, $CH_3SiCl_3$ and $(CH_3)_2SiCl_2$ by Mg electrodes under ultrasonic radiation. The effects of monomers and additives (p-dibromobenzene (DBB), naphthalene (NAPH) and anthracene (ANTH)) on the reaction rate were investigated. Polymerization of $PhSiCl_3$ among the four monomers showed the highest rate. p-dibromobenzene (DBB) was proved the most effective additive. Based on the observations, some possible reaction mechanisms of the polymerization were proposed.

• Journal of Soil and Groundwater Environment
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• v.12 no.4
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• pp.25-31
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• 2007

Characterizing the risk posed by a mixture of chemicals is a challenging task due to the chemical interactions of individual components that may affect their physical behavior and hence alter their exposure to receptors. In this study, cell tests that represent subsurface environment were carried out using benz[a]anthracene (BaA) and p-xylene focusing on phasetransforming interaction to verify increased mobility and risk of highly sorbed pollutants in the presence of less sorbed, mobile liquid pollutants. A transport model was also developed to interpret results and to simulate the same process on a field scale. The experimental results showed that BaA had far greater mobility in the presence of p-xylene than in the absence of that. The main transport mechanisms in the vadose zone were by dissolution to p-xylene or water. The transport model utilizing Defined Time Steps (DTS) was developed and tested with the experimental results. The predicted and observed values showed similar tendency, but the more work is needed in the future study for more precise modeling. The field-scale simulation results showed that transport of BaA to groundwater table was significantly faster in the presence of NAPL, and the oral carcinogenic risk of BaA calculated with the concentration in groundwater was 15${\sim}$87 times larger when mixed with NAPL than when solely contaminated. Since transport rate of PAHs is very slow in the subsurface without NAPL and no degradation of PAHs was considered in this simulation during the transport, the increase of risk in the presence of NAPL is expected to be greater for the actual contaminated site.

• Journal of the Korean Society of Marine Environment & Safety
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• v.14 no.4
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• pp.257-266
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• 2008

PAHs are of mainly anthropogenic origin from urban runoff, oil spill and combustion of fossil fuels. Some PAHs are potentially carcinogenic and mutagenic to aquatic organisms. This study was carried out to survey the contamination of PAHs in the column sediments around Gwangyang bay. Yeosu petrochemical industrial complex, POSCO(Pohang steel compony) and Gwangyang container harbor are located near the bay. The column sediments were collected at 4 stations(A, B, C and D) and fractionated at intervals of two-centimeter depth on July 29, 1999. PAHs in colmn sediment samples were extracted in soxhlet extractor and were identified and quantified by GC-MS. PAHs compounds were analyzed and found to be 13 species. Total PAHs concentrations in the column sediments ranged from 275.04 to 2,838.64${\mu}g/kg$ dry wt. Naphthalene had the highest concentration in the range of 40.60 to 2,294.06${\mu}g/kg$ dry wt. and Anthracene had the lowest concentration in the range of 2.63 to 11.30${\mu}g/kg$ dry wt. The correlation coefficients between individual PAHs and total PAHs in the column sediments were relatively higher in the low molecular compounds such as Naphthalene, Acenaphthylene and Phenanthrene. The relationship between the P/A(Phenanthrene/Anthracene)ratio and F/P(Fluoranthene/Pyrene)ratio showed that P/A ratio was generally above 10 and F/P ratio was above 1 in all sediment samples. These data indicate that PAHs in the column sediments around Gwangyang bay seem to be of both pyrolytic and petrogenic origin The values of PAHs in the column sediments were lower than the biological effect guidelines.

• Journal of the Korean Society of Marine Environment & Safety
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• v.13 no.1 s.28
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• pp.9-20
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• 2007

PAHs(Polycyclic Aromatic Hydrocarbons) are widespread contaminants in the marine environment. They are of mainly anthropogenic origin from urban runoff, oil spill and combustion of fossil fuels. Some PAHs are potentially carcinogenic and mutagenic to aquatic organism The contamination of PAHs in the coastal environments has not been well known yet in Korea. This study was carried out to survey the contamination of PAHs in sediments around Gwangyang bay. The Yeosu petrochemical industrial complex, POSCO(Pohang steel company) and Gwangyang container harbor are located around the bay. PAHs in sediment samples were extracted in soxhlet extractor and were identified and quantified by GC-MS(Gas Chromatography-Mass Spectrometry) TOC(Total Organic carbon) and textural parameters in sediment samples were also analyzed 13 species of PAHs were detected at all of the surface sediments. Total PAHs concentrations in the surface sediments ranged from 171.40 to $1013.54{\mu}g/kg$ dry wt.. In most of the surface sediments, Naphthalene was the highest in the range of 14.08 to $691.39{\mu}g/kg$ dry wt. and Anthracene was the lowest in the range of 0.49 to $22.66{\mu}g/kg$ dry wt.. The correlation coefficients between individual PAHs and Total PAHs in the surface sediments were relatively higher in the low molecular compounds such as Naphthalene and Phenanthrene. In the relationship of the P/A(Phenanthrene/Anthracene) ratio and F/P(Fluoranthene/Pyrene) ratio, P/A ratio was generally above 10 and F/P ratio was shown to be above 1 in all sediment samples. These data indicate that PAHs in sediments around Gwangyang bay seem to be of both pyrolytic and petrogenic origin. Total PAHs in the surface sediments were correlated with TOC and textural parameters. The values of PAHs in the surface and core sediments were lower than the biological effect guidelines.

• The Korean Journal of Pesticide Science
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• v.11 no.2
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• pp.95-105
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• 2007

The aim of this study was to determine the residual amounts of PAHs in environmental samples such as crop, soil and water collected from paddy, upland fields and forestlands near industrial zone and/or a thermal power plant in South Korea. All of the samples were analyzed by GC-mass spectrometer. The average contents of total PAHs in soil samples were 140.2 ${\mu}g\;kg^{-1}$ and the range was from 4.3 to $662.9{\mu}g\;kg^{-1}$. The detection of benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene and dibenzo(a,h) anthracene which have strong carcinogenecity was ranged from 14.2 to 167.8 ${\mu}g\;kg^{-1}$. The residual amounts and detection frequency of PAHs in soil samples from the iron and heavy industrial areas near Pohang and Busan were 3-folds more than those of the other areas. Amounts of PAHs in upland soil samples was 1.5 folds higher than those of paddy soil samples, suggesting that it may be related to the content of organic matter in soil. The average contents of total PAHs in crop samples were 9.7 ${\mu}g\;kg^{-1}$ which ranged from 4.5 to 52.2 ${\mu}g\;kg^{-1}$. However, the residual amounts of PAHs in water samples were not detected. These results showed that soils and crops were slightly contaminated with PAHs. Therefore, the investigation should be continued for evaluating a safety or risk assessment through expansion of regions and crops.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.724-726
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• 2004

Highly efficient blue organic light-emitting devices (OLEDs) utilizing the idea of copper phthalocyanine (CuPc)/N,N'-bis-(1-naphthyl)-N,N'-diphenyl,1,1'-biphenyl- 4,4'-diamine (NPB) composite hole transport layer (CPHTL) have been fabricated. The effect of inserting CPHTL upon the performance of blue OLEDs with 2-methyl-9,10-di(2-naphthyl)anthracene (MADN) as the blue emitter has been investigated. Compared with the luminous efficiency of the standard blue device without CPHTL (1.33 cd/A), that of the device with 40:60 CuPc/NPB CPHTL has been increased by more than twice up to 2.96 cd/A with a Commission Internationale d'Eclairage (CIE) coordinates of(x = 0.15, y = 0.10) and a power efficiency of 1.46 lm/W (20 mA/$cm^2$) at 6.39 V. The increased device efficiency is attributed to an improved balance between hole and electron currents arriving at the recombination zone.