• Journal of Internet Computing and Services
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• v.10 no.5
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• pp.13-26
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• 2009

Wireless Sensor Networks (WSNs) is one of the key technologies that make it possible to provide u-service in a ubiquitous society, however, it has disadvantages such as difficulty of managing sensor nodes and weaknesses of stability or mobility in large-scale WSNs. In order to solve these problems, 6LoWPAN that integrates with WSNs and IP networks has been studied widely. In this paper, we propose a Location Tracking Service Based on Google Map (LTSGM) system using 6LoWPAN. Since LTSGM system provides visual location information of sensor nodes through Google Map, it is possible to makes it easier than ever to manage sensor nodes in large-scale WSNs. Moreover, LTSGM can be used for various services such as applications for disaster or crime because it can trace the location of mobile nodes. Implementation of LTSGM system will be a test platform for 6LoWPAN.

• Korean Journal of Microbiology
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• v.30 no.3
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• pp.225-231
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• 1992

l o identil) ;~nclc li~iracterize; In iiscorhate oxiililinp enzyme in ('/rItrn~i~rlon~ir~c~t~itr~~lr.o\ r(1rii. we studicil ;is li)llows. Ascorh;ric oxiiliring cn/;jme activit) f ~ o ~thne crude extract 01' ( ' / ~ l o n ~ ~ . c l o t ~1~~oit~rl~1oin~/.t\ii W;I\ dctccietl by 5pecific active 5ta1ning through nati\e gel cletrophorcsi\ and ~iltra\~iolestp eciroscopy. Ascorb~ttco xidizing c n ~ y m ew i15 partilly 1~1rilieJ by \;~riousp roccclurcs inclucli~lga rnmoniu~ns uIl';~tcp recipit;iion. aJ\orption ~111-om;~togrophy on Iiy~lroxyapaiitca nd Scphailcx <;-I50 gel lillration chrornatogral>liy. Plie ~nolecularw eight 01' the nativc cnrytiic was ahour 88.000 tlalton hy nativc gel elcciroplloresis anci subunit niolecul;ir ~rciglit 55,000 ol' this cnrymc w;~c determined hy SIIS-P.ASI!. The optimum tcmper~tture ii)r the cnrymc nos ahout 5j$^{\circ}$C and pH 4.6 was the optimum. Moreover. ascorhaie oxi~losc in C: reinhardtii was confirmet1 by Ll1e\tcrn blotting technique.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2344-2346
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• 2002

A vacuum control system has been developed for using Ethernet Multi Serial Device Severs (EMSDS) for the Pohang Accelerator Laboratory (PAL) storage ring. There are 124 vacuum ion pumps at the storage ring. It was a very important problem to solve the problem how to control such a big number of vacuum pumps distributed around the ring. After discussions, we decided to develop a serial to ethernet interrace device sever that will be mounted in the control system rack. It has a 32-bits microprocessor embedded Linux, 12 ports RS485 (or RS232) slave interface. one channel 10/100BaseTx ethernet host port, one channel UART host port, and 16 Mbytes large memory buffer. These vacuum pumps are connected to Ion-Pump serial controllers, which chop the AC current so as to control the current in the pumps. The EMSDS connect either 100BaseTx or 10BaseT ethernet networks to asynchronous serial ports for communication with serial device. It can simultaneously control up to 12 ion-pump serial controllers. 12 EMSDS are connected to a personal computer (PC) through the network. The PC can automatically control the EMSDS by sending a set of commands through the TCP/IP network. Upon receiving a command from a PC running under Windows2000 through the network, the EMSDS communicate through the stave serial interrace ports to ion-pump controller. We added some software components on the top of EPICS (Experimental Physics and Industrial Control System) toolkit.

• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.2
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• pp.162-167
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• 2009

In this paper, we present a patient real-time vital sign information transmission system to effectively support developing real-time communication service by using a real-time object model named TMO (Time-Triggered Message-Triggered Object). Also, we describes the application environment as the PMS(Patient Monitoing System) to guarantee real-time service message with TMO structure in distributed network systems. We have to design to obtain useful vital sign information, which is generated at parsing data receiver modulor of HIS with TMO structure, that is offered by the central monitor of PMS. Vital sign informations of central monitor is composed of the raw data of several bedsite patient monitors. We are willing to maintain vital sign information of real time and continuity that is generated from the bedsite patient monitor. In the real time simulation techniques based on TMO object modeling, we have observed several advantages to the TMO structuring scheme. TMO object modeling has a strong traceability between requirement specification and design.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2002.02a
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• pp.192-197
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• 2002

1. 실시간 모니터링 -온실 내부환경의 계측장치로 모듈화된 단일 칩 마이크로프로세서를 이용한 하우스 모니터를 개발하였다. 개발된 다수의 하우스 모니터는 RS-485통신을 이용하여 개발된 프로토콜을 통하여 그룹 모니터와 통신하면서 계측 데이터를 전송하였고 안정된 계측 성능을 보였다. 또한 그룹 모니터는 하우스모니터로부터 수신한 데이터를 인터넷 환경 TCP/IP 통신에 의해 서버에 정보를 전송하고 데이터베이스 서버에 저장할 수 있었다. 2. 클라이언트 서버 모델 -클라이언트 모니터를 통하여 허용된 사용자들은 해당 온실의 상황을 원격지에서 파악할 수 있는 있었다. 또한 분산환경 기술을 이용하여 서버를 경유하여 데이터베이스 서버에서 데이터 셋을 가져와 과거 재배 사례 등을 조회 및 이용 가능하였다. 이는 전문가에게 접근을 허용함으로써 재배에 관한 지원이 가능하도록 하였다. 데이터 베이스 시스템으로 연계하여 온실환경 정보를 분석하는 것이 가능하였다. 3. 기대효과 및 나아가야 할 방향 -개발된 시스템을 식물 공장 내 작물의 재배환경을 데이터베이스화하여 재배사례 데이터베이스를 형성하고 작물이 가장 잘 자라는 최적 재배 환경을 연구하여 고품질의 작물 재배에 이용될 수 있다. 또한 식물공장의 운전실적, 환경 조건, 환경 조절비용 등의 분석에 효율적으로 이용될 수 있을 것으로 예상되며 각 환경인자들과의 관계를 구명하는데 도움을 줄 것이다. 축적된 작물의 재배 사례 데이터베이스를 이용하여 작물 특성 및 재배 연구에 도움을 줄 수 있을 것이다. 제어 장치들의 운영실적을 분석함으로써 제어 시스템의 효율적이고 경제적인 제어가 가능하도록 할 수 있을 것이다. 이들이 모두 완성되면 전문가 및 전문가 시스템으로부터 지원을 받는 지능형 식물공장이 가능할 것이다. 본 연구에서 개발한 계측 모듈 및 데이터베이스 시스템은 실제 농가에 설치된 전용선을 이용하여 실증 실험을 통해 수정·보완하여야 할 것이다. 또한 시설원예분야에서 있어서 통신체계에 대한 표준화 연구가 수행되어 앞으로 개발될 다른 시스템들과의 호환성을 갖도록 해야 할 것이다. 앞으로 온실의 경영 및 관리 데이터베이스를 개발하여 첨단온실의 통합 관리 및 정보 시스템을 구축하여야 할 것이다. 또한, 시설원예의 환경 설계의 기준을 적용할 수 있도록 하여야 할 것이다.

• Translational and Clinical Pharmacology
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• v.25 no.2
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• Genes and Genomics
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• v.40 no.11
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• pp.1181-1197
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• 2018

Tropical plant rubber tree (Hevea brasiliensis) is the sole source of commercial natural rubber and low-temperature stress is the most important limiting factor for its cultivation. To characterize the gene expression profiles of H. brasiliensis under the cold stress and discover the key cold stress-induced genes. Three cDNA libraries, CT (control), LT2 (cold treatment at $4^{\circ}C$ for 2 h) and LT24 (cold treatment at $4^{\circ}C$ for 24 h) were constructed for RNA sequencing (RNA-Seq) and gene expression profiling. Quantitative real time PCR (qRT-PCR) was conducted to validate the RNA-Seq and gene differentially expression results. A total of 1457 and 2328 differentially expressed genes (DEGs) in LT2 and LT24 compared with CT were respectively detected. Most significantly enriched KEGG pathways included flavonoid biosynthesis, phenylpropanoid biosynthesis, plant hormone signal transduction, cutin, suberine and wax biosynthesis, Pentose and glucuronate interconversions, phenylalanine metabolism and starch and sucrose metabolism. A total of 239 transcription factors (TFs) were differentially expressed following 2 h or/and 24 h of cold treatment. Cold-response transcription factor families included ARR-B, B3, BES1, bHLH, C2H, CO-like, Dof, ERF, FAR1, G2-like, GRAS, GRF, HD-ZIP, HSF, LBD, MIKC-MADS, M-type MADS, MYB, MYB-related, NAC, RAV, SRS, TALE, TCP, Trihelix, WOX, WRKY, YABBY and ZF-HD. The genome-wide transcriptional response of rubber tree to the cold treatments were determined and a large number of DEGs were characterized including 239 transcription factors, providing important clues for further elucidation of the mechanisms of cold stress responses in rubber tree.

• Journal of Periodontal and Implant Science
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• v.39 no.2
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• pp.119-128
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• 2009

Purpose: The aim of this study was to evaluate the stemness of cells from canine dental tissues and bone marrow. Methods: Canine periodontal ligament stem cells (PDLSC), alveolar bone stem cells (ABSC) and bone marrow stem cells(BMSC) were isolated and cultured. Cell differentiations (osteogenic, adipogenic and chondrogenic) and surface antigens (CD146, STRO-1, CD44, CD90, CD45, CD34) were evaluated in vitro. The cells were transplanted into the subcutaneous space of nude mice to assess capacity for ectopic bone formation at 8 weeks after implantation. Results: PDLSC, ABSC and BMSC differentiated into osteoblasts, adipocytes and chondrocytes under defined condition. The cells expressed the mesenchymal stem cell markers differently. When transplanted into athymic nude mice, these three kinds of cells with hydroxyapatite /${\beta}$- tricalcium phosphate (HA/TCP) carrier showed ectopic bone formation. Conclusions: This study demonstrated that canine dental stem cells have stemness like bone marrow stem cells. Transplantation of these cells might be used as a therapeutic approach for dental stem cell-mediated periodontal tissue regeneration.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.315-319
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• 1996

We have developed a prototype patient monitoring system including module-based bedside units, interbed network, and central stations. A bedside unit consists of a color monitor and a main CPU unit with peripherals including a module controller. It can also include up to 3 module cases and 21 different modules. In addition to the 3-channel recorder module, six different physiological parameters of ECG, respiration, invasive blood pressure, noninvasive blood pressure, body temperature, and arterial pulse oximetry with plethysmogaph are provided as parameter modules. Modules and a module controller communicate with up to 1Mbps data rate through an intrabed network based on RS-485 and HDLC protocol. Bedside units can display up to 12 channels of waveforms with any related numeric informations simultaneously. At the same time, it communicates with other bedside units and central stations through interbed network based on 10Mbps Ethernet and TCP/IP protocol. Software far bedside units and central stations fully utilizes gaphical user interface techniques and all functions are controlled by a rotate/push button on bedside unit and a mouse on central station. The entire system satisfies the requirements of AAMI and ANSI standards in terms of electrical safety and performances. In order to accommodate more advanced data management capabilities such as 24-hour full disclosure, we are developing a relational database server dedicated to the patient monitoring system. We are also developing a clinical workstation with which physicians can review and examine the data from patients through various kinds of computer networks far diagnosis and report generation. Portable bedside units with LCD display and wired or wireless data communication capability will be developed in the near future. New parameter modules including cardiac output, capnograph, and other gas analysis functions will be added.

• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.