• Title/Summary/Keyword: an ideal life

Search Result 279, Processing Time 0.033 seconds

Design, Combinatorial Library Synthesis and Biological Evaluation of Nonpeptide Scaffold for Beta Turns

  • Im, I-Sak;Thomas R.Webb;Dona Chianelli;Kim, Yong-Chul
    • Proceedings of the PSK Conference
    • /
    • 2003.10a
    • /
    • pp.91-91
    • /
    • 2003
  • The beta-turn has been implicated as an important conformation for biological recognition of peptides or proteins. We adapted the concept of general Ca atom positioning from the cluster analysis and recombination of each ideal beta-turn conformation pattern by Garland and Dean (1. Computer-Aided Molecular Design, 1999, 13, 469) as one strategy of designing non-peptide beta-turn scaffolds. (omitted)

  • PDF

A Study on "Viewing" and "Being Viewed" Found in Contemporary Fashion - Focus on the Perspectives of Freud, Lacan, and Merleau-Ponty - (현대 패션에 나타나는 ‘봄과 보임’에 관한 연구 - Freud, Lacan, Merleau-Ponty의 시각을 중심으로 -)

  • Kim, Yon-Son;Gaang, Byoung-Suk
    • Journal of the Korean Society of Costume
    • /
    • v.58 no.2
    • /
    • pp.134-148
    • /
    • 2008
  • Methods of delivering products to consumers do not act as less important factor than creative activities to create new product designs. Mobilizing various psychological elements based on human instinct and desire, fashion industry presents a product as an object of envy, gaining viewers' attention. Here, the viewer does not simply take the product as an object to view, but also imagine transformation it will bring. The study of the cause and effects of the interaction, which is found in the relationship between "the viewer" and "what is viewed" is an important factor that needs to be identified in the phase of creation as well as in the aspect of delivery. The relationship between the perceiver and what is perceived features in designs, product advertisements, related articles, and fashion shows in modern fashion, serving as a medium that enables the humans, who must inevitably exist between the two poles such as mind and body, the subject and the object, the ego and non-ego, and the reality and an ideal, to communicate between the poles. Humans cannot do arbitrary acts or make arbitrary selections only as they access to foreign things through instinct, desire, or experienced perception, and they are sometimes positioned passive by things. In the background, as there are human dual characteristics in which they are expressed as the ego and another ego who exists inside of the ego, they not only view an object, but also become an object to be viewed. Many products in modern fashion, as the objects of reciprocal transposition, grow giving illusions to humans. Having a desire for such objects is human's instinct and normal act to keep the life balanced between the reality and an ideal, which is based on the activation of reality function. Furthermore, freely acting rather than ignoring or overcoming the desire may be the act of retrieving one's ownership to the ego.

Edge-preserving demosaicing method for digital cameras with Bayer-like W-RGB color filter array

  • Park, Jongjoo;Chong, Jongwha
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • v.8 no.3
    • /
    • pp.1011-1025
    • /
    • 2014
  • A demosaicing method for a Bayer-like W-RGB color filter array (CFA) is proposed. When reproducing images from a W-RGB CFA, conventional color separation methods for W-RGB CFA are likely to cause blurring near the edges due to rough averaging using a color ratio of neighboring pixels. Moreover, these methods cannot be applied to real-life digital cameras with W-RGB CFA because the methods were proposed under an ideal situation, W=R+G+B, not a real-life situation, $W{\neq}R+G+B$. To improve edge performance, we propose a method of constant color difference assumption with inversed weight, which uses information from all edge directions for interpolating all missing color channels. The proposed method calculates the correlation between W, R, G, and B to enable its application to real-life digital cameras with W-RGB CFA. Simulations were performed to evaluate the proposed method using images captured from a real-life digital camera with W-RGB CFA. Simulation results shows that we can demosaic by using the proposed algorithm compared with the conventional one in about +34.79% SNR, +11.43% PSNR, +1.54% SSIM and 14.02% S-CIELAB error. Thus, the proposed method demosaics better than the conventional methods.

DYNAMIC MODELING AND ANALYSIS OF VEHICLE SMART STRUCTURES FOR FRONTAL COLLISION IMPROVEMENT

  • Elemarakbi, A.M.;Zu, J.W.
    • International Journal of Automotive Technology
    • /
    • v.5 no.4
    • /
    • pp.247-255
    • /
    • 2004
  • The majority of real world frontal collisions involves partial overlap (offset) collision, in which only one of the two longitudinal members is used for energy absorption. This leads to dangerous intrusions of the passenger compartment. Excessive intrusion is usually generated on the impacted side causing higher contact injury risk on the occupants compared with full frontal collision. The ideal structure needs to have extendable length when the front-end structure is not capable to absorb crash energy without violating deceleration pulse requirements. A smart structure has been proposed to meet this ideal requirement. The proposed front-end structure consists of two hydraulic cylinders integrated with the front-end longitudinal members of standard vehicles. The work carried out in this paper includes developing and analyzing mathematical models of two different cases representing vehicle-to-vehicle and vehicle-to-barrier in full and offset collisions. By numerical crash simulations, this idea has been evaluated and optimized. It is proven form numerical simulations that the smart structures bring significantly lower intrusions and decelerations. In addition, it is shown that the mathematical models are valid, flexible, and can be used in an effective way to give a quick insight of real life crashes.

Clinical implications of the Hippo-YAP pathway in multiple cancer contexts

  • Kim, Han-Byul;Myung, Seung-Jae
    • BMB Reports
    • /
    • v.51 no.3
    • /
    • pp.119-125
    • /
    • 2018
  • The Hippo pathway plays prominent and widespread roles in various forms of human carcinogenesis. Specifically, the Yes-associated protein (YAP), a downstream effector of the Hippo pathway, can lead to excessive cell proliferation and the inhibition of apoptosis, resulting in tumorigenesis. It was reported that the YAP is strongly elevated in multiple types of human malignancies such as breast, lung, small intestine, colon, and liver cancers. Recent work indicates that, surprisingly, Hippo signaling components' (SAV1, MST1/2, Lats1/2) mutations are virtually absent in human cancer, rendering this signaling an unlikely candidate to explain the vigorous activation of the YAP in most, if not all human tumors and an activated YAP promotes the resistance to RAF-, MAPK/ERK Kinase (MEK)-, and Epidermal growth factor receptor (EGFR)-targeted inhibitor therapy. The analysis of YAP expressions can facilitate the identification of patients who respond better to an anti-cancer drug treatment comprising RAF-, MEK-, and EGFR-targeted inhibitors. The prominence of YAP for those aspects of cancer biology denotes that these factors are ideal targets for the development of anti-cancer medications. Therefore, our report strongly indicates that the YAP is of potential prognostic utility and druggability in various human cancers.

A Study on the Application and Characteristics of Interior Design in the Traditional Housing from an Ecological Aspect (생태학적 관점에 의한 전통 주거의 실내디자인 특성과 적용에 관한 연구)

  • 한경희;김자경
    • Korean Institute of Interior Design Journal
    • /
    • no.29
    • /
    • pp.103-111
    • /
    • 2001
  • The ideal housing in the 21st century means that it can provide people with the balanced life between nature and human life, while is possible through the systematic harmony of nature, environment, and human. As our society increasingly pays attention to the importance of environment, environment friendly houses and ecological dwellings are being built. If we add our own cultural environment attribute and historical identity to the ecological housing, we can create the most unique Korean ecological architecture. This study examines ecological interior expression methods from the traditional housing architecture which started out of nature, in order to find out an ecological approach in the interior design of the dwelling space. Based upon this examination, it mainly focuses on how these methods can be applied to a modern housing architecture. From an ecological perspective, the traditional house interior has two distinct characteristics; nature friendly and human friendly, because it considered nature and human harmoniously. The interior of the traditional housing can be divided into three types; nature friendly, health friendly, and human friendly. Finally, this study investigates the ecological value of the three types and application of them to modern housing. It will help to find out the harmonious way of building a house harmonizing both nature and human. Especially, considering that the nature is being destructed and the health of human is deteriorating due to the destruction of the nature, this study will show a feasible alternative to build the most Korean style of environmental architecture.

  • PDF

Consumer Education through Experiential Learning: Developing Social Responsibility and Soft Skills as Consumer Professionals (경험학습을 통한 소비자교육: 소비자 전문가로서의 사회적 가치와 능력 개발을 중심으로)

  • 나종연
    • Journal of Families and Better Life
    • /
    • v.22 no.2
    • /
    • pp.59-67
    • /
    • 2004
  • As we enter into the 21C, it is important to reassess the knowledge and skills that are necessary for individual consumers and consumer professionals to be able to function efficiently in the rapidly changing society, and also to develop teaching tools fit to enhance the teaming of such knowledge and skills. The Purpose of this study is three-folds: 1) to identify key competencies necessary in the 21C consumer education, especially in higher education institutions, 2) to suggest 'experiential learning' as an ideal pedagogical tool for consumer education in the 21C century, and 3) to provide an example from an undergraduate classroom in the U.S. that applies 'service learning' as a teaching tool in a consumer studies curriculum. Discussions about the potentials for expanding this learning strategy are also provided.

Finding an Archetypal Landscape of Yongdam Village Conformity with Traditional Region Theories (전통지역이론(傳統地域理論)에 준거(準據)한 용담면(用潭面)의 주거경관상(住居景觀相))

  • Huh, Joon;Rho, Jae Hyun
    • Journal of Korean Society of Rural Planning
    • /
    • v.5 no.1 s.9
    • /
    • pp.87-94
    • /
    • 1999
  • The purpose of this study is to find through the algorithm of traditional region theory how nature has been recognized and occupied and harmoniously used by human beings. As seen Korean traditional villages, the natural elements such as mountains and streams in Yongdam are more remarkable than the artificial elements. The people in the village regards a radius of 4-12 km as their territory and an ideal space harmonized with natural landscape. The landscape structure of Yongdam shows traditional fengshui form and has a all the characteristics that Korean rural villages have. The landscape elements, such as mountains, rivers, plains, trees, soil color, etc. characterize Yongdam village and make the landscape of Yongdam a unique place. Traditional region theory is to study an emotional reaction to the quality of life, and landscape of a settlement. And it should be a basic theory to understand the whole landscape.

  • PDF

A Study on the behavior of the Elderly and the optimum scale of the Necessary space in Daycare Center (주간보호센터의 이용자 행동과 소요공간의 적정규모에 관한 연구)

  • Kil, Jong-Won;So, Kab-Soo
    • Korean Institute of Interior Design Journal
    • /
    • v.17 no.6
    • /
    • pp.152-160
    • /
    • 2008
  • The Cases of advanced nations which have advanced welfare policy, they have headed for the deinstitutionalization and the protection of the local society. So they have expanded and improved the various policies and welfare facilities to be able to keep daily life on the base of local area. Many problems have been caused by rising the average life span of the elderly in Korea now. Under the tendency, there have been many alternative proposals to solve the problems. One of those proposals, the deinstitutionalization theory that is rated the ideal way, is the community-based care than the care in facilities for the elderly. It shows that the most ideal facility for the care is Daycare center and that it matters the system of spatial construction and standard of the facilities. Under the undetailed Korean standard of facility design, it is very important that system of spatial construction to correspond to the needs of the users and standard of the facilities are prepared from the point of view of the standard design of the domestic facilities for the elderly. The study of the book grasps the regional present situation of the domestic Daycare center and surveys the tendency of the stay and features of occupation of the user there through some case, and aims to have a thorough grip of the spatial scale by the user's behavior. It is to utilize for a proposal for preparation of the space scale, and an institution standard corresponding to user's needs in a Daycare center.

Study on Weight Summation Storage Algorithm of Facial Recognition Landmark (가중치 합산 기반 안면인식 특징점 저장 알고리즘 연구)

  • Jo, Seonguk;You, Youngkyon;Kwak, Kwangjin;Park, Jeong-Min
    • The Journal of the Institute of Internet, Broadcasting and Communication
    • /
    • v.22 no.1
    • /
    • pp.163-170
    • /
    • 2022
  • This paper introduces a method of extracting facial features due to unrefined inputs in real life and improving the problem of not guaranteeing the ideal performance and speed of the object recognition model through a storage algorithm through weight summation. Many facial recognition processes ensure accuracy in ideal situations, but the problem of not being able to cope with numerous biases that can occur in real life is drawing attention, which may soon lead to serious problems in the face recognition process closely related to security. This paper presents a method of quickly and accurately recognizing faces in real time by comparing feature points extracted as input with a small number of feature points that are not overfit to multiple biases, using that various variables such as picture composition eventually take an average form.