Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10a
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- Pages.91-91
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- 2003
Design, Combinatorial Library Synthesis and Biological Evaluation of Nonpeptide Scaffold for Beta Turns
- Im, I-Sak (Laboratory of Drug Discovery, Department of Life Science, Kwangju Institute of Science and Technology) ;
- Thomas R.Webb (ChemBridge Research Labs., LLC, and ChemBridge Corporatio) ;
- Dona Chianelli (ChemBridge Research Labs., LLC, and ChemBridge Corporatio) ;
- Kim, Yong-Chul (Laboratory of Drug Discovery, Department of Life Science, Kwangju Institute of Science and Technology)
- Published : 2003.10.01
Abstract
The beta-turn has been implicated as an important conformation for biological recognition of peptides or proteins. We adapted the concept of general Ca atom positioning from the cluster analysis and recombination of each ideal beta-turn conformation pattern by Garland and Dean (1. Computer-Aided Molecular Design, 1999, 13, 469) as one strategy of designing non-peptide beta-turn scaffolds. (omitted)
Keywords