• 약학회지
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• 제55권4호
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• pp.284-288
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• 2011

The test method for biologics of lot release system is based on 'Test procedure and specification for biological products,' generally, thimerosal content is measured by chemical analysis using O.D. In this study, the comparative analysis was carried out using the gold amalgamation method for thimerosal content was compared to the existing methods, which are described above. The gold amalgamation method, which uses atomic absorption spectrophotometry, was meets all the method validation acceptance criteria. It is considered to be proper as the assay and identification test for thimerosal. In this study, the comparative analysis was performed three times. As a result, gold amalgamation method is more convenient and easy to perform as this assay doesn't have pre-treatment procedure. Also this assay showed good precision and reproducibility compared to the conventional method. Therefore, it is appropriate to alternate the assay method of thimerosal from the conventional chemical analysis to gold amalgamation method to improve the credibility of lot release system and the quality control of biologics, by standardizing test method.

• 대한중풍순환신경학회지
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• 제18권1호
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• pp.1-11
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• 2017

It is difficult to combine oriental and western medicine. Each medicine has a different academic background, perspective on the world, and studying methodology. The claim that two paradigms can not be combined is not obtained from an actual verification, but this means it is so hard to combine two medicines having different backgrounds. The amalgamation of oriental and western medicine should be phased in on the basis of the continuous reciprocal understanding and commitment. First, the strength and weakness of each medicine over the treatment and research are required to be identified. Then, a few complementary areas can be chosen enabling a trial of fusion on a small scale. A cycle of problem solving and a new research can be set by analyzing research results obtained through the implementation over a period of time. In other words, the researchers of oriental and western medicine should repeat a continuous and gradual complementary research process by identifying issues to be improved and complemented through a consensus. Once the methodology obtained through the process of problem solving and proficient implementation is established in a stable condition, a method to widen the fusion area by expanding the operating area and implementation method can be chosen. However, the integral system of oriental medicine shouldn't be substituted by mechanical idea or reductionism. What should be done primarily for oriental medicine is to objectify things through quantification. In particular, the oriental treatment should accept the microscopic diagnosis to determine the structure and observe the biochemical change.

• 한국정보처리학회논문지
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• 제7권4호
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• pp.1132-1140
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• 2000

The purpose of this paper was to present the method of progress efficiency of morphosyntaxical analyzer for French information processing in the view of multilingual information processing. This study indicated that he method prohibit the additional useless word type by decomposing word type by decomposing works which were created by morphological amalgamation. Findings also suggested the need of preprocessing in order to decrease the overload of morphosyntaxical analysis algorithm. In addition, general rules were proposed to divide word form and to decompose complex sentence.

• 한국환경보건학회지
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• 제45권2호
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• pp.154-163
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• 2019

Objectives: The hazardous heavy metal contents of cosmetics were investigated and the resulting values were compared by type of cosmetics: skin care preparations (SCP), hair preparations (HP), makeup preparations (MP), and eye makeup preparations (EMP). Methods: The hazardous heavy metal contents (Pb, As, Cd, Sb, Ni and Hg) were analyzed for 358 cosmetics products (187 SCP, 82 HP, 56 MP, and 33 EMP). Hg was measured by the amalgamation method, and other hazardous heavy metals were measured by inductively coupled plasma optical emission spectrometer (ICP-OES) after decomposition using the microwave method. Results: The mean contents of Pb, As, Cd, Sb, Ni, and Hg in cosmetics were 0.424, 0.068, 0.024, 0.398, $0.567{\mu}/g$, and Not Detected, respectively. All of the hazardous heavy metals were detected in most products, but below the recommended maximums of the Ministry of Food and Drug Safety. The level of Cd was the lowest at 14.8%, and Sb was the highest at 41.2%. Pb, Sb and Ni showed the highest mean value and detection rate in EMP. As, Cd, and Hg showed the highest in SCP, HP, and MP, respectively. Conclusion: Hazardous heavy metals were detected in most products. In particular, Pb, Sb, and Ni were broadly detected in EMP, meaning more stringent quality control is required.

• 약학회지
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• 제23권2호
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• pp.95-104
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• 1979

Total mercury content of Korean soils which were randomly sampled at 212 different localities were determined by quartz tube combustion-gold amalgamation method, 1) The mean and median values of total mercury content of Korean soils were 0.18PPM and 0.14PPM, respectively. 2) Among 212 localities, 14 have total mercury contents which are three times higher than the median value. The highest values was found to be 1.74PPM.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 G
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• pp.2962-2964
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• 1999

We know the traffic information about the velocity and position of vehicle by extraction and tracking vehicle from continuosly obtained road image of camera. The conventional method of vehicle detection indicate increment of error due to headlight and taillight in night road image. This paper show such as vehicle detection of binary, Edge detection. amalgamation of image are applied to extract the vehicle, and Kalman filter is adaptive methods for tracking position and velocity of vehicle.

• 한국학교수학회논문집
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• 제20권2호
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• pp.187-210
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• 2017

2015 개정 수학과 교육과정에서 문제해결능력 함양을 위한 교수 학습 방법으로 수학적 모델링이 제시되면서, 국내에서 1990년 이래로 꾸준하게 연구되어 온 수학적 모델링에 관한 논의가 더욱 활발해지고 있다. 이에 본 연구는 수학적 모델링의 교육적 가치와 현장 적용의 필요성을 재음미해보고자, 수학 교과 역량의 관점에서 수학적 모델링에 관한 선행 연구를 고찰하였다. 그 결과, 수학적 모델링은 수학 교과 역량 중 문제해결의 하위 요소로 제시되고는 있지만, 문제해결 뿐만 아니라 추론, 의사소통, 창의 융합, 정보 처리, 태도 및 실천을 지지하는 교수 학습 방법임을 확인할 수 있었다. 이러한 측면에서, 수학 교과 역량에서의 수학적 모델링의 위치에 대한 논의의 필요성과 학교 현장 적용을 위한 방안으로 수학적 모델링에 대한 교사 교육 및 수학 교과서와 수업에서 수학적 모델링 과제의 적극적인 활용을 제안하였다.

• Earthquakes and Structures
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• 제14권5호
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• pp.437-447
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• 2018

Computational cost is one of the major obstacles for detailed risk analysis of structures. This paper puts forward a methodology for efficient probabilistic seismic loss assessment of structures using the Endurance Time (ET) analysis and the first-order reliability method (FORM). The ET analysis efficiently yields the structural responses for a continuous range of intensities through a single response-history analysis. Taking advantage of this property of ET, FORM is employed to estimate the annual rate of exceedance for the loss components. The proposed approach is an amalgamation of two analysis approaches, ET and FORM, that significantly lower the computational costs. This makes it possible to evaluate the seismic risk of complex systems. The probability distribution of losses due to the structural and non-structural damage as well as injuries and fatalities of a prototype structure are estimated using the proposed methodology. This methodology is an alternative to the prevalent risk analysis framework of the total probability theorem. Hence, the risk estimates of the proposed approach are compared with those from the total probability theorem as a benchmark. The results indicate a satisfactory agreement between the two methods while a significantly lower computational demand for the proposed approach.

• 한국환경보건학회지
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• 제43권4호
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• pp.257-266
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• 2017

Objectives: The hazardous metals content of medicinal herbs distributed in the Daegu area was investigated, and the place of origin and the content of herbicides and medicinal components were studied. Methods: An analysis of hazardous metals content (10 types) was carried out on 164 samples of 99 types of herbal medicines. Among the total samples, 45 were domestic and 119 were imported. Hg was analyzed by the amalgamation method. Other hazardous metals content (nine types) was digested using the microwave method and measured by inductively coupled plasma optical emission spectrometry (ICP-OES). Results: The mean values of the hazardous metals content in the herbal medicines were Pb 1.0833 mg/kg, As 0.0136 mg/kg, Cd 0.0840 mg/kg, Cr 3.7120 mg/kg, Cu 4.2666 mg/kg, Mn 40.080 mg/kg, Ni 1.4330 mg/kg, Sb 0.1053 mg/kg, Al 202.64 mg/kg and Hg 0.0062 mg/kg. Three of the samples violated the Ministry of Food and Drug Safety (MFDS) regulatory guidance on cadmium (less than 0.3 mg/kg). The measured values of heavy metals (Pb, As, Cd, Hg) showed levels below the recommended levels for herbal medicines in MFDS regulatory guidance. In the comparison of domestic samples with imported herbal medicines, it was found that one domestic and two imported samples surpassed the maximum residue limits for cadmium. The median values of the hazardous metals detected in the three medicinal parts of the root, leaf (branch), and flower (seed and fruit) were as follows. Cr, Ni, Sb and Al were highly detected in roots, Pb, Cd, Mn, Hg in leafs (branch), and As, Cu in flowers (seed and fruit). Conclusion: There were various kinds of hazardous metals which were detected at high levels according to the place of origin of the medicinal herb and the parts the plant. For hazardous metals for which no acceptance criteria have been established, safety standards should be further studied and managed to ensure the safety of herbal medicines.

• 약학회지
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• 제29권4호
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• pp.223-226
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• 1985

0.1%-Merthiolate solutions were applied to rats with or without sodium selenite. Rat organs were excised under ether anesthesia. Mercury contents in rat tissues were determined by quartz tube combustion gold amalgamation method. Mercury contents were accumulated at about 3-fold in the brain, 143-fold in the kidney, 62-fold in the blood cell, 22-fold in the liver than those of untreated rats respectively, on the 1st day after application of mert iolate for 7 days. On the other hand, the addition of sodium selenite caused a shift in the tissue mercury distribution. Our study showed that simultaneous administration of sodium selenite increased the accumulation of mercury in the brain, but became to decrease it after 9 days, while decreased it in the kidney, but grew to increase it, respectively.