• BMB Reports
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• 제57권8호
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• pp.352-362
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• 2024

Hematopoietic stem cell transplantation (HSCT) remains an indispensable therapeutic strategy for various hematological diseases. This review discusses the pivotal role of bone marrow (BM) niches in influencing the efficacy of HSCT and evaluates the current animal models, emphasizing their limitations and the need for alternative models. Traditional animal models, mainly murine xenograft, have provided significant insights, but due to species-specific differences, are often constrained from accurately mimicking human physiological responses. These limitations highlight the importance of developing alternative models that can more realistically replicate human hematopoiesis. Emerging models that include BM organoids and BM-on-a-chip microfluidic systems promise enhanced understanding of HSCT dynamics. These models aim to provide more accurate simulations of the human BM microenvironment, potentially leading to improved preclinical assessments and therapeutic outcomes. This review highlights the complexities of the BM niche, discusses the limitations of current models, and suggests directions for future research using advanced model systems.

• 지식경영연구
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• 제22권1호
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• pp.21-37
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• 2021

본 연구의 목적은 일반적으로 공유되어 있지 않은 Multi Strategy 관련 금융투자 지식을 사례 연구를 통해 탐색하고 이를 국내 헤지 펀드 시장에 공유하는데 있다. 현재 국내에서 본격적인 사모 헤지펀드 시대가 열리면서 많은 펀드들이 만들어지고 있지만 전략의 다양성에 있어 부족한 것이 현실이다(이준서, 2016). 초기 단순한 Equity Long/Short 전략으로 시작되어 메자닌, 대체투자 등 여러 전략들이 활용되고 있지만 Multi Strategy를 활용한 펀드는 제한적인 상황이다. 본 연구에서는 증권사 Prop Trading에서 적극적으로 활용되고 있는 Multi Strategy 기법을 이용해 Absolute Return을 달성하는 과정과 결과에 대한 사례 분석을 바탕으로 헤지펀드 운용전략에 대한 실증적인 활용 방안을 제시하고자 한다. 본 연구의 결과를 통해 헤지펀드 시장에서 Multi Strategy를 활용해 Absolutr Return을 추구하고자 하는 연구자 및 실무에서 운용하는 펀드매니저가 지식을 탐색하고 공유해서 금융 경쟁력 강화를 도모하는데 기여하고자 한다.

• 에너지공학
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• 제2권2호
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• pp.139-153
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• 1993

20세기 인류가 이룩한 물질문명의 화려한 발전은 물질의 과량소비 에너지의 과다소비 공해물질의 대량배출 등의 바탕 위에 이룩되었다는 것을 아무도 부인하지 못할 것이다. 이 기간 동안 인류의 삶의 질은 향상되었을지 모르나 물질 및 에너지 자원의 고갈 지구환경의 파괴 질병의 유발 등과 같은 풀기 어려운 숙제를 후손들에게 남겨놓게 되었다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.1068-1071
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• 2002

In this study, first, we show that the furnace process which requires maintaining high temperature is effected grievously by the temperature of surrounding air. Second, an alternative which maintains the relatively constant temperature dispersion surrounding the furnace and at the same time has economical advantages will be proposed.

• 한국과학교육학회지
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• 제31권3호
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• pp.440-454
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• 2011

This study proposes a new instructional strategy and corresponding materials designed from various alternative frameworks to help students understand evolution as a biologically acceptable theory. Biology teachers have normally taught the evolutionary mechanism by means of comparing Lamarckism with natural selection. In this study, a new instructional strategy in which the Lamarckian explanation is first excluded because Lamarckism is known to be subsumed in a learner's cognitive structure as a strong preconception of evolution is suggested for teaching evolution. After mutation theory is introduced, Darwinism including natural selection is explained separately during the next class hour. Corresponding instructional materials that aid student understanding of the evolutionary mechanism were developed using recently published articles on human genetic traits as scientific evolutionary evidence instead of the traditional evolutionary subject matter, giraffe neck. Evolutionary evidence from human genetic traits allows students to exclude anthropocentric thoughts effectively and raise concern for the phenomenon of evolution positively. The administered instructional strategy and materials in this research improved student conception, concern, and belief of evolution and it is believed that they helped students understand the evolutionary mechanism effectively.

• 경영과정보연구
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• 제18권
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• pp.41-67
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• 2006

Value Creation issue for customers is emerging from the college education. Most colleges are facing to cope with over-supplied education facility problems against reducing population to apply to enter universities/colleges. The best way to overcome those problems might be to implement the Customer Satisfaction Management Strategy as if they were private firms for making profit. The main purpose in this study is to provide guidelines for CS strategy with a private college. It is focused on designing research plans and searching CS index. The process of this study is as follows; - Introduced the value creation strategy for customers with private colleges. - Proposed the CS management which is very important for enhancing competitive power - Evaluate various models to measure service quality and CSI for college service. - Provided some guidelines to research design of CS according to 6 customer categories. - Proposed some methodologies to apply a service quality measurement model. - Suggested a revised model from SERVPERF to adapt with college customers satisfaction. The result from this study showed that Customer Satisfaction Management would be the most important strategy to cope with confronting difficulties for private college and the revised model from SERVPERF would be an alternative solution. Further study is essential to assure the suggested model is valuable for private colleges because empirical test has not completed yet.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권8호
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• pp.2666-2687
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• 2022

As a new alternative communication scheme in 5G, unmanned aerial vehicle (UAV) is used as a relay in the remote base station (BS) for assistant communication. In order to ameliorate the quality of the backhaul link, a UAV backhaul transmission scheme based on improved Nash equilibrium (NE) strategy is proposed. First, the capacity of air-to-ground (A2G) channel by the link preprocess is maximized. Then, the maximum utility function of each UAV is used as the basis of obtaining NE point according to the backhaul channel and the backhaul congestion. Finally, the improved NE strategy is applied in multiple iterations until maximum utility functions of all the UAVs are reached, and the UAVs which are rejected by air-to-air (A2A) link during the process would participate in the source recovery process to construct a multi-hop backhaul network. Simulation results show that average effective backhaul rate, minimum effective backhaul rate increases by 10%, 28.5% respectively in ideal A2G channel, and 11.8%, 42.3% respectively in fading channel, comparing to pure NE strategy. And the average number of iterations is decreased by 5%.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2000
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• pp.501-508
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• 2000

It is demanded to find the dynamic model of a real structure to design a controller. However, as the structure has inherently infinite number of degree-of-freedom, it is impossible to obtain an exact dynamic model of the structure. Instead a reduction model with finite degree-of-freedom is used for the design of a controller. So there exists uncertainty between a real model and a reduction model which causes poor performance of control. All these uncertainties can degrade the control performance and even cause the control instability. Thus, robust control strategy considering the above uncertainties can be an alternative one to guarantee the performance and stability of the control. This study deals with the experimental verification of robust controller design for the active mass driver. $\mu$-synthesis technique is employed as a robust control strategy. Some weights are chosen based on the difference between the initial plant with which the controller is designed and the perturbed plant to be controlled having the actuator uncertainty. The robustness of $\mu$-synthesis technique is compared with the result of LQG strategy, which does not consider the uncertainty.

• 통상정보연구
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• 제9권1호
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• pp.333-353
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• 2007

This paper is to explore that there are structural problems in the Korea-U.S. Free Trade Agrement negotiation by examining the Korean FTA policy and to introduce some alternatives to overcome them. The structural problem stems in part from the inefficient system in FTA policy making and its implementation. Most importantly, there is a lack of ex-ante consensus building among stake-holders. As an alternative to the current FTA policy, we suggest two things. First, we argue that an FTA negotiation strategy should correspond to Korea's overall industrial development strategy. Second, the National Assembly should play an important part for enforce of trade policies as a tool for advancing a comprehensive strategic measures.

• 제어로봇시스템학회논문지
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• 제11권3호
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• pp.262-269
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• 2005

Automatic landing of UAVs receives increasing interest these days, with increasing number of the developed UAV systems. In this paper, a glidepath tracking algorithm of the subscale UAV was proposed and the performance was analyzed. Flight data analysis shows that the existing autolanding flight control algorithm has a classical type glidepath control. This paper presents an alternative glidepath tracking strategy based on embedded flight control law. The performance of the proposed strategy was investigated through the TDP(Touch Down Point) error analysis with regard to various flight environment: steady headwind, atmospheric disturbance, communication transfer delay. It was verified that the proposed glidepath tracking strategy can be successfully applied to the practical autolanding of UAV systems.