• 대한산업공학회지
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• 제27권3호
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• pp.297-304
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• 2001

Procurement decisions for inspection equipment are often made heavily based on the initial purchase price instead of the effects of inspection cost, equipment calibration and utilization over the lifetime. Cost of ownership(COO) models that take into account all of these cost factors together have been developed focusing on a single quality characteristic. In modern manufacturing environment, inspection equipment often can deal with more than one quality characteristic simultaneously. In this paper, we propose the revised COO model for the economic evaluation of the inspection equipment that can accommodate multiple quality characteristics. We also employ an engineering economy model to compare equipments with different life span. Software is developed for handy comparison of the COO of alternative equipments along with sensitivity analysis far the optimal procurement decision.

• Journal of Microbiology and Biotechnology
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• 제13권3호
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• pp.373-377
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• 2003

Various groups of industrial and agricultural pollutants (heavy metal ions, cyanides, and pesticides) can be detected by enzymes. Since heavy metal ions inhibit urease, cyanides inhibit peroxidase, organophosphorus and carbamate pesticides inhibit butyrylcholinesterase, these enzymes were co-immobilized into a bovine serum albumin gel on the surface of an ion-sensitive field effect transistor to create a bioprobe that is sensitive to the compounds mentioned above. The sensitivity of the present sensor towards KCN corresponded to $1\;\mu\textrm{M}$ with 1 min of incubation time. The detection limits for Hg(II) ions and the pesticide carbofuran were 0.1 and $0.5\;\mu\textrm{M}$, respectively, when a 10 min sensor incubation time in contaminated samples was chosen. The total time for determining the concentrations of all species mentioned did not exceed 20 min.

• 시스템엔지니어링학술지
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• 제8권2호
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• pp.57-67
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• 2012

It is the sensitivity and confidentiality of nuclear power plant decommissioning cost that prevent detailed cost information to be released to the public, which causes some limitation to analyze and reuse the costs. This limitation to access cost information means that the lessons learned from preceding cost estimating may not systematically feed back into following cost estimates. As an alternative, decommissioning cost estimation framework is indispensable to reflecting available experience and knowledge for decommission costs. This study provides the cost estimation framework including data flow and structuralization based on engineering and bottom up approach to enhance decommissioning cost estimation.

• 한국태양에너지학회 논문집
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• 제31권3호
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• pp.36-41
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• 2011

Nowadays, the solar expose right is very important with people's life. Therefore, in calculating the sunshine hours, the point analysis and area analysis methods are used in previous studies. Previous two methods have merits and faults. Therefore, ray-tracing method is used as a alternative. Ray-tracing method is adopted by the software of Autodesk Ecotect which is a widely used program by the architectural company and academic university. In this study first, ray-tracing methodology is studied with how to calculate the overshadowing area and, secondly, the sensitivity of the two major factors, overshadowing accuracy and sky subdivision, is analyzed. With these results, appropriate application of the ray-tracing method is presented.

• 대한전기학회논문지:전력기술부문A
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• 제55권2호
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• pp.76-84
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• 2006

Interstate electric power system, as an alternative for energy cooperation under regional economic block, has been hotly debated before progressing the restructure in electric power industry and rapidly expanded in many regions after 1990s. Especially, since northeast asia has strong supplementation in resource, load shape, fuel mix etc., interconnection of electric power systems in this region may bring considerable economic benefits. This paper implements a mathematical optimization model, ORIRES, proposed by Russia, in analysing the economic feasibility of system interconnection. Additional analyses on the environmental impact of the system interconnection, and sensitivity of key factor inputs have been performed.

• 한국병원경영학회지
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• 제2권1호
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• pp.22-47
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• 1997

This paper evaluated the relative efficiency of 33 provincial medical centers using Data Envelopment Analysis(DEA) and compared the DEA efficiency results with those of the current method conducted by the management evaluation team. DEA Was selected as an alternative efficiency evaluation method since it could handle multiple inputs and multiple outputs simultaneously and identify the sources of inefficiency. To analyze the sensitivity of productivity values to the variable sets, four different sets of input and output variables were identified. Results showed that most of the medical centers are operating far away from the efficiency frontier supporting the previous results. Some centers showed 100% efficiency regardless of the selected variable sets. DEA results are compared with current management evaluation results. Some inconsistencies were found for some DMUs between the results of two methods showing the existence of methodology bias. DEA results and ratio analyses results mostly agree for 1992 data.

• BMB Reports
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• 제31권1호
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• pp.101-105
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• 1998

Immunoassay of botulinum toxin (BTX) B type was investigated using two typed of biosensors: light addressable potentiometric sensor (LAPS) and surface plasmon resonance (SPR) sensor. Urease-tagged and immuno-filtration capture method have been used for LAPS. Tag-free and direct binding real-time detection method have been used for SPR sensor. The detection limit of sandwich assay format with LAPS was 10 ng/ml, which was the lowest among methods tested. SPR has the advantage of being more convenient because tag-free direct binding assay can be used and reaction time was reduced, regardless of low sensitivity. This result shows that sandwich assay format with LAPS can be used as an alternative method of BTX mouse bioassay which is known as the most sensitive method for the detection of BTX.

• 셀메드
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• 제3권1호
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• pp.6.1-6.6
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• 2013

Asthma is a chronic inflammatory disease of the lungs, characterized by increased sensitivity to bronchoconstriction associated with infiltration of immune cells and mucus hyper secretion. In South Africa, the indigenous plant Siphonochilus aethiopicus, is used by traditional health practitioners to treat colds and flu, wheezing of the chest, coughs, influenza, sinus problems and mild asthma. In this study we aimed to investigate the potential anti-inflammatory and immune-modulating properties of S. aethiopicus in vitro. The dried and powdered S. aethiopicus plant material was extracted with organic solvents. The dried extracts were screened in vitro in the transcription response, NF-${\kappa}B$ and a cytokine assay. Significant activity was observed for organic extracts of the plant in these assays. This study provides evidence that S. aethiopicus has anti-inflammatory and immune-suppressing properties in vitro. These findings may support anecdotal accounts of its effectiveness against allergic asthma.

• Journal of mucopolysaccharidosis and rare diseases
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• 제1권1호
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• pp.28-30
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• 2015

Biologics present a challenge to both the manufacturer and end user. They must usually be formulated as parenterals. However, they are often unstable in liquid form, due to their complex structure and composition. In that case, they must be manufactured using highly specialized processes, such as lyophilization (freeze-drying). Lyophilization nearly eliminates stability issues. Reducing a compound's sensitivity to temperature prolongs its shelf life. However, reconstitution can be cumbersome, involving multiple steps that increase the potential for error. Dual-chamber technology provides an effective alternative, combining a lyophilized drug and diluent in a closed system and enabling reconstitution in a few simple steps.

• 대한기계학회논문집A
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• 제25권10호
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• pp.1597-1604
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• 2001

Alternative computational scheme is presented fur reliability based optimal design using a modified advanced first order second moment (AFOSH) method. Both design variables and design parameters are considered as random variables about their nominal values. Each probability constraint is transformed into a sub -optimization problem and then is resolved with the modified Hasofer- Lind-Rackwitz-Fiessler (HL-RF) method for computational efficiency and convergence. A method of design sensitivity analysis for probability constraint is presented and tested through simple examples. The suggested method is examined by solving several examples and the results are compared with those of other methods.