• Journal of Korean Medicine Rehabilitation
• /
• v.24 no.1
• /
• pp.31-45
• /
• 2014

Objectives This study intends to clarify how Leejung-tang (here in after reffered to LJT) affect Wistar Rat whose osteoarthritis was induced by MIA. Methods Osteoarthritis was induced into rat by injecting MIA in its knee joint. Rats are divided into a total of 4 groups (n=6). Normal group are not treated at all without inducing osteoarthritis whereas control group were induced for osteoarthritis by MIA and oral medicated with 2 ml of physiological saline per day. Positive comparison group (Indomethacin) was injected with MIA and after 7 days, 2 mg/kg of Indomethacin was medicated. Experimental group (LJT) was injected with MIA and after 7 days that was medicated with 23 mg/kg of LJT. Indomethacin and LJT were oral medicated for each substance a total of 4 weeks with one time per day. After experiments (from 1 week after injection of MIA to 4 weeks elapsed), Hind paw weight bearing ability, Functions of liver and kidney, Serum prostaglandin $E_2$, TNF-${\alpha}$, IL-1${\beta}$, IL-6, Osteocalcin, TIMP-1, MMP-9, LTB4 and amount of cartilage were measured and histopathological variations for knee joint structures were observed. Results 1) Hind paw weight bearing ability of LJT administration group was increased but there was no statistical significance. 2) Functions of liver and kidney were not affected. 3) Serum prostaglandin $E_2$, IL-1${\beta}$, Osteocalcin, MMP-9 were significantly decreased and TNF-$\alpha$, IL-6, TIMP-1, LTB4 were also decreased but there were no statistical significance. 4) In H&E staining and Safranin-O staining, there were small histopathological changes in LJT administration group than control group. 5) In micro CT (computed tomography)-arthrography, cartilage destruction was more suppressed in LJT administration group than control group. Conclusions Based on all results mentioned above, Leejung-tang (LJT) is believed to be meaningful for suppressing the progress of osteoarthritis and its treatments because of its anti-inflammatory effects and alleviation of pain with histopathological effective efficacy.

• Smart Structures and Systems
• /
• v.20 no.3
• /
• pp.311-328
• /
• 2017

The characteristics of boundary layers have significant effects on the aerodynamic forces and vibration of the wind turbine blade. The incorporation of active trailing edge flaps (ATEF) into wind turbine blades has been proven as an effective control approach for alleviation of load and vibration. This paper is aimed at investigating the effects of external trailing edge flaps on the flow pattern and velocity distribution within a boundary layer of a NREL 5MW reference wind turbine, as well as designing a new type of velocity sensors for future validation measurements. An aeroelastic-aerodynamic simulation with FAST-AeroDyn code was conducted on the entire wind turbine structure and the modifications were made on turbine blade sections with ATEF. The results of aeroelastic-aerodynamic simulations were combined with the results of two-dimensional computational fluid dynamic simulations. From these, the velocity profile of the boundary layer as well as the thickness variation with time under the influence of a simplified load case was calculated for four different blade-flap combinations (without flap, with $-5^{\circ}$, $0^{\circ}$, and $+5^{\circ}$ flap). In conjunction with the computational modeling of the characteristics of boundary layers, a bio-inspired hair flow sensor was designed for sensing the boundary flow field surrounding the turbine blades, which ultimately aims to provide real time data to design the control scheme of the flap structure. The sensor element design and performance were analyzed using both theoretical model and finite element method. A prototype sensor element with desired bio-mimicry responses was fabricated and validated, which will be further refined for integration with the turbine blade structures.

• The Journal of Internal Korean Medicine
• /
• v.21 no.5
• /
• pp.897-902
• /
• 2000

Objective : The study was to investigate Diagnosis and Treatment Based on an Overall Analysis of Signs and Symtoms(證治) of a patient on stomach cancer stage IV by means of the clinical symptoms. Methods : The observation of the clinical progress was carried out by conducting Diagnosis and Treatment Based on an Overall Analysis of Signs and Symtoms(證治) with the patient diagnosed stomach cancer stage IV. Results : Treatments such as the invigoration of qi(補氣), the flow of qi(行氣), and the relieving pain(止痛) was given because the patient showed the qi deficiency of the spleen and stomach(脾胃氣虛). There were moderate effects for anorexia, indigestion, nausea, and general weakness, but there was not any clear effect for alleviation of abdominal pain except the first period. Specially, compared with two hospitalization treatments in 1998, the third hospitalization treatment did not show any apparent improvement. It was believed that this caused by the patients bodily weakness because of deterioration of anemia from bleeding in the progress of cancer. Conclusion : Diagnosis and treatment based on an overall analysis of signs and symtoms(證治) of a patient on stomach cancer stage IV had moderate effects on the improvement of the patients condition, but in this case we had difficulty in long-term observation because of short hospitalizations or insufficient examination by an oriental-western combined medicine group.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.34 no.6 s.119
• /
• pp.39-53
• /
• 2007

Unlike conventional roof landscaping, where various kinds of plants and structures are employed, a grass roof is a roof on which herbaceous plants are grown in planting medium and which is not accessed or maintained, mainly because it doesn't have sufficient load capacity to support a regular roof garden. They are mostly built on existing roofs, whether flat slab or gabled. Planting on roofs has numerous advantages, such as creating a biotope, purifying urban air, adding moisture to the atmosphere, storing rain water, preventing flash floods, reducing energy use for heating and air conditioning, enhancing the urban landscape and providing relaxation to the city dwellers, not to mention the alleviation of global warming by absorbing $CO_2$. In addition to the general merits of roof planting, the grass roof has its own unique qualities. Only herbaceous species are planted on the roof, resulting in light weight which allows roofs of existing buildings to be planted without structural reinforcement. The species chosen are mostly short, tough perennials that don't need to be maintained. These conditions provide an ideal situation where massive planting can be done in urban areas where roofs are often the only and definitely the largest space available to be planted. If roofs are planted on a massive scale they can play a significant role in alleviating global warming, heat island effects and energy shortages. Despite the advantages of grass roofs, there are some problems. The most significant problem is the invasion of neighboring plants. They may be brought in with the planting medium, by birds or by wind. These plants have little aesthetic value comparing to the chosen species and are usually taller. Eventually they dominate and prevail over the original species. The intended planting design disappears and the roof comes to look wild. Since the primary value of a grass roof is ecological, a change in attitude towards what constitutes beauty on the roofscape is necessary. Instead of keeping the roof neat through constant maintenance, people must learn that the wild grass with bird's nests on their roof is more beautiful as it is.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.27 no.2
• /
• pp.212-224
• /
• 2013

This study intends to clarify how Sayeok-tang(here in after reffered to SYT) affect C57BL/10 mice whose osteoarthritis was induced by papain. Osteoarthritis was induced by injecting papain in the knee joint of 3 groups(n=6) of mice. Normal group was non-treatment group and was not injected papain, whereas control mice were orally administered with $200{\mu}{\ell}$ of physiological saline. Positive comparison group was medicated with 100 mg/kg of Joins$^{(R)}$ mixed with $200{\mu}{\ell}$ of physiological saline. Experimental group was medicated with 400 mg/kg of SYT mixed with $200{\mu}{\ell}$ of physiological saline. Both Positive and experimental comparison groups were orally medicated once per day for 4 weeks. After the experiment, the functions of liver and kidney, inflammation cytokine values within serum, degree of revelation for inflammation cytokine genes, immune cells within blood, metabolism of arachidonic acid and amount of cartilage were measured and histopathological changes in the knee joint structures were observed. As results, SYT had no significant effect on the liver and kidney functions. Interleukin-$1{\beta}$(IL-$1{\beta}$), interleukin-6(IL-6), monocyte chemo attractant protein-1(MCP-1) and tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) were significantly decreased. Inflammation cytokines in joints were all significantly decreased. Prostaglandin $E_2(PGE_2)$, thromboxane $B_2(TXB_2)$ were significantly decreased. Destruction of cartilage on micro computed tomography(CT)-arthrography was meaningfully decreased. In terms of histopathology, infiltration of inflammation, proliferation of synovial membrane, subsidence of cartilage and bone due to penetration of excessive formation of synovial cell and destruction of cartilage were small. Based on all results mentioned above, Sayeok-tang(SYT) is believed to be meaningful for suppressing the progress of osteoarthritis and its treatments because of its anti-inflammatory effects and alleviation of pain with histopathological effective efficacy.

• The Journal of Korean Society for School & Community Health Education
• /
• v.15 no.2
• /
• pp.63-76
• /
• 2014

Objectives: The purpose of this study was to explore the effects of 'affirmative language' experiment upon freshmen nursing students' negative affect, self-efficacy and stress coping style. Methods: A nonequivalent control quasi-experiment was conducted on the subjects of 55 freshmen nursing students for 26(experimental group) and 29(control group). Data were analyzed using x2-test and t-test for participants' homogeneity test and conducted content analysis of process diary record and personal impressions. Results: As for negative affect, in case of the experimental group, depression(t=-2.384, p=.022) and anxiety(t=-2.243, p=.025) were significantly low with no difference for the control group. As for self-efficacy, both experimental and control groups showed significance and as for stress coping style, the control group used sub-categorized strategies better than the experimental group. There were 4 topics and subsequent 15 topics derived from the content analysis. 'Affirmative language' experiment showed alleviation of depression and anxiety helpful for study participants in self-reporting measurement, and helpful for stress self-management competence. Conclusion: It is necessary to connect the curriculum operation with interest of competence and practice of students stress self-management through the participating experiment experience.

• The Korea Journal of Herbology
• /
• v.27 no.3
• /
• pp.107-112
• /
• 2012

Objectives : This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris including the symptoms as chest oppressed and stabbing pain. Methods : Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with normal rodent diet. TXL was administered orally in the concentration of 10 mg/day for 2 weeks (TXL group). D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride in serum. Results : In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of hypercholesterolemia. Conclusion : These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of dyslipidemia.

• Human Ecology Research
• /
• v.52 no.6
• /
• pp.587-600
• /
• 2014

The purpose of this study was to examine the effects of family resources on social exclusion and the resilience of low-income families. To be more specific, this study categorized the level of social exclusion into five dimensions: work, housing, health, education, and social participation. Further, family resources were categorized into the two dimensions of "internal resources of the family" and "external resources of the family" in order to evaluate the effects of the two differentiated dimensions on social exclusion and the resilience of low-income families. The data of low-income families for the period of August 23 to September 28, 2012, were collected from community welfare centers that manage individual development accounts and local self-sufficiency centers; 302 cases were considered. The main results of this study were as follows: firstly, the model analysis proved that family resources as a parameter was significant, not only statistically but also theoretically and practically. Secondly, while a negative relationship was found between social exclusion and family resources, a positive relationship was found between family resources and resilience. This implied that the alleviation of a low-income family's social exclusion level could become an important intervention for the improvement of the family's functioning and strengths. Further, it implied that the qualitative improvement of the family's resources that affected the promotion of the resilience could be a basis for another practical intervention. These results suggested crucial implications for the development of comprehensive policies for addressing poverty issues.

• Asian-Australasian Journal of Animal Sciences
• /
• v.1 no.2
• /
• pp.89-98
• /
• 1988

Three experiments were conducted to determine whether cobalt (Co) or nickel (Ni) could prevent zinc (Zn) deficiency signs in pigs fed a high calcium (Ca) corn-soybean diet. The basal diet contained 1.3% Ca, .93% phytic acid and means of 34 to 48 ppm Zn. After weanling, pigs in experiment I were fed the basal diet for 9 weeks, and was found that 50 ppm Co or Ni for 5 weeks increased average daily weight gain (ADG) and reversed skin lesions toward normal. These effects were similar to those of 100 ppm supplemental Zn. The Zn content and alkaline phosphatase activity of serum from pigs supplemented with Co or Ni were higher at 2 weeks and 4 weeks (P<.05) than those of the basal group. Zn content of bone, liver and kidney, and alkaline phosphatase activity in bone were increase after 5 weeks of supplementation with Co or Ni. In experiments 2 and 3, addition of 54 ppm and 27 ppm of either Co or Ni increased (P<.05) ADG and decreased incidence of skin lesions except in one group supplemented with 27 ppm Ni. Supplemental Co or Ni increased Zn in serum and alkaline phosphatase activity in serum and bone in both experiments. Over all experiments, supplemental Co or Ni decreased Zn deficiency signs in the following order of effectiveness: 54 ppm Co, 54 ppm Ni, 27 ppm Co and 27 ppm Ni. The alleviation of signs of Zn deficiency by Co or Ni may have been the result of increased availability of dietary Zn.

• Journal of Korean Academy of Nursing
• /
• v.30 no.3
• /
• pp.619-631
• /
• 2000

This study was conducted to test whether a comprehensive health promotion program for promotion strategies and knowledge about the disease, thus leading to the improvement of health status by using repeated measure of quasi- experiment design. Eighteen RA patients who visited the RA clinic of an university hospital located in Inchon were invited to participate in the CHPPRA. According to the study results, it was shown that the CHPPRA had significant effects on the patients' health status such as pain, depression, and functional disability. Also, that the improvement of health status was achieved by a positive change in the four health promotion strategies, which consisted of goal setting, positive thinking, exercise, and knowledge about the disease. Goal setting, positive thinking, and knowledge about the disease could also affect the patients' depression. Thus it can be interpreted that the improvement of these strategies may result in a remarkable decrease of depression. In addition, alleviation of functional disability may be due to increase of exercise. However although the strategies which were directly associated with pain management were not significantly improved, pain was significantly reduced. On the other hand, the study result showed that the other health promotion strategies included in CHPPRA such as pain management, positive thinking, stress management, asking for assistance and communication were not significantly increased. although the health status such as pain, depression, and functional disability, which are final goals of the program, were significantly improved through the exposition of patients to those health promotion strategies.