• Journal of Life Science
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• v.34 no.5
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• pp.356-364
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• 2024

Lymph nodes (LNs) are crucial sites where immune responses are initiated to combat invading pathogens in the body. LNs are organized into distinctive compartments by stromal cells. Stromal cell subsets constitute special niches supporting the trafficking, activation, differentiation, and crosstalk of immune cells in LNs. Fibroblastic reticular cells (FRC) are a type of stromal cell that form the three-dimensional structure networks of the T cell-rich zones in LNs, providing guidance paths for immigrating T lymphocytes. FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. During inflammation, FRCs exert both spatial and molecular regulation on immune cells through their topological and secretory responses, thereby steering immune responses. Here, we propose a model in which FRCs regulate immune responses through a three-part scheme: setting up, supporting, or suppressing immune responses. FRCs engage in bidirectional interactions that enhance T cell biological efficiency. In addition, FRCs have profound effects on the innate immune response through phagocytosis. Thus, FRCs in LNs act as gatekeepers of immune responses. Overall, this study aims to highlight the emerging roles of FRCs in controlling both innate and adaptive immunity. This collaborative feedback loop mediated by FRCs may help maintain tissue function during inflammatory responses.

• The Journal of Korean Academy of Sensory Integration
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• v.21 no.3
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• pp.27-38
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• 2023

Objective : This study aims to verify the validity and reliability of the Korean version of the Sensory Processing and Self-Regulation Checklist (SPSRC) for children with and without autism spectrum disorder. Methods : The Pearson product-moment correlation coefficient was calculated using Short Sensory Profile (SSP) to verify concurrent validity. Construct validity was verified by comparing the sensory processing ability and self-regulation ability of the two groups. Cronbach's α was calculated in the case of internal consistency for reliability verification, and the test-retest reliability was verified through the Pearson correlation coefficient. Results : Based on the verification of the concurrent validity, the Korean version of SPSRC and SSP showed a statistically significant correlation (p < 0.01). The construct validity was found to have a statistically significant difference between the two groups in the area and sub-items of the Korean version of SPSRC (p < 0.001). For the internal consistency, Cronbach's α ranged from 0.700 to 0.975. The test-retest reliability showed that the correlation coefficient ranged from 0.937 to 0.997. Conclusion : The Korean version of SPSRC was confirmed to be an evaluation tool with high validity and reliability. It is expected to be used as an evaluation tool for planning treatment goals in clinical trials and as a meaningful basis for future research.

• Knowledge Management Research
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• v.24 no.4
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• pp.103-129
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• 2023

This study aims to analyze the network structure of technological innovation resources in SMEs, especially manufacturing firms, and reveal the differences between innovative and non-innovative firms. The study first analyzes connection centrality, flow-mediated centrality, and power centrality for all firms, and derives structural equivalence through CONCOR analysis. Then, the network structure of innovative and non-innovative firms was compared and analyzed according to innovation performance and creation. The results show that entrepreneurship and corporate innovation strategy have a significant impact on the analysis of technological innovation resources of all firms. According to the CONCOR analysis, the innovation resources of SMEs are organized into seven clusters, which can be defined as intrinsic product innovation resources, competitive advantage promotion resources, cooperative activities resources, information system resources, and innovation protection resources. The network analysis of innovative and non-innovative firms showed that innovative firms focused on enhancing competitiveness and improving quality, while non-innovative firms tended to focus more on existing products and customers. In addition, innovative firms had eight clusters, while non-innovative firms had six clusters, suggesting that innovative firms utilize resources diversely to pursue structural change and new value creation, while non-innovative firms operate technological innovation resources in a more stable form. This study emphasizes the importance of entrepreneurship and corporate innovation strategy in SMEs' technological innovation, and suggests that strong internal efforts are needed to increase innovativeness. These findings have important implications for strategy formulation and policy development for technological innovation in SMEs.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.6
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• pp.159-172
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• 2023

This study aims to empirically investigate the relative effects of business-to-business (vs. business-to-consumer) business model innovation (BMI) on innovation performance. The research examines the impact of three key components of BMI: 1. value creation, 2. value proposition, and 3. value capture, on innovation performance. The 2022 Entrepreneurship Survey data by the Korean Entrepreneurship Foundation was used to analyze 2,879 companies. An exploratory data analysis (EDA) including various categories such as industry, firm, CEO, and technology chracteristics was conducted to show the latest startup status in Korea. The results show that value creation of B2B (vs. B2C) firms has a more positive and significant impact on innovation performance. Whereas, value proposition of B2C (vs. B2B) firms was found to have a more positive and significant effect on innovation performance. Interestingly, value capture did not show any effects for either type of firms. Additionally, the study employed seemingly unrelated regression (SUR) analysis for robustness checks. These findings provide important insights about the relative effects of B2B-BMI (vs. B2C-BMI).

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.6
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• pp.1-10
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• 2023

Strong Critics of' Moral Hazard, due to plummeting severely their stock price down and damage falling on plain investor, has been skyrocketed against massively and simultaneously exercising stock option right of C-Level members in Stock market listed startups right after IPO regardless of proper and legal process followed. Korean Financial Supervisory Board initiate new act of extending to apply'Lock-up Rule'even to stock option of core interest group after IPO. However, it will cause startups and venture more difficulties to recruit top level of talented staffs. This paper aims to propose RSU(Restricted Stock Unit) as alternative to breakthrough the current deadlock issue with respect to stock option controversy many startups facing. This paper to meet goal, first, including Korean introducing status of RSU, it clarify the concept of RSU by comparing exploration with Restricted Stock and define characteristic of RSU by comparing Stock Option. Second, it bring more effective ways of startups introducing RSU in Korea overcoming its limitations and challenges. Third, it carry out FGI to legal expert deeply involved of introducing RSU in Korea at policy domain. FGI focus on defining core challenging factors and their level of huddles of introducing RSU in Korea with proposing breakthrough policies to landing RSU softly in Korea. Fourth, it suggest valid policies of introducing and stabilizing RSU in Korea completely. This paper expect some contributions Korean startups and venture on finding market friendly right breakthrough out of stock option dilemma currently in.

• Korean Journal of Construction Engineering and Management
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• v.25 no.1
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• pp.50-61
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• 2024

The market for compact houses is growing due to the demand for floor plans prioritizing user needs. However, clients often have difficulty communicating their spatial requirements to professionals including architects because they lack the means to provide evidence, such as spatial configurations or cost estimates. This research aims to create a framework that can translate sketched data-driven spatial requirements into 3D building components in BIM models to facilitate spatial understanding and provide building performance analysis to aid in budgeting in the early design phase. The research process includes developing a process model, implementing, and validating the framework. The process model describes the data flow within the framework and identifies the required functionality. Implementation involves creating systems and user interfaces to integrate various systems. The validation verifies that the framework can automatically convert sketched space requirements into walls, floors, and roofs in a BIM model. The framework can also automatically calculate material and energy costs based on the BIM model. The developed frame enables clients to efficiently create 3D building components based on the sketched data and facilitates users to understand the space and analyze the building performance through the created BIM models.

• Journal of Industrial Convergence
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• v.22 no.1
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• pp.75-84
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• 2024

This study aims to provide basic data for improved the level of subjective health awareness in the physical and mental aspects of prospective seniors by verifying the effect of self-esteem of pre-elderly on subjective health awareness and the mediating effect of interpersonal skills. For the analysis, data were collected through a survey of 270 prospective seniors aged 55 and over to 64 years old, who participated in the prospective elderly program operated by social welfare institutions in the metropolitan area, from February 16 to March 16, 2023, and SPSS WIN 25.0 and PROCESS MACRO were used. Frequency analysis, descriptive statistics analysis, and correlation analysis were conducted as analysis methods, and the mediating effect of interpersonal ability was verified through structural equation analysis, and the main analysis results are as follows. First, it was found that the self-esteem of the pre-elderly had a positive (+) effect on subjective health perception. Second, interpersonal ability showed a mediating effect in the relationship between self-esteem and subjective health perception of pre-elderly. Based on these results, it is significant in that it presents basic data for a successful and active retirement life in the future old age.

• Journal of Industrial Convergence
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• v.22 no.1
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• pp.137-148
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• 2024

This study aims to analyse the research trends and identify issues in elementary physical education in the new normal era. For this purpose, the taxonomic analysis method proposed by Spradley (2016) was applied, and 43 Korean academic articles were finally categorised and analysed. The findings are as follows. First, due to the changes in the educational environment caused by COVID-19, most of the remote and online physical education classes were conducted as content-oriented classes. It was found that there was a lack of communication between teachers and students in online physical education classes. Second, the difficulties of remote and online physical education classes and online and offline combined physical education classes, as well as research on how to overcome and improve them, were concentrated. Third, the need for evolution of physical education teachers and training of future professionals in line with the methodological transformation of primary physical education and the current situation was raised. In addition, the number of studies utilising blended learning, flipped learning, and new technologies, which have gained attention in primary physical education due to COVID-19, has increased. Based on the findings, we proposed the direction and future tasks of elementary physical education in the new normal era.

• The Journal of KAIRB
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• v.6 no.1
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• pp.17-31
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• 2024

Purpose: This study aims to develop preliminary items for measuring the perceived service quality of clinical trials among participants and to verify content validity. Methods: This study was designed as a methodological study. A conceptual framework was established based on Brady and Cronin's hierarchical model, and preliminary items were prepared through translation-back-translation, a review of existing instruments, and in-depth interviews with clinical trial participants and clinical research coordinators. The final items were completed through content validity testing by experts and a review of items by clinical trial participants for the prepared preliminary items. Results: Through this study, a set of 58 items across four domains (quality of interaction with researchers, the physical environment, performance procedures, and performance results) and 9 components (information·education·communication, trust, respect for participant preferences, securing facilities and space, accessibility, comfortability, informed consent, coordination of care, subjective understanding of clinical trials) on the service quality of clinical trials were completed. The scale content validity index of all preliminary items was 0.96, meeting the recommended standards. The individual-item content validity index also meets the recommended criteria for most items, excluding four items. Conclusion: This study holds significance in developing items to measure the quality of clinical trial execution from the perspective of participants. By verifying the reliability and validity of these items through subsequent research, it is expected that they can be utilized as a valuable instrument to devise strategies for improving the quality of clinical trials.

• Journal of Music and Human Behavior
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• v.21 no.1
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• pp.49-68
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• 2024

This study aims to acoustically analyze Korean language characteristics and convert these findings into musical elements, providing foundational data for evidence-based music-language rehabilitation. We collected voice data from thirty men and thirty women aged 19-25, each providing six-syllable prosodic units composed of two accentual phrases, including both declarative and interrogative sentences. Analyzing this data with Praat, we extracted syllabic acoustic properties and conducted statistical analyses based on acoustic properties, sentence type, gender, and particle presence. Significant differences were found in syllable frequency and duration based on accentual phrases and prosodic units (p < .001), with interrogative showing higher frequencies and declaratives longer durations (p < .001). Female frequencies were significantly higher than males' (p < .001), with longer durations observed (p < .001). Particle syllables also showed significantly stronger intensities (p < .001). Finally, we presented melodies converted from these acoustic properties into musical scores based on pitch, duration, and accent. The insights from this analysis of six-syllable Korean sentences will guide further research on developing a system for melodizing large-scale Korean speech data, expected to be crucial in music-based language rehabilitation.