• Journal of the Korean Chemical Society
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• v.68 no.3
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• pp.151-159
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• 2024

Indian spices are well known for their numerous health benefits, flavour, taste, and colour. Recent Advancements in chemical technology have led to better extraction and identification of bioactive molecules (phytochemicals) from spices. The therapeutic effects of spices against diabetes, cardiac problems, and various cancers has been well established. The present in silico study aims to investigate the binding affinity of 29 phytochemicals from 11 Indian spices with two prominent proteins, BCL3 and CXCL10 involved in invasiveness and bone metastasis of breast cancer. The three-dimensional structures of 29 phytochemicals were extracted from PubChem database. Protein Data Bank was used to retrieve the 3D structures of BCL3 and CXCL10 proteins. The drug-likeness and other properties of compounds were analysed by ADME and Lipinski rule of five (RO5). All computational simulations were carried out using Autodock 4.0 on Windows platform. The proteins were set to be rigid and compounds were kept free to rotate. In-silico study demonstrated a strong complex formation (positive binding constants and negative binding energy ΔG) between all phytochemicals and target proteins. However, piperine and sesamolin demonstrated high binding constants with BCL3 (50.681 × 10³ mol^-1, 137.76 × 10³ mol^-1) and CXCL10 (98.71 × 10³ mol^-1, 861.7 × 10³ mol^-1), respectively. The potential of these two phytochemicals as a drug candidate was highlighted by their binding energy of -6.5 kcal mol^-1, -7.1 kcal mol^-1 with BCL3 and -6.9 kcal mol^-1, -8.2 kcal mol^-1 with CXCL10, respectively coupled with their favourable drug likeliness and pharmacokinetics properties. These findings underscore the potential of piperine and sesamolin as drug candidates for inhibiting invasiveness and regulating breast cancer metastasis. However, further validation through in vitro and in vivo studies is necessary to confirm the in silico results and evaluate their clinical potential.

• Journal of The Korean Association For Science Education
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• v.26 no.2
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• pp.246-257
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• 2006

TIMSS (Trends in International Mathematics and Science Study) aims to produce reliable and internationally comparable indicators of student achievement. The TIMSS science achievement scale summarizes student performance on test items designed to measure a wide range of student knowledge and proficiency. This study analyzed Korean middle school students' science achievement at the advanced and high international benchmarks of the four benchmark levels of the benchmarks classified in TIMSS 2003 in light of science content areas (physics, chemistry, biology, earth science, and environmental science) and item characteristics. The average percent correct on items at the advanced benchmark by Korean students was highest in physics followed by earth science, biology, chemistry, and environmental science, whereas internationally the order was earth science, chemistry, biology, physics and lastly environmental science. Korean students performed relatively better in physics yet somewhat worse in chemistry than other top-performing countries. According to item analysis, Korean students reaching the advanced international benchmark understood some fundamentals of scientific investigation, but demonstrated weakness in written explanations of scientific principles, abstract science concept comprehension, and application of scientific concepts to solve quantitative problems. In addition, Korean students reaching the high international benchmark demonstrated relative weak conceptual understanding of ecology compared with other countries.

• Journal of The Korean Association For Science Education
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• v.26 no.3
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• pp.376-384
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• 2006

The purposes of this study were to analyze the frequency and type of volition strategy, according to achievement level, employed by students with high learning motivation, and to identify the role volition strategy plays in keeping students motived to learn science. To accomplish these aims, two groups of students(each containing three members) were selected. Students in the two groups both had the same cognitive level and high learning motivation. However, one group's science achievement was high, and the other was low. Through interviews and class observations, volition strategies students in the two groups used when they encountered hindrances in science learning were compared. Results of the study revealed a relationship between achievement level and volition strategy. Students showed differences in the frequency and types of volition strategies used according to science achievement. It was found that students with higher achievement levels used volition strategies more often to overcome hindrances in science learning than those with lower achievement levels. Furthermore, students with higher achievement levels generally used internal mind control strategies while those with lower achievement levels used environmental control strategies. Lastly, findings found that the types of volition strategies used by lower achievement level students were very limited.

• Journal of The Korean Association For Science Education
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• v.26 no.4
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• pp.527-536
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• 2006

This study investigated the components of science teacher professionalism, the meaning of PCK (Pedagogical Content Knowledge), examples of science PCK, and complementary measures that should be taken to improve teacher professionalism. Six science teachers recommended by their colleagues explained that the science teacher's professionalism (or professional knowledge) consists of science content knowledge, knowledge about teaching, knowledge about learners, and improvement efforts. Science teachers' definition of PCK, which is the professional knowledge that members of the wider society expect teachers to possess, is the teacher's materialized knowledge that aims at students' understanding and PCK is the accumulated know-how of teachers as they strive to make their teaching comprehensible by students. Science teachers also contended that teachers as professionals need to complement an accountability system, acknowledgement of continuous self-developmental efforts, collegiality, and securing validity in the teacher employment test. The teachers argued that the societal recognition of teaching professionalism is essential for a high quality teaching. Suggestions for how to improve science teaching professionalism are also discussed.

• Journal of The Korean Association For Science Education
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• v.29 no.4
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• pp.423-436
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• 2009

This study aims to develop an analytic framework that can be used to classify scientific models in science textbooks according to modes and attributes of representation and to investigate types of scientific models presented in the biology section of science textbooks for the $7^{th}$ to $10^{th}$ grades. The results showed that modes of representation of scientific models are related to the nature of sub-areas of biology sections. Generally, the iconic model and symbolic model were in dominant use, including drawings of organs and explanations of working of systems. However, the chapters on 'The Organization of Life' and 'The Continuity of Life' showed a relatively high frequency in use of the actual model. The theoretical model was presented in a part of 'The Continuity of Life', due to its highly abstract characteristics. Moreover, the gestural model and analogical model showed very low frequency. From the perspective of attributes of representation, frequency of the static model was very high, while one of the dynamic models was very low. Therefore, efforts to recognize the properties of scientific concepts more clearly and to develop diverse types of models that can represent the concepts adequately are required. Analysis of these types of scientific models can offer recognition of the usefulness and limitations of models in representing the concepts or phenomena, and can help us to design adequate models depicting particular properties of given concepts. Also, this type of analysis may motivate researchers to strive to reveal correct methods for and limits of using the scientific models that are presented in existing science textbooks, as well as to provide useful information to organize the science textbooks according to the revised $7^{th}$ national science curriculum.

• Journal of The Korean Association For Science Education
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• v.26 no.7
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• pp.835-842
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• 2006

The aims of this study are to investigate how Kepler found a scientific problem for the retinal image theory and how abductive reasoning was used in his theory development, and to find implications for teaching creativity in science class from his thinking processes in the scientific discovery. Through the analysis of the related literatures, it was found that Kepler's problem finding in his retinal image theory came from the critical analysis of contemporary theories of vision, based on his relevant knowledge of optics, as he formulated his own hypothesis to build a new theory in eye vision employing optical phenomenon in spherical lens, which is a kind of abductive reasoning. From the results, three suggestions are proposed, that: (a) in the development of creativity teaching material, the situations like Kepler's problem finding need to be included in the programs; (b) it should be taught that relevant scientific knowledge is important for problem finding and hypothesis formulating; and (c) the experience of successful problem solving by themselves could help them find new scientific problem(s).

• Journal of The Korean Association For Science Education
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• v.29 no.6
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• pp.712-729
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• 2009

This study aims to research high school students' misconception of botanic photosynthesis and respiration, and as the measure of rectifying the misconception, to develop the teaching program based on Driver's conceptual change model, applying it to classes and observing the effect. Selected as the research subject was sixty-six students in 1st year of a highschool located in Busan who had chosen Biology Learning as discretionary subject, with their conceptual level on botanic photosynthesis and respiration researched through tests in drawing and descriptive writing. As a consequence of applying drawing as a way of classifying the levels of students' misconception on photosynthesis and respiration, many students' drawings included their misconception caused by textbooks or scientists, but after application of Driver's conceptual change model, they drew scientific drawings including the fundamental factors of botanic photosynthesis and respiration such as light, carbon dioxide, water, glucose, oxygen, leaf, chloroplast, mitochondria, stoma, and energy. Likewise, as a result of the descriptive writing test implemented for researching the students' conception on the various aspects of botanic photosynthesis and respiration, many students in the pretest showed misconception on the point of time and location at which botanic photosynthesis and respiration occur, botanic nutrient, the role of a leaf in photosynthesis, and the relation between botanic photosynthesis and respiration, but after teaching based on Driver's conceptual change model, their misconceptions on photosynthesis and respiration were rectified to a high degree.

• Journal of The Korean Association For Science Education
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• v.27 no.5
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• pp.456-464
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• 2007

The aims of this research are to analyze the representations and conceptual sequence of eye vision in Korean science textbooks and to suggest a contents construct about eye vision where the conceptual sequence is considered. Research method was literature review, and the literatures that were used for analysis were the 7th Korean science curriculum which was revised in 1997, and the science and physics textbooks developed based on the 7th Korean science curriculum. The research results are as follows: 1) Although the science curriculum seems to have no problem on sequence in the eye vision concepts, the science and physics textbooks based on the curriculum reveal problems on the sequence in the eye vision concepts; 2) Some Korean science textbooks explain retinal image formation according to the Alhazen's idea, except in inverse image; 3) Some Korean science textbooks explain about the reasons of near- and far-sightedness without consistency between the textbooks for 7th and 8th grade students; 4) A few Korean science textbooks give an inappropriate explanation about the principle of eye sight correction by eye glasses; 5) According to the analysis result, the concepts related to eye vision should be presented in the order of explanation about light refraction phenomena, image formation process by convex lens, structure of human eye and retinal image formation process, correction of eye sight using lens.

• Journal of The Korean Association For Science Education
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• v.44 no.3
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• pp.263-271
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• 2024

The demand for inclusive education in school settings has been constantly increasing. Yet, within the context of general subject teacher education, rather than special teacher education, preparation for this remains insufficient. This study aims to investigate and analyze the teacher efficacy for inclusive practices of pre-service science teachers with a focus on identifying differences based on respondent variables. In this research, teacher efficacy for inclusive practices is defined as self-belief in the ability to effectively teach students, including students with disabilities, in inclusive educational environments. It encompasses three sub-dimensions: efficacy in using inclusive instruction, efficacy in collaboration, and efficacy in dealing with disruptive behaviors. Utilizing data from 61 pre-service science teachers using 'Teacher' Efficacy for Inclusive Practices' survey tool, this study examines the distribution of teacher efficacy in inclusive practice across sub-dimensions and differences in distribution based on respondent background. The findings indicate that pre-service science teachers show a generally positive state across all three sub-dimensions, with efficacy to use inclusive instructions and efficacy in collaboration being the highest and efficacy in dealing with disruptive behaviors the lowest. he teachers' efficacy for inclusive practices of pre-service science teachers exhibited some tendencies of difference based on gender, experience with volunteering for individuals with disabilities, experience with inclusive education, and the extent of coursework in special education. However, none of these factors showed statistically significant differences.

• Journal of the Society of Disaster Information
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• v.20 no.2
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• pp.369-378
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• 2024

Purpose: This study aims to verify structural stability by manufacturing a 40m full-scale specimen composed of a segmental U-shaped PSC girder with integrated tensioning systems and a concrete slab, proceeding dynamic behavior tests, and compare the results of the tests with the results of numerical analysis. Method: Dynamic behavior tests were conducted on a full-scale, undamaged specimen using an impact hammer, and the natural frequency and damping ratio were measured and compared with numerical analysis techniques and the general damping ratio of the facilities. Result: The natural frequency of the numerical analysis model consisting of a girder and slab composite section was calculated to be 2.561Hz, the natural frequency of the full-scale specimen was measured to be 2.670Hz, and the damping ratio was calculated to be 0.42~0.68%. Conclusion: The natural frequency of the full-scale specimen was found to be 4.3% larger than that of the numerical analysis model. Since the masses of the full-scale specimen and the numerical analysis model are the same as 99.97%, it can be derived that the stiffness of the full-scale specimen has secured structural safety and stability. As a result, the dynamic behavior stability of the specimen was verified. The measured damping ratio of 0.42~0.68% was found to be a stable dynamic behavior compared to the PSC structures damping ratio of 0.5~1.0% in the elastic region.