• 한국체육학회지인문사회과학편
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• v.58 no.4
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• pp.481-492
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• 2019

The purpose of this study was to investigate the effects of treadmill exercise on cerebellar astrocyte activation and purkinje cells, neurotrophic factors expression, and motor function in aged rats. Sprague-Dawley (SD) rats were used and divided into three groups; (1) Young Control Group (YCG; 3months aged, n=10); (2) Old Control Group; (OCG; 24months aged, n=10); (3) Old Exercise Group (OEG; 24months aged, n=10). Rats were then subjected to treadmill exercise for 5 days per week for 12 weeks during which time the speed of the treadmill was gradually increased. The results revealed that in the rota-rod test, motor function was significantly increased in the OEG compared to the OCG (p<.05), and similarly YCG. Number of calbindin-positive purkinje cell expression significantly increased in the cerebellar vermis of OEG compared to the OCG (p<.05), and similarly YCG. GFAP-, NMDAR-positive cell expression significantly increased in the OEG (respectively p<.001), GFAP and GLAST protein levels were significantly increased in the cerebellum of OEG compared to the OCG (p<.05, p<.001) and similarly YCG. BDNF and NGF protein levels were highest in the YCG, increased in the OEG compared to OCG (p<.001, p<.05). These result show that regular exercise not only improved astrocyte activation, but also increased purkinje cell expression in the cerebellum and motor function by increasing the neurotrophic factors in aged rats.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.444-456
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• 2021

Economic abundance and the development of medical technology led to an aging society with an average life expectancy of 100 years, but retiring from the labor market at the age of 65 has become more difficult. This study aims to identify the influence of entrepreneurship, social support, and entrepreneurship mentoring as an effective support method to increase the entrepreneurial intention in order to enhance the entrepreneurial intention as an adult's second career development. In this study, data were collected using questionnaires from 340 adults, but only 319 were selected because 21 were judged to be inappropriate. For statistical analysis, SPSS 18.0 was used, and reliability test, factor analysis, and multiple regression analysis were used for hypothesis testing. The research results are as follows. First, as a result of examining the effects of adult entrepreneurship factors on entrepreneurship, it was found that among entrepreneurship, innovation and initiative had a significant positive (+) effect on entrepreneurship. Second, as a result of examining the effect of social support on entrepreneurial intention, it was found that family support had a significant negative (-) effect on entrepreneurial intention. Third, as a result of examining the effect of entrepreneurship mentoring on entrepreneurial intentions, it was found that role models and mentors had a positive (+) effect on entrepreneurial intentions. Fourth, as for the mediating effect of entrepreneurial efficacy, there were significant mediating effects of innovativeness → entrepreneurial efficacy → entrepreneurial intention, role model → entrepreneurial efficacy → entrepreneurial intention, mentor → entrepreneurial efficacy → entrepreneurial intention.

• The Journal of Engineering Geology
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• v.31 no.3
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• pp.381-393
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• 2021

Physical, mechanical, hydraulic, and geophysical tests were applied to validate methods of inspecting the effectiveness of grouting on an agricultural reservoir dam. Data obtained from series of in situ and laboratory tests considered four stages: before grouting; during grouting; immediately after grouting; and after aging the grouting for 28 days. The results of SPT and triaxial tests, including the unit weight, compressive strength, friction angle, cohesion, and N-value, indicated the extent of ground improvement with respect to grout injection. However, they sometimes contained errors caused by ground heterogeneity. Hydraulic conductivity obtained from in situ variable head permeability testing is most suitable for identifying the effectiveness of grouting because the impermeability of the ground increased immediately after grouting. Electric resistivity surveying is useful for finding a saturated zone and a seepage pathway, and multichannel analysis of surface waves (MASW) is suitable for analyzing the effectiveness of grouting, as elastic velocity increases distinctly after grouting injection. MASW also allows calculation from the P- and S- wave velocities of dynamic properties (e.g., dynamic elastic modulus and dynamic Poisson's ratio), which can be used in the seismic design of dam structures.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.6
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• pp.547-553
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• 2020

As aging infrastructures increase along with time, the efficient maintenance becomes more significant and accurate responses from the sensors are pre-requisite. Among various responses, strain is commonly used to detect damage such as crack and fatigue. Optical fiber sensor is one of the promising sensing techniques to measure strains with high-durability, immunity for electrical noise, long transmission distance. Fiber Bragg Grating (FBG) is a point sensor to measure the strain based on reflected signals from the grating, while Brillouin Optic Correlation Domain Analysis (BOCDA) is a distributed sensor to measure the strain along with the optical fiber based on scattering signals. Although the FBG provides the signal with high accuracy and reproducibility, the number of sensing points is limited. On the other hand, the BOCDA can measure a quasi-continuous strain along with the optical fiber. However, the measured signals from BOCDA have low accuracy and reproducibility. This paper proposed a multi-fidelity data-fusion method based on Gaussian Process Regression to improve the fidelity of the strain distribution by fusing the advantages of both systems. The proposed method was evaluated by laboratory test. The result shows that the proposed method is promising to improve the fidelity of the strain.

• Journal of dental hygiene science
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• v.20 no.4
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• pp.221-229
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• 2020

Background: The purpose of this study was to investigate the anti-oral microbial activity and anti-inflammatory effects of rosmarinic acid (RA) in lipopolysaccharide (LPS)-stimulated MC3T3-E1 osteoblastic cells on a titanium (Ti) surface during osseointegration, and to confirm the possibility of using RA as a safe natural substance for the control of peri-implantitis (PI) in Ti-based dental implants. Methods: A disk diffusion test was conducted to confirm the antimicrobial activity of RA against oral microorganisms. In order to confirm the anti-inflammatory effects of RA, inflammatory conditions were induced with 100 ng/ml of LPS in MC3T3-E1 osteoblastic cells on the Ti surface treated with or without 14 ㎍/ml of RA. The production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated MC3T3-E1 osteoblastic cells on the Ti surface was confirmed using an NO assay kit and PGE2 enzyme-linked immunosorbent assay kit. Reverse transcription polymerase chain reaction and western blot analysis were performed to confirm the expression of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in total RNA and protein. Results: RA showed weak antimicrobial effects against Streptococcus mutans and Escherichia coli, but no antimicrobial activity against the bacteria Aggregatibacter actinomycetemcomitans and the fungus Candida albicans. RA reduced the production of pro-inflammatory mediators, NO and PGE2, and proinflammatory cytokines, TNF-α and IL-1β, in LPS-stimulated MC3T3-E1 osteoblastic cells on the Ti surface at the protein and mRNA levels. Conclusion: RA not only has anti-oral microbial activity, but also anti-inflammatory effects in LPS-stimulated MC3T3-E1 osteoblasts on the Ti surface, therefore, it can be used as a safe functional substance derived from plants for the prevention and control of PI for successful Ti-based implants.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.4
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• pp.349-355
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• 2020

Recently, the detection of Mycobacterium tuberculosis complex (MTBC) in respiratory specimens has decreased, and nontuberculous mycobacteria (NTM) has increased. This study examined the increase in NTM lung disease patients and their age and sex distribution compared to the increase in NTM detection in 132,359 respiratory specimens examined in a Gwangju Secondary Hospital from 2010 to 2019. Furthermore, the prevalence of pulmonary tuberculosis infection in NTM positive patients was investigated. The positive rates of the mycobacterial culture were 21.9% (1,624/7,403) in 2010 and 17.4% (1,937/11,161) in 2019. The NTM recovery rate increased from 38.0% (617/1,624) in 2010 to 72.4% (1,403/1,937) in 2019. The average diagnosis rate of NTM lung disease in the NTM positive patients was 27.1%. Among them, cases of current pulmonary tuberculosis infection decreased from 44.9% in 2010 to 23.4% in 2019, and cases of previous diagnosis or treatment decreased from 15.8% to 10.7%. Of all NTM lung diseases, 69.0% were in their 60s or older, with more females than males. In the future, according to aging and tuberculosis management policies, NTM detection is expected to increase while MTBC decreases and laboratories must pay close attention to this phenomenon and constantly monitor the test results.

• The Journal of the Korea Contents Association
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• v.21 no.6
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• pp.609-619
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• 2021

The purpose of this study was not only to identify the level of health literacy, self-management knowledge and self-care behavior, but also to identify the relations those variables in elders with hemodialysis. The subjects of this study are 193 patients from dialysis clinics of nine hospitals in Incheon who aging over 60 years old. Data collection was conducted by using Health Literacy Scale, Self-Management Knowledge Scale, and Self-Care Behavior Scale. The data were analysed by descriptive analysis, t-test, ANOVA, and Pearson correlation coefficient using SPSS statistics 23.0 program. In the results, average score of subjects' health literacy, self-management knowledge and self-care behavior were 13.66(±2.09), 13.33(±1.85) and 63.95(±10.32), respectively. There were significant positive correlation between self-management knowledge and health literacy (r=0.37, p<.001) and reading comprehension part which is subscale in health literacy (r=.25, p=.001). Also, there was significant positive correlation between self-management knowledge and self-care behavior (r=0.15, p<.05). According to the above results, for improving the self-care behaviors in elders with hemodialysis, it is necessary to provide tailored education based on his/her level of health literacy.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.786-800
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• 2021

The subjects of this study were 463 people aged 65 and older in the senior welfare center in Seoul and Gyeonggi. The purpose of the study is to analyze the differences between physical fitness factors and cognitive functions, activities of daily living, instrumental activities of daily living, and psychological variables in the participation of the elderly in physical activities. Data ware analyzed by frequency analysis, reliability analysis, independent sample t-test and one-way ANOVA, and Pearson's correlation analysis, with SPSS 25.0 statistics program. The results of this study are as follows. First, there are statistically significant differences in physical fitness, cognitive function, activities of daily living, instrumental activities of daily living, and psychological factors such as depression and quality of life, depending on whether the elderly participate in physical activity. There were statistically significant differences in physical fitness, cognitive function, ADL, IADL, depression and quality of life, depending on the frequency of participation of older people in physical activity. A statistically significant difference in physical fitness appeared depending on the participation time of the elderly who participated in physical activity. Second, a study of the correlation between physical fitness and cognitive function, ADL, IADL, depression, and quality of life revealed a correlation for most factors. Based on these research results, it is necessary to develop a systematic arbitration strategy including physical activity for the successful aging of the elderly and the independent life of old age.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.1
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• pp.65-73
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• 2021

It is very important to control the inflammation of the skin because it can develop into diseases such as atopy as well as scarring and aging. In this work, we recently identified the in vitro synthesis of specialized pro-resolving mediators (SPMs) known to control inflammation in the human body and the applicability of cosmetics. Using recombinant protein of lipoxygenase from Glycine max, we succeeded to prepare mixtures of mono- or di-hydroxy DHA named as S-SPMs and used them for in vitro efficacy test. To investigate anti-inflammatory effect of S-SPMs, mRNA level of TNF-α and IL-6 were analyzed. Under UVB exposed condition, expression of both were decreased by S-SPMs treatment. And we observed reduced production of nitric oxide (NO) by S-SPMs application under the condition with diesel particulate matter (DPM). At the same experimental condition, malondialdehyde (MDA) production was decreased by S-SPMs, indicating the inhibitory effect of S-SPMs in lipid peroxidation. In addition, S-SPMs treatment resulted in reduction of matrix metalloproteinases-1 (MMP-1) expression and elevation of procollagen type I synthesis. Together with this, mRNA level of filaggrin and loricrin were increased by S-SPMs, indicating enhancement of skin barrier function. These results demonstrate that S-SPMs is a good candidate to develop as a cosmetic ingredient for anti-inflammation, anti-wrinkle, and improvement of skin barrier function.

• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.625-634
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• 2022

The objective of this study was to examine the relationship between physical activity (PA) level and functional fitness (FF) parameters in community-dwelling older adults aged 65 or above in Korea. Subjects' (M: 1,645; F: 2,394) PA level were assessed using a questionnaire. The subjects were divided into two groups: one below the recommended level of PA(LPA) and one above the recommended level (PA). PA was further classified by intensity level into medium- and high-intensity PA (MIPA and HIPA respectively) groups. FF was assessed based on six test items representing the following fitness areas: lower and upper body strength, agility and dynamic balance, flexibility, aerobic capacity, coordination, and body composition. Of the subjects, 36% met the recommended level of PA. Both MIPA and HIPA were superior to LPA in all FF items(p<.05). The HIPA group was significantly better in terms of agility and dynamic balance, coordination, and lower body strength (only in women) than was the MIPA group(p<.05). In conclusion, PA above the recommended level is needed to maintain functional fitness. In addition, HIPA seems to promote fall-related functional fitness and should be encouraged when safe and feasible.