• Title/Summary/Keyword: aging stability

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Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging

  • Sang-Woon Choi ;Simonetta Friso
    • Nutrition Research and Practice
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    • v.17 no.4
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    • pp.597-615
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    • 2023
  • Healthy aging can be defined as an extended lifespan and health span. Nutrition has been regarded as an important factor in healthy aging, because nutrients, bioactive food components, and diets have demonstrated beneficial effects on aging hallmarks such as oxidative stress, mitochondrial function, apoptosis and autophagy, genomic stability, and immune function. Nutrition also plays a role in epigenetic regulation of gene expression, and DNA methylation is the most extensively investigated epigenetic phenomenon in aging. Interestingly, age-associated DNA methylation can be modulated by one-carbon metabolism or inhibition of DNA methyltransferases. One-carbon metabolism ultimately controls the balance between the universal methyl donor S-adenosylmethionine and the methyltransferase inhibitor S-adenosylhomocysteine. Water-soluble B-vitamins such as folate, vitamin B6, and vitamin B12 serve as coenzymes for multiple steps in one-carbon metabolism, whereas methionine, choline, betaine, and serine act as methyl donors. Thus, these one-carbon nutrients can modify age-associated DNA methylation and subsequently alter the age-associated physiologic and pathologic processes. We cannot elude aging per se but we may at least change age-associated DNA methylation, which could mitigate age-associated diseases and disorders.

Dry aging of beef; Review

  • Dashdorj, Dashmaa;Tripathi, Vinay Kumar;Cho, Soohyun;Kim, Younghoon;Hwang, Inho
    • Journal of Animal Science and Technology
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    • v.58 no.5
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    • pp.20.1-20.11
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    • 2016
  • The present review has mainly focused on the specific parameters including aging (aging days, temperature, relative humidity, and air flow), eating quality (flavor, tenderness and juiciness), microbiological quality and economic (shrinkage, retail yields and cost) involved beef dry aging process. Dry aging is the process where beef carcasses or primal cuts are hanged and aged for 28 to 55 d under controlling environment conditions in a refrigerated room with $0^{\circ}$ to $4^{\circ}C$ and with relative humidity of 75 to 80 %. However there are various opinions on dry aging procedures and purveyors of such products are passionate about their programs. Recently, there has been an increased interest in dry aging process by a wider array of purveyors and retailers in the many countries. Dry aging process is very costly because of high aging shrinkage (6 to 15 %), trims loss (3 to 24 %), risk of contamination and the requirement of highest grades meat with. The packaging in highly moisture-permeable bag may positively impact on safety, quality and shelf stability of dry aged beef. The key effect of dry aging is the concentration of the flavor that can only be described as "dry-aged beef". But the contribution of flavor compounds of proteolysis and lipolysis to the cooked dry aged beef flavor is not fully known. Also there are limited scientific studies of aging parameters on the quality and palatability of dry aged beef.

Effects of aging and freezing/thawing sequence on quality attributes of bovine Mm. gluteus medius and biceps femoris

  • Kim, Hyun-Wook;Kim, Yuan H. Brad
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.2
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    • pp.254-261
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    • 2017
  • Objective: The effects of aging and freezing/thawing sequence on color, physicochemical, and enzymatic characteristics of two beef muscles (Mm. gluteus medius, GM and biceps femoris, BF) were evaluated. Methods: Beef muscles at 3 d postmortem were assigned to four different combinations of aging and freezing/thawing sequence as follows; aging at $2^{\circ}C$ for 3 wk (A3, never-frozen control), freezing at $-28^{\circ}C$ for 2 wk then thawing (F2, frozen/thawed-only), aging at $2^{\circ}C$ for 3 wk, freezing at $-28^{\circ}C$ for 2 wk then thawing (A3F2), and freezing at $-28^{\circ}C$ for 2 wk, thawing then further aging at $2^{\circ}C$ for 3 wk (F2A3). Results: No significant interactions between different aging/freezing/thawing treatments and muscle type on all measurements were found. Postmortem aging, regardless of aging/freezing/thawing sequence, had no impact on color stability of frozen/thawed beef muscles (p<0.05). F2A3 resulted in higher purge loss than F2 and A3F2 treatments (p<0.05). A3F2 and F2A3 treatments resulted in lower shear force of beef muscles compared to F2 (p<0.05). Although there was no significant difference in glutathione peroxidase (GSH-Px) activity, F2A3 had the highest ${\beta}-N-acetyl$ glucominidase (BNAG) activity in purge, but the lowest BNAG activity in muscle (p<0.05). GM muscle exhibited higher total color changes and purge loss, and lower GSH-Px activity than BF muscle. Conclusion: The results from this present study indicate that different combinations of aging/freezing/thawing sequence would result in considerable impacts on meat quality attributes, particularly thaw/purge loss and tenderness. Developing a novel freezing strategy combined with postmortem aging will be beneficial for the food/meat industry to maximize its positive impacts on tenderness, while minimizing thaw/purge loss of frozen/thawed meat.

Rapid Discoloration of Aged Beef Muscles after Short-Term/Extreme Temperature Abuse during Retail Display

  • Kim, Hyun-Wook;Setyabrata, Derico;Choi, Yun-Sang;Kim, Yuan H. Brad
    • Food Science of Animal Resources
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    • v.36 no.3
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    • pp.343-351
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    • 2016
  • The objective of this study was to evaluate the effects of a short-term/extreme temperature abuse (STA) on color characteristics and oxidative stability of aged beef muscles during simulated retail display. Two beef muscles (longissimus lumborum, LL and semitendinosus, ST) were aged for 7 (A7), 14 (A14), 21 (A21), and 28 d (A28), and further displayed at 2℃ for 7 d. The STA was induced by placing steak samples at 20℃ for 1 h on the 4th d of display. Instrumental and visual color evaluations, ferric ion reducing capacity (FRC) and 2-thiobarbituric acid reactive substances (TBARS) assay were performed. Initially, redness, yellowness and hue angle of all beef muscles were similar, regardless of aging time before display (p>0.05). An increase in postmortem aging time increased lipid oxidation and caused a rapid discoloration after STA during display (p<0.05). ST muscle was more sharply discolored and oxidized after STA, when compared to LL muscle (p<0.05). The FRC value of beef muscles was decreased after 7 d of display (p<0.05). The results from the current study indicate adverse impacts of postmortem aging on color and oxidative stabilities of beef muscles, particularly under temperature abusing conditions during retail display. Thus, developing a specific post-harvest strategy to control quality attributes in retail levels for different muscle types and aging conditions would be required.

Microstructure, Electrical Properties, and Accelerated Aging Behavior of Er-Added ZPCC-YE Varistors

  • Nahm, Choon-Woo;Park, Jong-Hyuk
    • Transactions on Electrical and Electronic Materials
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    • v.11 no.5
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    • pp.216-221
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    • 2010
  • The microstructure, electrical properties, and DC-accelerated aging behavior of the Zn-Pr-Co-Cr-Y-Er (ZPCC-YE) varistors were investigated for different amounts of erbium oxide ($Er_2O_3$). The microstructure consisted of zinc oxide grain and an intergranular layer ($Pr_6O_{11}$, $Y_2O_3$, and $Er_2O_3$-rich phase) as a secondary phase. The increase of $Er_2O_3$ amount decreased the average grain size and increased the sintered density. As the $Er_2O_3$ amount increased, the breakdown field increased from 5094 V/cm to 6966 V/cm and the nonlinear coefficient increased from 27.8 to 45.1. The ZPCC-YE varistors added with 0.5 to 1.0 mol% $Er_2O_3$ are appropriate for high voltage, with high nonlinearity and stability against DC-accelerated aging stress.

Financing Plan for Improving the Aging Architectural Facilities in the United Korean Peninsula (통일 한반도의 노후화 건축 인프라 개선을 위한 자금조달방안)

  • Kim, Chang-Won;Kim, Taehoon;Kim, Min Ju;Cho, Hunhee;Kang, Kyung-In
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2016.05a
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    • pp.170-171
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    • 2016
  • The unity of korean peninsula have traditionally been established as major policy in korea government. Present government also set Trust Process on the Korean Peninsula as national high-level strategies for unity, and construction field related directly to living of north korean as major industry which would be implemented in early stage. Deterioration level of architectural facilities in north korea is known as very high, so a huge budget would be required to improve aging architectural facilities for stability of social and living of north korean. Therefore the purpose of this study deduct financing plan for improving aging architectural facilities in north korea and selection of optimal alternative securing effectiveness. The results of this study could be utilized as preliminary data for establishment of master plan and policy for improving deteriorated facilities in situation of united korean peninsula.

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Effect of Aging and Freezing Conditions on Meat Quality and Storage Stability of 1++ Grade Hanwoo Steer Beef: Implications for Shelf Life

  • Cho, Soohyun;Kang, Sun Moon;Seong, Pilnam;Kang, Geunho;Kim, Youngchoon;Kim, Jinhyung;Chang, Sunsik;Park, Beomyoung
    • Food Science of Animal Resources
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    • v.37 no.3
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    • pp.440-448
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    • 2017
  • This study was conducted to establish the shelf life of $1^{++}$ grade Hanwoo beef by evaluating the changes in meat quality and storage stability under distribution conditions similar to those during export to Hong Kong and China. Four muscles of the loin, striploin, tenderloin, and top round muscles were obtained from 10 animals of $1^{++}$ grade Hanwoo steers. The distribution conditions were 0, 7, or 14 d of aging at $2^{\circ}C$ and continuous storage at $-18^{\circ}C$ for 0, 3, 6, or 9 mon. The lightness (CIE $L^*$) values decreased as the duration of freezer storage increased (p<0.05). The water-holding capacity of 4 muscles increased as the aging time increased when they were frozen for 3 mon (p<0.05). The cooking loss values of the four muscles were significantly increased as the duration of freezer storage increased (p<0.05). The Warner-Bratzler shear force values were significantly decreased in the loin, striploin, and top round muscles as the aging time increased (p<0.05). The changes in volatile basic nitrogen (16.67-18.49 mg%) and thiobarbituric reactive substance values (0.75-0.82 mg MA/kg meat) were significantly increased when the meat was frozen for 9 mon after 14 d of aging. On the basis of these observations, the shelf life of $1^{++}$ grade Hanwoo beef during distribution should be limited to less than 9 mon of freezer storage at $-18^{\circ}C$ after 14 d of aging at $2^{\circ}C$.

DC Accelerated Aging Characteristics of Praseodymium-Based ZnO Varistors Doped with $Dy_2O_3$ ($Dy_2O_3$가 첨가된 프라세오디뮴계 ZnO 바리스터의 DC 가속열화특성)

  • Ryu, Jung-Sun;Jung, Young-Chul;Kim, Hyang-Suk;Nahm, Choon-Woo
    • Proceedings of the KIEE Conference
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    • 2001.11a
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    • pp.78-80
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    • 2001
  • DC accelerating aging characteristics of praseodymium-based ZnO varistors doped with $Dy_2O_3$ were investigated with sintering time. The varistor sintered for 1h exhibited the highest nonlinearity, with a nonlinear exponent of 66.61 and a leakage current of $1.16{\mu}A$, whereas they did not exhibit relatively high stability. The varistor sintered for 2h having nonlinear exponent of 54.81 and leakage current of $2.52{\mu}A$ showed very excellent stability, which the variation rates of varistor voltage, nonlinear exponent, and leakage current are -1.19%, -4.00%, and +75.79% for 2h, under DC accelerated aging stress, such as ($0.85\;V_{1mA}/115^{\circ}C$/24h)+($0.90\;V_{1mA}/120^{\circ}C$/24h)+($0.95\;V_{1mA}/125^{\circ}C$/24h)+($0.95\;V_{1mA}/150^{\circ}C$/24h).

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The Properties of Concrete mixed with Steam Aging Converter slag (증기 에이징을 실시한 전로슬래그 콘크리트의 특성)

  • 곽기주;손순종;서병철;곽동림
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.37 no.5
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    • pp.43-52
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    • 1995
  • To examine the appicability of the converter slag to aggregate, tests were performed for the converter slag specimens which were aged with steam, and the stability of expansion was investigated. The strength of the converter slag was found to he lower than that of the natural aggregate. But the strength of the concrete mixed with the converter slag and the granular slag was increased with an increase of the content of the granular slag. The slump value was larger for the specimen of the converter slag than that for the natural aggregate. The specific weight of the converter slag was decreased with an increase of the aging peroid. The aging time for the converter slag was accessed to be about 48 hours to accommodate the full stability of the expansion. The amount of the steam needed to age one ton of converter slag to full expansion was accessed to be 60 kg. From the regression analysis for splitting tensile strength (t), and flexural strength (f), the compressive strength (c) based on the following formulas were proposed $\sigma$t=0.1506 $\sigma$c+4.5(kg/cm$^2$) (r=0.876) $\sigma$f=O.l537.~+30.5(kg/cm$^2$) (r=0.796)

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The Study of Restoration Technique of Wax-Treated Volume for the Annals of the Joseon Dynasty(II) - Evaluation of aging characteristics of Korean traditional paper, Hanji as the restoration material of the annals - (조선왕조실록 밀랍본 복원기술연구(제2보) - 실록의 복원용지 탐색을 위한 전통한지의 열화특성 평가 -)

  • Jeong, Seon-Hwa;Jeong, So-Young;Seo, Jin-Ho
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.40 no.2
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    • pp.43-56
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    • 2008
  • The purpose of the experiment was to evaluate the material stability of the paper of the annals of Joseon Dynasty for the conservation purpose and the categories were as listed below : 1. Procuring traditional Hanji and semi-Hanji from different regional hanji paper mill. 2. Artificial accelerated aging treatment to examination its stability (UV irradiation, dry heat) 3. Analysis of optical, physical characteristic. The suitable Hanji for categories would be used as a reconstruction material for the waxel paper in the papers of the annals of Joseon Dynasty.