• Journal of Ginseng Research
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• v.42 no.1
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• pp.68-74
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• 2018

Background: Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation. Methods: Mouse peritoneal macrophages were polarized into M1 or M2 phenotypes. Reverse transcription-polymerase chain reaction, Western blotting, and measurement of nitric oxide (NO) and prostaglandin $E_2$ levels were performed in vitro and in a zymosan-induced peritonitis C57BL/6 mouse model. Results: Ginsenoside $Rg_3$ was identified as a proresolving ginseng compound based on the induction of M2 macrophage polarization. Ginsenoside $Rg_3$ not only induced the expression of arginase-1 (a representative M2 marker gene), but also suppressed M1 marker genes, such as inducible NO synthase, and NO levels. The proresolving activity of ginsenoside $Rg_3$ was also observed in vivo in a zymosan-induced peritonitis model. Ginsenoside $Rg_3$ accelerated the resolution process when administered at peak inflammatory response into the peritoneal cavity. Conclusion: These results suggest that ginsenoside $Rg_3$ induces the M2 polarization of macrophages and accelerates the resolution of inflammation. This finding opens a new avenue in ginseng pharmacology.

• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2589-2594
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• 2009

Aging phenomena of plasma polymer films were studied by using the surface analysis techniques of contact angle measurement, X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (TOFSIMS), and atomic force microscopy (AFM). The polymer films were grown on an aluminum substrate by using a plasma polymerization method from a gas mixture of acetylene and helium, and the films were subsequently modified to have a hydrophilic surface by oxygen plasma treatment. Aging of the polymer films was examined by exposing the samples to water and air environments. The aging process increased the hydrophobicity of the surface, as revealed by an increase in the advancing contact angle of water. XPS analysis showed that the population of oxygen-containing polar groups increased due to the uptake of oxygen during the aging, whereas TOF-SIMS analysis revealed a decrease in the polar group population in the uppermost surface layer. The results suggest that the change in surface property from hydrophilic to hydrophobic nature results from the restructuring of polymer chains near the surface, rather than compositional change of the surface. Oxidative degradation may enhance the mobility and the restructuring process of polymer chains.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.2
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• pp.131-137
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• 2021

Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a well-known C-glucoside xanthone in mango leaves with lots of beneficial properties. In this study, rat model of cardiac fibrosis was induced by injected with 150 mg/kg/d D-galactose for 8 weeks. The age-related cardiac decline was estimated by detecting the relative weight of heart, the serum levels of cardiac injury indicators and the expression of hypertrophic biomakers. Cardiac oxidative stress and local inflammation were measured by detecting the levels of malondialdehyde, enzymatic antioxidant status and proinflammatory cytokines. Cardiac fibrosis was evaluated by observing collagen deposition via masson and sirius red staining, as well as by examining the expression of extracellular matrix proteins via Western blot analysis. The cardiac activity of profibrotic TGF-β1/p38/MK2 signaling pathway was assessed by measuring the expression of TGF-β1 and the phosphorylation levels of p38 and MK2. It was observed that mangiferin ameliorated D-galactose-induced cardiac aging, attenuated cardiac oxidative stress, inflammation and fibrosis, as well as inhibited the activation of TGF-β1/p38/MK2 signaling pathway. These results showed that mangiferin could ameliorate cardiac fibrosis in D-galactose-induced aging rats possibly via inhibiting TGF-β/p38/MK2 signaling pathway.

• 한국노년학
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• v.41 no.4
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• pp.527-546
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• 2021

This study examined the effect of past acceptance on suicidal ideation in older adults and verified double mediation effects of attitude to aging and depression. The responses of 329 aged 65 years or older who participate in senior welfare centers in Seoul and Gyeonggi-do were used. As an analysis method, the double mediation effect was confirmed through serial multiple mediation model verification using the SPSS PROCESS macro program. The followings are the results of the study. First, the past acceptance had a significant effect on the aging attitude, the aging attitude on the depression, and the depression on the suicidal ideation, but the direct effect of past acceptance on the suicidal ideation was not significant. Second, double mediation effects of attitude to aging and depression were significant in the relationship between past acceptance and suicidal ideation. Based on these results, practical and policy interventions to prevent suicide in old age were suggested.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2001.04a
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• pp.281-286
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• 2001

Titanium alloy conducted in this experimental study has superior corrosive resistant and is mainly used in aerospace, automotive and petro-chemical industries. It is also treated with important materials of domestic goods due to improvement of the standard of living. In this study specimens were processed in the wire EDM after annealing, solution treatment and aging. Results were obtained through repeated experments of main rough process and finish process with the change of process parameters. Processing characteristics such as surface hardness, surfaces roughness, shape of processed surface and components were measured. The results confirmed that the above mentioned elements were improved in accordance with the number of process. Therefore, the optimal wire EDM condition in accord with processing characteristics is proposed in this experiment.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.28-30
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• 2009

PDP panels with MgO protective layer are manufactured by using the "all-in-vacuum" process we have established [1]. This is the process aiming to keep the MgO surface as clean as possible after the evaporation. The panels are evaluated in term of discharge voltage, aging time, luminance, luminous efficacy, discharge time-lag. It is confirmed that the "all-in-vacuum" process particularly improves the aging time, discharge voltage and the discharge time-lag.

• Industry Promotion Research
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• v.8 no.3
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• pp.69-78
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• 2023

Based on the perception that integrated retirement preparation in various areas is needed in preparation for increased old age, this study aims to identify the status and characteristics of retirement preparation of middle-aged people and reveal the relationship with successful aging. In addition, it aims to find out the mediating effect of social support in the relationship between retirement preparation and successful aging for the middle-aged. To confirm this, 1,037 men and women aged 50 to 64 who responded to the third, fourth, and fifth additional surveys of the Korean Retirement & Income Study (KReIS) conducted by the National Pension Research Institute were analyzed. When the preparation of middle-aged people for retirement affects successful aging, bootstrapping with IBM SPSS 26 Process Macro Model 4 was conducted to verify the mediating effect of social support. As a result of verifying the significance of independent variables on the parameters, preparation for retirement was positively (+) significant. In other words, it was verified that the higher the preparation for retirement, the higher the social support. Furthermore, it was discovered that social support, an independent variable, had a significant impact on successful aging, and social support, an independent variable, had a significant impact on successful aging. The results of this study suggest the need for social support for successful aging through the preparation of middle-aged people for retirement. It is intended to derive policy implications for preparing for retirement and provide them as basic data to increase the level of successful aging.

• Journal of Korean Foot and Ankle Society
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• v.11 no.2
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• pp.123-129
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• 2007

Purpose: The aim of this study was to analyze radiological change of Kager's triangle in patients with retrocalcaneal disorders. Materials and Methods: Areas of Kager's triangle and calcaneus were calculated with Heron's Formula. Average of area ratio (area of Kager's triangle / area of calcaneus) was calculated for comparison and analysis, according to disease activity and aging process. One-tailed Z-test was done with the average of area ratio. Results: Average of area ratio (area of Kager's trianlge / area of calcaneous) tends to decrease according to aging process and disease existence. Conclusion: Because area of Kager's triangle in patients with retrocalcaneal disorders tends to change according to disease activity and aging process, we should consider clinical correlation between the anatomical structure of Kager's triangle and retrocalcaneal symptoms.

• Applied Microscopy
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• v.22 no.1
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• pp.113-127
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• 1992

The present study was investigated to elucidate the effects of chlorambucil the heart tissue of various-aged rats. The male rats ranging from 3 to 36 months were used. The cytochemical and biochemical changes in myocardium of the rats were studied in the aspect of free radical roles in aging process. With the goals of evaluating the potential roles of free radicals in aging process, evidence was shought for alterations of myocardial lipid peroxide levels in control and chlorambucil treated rats. The result are summarized as follows: 1. Cytochemical studies showed that the activities of $Mg^{++}$-ATPase and succinic dehydrogenase increased with age. However, these enzyme activities were decreased with treatment of chlorambucil, when compared with control group. Interestingly it was observed that chlorambucil treatment increased the activity of acid phosphatase from 6 months upto 18 months, and decreased after 18 months. 2. The lipid peroxide level in myocatdium was increased with age; chlorambucil-treated group was higher than that of control group. 3. Age-dependent increase in activities of monoamine oxidase, xanthine oxidase and catalase was observed. But the increase of catalase activity was higher than that of monoamine oxidase and xanthine oxidase activity in control group. However, in chlorambucil-treated group, age-dependent decrease of these enzyme activities was observed, and catalase activity was more significant particularly with regard to other enzymes. In consequently, the morphological alterationsof myocardium due to chlorambucil treatment was exclusively observed. We demonstrate that this alteration is occured by lipid peroxidation upon chlorambucil treatment.

• Journal of Korea Foundry Society
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• v.20 no.4
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• pp.269-276
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• 2000

So far, the study on semi-solid process has been carried out to develop and research new advanced materials without some casting defects. In this study, A356 billets consisted of various dendritic shapes were prepared using electro-magnetic stirring process continuously. As-cast respectively has liquidus temperature of $625.6^{\circ}C$ and solidus temperature of $573.55^{\circ}C$ A356 slugs were reheated homogeneously at different temperatures of 580, 590 and $605^{\circ}C$, followed by squeezing in a mold insulated with applied pressures(0, 25, 50 and 70 MPa). In order to investigate on aging responce for casts, 50 MPa squeezed specimen among all specimens was prepared in aging treatments, which conditions are aging temperature of $160^{\circ}C$ and holding times of 0, 45, 90, 270, 360, 720, 1440 and 2880 min after solution treatment ($540^{\circ}C$ for 10 hr). SSM ingot with the output velocity of 150mm/min appeared more spheroidal shape and fine structure than that with the output velocity of 250 mm/min. According to increasing in reheating temperature, numbers of fatigue cycles, U.T.S and elongation increased at same time.