• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.1 s.49
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• pp.121-125
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• 2005

Most of the cells, specially in the skin, free radicals and reactive oxygen species induced aging, accompanying with diseases. The pinaceae family is very familiar plant with Korean spirit. However, those plants were not estimated for natural products in manufactural process. We employed 4 different plants, Pinus koraienis S et Z. Pinus banksiana LAMBERT. Pinus rigida MILL. Pinus densiflora S. et Z. in pinceae family. The ethanol extracts were prepared for three different parts of plant, wood, bark and leaf, respectively. In this study, we carried out free radical and superoxide radical scavenging assay to investigate the anti-oxidative activity The bark and leaf part of plants showed similar anti-oxidant effect. L-ascorbic acid and $\alpha$-tocopherol at $10{\mu}g/mL$. Also we tried to investigate inhibitory effects of elastase activity in in vitro experiments on pinaceae plant extract as a matters for functional cosmetics. Among those plants, the bark of Pinus rigida MILL. and Pinus densiflora S. et Z. showed inhibitory effect. The cell viability was evaluated with MTT assay. The potential relationship was shown between the cell viability and anti-oxidant effect because the anti-oxidant effects were positively correlated wvith the cell growth in MTT assay. As the results in our experiments, we expect the potential activities of pinaceae as a material of functional cosmetics.

• Journal of Christian Education in Korea
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• v.67
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• pp.77-116
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• 2021

The purpose of this study is to argue that religious maturity is necessary for the healthy life of the aged of Korean churches in the rapidly aging society. It is also to suggest educational method for the formation and development of a positive image of God for relations with God, which is essential factor in religious maturity. To this end, this study argues that the direction and task of senior education should be religious maturity through the search for prior research on church education of senior citizens. This study also looked at the variables involved in how religious maturity affects many areas of human life. To achieve the task of religious maturity, the biblical and theological concept of maturity and religious psychological concepts of maturity are summarized, and the concept of God's image for relations with God, which is important in religious maturity, and the variables related to mature human life are examined. This study was proposed methods of church education for the formation and development of a positive image of God in order to have the right relationship with God for the religious maturity of the elderly on intellectual, emotional and behavioral levels. In the intellectual aspect, it was proposed to educate the concept of biblical and theological God and and to educate the elderly to recognize themselves as beings that need to grow and mature in order to constantly establish relationships with God. In the affective aspect, it was proposed to educate the elderly to reflect on and identify the origin and formation process of God's image and to heal their distorted God's image with an educational counseling approach. In the behavioral aspect, it was suggested to educate their roles of faith education for the next generation as parents and grandparents and to educate using educational methods that induce them to practice their relationship with God to appear in daily life.

• Journal of Life Science
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• v.31 no.9
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• pp.796-805
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• 2021

Hepatic endoplasmic reticulum (ER) stress contributes to the development of steatosis and insulin resistance. The components of unfolded protein response (UPR) regulate lipid metabolism. Recent studies have reported an association between ER stress and aberrant cellular lipid control; moreover, research has confirmed the involvement of sterol regulatory element-binding proteins (SREBPs)-the central regulators of lipid metabolism-in the process. However, the exact role of SREBPs in controlling lipid metabolism during ER stress and its contribution to fatty liver disease remain unknown. Here, we show that SREBP-1c deficiency protects against ER stress-induced hepatic steatosis in mice by regulating UPR, inflammation, and fatty acid oxidation. SREBP-1c directly regulated inositol-requiring kinase 1α (IRE1α) expression and mediated ER stress-induced tumor necrosis factor-α activation, leading to a reduction in expression of peroxisome proliferator-activated receptor γ coactivator 1-α and subsequent impairment of fatty acid oxidation. However, the genetic ablation of SREBP-1c prevented these events, alleviating hepatic inflammation and steatosis. Although the mechanism by which SREBP-1c deficiency prevents ER stress-induced inflammatory signaling remains to be elucidated, alteration of the IRE1α signal in SREBP-1c-depleted Kupffer cells might be involved in the signaling. Overall, the results suggest that SREBP-1c plays a crucial role in the regulation of UPR and inflammation in ER stress-induced hepatic steatosis.

• Journal of the Society of Disaster Information
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• v.17 no.2
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• pp.254-265
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• 2021

Purpose: Inspection and diagnosis on the performance and safety through domestic port facilities have been conducted for over 20 years. However, the long-term development strategies and directions for facility renewal and performance improvement using the diagnosis history and results are not working in realistically. In particular, in the case of port structures with a long service life, there are many problems in terms of safety and functionality due to increasing of the large-sized ships, of port use frequency, and the effects of natural disasters due to climate change. Method: In this study, the maintenance history data of the gravity type quay in element level were collected, defined as big data, and a predictive approximation model was derived to estimate the pattern of deterioration and aging of the facility of project level based on the data. In particular, we compared and proposed models suitable for the use of big data by examining the validity of the state-based deterioration pattern and deterioration approximation model generated through machine learning algorithms of GP and SGP techniques. Result: As a result of reviewing the suitability of the proposed technique, it was considered that the RMSE and R² in GP technique were 0.9854 and 0.0721, and the SGP technique was 0.7246 and 0.2518. Conclusion: This research through machine learning techniques is expected to play an important role in decision-making on investment in port facilities in the future if port facility data collection is continuously performed in the future.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.5
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• pp.114-126
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• 2021

This paper compared bridge maintenance in United Stated, United Kingdom, Japan, and Korea. Bridges play an essential role in transportation network and in the economic production process. To provide a desirable level of service to the public within limited budgets, it is required to provide effective bridge maintenance activities (e.g. inspection and repair/rehabilitation) at acceptable level of bridge service. A number of bridges are expected to age rapidly in Korea, which will be the excess burden of government. Since several countries have experienced a number of deteriorated bridges because of aging, the countries aforementioned in this study have already developed comprehensive bridge maintenance programs such as inspection practice and repair/rehabilitation techniques. Therefore, the goal of this paper is to synthesize and to compare useful knowledge on bridge maintenance and bridge crack repair/restoration of deteriorated concrete bridge in the four countries. Finally, recommendations that will serve as guidance to transportation agencies for potential enhancements to bridge maintenance and bridge repairs are presented.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.2
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• pp.95-111
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• 2021

As the population decreases in an aging society, the average age of drivers increases. Accordingly, the elderly at high risk of being in an accident need autonomous-driving vehicles. In order to secure driving safety on the road, several technologies to respond to various obstacles are required in those vehicles. Among them, technology is required to recognize static obstacles, such as poor road conditions, as well as dynamic obstacles, such as vehicles, bicycles, and people, that may be encountered while driving. In this study, we propose a deep neural network algorithm capable of simultaneously detecting these two types of obstacle. For this algorithm, we used 1,418 road images and produced annotation data that marks seven categories of dynamic obstacles and labels images to indicate road damage. As a result of training, dynamic obstacles were detected with an average accuracy of 46.22%, and road surface damage was detected with a mean intersection over union of 74.71%. In addition, the average elapsed time required to process a single image is 89ms, and this algorithm is suitable for personal mobility vehicles that are slower than ordinary vehicles. In the future, it is expected that driving safety with personal mobility vehicles will be improved by utilizing technology that detects road obstacles.

• 재활복지
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• v.18 no.4
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• pp.221-235
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• 2014

Recently, the frequency of stroke disease is increased due to the rapid aging population, and is contributed to the major occurrence factors of the posteriori acquired disability. This study is about an postural change device for the control of supine posture which is an assisted equipment using in daily rehabilitation process for overcoming the disability by the aftereffects of the stoke disease. In this paper, the existing domestic and Japan postural appliances is examined and its comparison and categorization is performed according to its functions and purposes. Here, in order to control the supine posture state, the design method for advanced multi functional system is proposed, which is devised to have an unified mattress control operations of combining the bedsore prevention tube with the supine posture tilting tube. And also, in addition of an smart function, it is designed to enable to perform an RF functions such as the monitoring of the present device state, the alteration of the basic position and the control of alternative floating and supine posture. This system control hardware consists of three main parts : the sensor detection part, the motor driving /control part, and the system control part for bluetooth communication. In results, we confirmed that the system designed by this research is possible to make it practical as an advanced smart postural change device combined by IoT technology in the application field of the recent IT technology.

• Journal of Life Science
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• v.28 no.12
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• pp.1455-1460
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• 2018

Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of $PGC-1{\alpha}$ in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.

• Korean Journal of Heritage: History & Science
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• v.46 no.3
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• pp.150-171
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• 2013

The most important part of conservation treatment of murals is to preserve them against the risk of a damage by injecting fixative into them when the painting loses its cohesion or powderization of pigments occurred due to occurrence of cracks inside the painting layer. However, studies on the stability of fixative used for painting layers of murals are still insufficient. This study manufactured a mural as a specimen and colored it with four kinds of pigments including oyster shell white, cinnabar, malachite and red clay and applied four kinds of fixative, including, Paraloid $B-72^{(R)}$, Caparol-$binder^{(R)}$, glue and Hydoxypropyl $cellulose^{(R)}$. artificially generated environmental changes in temperature, humidity and ultraviolet rays which may occur after the completion of conservation treatment. Then the changes in physical properties were observed in multifaceted ways such as color stability, contact angle, brilliance, adhesive strength and surface. As a result, this study found that ultraviolet rays and hot?humid environment have a large impact on color stability causing changes in brightness and chroma of all painting layers where the fixative were applied, except for oyster shell white and are considered the main factors of decomposition by accelerating the aging process of fixatives applied. In comparison to the synthetic resins that were also tested in this study, the traditional glue showed satisfactory results in terms of color stability and influence preservation and the hydrophile property. As it showed exceptionally outstanding adhesive strength in all painting layers in the aspect of adhesive strength, it is considered to be highly stabile for the fixation treatment of painting layers of mural.

• Korean Journal of Pharmacognosy
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• v.50 no.3
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• pp.219-225
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• 2019

This study was done to examine immunomodulative effects of aged doraji (AD) in the immune-suppressed mice induced by cyclophosphamide. The immune-stimulating effects of ethanol AD extract in in vivo at 75 and 150 mg/kg body weight (BW) for AD and 2AD groups were evaluated and compared to the normal doraji group (2ND, 150 mg/kg BW) treated with a doraji without aging process. After the 10 days of oral supplement, body and immune related organ weights, serum immunoglobulin G (IgG) and cytokines levels, splenocytes proliferation rate, and splenic NK cell activity were measured as immune-related biomarkers. Body weight and serum IgG level increased in the 2AD group. But, the serum Th2 cytokine (IL-6, $TNF-{\alpha}$) levels were lower in the AD and 2AD groups, respectively. Splenic T cell and B cell proliferation and NK cell activity increased in the doraji groups and the significant increases were found only in the 2AD group. Thus, the aged doraji extract may affect body weight, serum IgG level, splenocytes proliferation, and splenic NK cell activity, and normalize the Th2 cytokine levels in the immune-suppressed mice. The results suggest that the aged doraji improves effectively immune system rather than the normal one.