• Title/Summary/Keyword: aging process

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Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

  • Widowati, Wahyu;Rani, Andani Puspita;Hamzah, R. Amir;Arumwardana, Seila;Afifah, Ervi;Kusuma, Hanna Sari W.;Rihibiha, Dwi Davidson;Nufus, Hayatun;Amalia, Annisa
    • Natural Product Sciences
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    • v.23 no.3
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    • pp.192-200
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    • 2017
  • Skin aging is a complex biological process due to intrinsic and extrinsic factors. Free radical oxidative is one of extrinsic factors that induce activation of collagenase, elastase and hyaluronidase. Natural product from plants has been used as antioxidant and antiaging. This study aimed to evaluate antioxidant and antiaging properties of Hibiscus sabdariffa extract (HSE) and its compounds including myricetin, ascorbic acid, and ${\beta}$ carotene. The phytochemical of H. sabdariffa was determined using modified Farnsworth method and presence of phenols, flavonoids and tannins were in moderate content, whereas triterpenoids and alkaloids were in low content. Total phenolic content performed using Folin-Ciocalteu method, was $23.85{\mu}gGAE/mg$. Quantitative analysis of myricetin, ${\beta}-carotene$, and ascorbic acid of HSE was performed with Ultra-High Performance Liquid Chromatography (UHPLC) that shows $78.23{\mu}g/mg$ myricetin, $0.034{\mu}g/mg$ ${\beta}-carotene$, whilst ascorbic acid was not detected. HSE has lower activity on DPPH ($IC_{50}=195.73{\mu}g/mL$) compared to ${\beta}-carotene$, the lowest in ABTS assay ($IC_{50}=74.58{\mu}g/mL$) and low activity in FRAP assay ($46.24{\mu}MFe(II)/{\mu}g\;$) compared to myricetin, ${\beta}-carotene$. Antiaging was measured through inhibitory activity of collagenase, elastase, and hyaluronidase. HSE had weakest collagenase inhibitory activity ($IC_{50}=750.33{\mu}g/mL$), elastase inhibitory activity ($103.83{\mu}g/mL$), hyaluronidase inhibitory activity ($IC_{50}=619.43{\mu}g/mL$) compared to myricetin, ${\beta}-carotene$, and ascorbic acid. HSE contain higher myricetin compared to ${\beta}-carotene$. HSE has moderate antioxidants and lowest antiaging activities. Myricetin is the most active both antioxidant and antiaging activities.

Chromatin Interacting Factor OsVIL2 Is Required for Outgrowth of Axillary Buds in Rice

  • Yoon, Jinmi;Cho, Lae-Hyeon;Lee, Sichul;Pasriga, Richa;Tun, Win;Yang, Jungil;Yoon, Hyeryung;Jeong, Hee Joong;Jeon, Jong-Seong;An, Gynheung
    • Molecules and Cells
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    • v.42 no.12
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    • pp.858-868
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    • 2019
  • Shoot branching is an essential agronomic trait that impacts on plant architecture and yield. Shoot branching is determined by two independent steps: axillary meristem formation and axillary bud outgrowth. Although several genes and regulatory mechanism have been studied with respect to shoot branching, the roles of chromatin-remodeling factors in the developmental process have not been reported in rice. We previously identified a chromatin-remodeling factor OsVIL2 that controls the trimethylation of histone H3 lysine 27 (H3K27me3) at target genes. In this study, we report that loss-of-function mutants in OsVIL2 showed a phenotype of reduced tiller number in rice. The reduction was due to a defect in axillary bud (tiller) outgrowth rather than axillary meristem initiation. Analysis of the expression patterns of the tiller-related genes revealed that expression of OsTB1, which is a negative regulator of bud outgrowth, was increased in osvil2 mutants. Chromatin immunoprecipitation assays showed that OsVIL2 binds to the promoter region of OsTB1 chromatin in wild-type rice, but the binding was not observed in osvil2 mutants. Tiller number of double mutant osvil2 ostb1 was similar to that of ostb1, suggesting that osvil2 is epistatic to ostb1. These observations indicate that OsVIL2 suppresses OsTB1 expression by chromatin modification, thereby inducing bud outgrowth.

Study on the Tracking Characteristics Depending on Accelerated Degradation of PVC Insulation Material (PVC 절연재료의 가속열화에 따른 트래킹 특성에 관한 연구)

  • Choi, Su-Gil;Kim, Si-Kuk
    • Fire Science and Engineering
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    • v.31 no.6
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    • pp.91-98
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    • 2017
  • The present paper is a study on the tracking characteristics depending on accelerated degradation of PVC insulation material. In order to insulation degradation of PVC insulation material, the Arrhenius equation, a type of accelerated degradation test formula, was used to conduct accelerated degradation experiments with experiment samples prepared at the following age equivalents: 0, 10, 20, 30 and 40 years. Afterwards, a tracking experiment was conducted on the accelerated experiment samples as part of the KS C IEC 60112 criteria. When measuring the PVC tracking features according to the accelerated aging, the results showed that when 0.1% of ammonium chloride was added to the PVC insulating material, but no tracking occurred. However, depending on the age equivalent, The results of analyzing the current waveform and voltage waveform of the tracking propagation process showed the age equivalent from 0 years to 40 years displayed a break down in insulation resistance and even the BDB(before dielectric breakdown) sections did not maintain the same functionality of the original material. Based on a criterion of an age equivalent of 0 years, material with an age equivalent of 10 years posed a 1.4 times greater risk, material with an age equivalent of 20 years posed a 2 times greater risk, material with an age equivalent of 30 years posed a 4.6 times greater risk, and material with an age equivalent of 40 years posed a 7 times greater risk.

The Influence of Senior Entrepreneurial Decision Making Types and Entrepreneurial Supporting Policy on Start-up Performance (시니어 창업의사결정유형과 창업지원사업이 창업성과에 미치는 영향)

  • Ryu, Sang-Jung;Yang, Hae-Sool
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.4
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    • pp.106-121
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    • 2016
  • While economic crises are happening internationally due to the global financial crisis and the long-term recession of the domestic economy, South Korea is also experiencing an aging society with the retirement of the baby-boomers and a low birth-rate. The rapid retirement of baby-boomers, which is one of the essential parts of the Korean economy, is ongoing. Consequently, the number of seniors showing interest in entrepreneurship, as a way to avoid the economic threat, is increasing. Therefore, this study examined the correlation between two factors and its success, which can be stated as the influence of decision making in entrepreneurship and the influence of promotion policies to entrepreneurship. A survey was taken from 393 people, who received academic and managerial assistance from the Senior-Founded Support Center of Small Business Market Corporation and Adults Incubators of Seoul-Business Agency. and 'Hypothesis 1-1' and 'Hypothesis 2-2' were selected, because a positive effect was derived at each verification process. As a result, under the decision making types of entrepreneurship, only a reasonable type showed a positive effect at both the financial outcome and non-financial outcome of success, and the intuitive type was affected positively by the non-financial outcome. In addition, under the entrepreneur supporting business, among financial support, managerial support and educational support only managerial support had a positive effect.

Economic Evaluation System for Deteriorated Military Facilities (노후 군시설물의 경제성 평가 시스템)

  • Jang, Won-Suk;Lim, Tae-Kyung;Lee, Dong-Eun
    • Journal of the Korea Institute of Building Construction
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    • v.13 no.2
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    • pp.181-192
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    • 2013
  • Given both structural safety and economic benefits of aging facilities, remodelling of the existing facilities is preferable to reconstruction. This recognition provides an opportunity to reduce the commitment of resources and national budget. However, when a subordinate troop asks for remodeling or reconstruction of a deteriorated facility, it is difficult to ensure the consistency and objectivity in the process of decision making for the alternatives due to the absence of systematic and quantitative rating methodology. Their economic evaluation methodology only exists in a manual format. Thus, further research is required for converting the methodology into an automated system in view of practicality such as rapid and accurate data processing. The contributions of this study are as follows: 1) Literature review found out a representative economic evaluation model focused on military facilities, and comparative analysis with a similar study identified the strength and weakness. 2) this study presented how to convert the theoretical framework which enables to solve a specific subject matter into an automated system. 3) it developed a user friendly interfaces which consist of four functional modules by considering the usability and accessibility of the system user. 4) the developed system was verified by a case study in terms of four kinds of performance indicators.

The Effect of Compression on Strain Ageing of Ferrovac E Iron

  • Kim, Young-Won;Lee, Byoung-Whie;Hahn, Bong-Hee
    • Nuclear Engineering and Technology
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    • v.5 no.1
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    • pp.55-64
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    • 1973
  • The effect of compression in the strain ageing of Ferrovac E iron has been examined with compressive testing following the prestrain in compression. Both prestraining and testing were preformed at room temperature with the strain rate of 1.9$\times$10$^{-4}$ se $c^{-1}$ and that of 0.95$\times$10$^{-4}$ se $c^{-1}$ , respectively. Ageing was carried out at several temperatures below 8$0^{\circ}C$ using thermostatically controlled oil baths with a temperature control within$\pm$1$^{\circ}C$. It was found that the rate of strain ageing obeyed the $t^{2}$3/ law up to about five hours ageing at 6$0^{\circ}C$. The rate was slower than theses reported in case of the tensile prestrained iron. Activation energy for strain ageing has been estimated as 21.5 Kcal/mole at tile first stage of the aging process. At the second stage of ageing where the $t^{2}$3/ law is still valid, however, the activation energy was somewhat decreased. The activation energy at the first stage of ageing was about 10% larger than published results on the tensile-prestraining. This difference between the activation energies is explained in terms of the residual stress field in lattice.

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A Study on the Direction of Funeral service focused on Thick Data Analysis (Thick데이터 분석에 기반한 장례서비스 방향성 연구)

  • Ahn, Jinho;Lee, Jeungsun
    • Journal of Service Research and Studies
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    • v.10 no.1
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    • pp.85-96
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    • 2020
  • In Asia, where the aging population is growing rapidly, as the funeral service industry develops and the market grows. The economic value and interest of funeral services is increasing. However, Korea's funeral services are being developed in a biased direction, focusing only on funeral services, after death. Compared to the case of advanced funeral services in the United States, the United Kingdom, and Japan, not only the funeral but also the care of the deceased's family and acquaintances around us are developing. It is appropriate to use a method based on ethnography and User eXperience. For this purpose, the method of collecting and analyzing the ethnography and user experience data of actual resident and visitor was deduced in persona method in the next ten years, and funeral service centered on resident and visitor. In this study, qualitative data centered on the future direction of funeral services, focusing on the resident (family) and the guest who are the principals of services from the perspective of service science. It is difficult to derive meaningful results from the process of collecting, processing, and interpreting big data in general, and in this case, the data analysis method is based on ethnography and user eXperience.) Is appropriate. For this purpose, the method of collecting and analyzing the ethnography and user experience data of the actual resident and the visitor was deduced in the persona method in detail after 10 years. In addition, the future direction of funeral services centered on residence and visitor was presented.

Quality characteristics and antioxidant capacities of oriental melon wine depending on pretreatments (전처리 방법에 따른 참외와인의 품질특성과 항산화능)

  • Hwang, Hee-Young;Ha, Hyoung-Tae;Ha, Se-Bi;Seong, Gi-Un;Hwang, In-Wook;Chung, Shin-Kyo
    • Food Science and Preservation
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    • v.22 no.3
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    • pp.421-427
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    • 2015
  • Oriental melon (Cucumis melo L. var. makuwa) has been widely consumed as various processed foods, such as dried products, jelly, wine, juice, and vinegar, in Asian countries. In fruit processing, blanching and pressure treatments affect its quality, such as antioxidant activities, sensory characteristics, and etc. This study was conducted to evaluate the effects of blanching and pressure pre-treatments on oriental melon wine-making (BP, blanching and pressure filtration; BNP, blanching and non-pressure filtration; NBP, non-blanching and pressure filtration; and NBNP, non-blanching and non-pressure filtration). Physicochemical properties and antioxidant capacities by ${\alpha}$, ${\alpha}$-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, ferric ion reducing antioxidant power (FRAP) assay, and total phenolic and total flavonoid contents were measured for comparison of the different pre-treatment methods. After the aging process, the alcohol contents and pH values showed no statistical differences, whereas the amount of soluble solids, reducing sugar, and titratable acidity were slightly different among the pre-treatments (p<0.05). The samples with blanching pre-treatment showed higher antioxidant capacities than those of other pre-treatments. In the sensory evaluation, the BNP was the best in overall acceptability. Thus, this study showed that the blanching treatment enhanced the antioxidant capacities and sensory qualities of the oriental melon wine.

Characteristics of Alcohol Fermentation in Citrus Hydrolysate by Different Kinds of Sugar (첨가당의 종류에 따른 감귤 가수분해물의 알코올발효 특성)

  • Park, Chan-Woo;Woo, Seung-Mi;Jang, Se-Young;Choi, In-Wook;Lee, Sang-Il;Jeong, Yong-Jin
    • Food Science and Preservation
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    • v.18 no.5
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    • pp.773-778
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    • 2011
  • This study investigated the alcohol fermentation characteristics of citrus hydrolysate by adding various sugars(sucrose, honey, fructose and fructooligosaccharide). As a result, the alcohol content was shown to be similar among all the sugars. Fructose, glucose, sucrose and maltose were detected as a major free sugar. In particular, the contents of fructose and glucose were shown to be higher in sucrose addition, lactic, citric and malic acids were detected as major organic acids of citrus wine. When the sensory characteristics of citrus wines were compared, flavor was shown to have a sensory score of 5.1 in sucrose addition, showing the most preference. However, no significant difference in preference was found among the sugars. Color, taste and overall acceptability were shown to have the most preference in sucrose addition, and then in honey, fructose, and fructooligosaccharide in order. Therefore, a further study on the improvement of quality and sensory preference using aging process and complex sugars is required.

Analysis on Importance of Information Security Factors for Smart Work using AHP -Based on the Mobile Office for Small Businesses- (AHP를 활용한 스마트워크 정보보호 요소의 중요도 분석 -중소기업의 모바일 오피스를 중심으로-)

  • Kang, Kyung-Hoon;Lim, Chae-Hong;Lim, Jong-In;Park, Tae-Hyoung
    • Journal of Digital Convergence
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    • v.11 no.3
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    • pp.415-426
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    • 2013
  • Smart work has recently introduced as a way to solve problems such as greenhouse gas emissions, low birth rate and aging as well as to improve productivity. Because of development of ICT infrastructure and the proliferation of smart devices, the mobile office has the most commonly used within types of smart work in Korea. But the adoption of the mobile office in small businesses is only half of that of large corporations. The security issue appears to be one of the biggest obstacles to the introduction of smart work in small businesses. Therefore, the purpose of this study is to analyze the information security factors that should be considered when the mobile office is introduced to small businesses. By analyzing the previous studies, the information security factors of the mobile office are classified 5 groups composed of 24 factors. 5 groups are terminals, applications and platforms, networks, servers and users. According to the survey result using AHP, 'User' was drawn to the most important group, and 'Data Encryption', 'Wireless LAN Control' and 'Terminal Recovery When Leaving' were drawn to the important information security factors of the mobile office among 24 factors.