• Proceedings of the Ginseng society Conference
• /
• 1998.06a
• /
• pp.12-20
• /
• 1998

Primary neuronal culture was studied for observing effect of ginsenoside Rgl (Rgl) on serum-free medium induced apoptosis. Results showed that Rgl at concentration of 1 umol$.$ L-1 and 10 umol$.$L-1 could inhibit apoptosis, decrease intracellular calcium concentration in cultured cortical neurons, enhance SOD activity in both aged rat cortex and cultured cortical neurons, scavenge cytotoxic oxygen free radicals, decrease NO content and NOS activity in aged rat cortex and cultured cortical neurons, increase bel-2 gene expression in rat brain. These results provided new data for elucidating the anti-aging effect of Rgi. Rgl is considered to be a useful drug for treatment of Alzheimer's disease and brain aging.

• Journal of Korean Society for Geospatial Information Science
• /
• v.22 no.3
• /
• pp.107-112
• /
• 2014

In keeping with the increasing demand for medical services in accordance with the economic development, the use of oriental medicine is on the rise year by year. In particular, it is a tendency that the elderly over age 65 prefer the oriental medicine to the western medicine in Korea. Under the circumstance, changing into an aging society, the importance of oriental medical services has been growing. In this regard, this study evaluated the quality of medical services by conducting the density analysis and the accessibility analysis of oriental medical clinic targeting Jinju, which is one of local small and medium-sized cities. The study results reveal that oriental medical hospitals accounted for 27% of the entire medical facilities in Jinju, and there was an imbalance in the quality of the oriental medical services according to districts(called dong) because oriental medical hospitals were mainly concentrated in the central commercial areas. In particular, in terms of the analysis on the accessibility of an aging population over age 65 to the oriental medical hospitals, over 50% of the whole districts (dongs) in Jinju were blind spots in medical services, showing a very vulnerable condition. Accordingly, it is judged that systematic measures for improvement in support of the oriental medical services in local small and medium-sized cities should be provided in Korea when we consider the characteristics of Korea where an aging population is rapidly increasing.

• Journal of the Korean Institute of Rural Architecture
• /
• v.21 no.4
• /
• pp.17-24
• /
• 2019

It has been long time since the local small-and-medium cities had lost their vitality due to the progress of aging, economic decline in urban areas, the lack of new growth engines, and the declining population in korea. In addition, since the implementation of the local self-governing system, the creation of new urban areas and the transfer of the administrative institutions to the outskirts of a city have accelerated the decline of old downtown. Rather, local small-and-medium cities would have a problem to make urban regeneration impossible. Under the recognition of such problems, individual self-governing entities have come up with numerous policies and implemented various policies for the revitalization of local small-and-medium cities, but it is a condition that the effect of their efforts falls shorts of expectations, such as the space of the similar style, which has been widespread in developed countries, simple restoration, and a few structural changes. In this regard, the part to be realized anew is to enhance the attractiveness of small-and-medium cities. However, is not possible to raise the overall attractiveness in a short time in reality. To select local assets to be utilized in urban regeneration, it is judged that gathering opinions of local residents is more important than any other thing. Accordingly, this study intends to present positive outcome for the purpose of the revitalization of local small-and-medium cities by finding the factors which can remind us of the collective memory of Jinju city and selection the critical factors to determine a detailed project plan from the perspective of urban regeneration.

• The Journal of Advanced Prosthodontics
• /
• v.14 no.5
• /
• pp.334-334
• /
• 2022

• Journal of Industrial Convergence
• /
• v.20 no.8
• /
• pp.25-31
• /
• 2022

This study examines the impact of residential environmental satisfaction on AIP(Aging in Place), and analyzes how their relationship differs depending on housing characteristic variables (ownership type, housing type, and residential area). For this purpose, as of November to December 2020, a questionnaire analysis was conducted on 373 adult males and females residing in Busan and Gyeongnam. The results of this study are summarized in two ways as follows. First, the higher the satisfaction with the residential environment, the higher the AIP. Second, it was analyzed that the positive relationship between satisfaction with the residential environment and AIP was higher in ownership than in rental cases, and further decreased in detached houses compared to apartment houses. In addition, compared to other regions, metropolitan cities or small and medium-sized cities had a higher positive (+) relationship between satisfaction with the residential environment and AIP. This study will provide important implications for policymaking related to population and urban planning.

• Journal of dental hygiene science
• /
• v.23 no.2
• /
• pp.169-175
• /
• 2023

Background: Although microbial infection is direct cause of periodontal disease, various environmental factors influence the disease severity. Aging is considered a risk factor for oral diseases, with the prevalence of periodontal diseases increasing with age. Moreover, senescence-associated secretory phenotype (SASP) expressed in age-related diseases is a key marker of chronic inflammation and aging phenotypes. Therefore, this study aimed to understand the relevance of senescent cells to periodontal health and disease, investigate the possibility of regulating the expression of aging- and osteolysis-related factors in gingival fibroblasts, and investigate the effect of senescence induction in gingival fibroblasts on osteoclast differentiation in mouse bone marrow-derived macrophages (BMMs). Methods: After stimulation with 400 nM hydrogen peroxidase, human gingival fibroblasts (HGFs) were examined for senescence-associated β-galactosidase. Western blot and enzyme-linked immunosorbent assays were performed to assess the expression of SASP. Osteoclast formation was assessed in BMMs using a conditioned medium (CM) from hydrogen peroxide-stimulated HGFs. Osteoclastic differentiation was investigated using tartrate-resistant acid phosphatase (TRAP) staining and activity. Data analysis was performed using SPSS version 25.0. Results: The expression of senescence-related molecules, including p53, p16, and p21, and the expression of osteolytic factors, including IL-6, IL-8, and IL-17, were found to be significantly higher in the hydrogen peroxide-stimulated HGF than in the control group. Regarding the indirect effects of senescent gingival cells, the number of osteoclasts and TRAP activity increased according to the differentiation of BMM cultured in CM. Conclusion: Our results on the of between osteolytic factors and cellular senescence in gingival fibroblast cells helped to reveal evidence of pathological aging mechanisms. Furthermore, our results suggest that the development of novel therapies that target specific SASP factors could be an effective treatment strategy for periodontal disease.

• Journal of Korea Technical Association of The Pulp and Paper Industry
• /
• v.41 no.4
• /
• pp.73-81
• /
• 2009

The document archives like official documents, books, maps and historic paper artifacts are primarily based on the organic cellulosic materials. As the passage of time, these organic cellulosic materials are slowly deteriorated by various aging factors, like light, polluted air and biological fungi. Many researchers have been carried out the examination method of deteriorating origins, the mechanism of aging hysteresis, and the preserving method of archival materials. One of the most simple and easiest ways for conservation of organic archival documents is the proper storage under environmental control. Corrugated board for archival quality container has been developed and already used in advanced country, like Japan, USA, German, UK and Europe. In case of Korea, corrugated board for archival quality container has been used a decade ago, but totally imported. This study was tried to develop the corrugated board for archival quality container. Liner and corrugated medium were specially produced and finally manufactured to E flute corrugated board. The physical and strength properties of permanent base paper and corrugated board were evaluated, and compared with imported corrugated board. 4 kinds of corrugating adhesives were considered various in order to investigate optimum adhesive for flute development between liner and corrugating medium, and evaluate adhesion strength under conditions of storage and curing temperatures.

• The Journal of Advanced Prosthodontics
• /
• v.13 no.3
• /
• pp.160-171
• /
• 2021

Purpose. This in-vitro study evaluated and compared the color stability of 3D-printed and conventional heat-polymerized acrylic resins following aging, mechanical brushing, and immersion in staining medium. Materials and methods. Forty disc-shaped specimens (10 mm in diameter and 3 mm thick) were prepared from two 3D-printed [DentaBASE (DB) and Denture 3D+ (D3D)] and one conventional polymethylmethacrylate (PMMA) denture materials. The specimens were thermo-cycled, subjected to mechanical brushing, and were immersed in either coffee, lemon juice, coke, or artificial saliva (AS) to simulate one and two years of oral use. Color measurements of the specimens were recorded by a spectrophotometer at baseline (T0), and after one (T1) and two years (T2) of simulation. The color changes (ΔE) were determined and also quantified according to the National Bureau of Standards (NBS) units. Descriptive statistics, followed by factorial ANOVA and Bonferroni post-hoc test (α=.05), were applied for data analysis. Results. The independent factors, namely material, staining medium, and immersion time, and interaction among these factors significantly influenced ΔE (P<.009). Irrespective of the materials, treatments, and time, the highest and the lowest mean ΔEs were observed for PMMA in lemon juice (4.58 ± 1.30) and DB in AS (0.41 ± 0.18), respectively. Regarding the material type, PMMA demonstrated the highest mean ΔE (2.31 ± 1.37), followed by D3D (1.67 ± 0.66), and DB (0.85 ± 0.52), and the difference in ΔE between the materials were statistically significant (P<.001). All the specimens demonstrated a decreased color changes at T2 compared to T1, and this difference in mean ΔE was statistically significant (P<.001). Conclusion. The color changes of 3D-printed denture resins were low compared to conventional heat polymerized PMMA. All the tested materials, irrespective of the staining medium used, demonstrated a significant decrease in ΔE values over time.

• Food Science and Preservation
• /
• v.24 no.4
• /
• pp.491-496
• /
• 2017

Paddy rice is typically stored during postharvest until rice grain is processed into brown rice and milled rice by hulling and milling procedure, respectively. Recently, instead of storing paddy rice, storage of brown rice has been in the spotlight because it is more convenient and economically feasible. Different brown rice cultivars with varying amylose contents including waxy rice, medium-waxy rice, and non-glutinous rice were stored in room temperature storage for four months, and the changes in grain qualities of brown rice were evaluated. Amylose content significantly affected pasting properties in which rice cultivar with higher amylose content showed longer pasting time and higher peak viscosity. Storage also affected pasting viscosities, showing an increase in peak viscosity, but a decrease in breakdown viscosity. The changes in pasting viscosity during storage could be an important starch property for aged brown rice utilization. Waxy brown rice showed the weakest aging property in terms of free fatty acids (FFA) accumulation, whereas non-glutinous rice was more substantial grain quality against aging. The FFA values of two months storage were not significantly different from the initial FFA contents, suggesting that brown rice stored in room temperature for two months could be feasible for direct consumption of brown rice.

• Journal of International Academy of Physical Therapy Research
• /
• v.9 no.4
• /
• pp.1591-1595
• /
• 2018

The number of healthy older adults is rapidly increasing recently owing to the increase of the elderly population. Therefore, programs for improving the cognitive functions of these healthy seniors are actively being expanded. This study aimed to prevent the decline of cognitive function due to aging by applying a program enhancing cognitive functions to healthy older adults. The objective of this study was to evaluate the effects of Korean computer-based cognitive rehabilitation program (CoTras), which is commonly used in cognitive therapy for the aging, on the memory of the elderly. The subjects had scored at least 24 points in MMSE-K. CoTras was applied once a week (30 minutes) for one month. Electronic pegboard programs were used as an evaluation tool: order memory (difficulty=low) and location memory (difficulty=medium). The order and location memories were compared before and after the intervention. The Wilcoxon signed rank-sum test was used for the study at the significance level of ${\alpha}=.05$. The results showed that CoTras significantly improved order memory and location memory. Therefore, CoTras can be applied to the healthy elderly for improving that memory improvement training has a positive impact on healthy older adults result in the development of memory enhancement programs can be expanded in the future.