• Title/Summary/Keyword: aggressive response

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A Survey of University Students' Preference and Awareness and Uses of Commercial Kimchi - in Daegu Area - (김치에 대한 남.여 대학생들의 인식, 기호도 및 시판 김치의 이용 실태 조사 - 대구지역을 중심으로 -)

  • Cho, Yeon-Sook;Lee, So-Young;Lee, Eun-Kyung
    • Journal of the East Asian Society of Dietary Life
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    • v.18 no.6
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    • pp.907-917
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    • 2008
  • This study was conducted to investigate the recognition, utilization, preference and application of kimchi, as well as to evaluate the recognition and requirement for commercial kimchi to university students. A questionnaire was answered by 180 (44.0%) male and 229 (56.0%) female university students in Daegu. The methods used to analyze the items were frequency analysis, Chi-squared tests and t-tests. Most of the respondents reported that they liked kimchi and had a preference for ripened kimchi In addition, most students were likely to cook kimchi by pan-broiling which indicates that the development of kimchi designed for pan-broiling may lead to an increase in the intake of kimchi. The recognition and utilization of commercial kimchi abutted through wholesale market very much, and were buying The marketing points that could most increase the sales of kimchi appeared to be 'hygiene' and 'standardization of taste and ageing' for male students 42 (23.7%) and 'hygiene' for female students 94 (41.4%) (p<0.01). All students responded that among marketing techniques for the sale of kimchi, diversification of taste, and increasing the recognition of kimchi were the most important parameters for aggressive globalization of the sale of kimchi. Therefore, the consumption of kimchi will increase in response to changes a dietary life style and activation is a plan getting done, and it is thought consumption of a kimchi to reflect these results well.

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Gefitinib-Related Interstitial Pneumonia (Gefitinib 투여 후 발생한 간질성 폐렴)

  • Lee, Ho Jin;Nam, Seung Bum;Jung, Jae Wook;Na, Im Il;Kim, Cheol Hyeon;Ryoo, Baek-Yeol;Choe, Du Whan;Kang, Jin Hyung;Lee, Jae Cheol
    • Tuberculosis and Respiratory Diseases
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    • v.62 no.2
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    • pp.134-139
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    • 2007
  • Gefitinib is a novel drug used to treat advanced non-small cell lung cancer. However, drug-related interstitial pneumonia is a major life-threatening side effect, which has a worldwide prevalence of 0.3-0.4%. In Japan, the prevalence is high as 3-4% but the actual frequency in Korea has not been officially assessed. We report two cases of gefitinib-induced interstitial lung disease during the treatment of non-small cell lung cancer. High-resolution computerized tomography (HRCT) of one case showed nonspecific ground glass opacity and the chest x-ray of another case showed diffuse bilateral ground glass opacity. The former patient showed a rapid good response to corticosteroid treatment whereas the latter died despite receiving aggressive treatment with high dose corticosteroid and empirical antibiotics.

MULTILOCULAR UNICYSTIC AMELOBLASTOMA ASSOCIATED WITH DENTIGEROUS CYST (함치성 낭종과 연관된 다방성의 낭종성 법랑아세포종)

  • Lee, Jae-Hwy;Oh, Seong-Seob
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.14 no.1_2
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    • pp.160-168
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    • 1992
  • Ameloblastoma is an aggressive but benign epithelial neoplasm of odontogenic origin, and the occurrence of odontogenic epithelium in the wall of a dentigerous cyst is well-known entity. The presence of ameloblastic proliferation in the walls of odontogenic cysts has been reported for many years. Cahn in 1933 described a case in which he considered an ameloblastoma to have originated in a dentigerous cyst, and numerous other cases of ameloblastomatous proliferation have since been reported. In 1977, Robinson and Martinez described a distinct variant of ameloblastoma in which the response to curettage was found to be favorable with a recurrence rate of 25%. The gross and microscopic features indicated that this variant vas associated with a large cystic cavity with either luminal or mural proliferation of ameloblastic tumor cells, and they referred to this variant as unicystic ameloblastoma. Unicystic ameloblastoma occurs most commonly in the second and third decades of life, which is considerably younger than the average age of discovery for the classical ameloblastoma. For the accurate histopathological diagnosis of the unicystic ameloblastoma, the specimen obtained the excisional biopsy, complete enucleation or incisional biopsy from the multiple site of the lesion. This article provides histopathologic evidence of multilocular unicystic ameloblastoma in which ameloblastic tissue was associated with a dentigerous cyst that was found in a 31-year-old female, and complete radiographic, photographic, and microscopic documentation is presented.

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A Case of Combined Small Cell Carcinoma with Non-Small Cell Lung Carcinoma, Adenocarcinoma and Squamous Cell Carcinoma (편평상피세포암종과 선암종이 동반된 복합형 소세포암종(Combined Small Cell Carcinoma) 1예)

  • Park, Hye-Jung;Mun, Yeung-Chul;Yu, Sung-Keun;Shin, Kyeong-Cheol;Chung, Jin-Hong;Lee, Kwan-Ho;Kim, Mi-Jin;Lee, Jung-Cheul
    • Tuberculosis and Respiratory Diseases
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    • v.48 no.1
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    • pp.72-77
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    • 2000
  • A proper pathologic diagnosis of small cell lung cancer(SCLC) is essential for the application of aggressive treatment modalities. However, various authors have suggested several subtypes of SCLC based on morphological features. Among them, the incidence of small cell lung cancer(SCLC) combined with squamous cell and/or adenocarcinoma, represents less than 1% to 3% of all SCLC tumors. Because of the rarity of SCLC combined with squamous cell and/or adenocarcinoma, very little is known about its clinical characteristics and response to therapy. We report a case of SCLC combined with squamous cell and adenocarcinoma in a 68 year old male who experienced pneumonectomy of the left lung.

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Diagnostic and Prognostic Relevance of Bone Marrow Microenvironment Components in Non Hodgkin's Lymphoma Cases Before and After Therapy

  • Soliman, Amira H
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.12
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    • pp.5273-5280
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    • 2016
  • Objective: To evaluate stromal cells of the bone marrow microenvironment (BMM) in bone marrow trephine biopsy (BMTB) specimens, with a focus on fibronectin, tumor necrosis factor- alpha (TNF-${\alpha}$) and L-selectin in Non-Hodgkin's lymphoma (NHL) patients, before and after therapy. Materials and Methods: A total of 80 de novo NHL patients, 64 with B-cell lymphomas 80%, (follicular cell lymphoma (FCL) in 32, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in 12, and diffuse large cell lymphoma in 20) and 16 with T-cell lymphomas (20%) all diagnosed as T-Lymphoblastic lymphomas, were evaluated before and after therapy. For comparison, 25 age and sex matched BM donors, were included as a control group. BMTB material and BM aspirates were taken for morphological assessment of stromal cells, the plasma of these samples being examined for $TNF{\alpha}$ and L-selectin by ELISA, and fibronectin by radial immunodiffusion (RID). Results: BM stromal cells comprising reticular macrophages and fibroblasts were elevated in 53.3% of NHL cases at diagnosis, while BM fibronectin levels were decreased and BM $TNF{\alpha}$ and L-selectin were higher than in controls (p<0.05). In NHL cases, elevated values of BM $TNF{\alpha}$ and BM L-selectin were associated with signs of aggressive disease, including >1 extra nodal sites, detectable B symptoms, high grade, BM and CNS invasion, and a high International prognostic index (IPI) (p<0.05). Conclusion: BMM components, $TNF{\alpha}$, L-selectin and fibronectin, in NHL can be useful in evaluating disease activity, extent and response to treatment and as prognostic markers according to the IPI.

Characteristics and Strategic Implications of China's Naval Strategy during the Xi Jinping Era (시진핑(習近平) 시기 중국의 해군전략 특징 및 전략적 함의)

  • Ahn, Seul-Ki
    • Maritime Security
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    • v.1 no.1
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    • pp.61-92
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    • 2020
  • This paper attempts to examine the changes in China's naval strategy and to analyze the goal, range, and method of each strategy during the Xi Jinping's era. Since the founding of New China, the People's Liberation of Army Navy(PLAN) has made four changes in the naval strategy. Under Xi Jinping's administration, China's naval strategy is far seas operation combined with near seas active defense. Now, China's naval strateg y is shifting from a defensive to an aggressive one, increasing the proportion of offensive weapon systems and the number of state-of-the-art warships, and the scope of the naval strategy has been specified in the second island chain including the Indian Ocean. With the changes of naval strategy, the PLAN will set a new strategic goal to secure maritime dominance and implement an assertive strategy to actively respond to the intervention and intrusion of external forces. Moreover, the PLAN will also improve its sea-based deterrence force and the maneuver force to block other countries in the long-distance maritime conflict zones. The operation method of China's future naval strateg y will gradually shift from 'interdiction' to 'rapid-response.'

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US-China Hegemony Competition and Gray-Zone Conflict in the Post-Coronavirus Era: Response strategies of the Korean Navy and Coast Guard (포스트 코로나시대 미중 패권경쟁과 회색지대갈등: 한국 해군·해경의 대응전략)

  • Lee, Shin-wha;Pyo, Kwang-min
    • Maritime Security
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    • v.1 no.1
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    • pp.149-173
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    • 2020
  • While the United States and other Western states are in trouble with COVID-19 crisis, China is continuing its aggressive ocean expansion with its Gray-zone strategy. The Gray-zone strategy, which China uses around the South China Sea, refers to a strategy that promotes a change in international politics by creating an unclear state, neither war or peace. China, which is trying to expand its influence across East Asia, will also try to project a Gray zone strategy on the Korean Peninsula. The possible scenarios are as follows: 1) South Korea is accidentally involved in a dispute in the South China Sea, 2) Military conflicts between South Korea and China is caused by illegal fishing of Chinese boats in Yellow Sea, 3) China tries to interfere with Socotra Rock, 4) Unlikely, but possible in the future that China induce the military conflicts between Korea and Japan on the Dokdo issue. In order to cope with these scenarios, Korea should prepare the following measures from a long-term perspective: the creation of an Asian maritime safety fleet, the integ rated operation of the navy and the coast guard in the framework of the national fleet, and strengthening the conflict control system for China's provocations.

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Ubiquitin E3 ligases in cancer: somatic mutation and amplification

  • Eun-Hye Jo;Mi-Yeon Kim;Hyung-Ju Lee;Hee-Sae Park
    • BMB Reports
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    • v.56 no.5
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    • pp.265-274
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    • 2023
  • Defects in DNA double-strand break (DSB) repair signaling permit cancer cells to accumulate genomic alterations that confer their aggressive phenotype. Nevertheless, tumors depend on residual DNA repair abilities to survive the DNA damage induced by genotoxic stress. This is why only isolated DNA repair signaling is inactivated in cancer cells. DNA DSB repair signaling contributes to general mechanism for various types of lesions in diverse cell cycle phases. DNA DSB repair genes are frequently mutated and amplified in cancer; however, limited data exist regarding the overall genomic prospect and functional result of these modifications. We list the DNA repair genes and related E3 ligases. Mutation and expression frequencies of these genes were analyzed in COSMIC and TCGA. The 11 genes with a high frequency of mutation differed between cancers, and mutations in many DNA DSB repair E3 ligase genes were related to a higher total mutation burden. DNA DSB repair E3 ligase genes are involved in tumor suppressive or oncogenic functions, such as RNF168 and FBXW7, by assisting the functionality of these genomic alterations. DNA damage response-related E3 ligases, such as RNF168, FBXW7, and HERC2, were generated with more than 10% mutation in several cancer cells. This study provides a broad list of candidate genes as potential biomarkers for genomic instability and novel therapeutic targets in cancer. As a DSB related proteins considerably appear the possibilities for targeting DNA repair defective tumors or hyperactive DNA repair tumors. Based on recent research, we describe the relationship between unstable DSB repairs and DSB-related E3 ligases.

Experimental Study on the Flexural Behavior Effect of RC Beam Repaired and Strengthened by Latex Modified Concrete (라텍스개질콘크리트로 보수·보강된 RC 보의 휨 거동에 관한 실험적 연구)

  • Kim, Seong-Hwan;Yun, Kyong-Ku;Kim, Yong-Gon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.5A
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    • pp.503-510
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    • 2009
  • Latex modified concrete (LMC) is a successful polymer-portland cement concretes, which have been developed and used for many years, in overlaying bridge decks and resurfacing industrial floors. The excellent bond strength to substrate, easy application and high resistance to impact, abrasion, wear, aggressive chemicals and freeze-thaw deterioration have made this material used widely. The objective of this study was to determine experimentally the load-deflection response and ultimate strength of reinforced RC beams. The cracking patterns and the mode of failure were observed. Because of excellent bond strength and repairing effects, the RC beams repaired by LMC at compression or tension zone showed over 100% recovery from damaged structures. The RC beams overlaid by LMC showed significant improvement at load carrying capacity as overlay thickness increases. However, the beams repaired of tension zone without shear stirrups almost showed no strengthen effect, and indicated an interfacial failures. The interfacial behavior was estimated by numerical method adopting the concept of shear flow.

The Lure of the Racial Other: Race and Sexuality in D. H. Lawrence's Quetzalcoatl (인종적 타자의 매혹 -로런스의 『께짤코아틀』에 그려진 인종과 성)

  • Kim, Sungho
    • Journal of English Language & Literature
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    • v.55 no.4
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    • pp.693-718
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    • 2009
  • Kate Burns, a disillusioned Irish woman in Quetzalcoatl, has alternating feelings of fear, repulsion, oppression, compassion, and fascination vis-à-vis Mexican people. Together, these feelings are constitutive of a psychic process in which an imaginary appropriation of the other takes place. In this process white subjectivity represents or reconstructs the dark race precisely as its other. At the same time, Kate's feelings register her anxious recognition of the resistant, unappropriated being of the dark people: their true 'otherness,' or what Žižek calls "the excess of existence over representation." The otherness, frequently racial and sexual, evokes mixed feelings in the white subject. Kate's at once amorous and aggressive response to Ramón's body provides a case in point. Kate's emotional undulation is considerably mitigated in The Plumed Serpent, the revised version of the novel in which the theme of 'blood-mixing' is pushed to the ultimate point. Yet the interracial marriage resolves neither the racial nor the ontologico-sexual issues raised in the first version. Kate is still attracted to Ramón in his sagacious sensuality but goes on to get married to Cipriano, a pure Indian, only to find his mechanical masculinity ever unpalatable. This shows, not just Lawrence's wilful commitment to the 'blood-mixing' theme, but perhaps his lingering taboo against miscegenation as well. Changes in the plot entail those in the narrative voice. In Quetzalcoatl, Owen, a spectatorial and gossipy character, frequently competes for narration with the fully participant third-person narrator. In The Plumed Serpent, the third-person narrator becomes predominant, now attempting with greater confidence to present the reality of the racial other immediately to European readership. While such immediacy is illusional, narrative insistence on it implies a struggle to displace racial stereotypes and offer an experiential understanding of the other.