• Development and Reproduction
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• v.24 no.3
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• pp.167-176
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• 2020

The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epididymal fat at different postnatal ages, including 2, 5, 8, and 12 months of age. The quantitative real-time PCR analysis showed continuous increases of expression levels of delta like non-canonical Notch ligand 1, leptin, and resistin as postnatally aged. The transcript level of peroxisome proliferator-activated receptor gamma was the highest at 5 months of age, remaining at a steady level until 12 months of age. Expression levels of fatty acid binding protein 4, leptin, and adiponectin were significantly increased until 8 months of age, persisting the level at 12 months of age. The transcript level of fatty acid synthase was significantly increased at 8 months of age, without a further change of the level at 12 months of age. These findings exhibited the expression of adipocyte-associated genes which were also detected at the ordinary epididymal fat pad. However, expression patterns of these genes in the tail epididymal fat are different with those in the distal and proximal epididymal fat, suggesting distinct characteristics and/or functions of the tail epididymal fat.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.351-356
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• 2011

Purpose: The most common symptoms of eyes on VDT syndrome and symptoms-related the factors were investigated. Methods: Self-questionnaire for VDT syndrome was done with 250 teachers from 1st to 15th October, 2010, and the data from 231 teachers (68 male, 163 female) was statistically analyzed to find the factors related to ocular symptoms. Results: The most common ocular symptom on VDT syndrome was 'feeling of eyes fatigue', and the factors which have correlation significantly to ocular symptoms were regular exercise, ages, VDT work time, and regular resting. Conclusions: Taking a rest and regular exercise contribute to relieve the ocular symptoms related to VDT syndrome.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.561-567
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• 2005

We statistically analyzed the relationship between the constitution and the thickness and stiffness of skin depending on sex and age, using 1079 clinical data registered to SCIB(Sasang constitution Information Bank), and the following results are obtained : The thickness of skin has big discrimination ability in classification of Taeeumin and Soyangin, especially in women and in ages 21 or more. The stiffness of skin also has big discrimination ability in classification of Taeeumin and Soeumin, especially in Taeumin women and Soeumin man and in ages 21-60. The differences stated above have been proved to be meaningful enough by Chi-square test.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.536-543
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• 2005

We statistically analyzed the relationship between the constitution and the refineness and tactile of skin depending on sex and age, using 1079 clinical data registered to SCIB(Sasang constitution Information Bank), and the following results are obtained: The thickness of skin has big discrimination ability in classification of Taeeumin and Soyangin, especially in women and in ages 21 or more. The stiffness of skin also has big discrimination ability in classification of Taeeumin and Soeumin, especially in Taeumin women and Soeumin man and in ages 21-60. The differences stated above have been proved to be meaningful enough by Chi-square test.

• Biomolecules & Therapeutics
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• v.17 no.2
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• pp.133-137
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• 2009

The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including $\gamma$-aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.158-164
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• 2017

Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of diabetes-associated complications and atherosclerosis. Hypericin, a naphthodianthrone isolated from Hypericum perforatum L. (St. John's Wort), is a potent and selective inhibitor of protein kinase C and is reported to reduce neuropathic pain. In this work, we investigated the protective effect of hypericin on MGO-induced apoptosis in human umbilical vein endothelial cells (HUVECs). Hypericin showed significant anti-apoptotic activity in MGO-treated HUVECs. Pretreatment with hypericin significantly inhibited MGO-induced changes in cell morphology, cell death, and production of intracellular reactive oxygen species. Hypericin prevented MGO-induced apoptosis in HUVECs by increasing Bcl-2 expression and decreasing Bax expression. MGO was found to activate mitogen-activated protein kinases (MAPKs). Pretreatment with hypericin strongly inhibited the activation of MAPKs, including P38, JNK, and ERK1/2. Interestingly, hypericin also inhibited the formation of AGEs. These findings suggest that hypericin may be an effective regulator of MGO-induced apoptosis. In conclusion, hypericin downregulated the formation of AGEs and ameliorated MGO-induced dysfunction in human endothelial cells.

• Journal of the Korean Wood Science and Technology
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• v.47 no.6
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• pp.700-708
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• 2019

To verify the possibility of using resistograph to estimate the age of big old living trees, we selected three Zelkova serrata and seven Pinus densiflora in Goesan. The mean diameters at breast height of Z. serrata and P. densiflora were 102 (92-116) cm and 80 (65-110) cm, respectively. The heights measured from the ground using a resistograph ranged at 1.2-4.3 m and 0.6-1.1 m for Z. serrata and P. Densiflora, respectively. The most appropriate needle speed to determine tree-ring boundaries for measuring ring width was 1500 r/min for both tree species. Alternatively, the suitable feed speeds for Z. serrata and P. densiflora were 50 cm/min and 150 cm/min, respectively. From the measured data, the mean numbers of tree rings of Z. serrata and P. densiflora were 57 (43-68) and 104 (93-124), respectively, and the mean tree-ring widths were 4.27 mm (3.18-5.09 mm) and 2.93 mm (2.32-3.34 mm), respectively. A comparison between the time series of tree-ring widths by resistograph and that from the local master chronologies tallied for the heartwood part. Finally, this study showed that resistograph can be used to estimate tree ages when a local master chronology is available.

• YAKHAK HOEJI
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• v.50 no.4
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• pp.215-219
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• 2006

This study was carried out to obtain the basic information for non-saponin contents that can be used to index fresh ginseng roots (Panax ginseng C. A. Meyer) cultivated in the Republic of Korea and China. Non-saponin components in fresh gingeng roots which were cultivated in various areas and ages in Korea were determined. Acidic polysaccharide, total polysaccharide, crude polyacetylene were quantitatively analyzed by using the method of spectrophotometric determination, while the total protein was analyzed by using Lowry method. The results show that there were no statistically significant differences for the average contents of four non-saponins among 4-years-old, 5-years-old, and 6-years-old fresh ginseng roots. Additionally, this study assessed the average contents of non-saponin components in 4-years-old fresh ginseng roots (Panax ginseng C. A. Meyer) which were cultivated in Korea and China. The result showed that the average contents of crude polyacetylene and acidic polysaccharide were statistically significant. Four-years-old fresh ginseng roots cultivated in Korea had the higher average contents of crude polyacetylene and acidic polysaccharide than those cultivated in China. However the average contents of total polysaccharide and total protein had no statistically significant difference.

• Steel and Composite Structures
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• v.39 no.3
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• pp.307-318
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• 2021

Utilizing fibers is an effective way to avoid the brittle behavior of the conventional concrete and can enhance its ductility. In particular, propylene fibers can improve concrete properties, including energy absorption, physical and mechanical properties, controlling shrinkage cracks. The increase of fiber density leads to an increase of the overlapping surface of the fiber of concrete and, in turn, a decrease of cracks developed in the concrete. However, the workability of fiber reinforced concrete tends to be lower than the conventional concrete owing mainly to the hairline thickness and excessive concentration of fibers. The low slump of concrete impedes the construction of reinforced concrete members. In this research, we study if the utilization of magnetic water can alleviate the workability issue of young fiber reinforced concrete. To this end, the compressive and flexural strength of four types of concrete (conventional concrete, fiber reinforced concrete, magnetic concrete, magnetic fiber-reinforced concrete) is studied and compared at three different ages of 7, 14, and 28 days. In order to study the influence of the fiber density and length, a study on specimens with three different fiber density (1, 2, 5 kg of fiber in each cubic meter of concrete) and fiber length (6, 12, 18 mm) is undertaken. The result shows the magnetic fiber concrete can result in an increase of the flexural and compressive strength of concrete at higher ages.

• Advances in concrete construction
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• v.11 no.4
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• pp.307-314
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• 2021

Activated hwangtoh (ACT) is a natural resource abundant in South Korea, approximately 15.0% of soil. It is an efficient mineral admixture that has activated pozzolanic properties through high-temperature heating and rapid cooling. The purpose of this study is to improve a curb mixture that can reduce NOx outside and investigate durability performance. To this end, mortar curb specimens were manufactured by replacing OPC with ACT. The ACT substitution ratios of 0.0, 10.0, and 25.0% were considered, and mechanical and durability tests on the curb specimens were conducted at 28 and 91 days of age. Steam curing was carried out for three days for the production of curbs, which was very effective to strength development at early ages. The reduction in strength at early ages could be compensated through this process, and no significant performance degradation was evaluated in the tests on chloride attack, carbonation, and freezing and thawing. The mortar curb with an ACT of 10.0~25.0% replacement ratio exhibited clear NOx reduction through photocatalytic (TiO2) treatment. This is due to the increase in physical absorption through surface absorption and the photocatalyst-containing TiO2 coating. In this study, the reasonable range of the ACT replacement ratio for NOx reduction was quantitatively evaluated through a comprehensive analysis of each test.