• Journal of Microbiology and Biotechnology
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• v.20 no.4
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• pp.737-748
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• 2010

Glutaminase production in Zygosaccharomyces rouxii by solid-state fermentation (SSF) is detailed. Substrates screening showed best results with oatmeal (OM) and wheatbran (WB). Furthermore, a 1:1 combination of OM:WB gave 0.614 units/gds with artificial sea water as a moistening agent. Evaluation of additional carbon, nitrogen, amino acids, and minerals supplementation was done. A central composite design was employed to investigate the effects of four variables (viz., moisture content, glucose, corn steep liquor, and glutamine) on production. A 4-fold increase in enzyme production was obtained. Studies were undertaken to analyze the time-course model, the microbial growth, and nutrient utilization during SSF. A logistic equation ($R^2$=0.8973), describing the growth model of Z. rouxii, was obtained with maximum values of ${\mu}_m$ and $X_m$ at $0.326h^{-1}$ and 7.35% of dry matter weight loss, respectively. A goodfit model to describe utilization of total carbohydrate ($R^2$=0.9906) and nitrogen concentration ($R^2$=0.9869) with time was obtained. The model was used successfully to predict enzyme production ($R^2$=0.7950).

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.2
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• pp.89-95
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• 1999

This study investigates the population model of the spread of HIV/AIDS which the infection is generated by an infectious individual in a population of susceptible. A mathematical model is presented for the transmission dynamics of HIV infection within the communities of homosexual males. The pattern on the epidemic character of HIV, the causative agent of AIDS, was analysed by the mathematical model of AIDS system which is derived according to the ecological relationship between five epidemilogic states of individuals. The computer simulation was performed using real data and the following conclusions are drawn on the basis of the simulations. 1. The model structure and the algorithm described n the thesis is good. 2. In proportion to increase Ro, the population of AIDS patient increases and the time of its widespread reaches earlier. 3. The AIDS patients will be maximum between 7 and 21 years after an attack of AIDS and widespread between 10 and 20 years. 4. Considering the properties of the incubation periods, the maximum number of infected person is increased, and the attack rate is decreased.

• Journal of the Regional Association of Architectural Institute of Korea
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• v.20 no.6
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• pp.71-80
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• 2018

The path and visibility of nurses in general hospital wards have been treated as architectural planning factors. However, the analysis approach of existing studies shows limitations that only fixed physical elements are considered without considering the behavior of users using space. Consider factors for analysis of ward and models based on this study model. Select a case hospital to apply the analysis technique and conduct the nurse questionnaire and route survey of the hospital. Establish a framework for analysis model applied with the path of nurse movements. The analysis model applies to the case hospital. The analysis results are aggregated to derive design suggestion for reference to the spatial improvement of the ward. Visible visibility to observe the bedside in the nursing station, visibility to observe the beds in the nurse's path, and visibility to observe patients moving in the nurse's path were derived from visual access frequency and exposure frequency. The survey of nurses' movements at the site allowed the nurses to calculate the distance required to move. Reflecting the path of nurse movement, a model was presented for a comprehensive analysis of nursing distance and nursing visibility, which could lead to improvement in the observation and visibility of nurses and the layout of patient rooms or day rooms.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.61-67
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• 2009

Purpose : The purpose of this study was to investigate the applicability of poly-L-guluronic alginate (PGA) gel in vascular embolization with angiography simulation. Materials and Methods : To prepare a gel-forming PGA from no guluronate-rich Laminaria japonica, a new acid hydrolysis method was employed with a lower HCL concentration (0.03 M) and a shorter treatment time (5 min). The obtained PGAs were selected based on gel stability and viscosity. Glass aneurysm model was used to simulate gel embolization in vitro. Then, finally, the PGA was used to embolize the renal vascular system by using a rabbit model and angiography. Results : Glass aneurysm model was made to simulate gel embolization procedure. PGA solution was injected from pump through 2-way catheter. Subsequent injection of $CaCl_2$ successfully formed gels inside aneurysm model that conforming to its inner contour. In rabbit model, first, renal artery and aorta leading to the right kidney were ligated to block blood flow, then conventional contrast agent was injected through aorta to check the arterial patency to the left kidney. In sequential artery injection method, PGA and $CaCl_2$ were injected through renal artery sequentially via a single catheter. Re-injection of contrast agent after removing ligated aorta showed blood flow to the right kidney but no flow in the left kidney. This result demonstrated a complete blocking of blood flow due to gel formation in vascular bed of the left kidney. Conclusion : Instillation of calcium alginate into aneurysm model and arterial system in vivo produced an embolization that better fills and conforms to the contour of aneurysms or blocking vascular bed completely. Therefore, PGA was effective endovascular occlusion materials and provide an efficiency of vascular angiography.

• Asia pacific journal of information systems
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• v.20 no.1
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• pp.127-140
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• 2010

The benefit that a consumer derives from the use of a good often depends on the number of other consumers purchasing the same goods or other compatible items. This property, which is known as network externality, is significant in many IT related industries. Over the past few decades, network externalities have been recognized in the context of physical networks such as the telephone and railroad industries. Today, as many products are provided as a form of system that consists of compatible components, the appreciation of network externality is becoming increasingly important. Network externalities have been extensively studied among economists who have been seeking to explain new phenomena resulting from rapid advancements in ICT (Information and Communication Technology). As a result of these efforts, a new body of theories for 'New Economy' has been proposed. The theoretical bottom-line argument of such theories is that technologies subject to network effects exhibit multiple equilibriums and will finally lock into a monopoly with one standard cornering the entire market. They emphasize that such "tippiness" is a typical characteristic in such networked markets, describing that multiple incompatible technologies rarely coexist and that the switch to a single, leading standard occurs suddenly. Moreover, it is argued that this standardization process is path dependent, and the ultimate outcome is unpredictable. With incomplete information about other actors' preferences, there can be excess inertia, as consumers only moderately favor the change, and hence are themselves insufficiently motivated to start the bandwagon rolling, but would get on it once it did start to roll. This startup problem can prevent the adoption of any standard at all, even if it is preferred by everyone. Conversely, excess momentum is another possible outcome, for example, if a sponsoring firm uses low prices during early periods of diffusion. The aim of this paper is to analyze the dynamics of the adoption process in markets exhibiting network effects by focusing on two factors; switching and agent heterogeneity. Switching is an important factor that should be considered in analyzing the adoption process. An agent's switching invokes switching by other adopters, which brings about a positive feedback process that can significantly complicate the adoption process. Agent heterogeneity also plays a important role in shaping the early development of the adoption process, which has a significant impact on the later development of the process. The effects of these two factors are analyzed by developing an agent-based simulation model. ABM is a computer-based simulation methodology that can offer many advantages over traditional analytical approaches. The model is designed such that agents have diverse preferences regarding technology and are allowed to switch their previous choice. The simulation results showed that the adoption processes in a market exhibiting networks effects are significantly affected by the distribution of agents and the occurrence of switching. In particular, it is found that both weak heterogeneity and strong network effects cause agents to start to switch early and this plays a role of expediting the emergence of 'lock-in.' When network effects are strong, agents are easily affected by changes in early market shares. This causes agents to switch earlier and in turn speeds up the market's tipping. The same effect is found in the case of highly homogeneous agents. When agents are highly homogeneous, the market starts to tip toward one technology rapidly, and its choice is not always consistent with the populations' initial inclination. Increased volatility and faster lock-in increase the possibility that the market will reach an unexpected outcome. The primary contribution of this study is the elucidation of the role of parameters characterizing the market in the development of the lock-in process, and identification of conditions where such unexpected outcomes happen.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.84-91
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• 2000

Mycopasma contamination of tissue culture cells easily evades detection and, thus, represents a continous therat to cell biologists. In case where infected cell can not simply be replaced, attempts have to be made to eradicate mycoplacma from the tissue culture cells. A variety of anti-microbial agents have been shown to be toxic to mycoplasma strains ; however, cell associated mycoplasma are often protected from antibiotics at concentrations shown to be effective in vitro. Antibiotic concentrations high enough to be lethal to cell as sociated mycoplasmas frequently are also detrimentrations to the host cells, while moderately increased antibiotic levels tolerated by the host cells often lead to only temporary growth suppression and/or to the emergence of mycoplasma strains resistanct even to high concentrations of the antibiotis applied. Hare, a genetic approach for the elimination of mycoplasma from tissue culture cells that overcomes thens limitations is described. By expression of a selection marker conferring resistance to an otherwise toxic agent, Acholeplasma laidlawii infected BHK-21 cells used as the model system were enabled to temporarily tolerate antibiotic concentrations high enough to be lethal to cell associated mycopalsma while leaving the host cells unharmed. Upon successful mycoplasma eradicated, cultvation of the cured host cells in the absence of the selective agent yielded revertant cell clones that had regained susceptibillity to the toxic agent. Cressation of the selection marker expression was shown to result from the loss of the selection marker DNA, which is a consequence of the fact that the stable and permanent integration of foreign DNA in eucaryotic cell chrosomes is highly inefficient. Thus, the cells were cured from mycoplasma yet remained biochemically unaltered.

• The KIPS Transactions:PartC
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• v.11C no.4
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• pp.519-526
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• 2004

This paper presents an efficient interoperation scheme of a VPN(Virtual Private Network) and Mobile IP using a hierarchical structure of a FA(Foreign Agent). In the proposed scheme, the GFA(Gateway Foreign Agent) plays a role of VPN gateway on behalf of the MN(Mobile Node). When the MN moves in the same GFA domain, because the GFA has already an IPsec security association with a VPN gateway in the home network of the MN, the MN does not need an IPsec re-negotiaion. In this way, our mechanism reduces a message overhead and a delay resulted from an IPsec negotiation. And a MN can send a data to a correspondent node without a packet leakage. We show a performance of our scheme by using a discrete analytical model. Analytical results demonstrated that the total processing cost calculated by a registration update cost and a packet delivery cost is significantly reduced through our proposed scheme.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.7
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• pp.545-549
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• 2007

The Bio-Inspired System focuses on the creation of an effective system model for massive network applications and is being widely developed. However, the system has a problem-difficulty implementing three features in the system, which includes scalability, adaptability and survivability. To solve this problem, we designed an Ecogent as a multiple intelligence agent, and a Bio-platform to address the three features of scalability, adaptability and survivability. The Bio-Inspired System Platform consists of an ERS (Ecogent Runtime Services) Platform and a Bio-Platform. The ERS platform serves the basic functions of mobile agents, such as Registration, Life Cycle, Migration, Communication, Location and Fault Tolerance. The Bio-Platform includes the functions of Evolution Control and Stigmergy Control to address evolution and adaptation.

• The Journal of the Korea Contents Association
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• v.20 no.11
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• pp.292-300
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• 2020

According to the development of artificial intelligence technology, attempts have been made to interpret phenomena in various fields of the real world such as economic, social, and scientific fields through computer simulations using virtual artificial agents. In the existing artificial agent-based bargaining game analysis, there was a problem that did not reflect the cost incurred when the stage progresses in the real-world bargaining game and the depreciation of the bargaining target over time. This study intends to observe the effect on the bargaining game by adding the cost incurred in the bargaining stage and depreciation of the bargaining target over time (bargaining cost) to the previous artificial agent-based bargaining game model. As a result of the experiment, it was observed that as the cost incurred in the bargaining stage increased, the two artificial agents participating in the game had a share close to half the ratio and tried to conclude the negotiation in the early stage.

• Journal of Ocean Engineering and Technology
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• v.17 no.5 s.54
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• pp.82-87
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• 2003

A practical method to investigate the sharing architecture of FMS, for small and medium enterprises, on distributed heterogeneous environmental conditions is investigated. Because the industrial FMS model requires a reasonable size for actual work-site flexible operation, the initial facility expense is very heavy. The support for flexible cooperation of FMS, with some external different FMS, can reduce expenditures and provide greater functionality. While most FMS provide their operation process using an adequate mechanism, when used in isolation, such as island of automation, there is increasing demand for FMS that can cooperate. By exchanging intermediate products and information with other external FMS, products can be produced that cannot be produced alone, such as those that require various processes. This study first considers the sharing architecture of FMS for small and medium enterprises, and investigates the effects of the general sharing architecture of FMS on distributed heterogeneous environments, by using transducer approach to agentification. In this study, set-up station or in-out station takes charge of the gateway of intermediate products, and routes them among distributed heterogeneous FMS plants. The transducer approach is applied to web agent and set-up agent established interfaces, with system controller and setup controller. In this study, the FMS-established sharing architecture is able to obtain not only the internal flexibility, but also the external flexibility.