• Archives of Pharmacal Research
• /
• v.22 no.3
• /
• pp.279-287
• /
• 1999

Therapeutic use of anti-inflammatory steroids is limited due primarily to their systemic suppressive effects on pituitary function and the immune system.. To overcome the clinical limitation, a new approach toward the discovery of non-systemic anti-inflammatory steroids is based upon the antedrug concept introduced by this laboratory. The new concept describes locally active agents which are designed to undergo a predictable biotransformation to inactive metabolites upon entry into systemic circulation from the applied site. Thus, true antedrugs are devoid of systemic adverse effects. In a continuing effort, 16$\alpha$-carboxylate and isoxazoline derivatives of prednisolone have been synthesized and screened. In the croton oil-induced ear edema bioassay, the following relative potencies were obtained setting hydrocortisone=1.0; 3a, 1.5; 3b, 3.1; 4a, 4.0; 4b, 12.2; 5b, 8.2; 6b, 11.2; 7a, 1.9; 7b, 4.1; 8a, 3.3; 8b 6.8; 9a, 0.7; 9b 8.6; 10a 2.6; 10b, 7.4. Results of the five-day bioassay indicated that, in contrast to the parent compound, the novel steroidal antedrugs did not significantly alter body weight gain, thymus weights, adrenal weights or plasma corticosterone levels. Taken together, the antedrug concept appears to be a fundamentally sound strategy for the separation of local anti-inflammatory activity form systemic adverse effects.

• The Journal of Internal Korean Medicine
• /
• v.43 no.5
• /
• pp.795-808
• /
• 2022

Objectives: The purpose of this study is to report two cases of prostate cancer patients whose side effects after surgery were treated with traditional Korean medicine. Methods: Two prostate cancer patients underwent robot-assisted laparoscopic prostatectomy, and both patients were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Daily life vitality was evaluated by the Eastern Cooperative Oncology Group. Results: After treatment with traditional Korean medicine, discomfort symptoms that occurred after surgery, such as frequent urination, nocturia, insomnia, and depression, all gradually improved, and Eastern Cooperative Oncology Group scores also improved from two points to one point. Additionally, there were no hematologic side effects from the traditional Korean medicine treatment. Conclusions: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by robot-assisted laparoscopic prostatectomy, quality of life, and immunity.

• The Journal of Internal Korean Medicine
• /
• v.44 no.1
• /
• pp.53-65
• /
• 2023

Objective: The purpose of this study is to report two cases of breast cancer patients whose side effects after Tamoxifen were treated with traditional Korean medicine. Methods: Two breast cancer patients underwent Tamoxifen after breast-conserving surgery, and both were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 5.0. Results: After treatment with traditional Korean medicine, the discomfort symptoms that occurred after Tamoxifen, such as osteoarthritis, hot flushes, and cold sweat, all gradually improved. In addition, no hematologic, hepatic, or renal side effects were observed from the traditional Korean medicine treatment. Conclusion: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by Tamoxifen and enhance the quality of life of patients.

• The Journal of Korean Medicine
• /
• v.44 no.4
• /
• pp.193-207
• /
• 2023

Objectives: The purpose of this study was to evaluate the effectiveness and safety of traditional herbal medicine as a stand-alone treatment group through major English databases due to the lack of RCTs in Korea, and to provide a review of the herbal interventions used. Methods: Using four databases (Pubmed, EMBASE, OASIS, RISS), combination of words such as "Coronavirus" "RCT" "Herb" "Decoction" "TCM" were used. RCTs using herbal medicines to treat coronavirus were searched. Final 4 studies were selected by two authors according to inclusion and exclusion criteria. Results: A total of 1,435 patients were studied. The Chinese herbs used in the treatment group were Shengmai Yin, JingYinGuBiao granules, Jinhua Qinggan granules, and Bufei Huoxue capsules. The intervention group showed greater attenuation of pneumonia lesions on CT. Also, improvement in 6-min walk distance (6MWD), and negative conversion rate in treatment group were reported. Furthermore, scores on the Fatigue Assessment Inventory (FAI) were lower in the herbal group than in the placebo group. The median time to recovery of COVID-19 related symptoms was shorter in TCM group compared to the control group. Reported adverse effects were diarrhea, liver dysfunction, and excessive menstruation, and two papers did not mention side effects in detail. Conclusion: Herbal medicine alone can increase the conversion rate of viral negativity and relieve COVID-19 related symptoms without significant adverse effects.

• Journal of Environmental Health Sciences
• /
• v.46 no.4
• /
• pp.359-367
• /
• 2020

Objectives: Exposure to mold is strongly associated with adverse health effects (development or exacerbation of allergic diseases). We reviewed the health effects of mold exposure and explored to determine the annual distribution of indoor mold in facilities with susceptible populations. Methods: The health effects of mold exposure were mainly summarized by reviewing related papers and WHO research reports. We selected 10 facilities, including daycare centers, postpartum care centers, medical institutions, and elderly care facilities within the Seoul Metropolitan. Mold sampling was performed once every week or once every quarter from February 2016 to 2017. In addition, fungal species analyses was performed, and distribution status by month and facility was analyzed in the same manner as concentration. Results: Adverse health effects attributed to fungal exposure are largely divided into allergic symptoms, toxic effects, and infectious effects. Monthly mean concentrations of mold indoors and outdoors was 368.8 CFU/㎥ (geometric mean 213.4 CFU/㎥) and 496.0 CFU/㎥ (327.9 CFU/㎥), respectively. The indoor concentration has begun to increase in February, peaked in July, declined in August, increased again until October, and then decreased in November. About 36 genera of indoor fungal species were found in each facility. Cladosporium sp., Penicillium sp., Fusarium sp., Aspergillus sp., Alternaria sp., and Arthrinium sp. were observed as the dominant species. Conclusions: Our findings showed that the overall level of indoor mold was below the 500 CFU/㎥ level recommended by the Ministry of Environment. The development of DNA-based assessment and expanding facilities to be monitored for mold would be necessary for preventive aspects.

• Journal of Applied Biological Chemistry
• /
• v.62 no.3
• /
• pp.247-250
• /
• 2019

Wheat is one of the most important grains. Its consumption is increasing globally. Many countries are making efforts to increase the extent of wheat harvest. It is known that plant growth promoting rhizobacteria (PGPRs) have beneficial effects on various plants. Two PGPRs including Paenibacillus pabuli strain P7S (PP7S) and Pseudomonas nitroreducens strain IHB (PnIHB) were employed to investigate effects of PGPRs on early growth of three wheat cultivars (Koso, Seakumkang, and Jokyung). While PP7S had adverse effects on Seakumkang and Jokyung, PP7S had positive effects on Koso except root length compared to control group having no treatment of PP7S. However, all treatments with PnIHB had adverse effects on germination rate, root/shoot lengths, vigor index, and dry root/shoot weights of all three wheat cultivars. These positive effects with PP7S on Koso might be related to the earlier emergence of wheat seed above soil which is known to be an indicator of increased yield. Results of the present study suggest that if proper PGPR strains are selected, they could have positive effects on early growth rate of a wheat cultivar.

• Korean Journal of Clinical Pharmacy
• /
• v.15 no.2
• /
• pp.105-117
• /
• 2005

Following intracoronary stenting, antiplatelet therapy lead to greater protection from thrombotic complication. A few data are available about the effect of clopidogrel versus cilostazol, an antiplatelet commonly used after intracoronary stenting. To evaluate the efficacy and safety of clopidogrel plus aspirin compared with those of cilostazol plus aspirin in coronary stenting and to evaluate the efficacy of clopidogrel loading dose prior to coronary stealing in clopidogrel group. Data were retrospectively collected from medical charts of patients who had undergone coronary stenting and received either clopidogrel with or without loading 300 mg followed by 75 mg/d (n=58), or 200 mg/d cilostazol(n=72) for 1 year, between January 2000 and May 2002. All patients in both groups received aspirin 200 mg/d throughout the study. The primary endpoints at 7, 30, 180 and 365 days after stealing were the composite of death, Myocardial Infarction, stroke, angina, and revascularization in the intent to treat population and restenosis at follow up angiography. The secondary endpoints were the incidence of bleeding complications at 7, 30, and 365 days, and durg adverse effects at 365 days after stenting. At 180 and 365 days after stenting, the combined primary endpoints were significantly reduced in clopidogrel plus aspirin group (relative risk 0.39; 95% CI 0.17 to 0.92; p=0.021, RR 0.43; 95% CI 0.22 to 0.84; p=0.0085, respectively). However, the combined primary endpoints were not significantly different between the two groups at 7 and 30 days (p:1.00, p=0.79, respectively). Angiographic restenosis rate was 14.3% in clopidogrel plus aspirin uoup and 32.1% in cilostazol plus aspirin group (p=0.19). 300mg of clopidogrel loading dose did not significantly reduce the combined primary endpoints at 30 days after stenting (RR 0.14; 95% CI 0.01 to 2.65; p=0.23). The rate of bleeding complications and drug adverse effects were not different between the two groups. In patients undergoing intracoronary stenting, clopidogrel plus aspirin therapy is more beneficial than cilostazol plus aspirin in reducing major adverse cardiac events with similar rate of bleeding complication. A loading dose of clopidogrel did not lead to a statistically significant reduction in major adverse cardiac events.

• The Journal of Korean Academy of Sensory Integration
• /
• v.21 no.3
• /
• pp.13-26
• /
• 2023

Objective : The purpose of this study is to examine the impact of maternal risk factors for adverse childhood experiences on children's emotional and physical abuse and neglect as well as parenting stress. Methods : This is a secondary data analysis study utilizing raw data from the 2017 National Survey of Child and Family Life Experiences. A total of 1,937 mothers with at least one adverse childhood experience were categorized into low-risk (1-3), moderate-risk (4-6), and high-risk (7 or more) groups to examine the differences in children's emotional and physical abuse and neglect and parenting stress and identify the influencing factors through regression analysis. Results : Maternal adverse childhood experiences were 50.4% in the low-risk group, 39.8% in the medium-risk group, and 9.7% in the high-risk group. Child emotional abuse was 45.0%, child physical abuse was 13.2%, child neglect was 3.5%, and parenting stress was 2.13 (±0.61) on average. Adverse childhood experiences were significantly more likely to be associated with emotional and physical abuse, neglect, and parenting stress in the medium- and high-risk groups than in the low-risk group. The regression analysis showed that the model explained 35% of child emotional abuse, 25% of child physical abuse, 19% of child neglect, and 16% of parenting stress. Conclusion : The higher the risk of adverse childhood experiences of parents, the more their children experience emotional abuse, physical abuse, child neglect, and parenting stress.

• Journal of Acupuncture Research
• /
• v.18 no.4
• /
• pp.205-211
• /
• 2001

Objective : There was no report on traumatic pneumothorax associated with acupuncture in korea yet, although many people guess at its possibility. In order to make known that acupuncture can cause pneumothorax in reality and to prevent more acupuncture-related adverse effect cases in future, this report was made. Methods : Close observation was done on clinical symptoms & radiologic examination of acupuncture-related traumatic pneumothorax patient. Results : During acupuncture therapy on neck stiffness & shoulder pain, a acupuncture needle was inserted too deeply into upper part of thorax unintentionally, patient showed dyspnea, chest pain & discomfort, cough, sweating and mild rupture of right lung in chest radiologic findings, and recovered after 2 weeks of conservative treatment. Conclusion : In order to prevent traumatic pneumothorax during acupuncture therapy, needling into thorax sometimes requires tilted acupuncture needle inserting under consideration of needle width & length. At least 0.40mm width of needle is generally considered appropriate in needling into taut band of thoracic muscles, because too thin and long needle sometimes can be bent and inserted into wrong way, which can cause adverse effects like pneumothorax.

• Korean Journal of Clinical Pharmacy
• /
• v.30 no.1
• /
• pp.59-64
• /
• 2020

The emergence of phosphodiesterase (PDE) 5 inhibitors gave rise to the solution for erectile dysfunction, starting with the development of sildenafil. Although their efficacy in treating erectile dysfunction has been shown, the side effects of PDE5 inhibitors, especially sildenafil, must be taken into consideration. A 64-year-old man received 100 mg of sildenafil and experienced blue vision in both eyes; however, after a day or so, his symptoms improved. The symptoms disappeared when he stopped administering sildenafil, but reappeared when the medication was re-administered. Therefore, he discontinued sildenafil treatment and was prescribed udenafil instead. After that, visual adverse events no longer occurred. Causality assessment showed that in this case, sildenafil-induced cyanopsia was "certain" under the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria and Korean causality assessment algorithm (Ver.2), and was "probable" according to the Naranjo scale. In addition, sildenafil also led to abnormal visual reactions in other cases. Sildenafil can also inhibit PDE6, which is present in retinal cells, unlike other PDE5 inhibitors. Thus, visual adverse reactions, such as blue vision, are the unique results of sildenafil, and other PDE5 inhibitors may be used to prevent them.