• 대한토목학회논문집
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• 제30권2C호
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• pp.119-131
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• 2010

본 연구에서는 국내 해양오염 준설퇴적물을 활용한 시제품 제작 및 역학적, 환경적 실험을 통한 건설재료로서의 활용성을 조사하였다. 울산 방어진에서 수거한 준설토로 고화처리토 및 경량혼합토 공시체를 제작하여 압축특성 및 응력-변형 거동 등 물리적 특성을 파악하는 다양한 공학적 조사를 수행하였다. 해양오염토 유효활용을 위해 물리적 특성 외에 환경실험도 실시하였다. 제안된 준설토사 처리활용기준에 적용하였을 때는 구리성분 만이 활용가능기준을 약간 초과하였고 준설토 활용우려기준에는 모든 기준에 적합하여서 건설재료로 재활용하여도 환경적인 유해성은 없는 것으로 나타났다. 매립복토재로서 활용성 검토를 위한 준설토의 입도분석, 다짐시험, 아터버그 한계시험, 비중시험 및 단위중량시험 등을 수행한 결과, 모든 조건의 고화처리토는 매립작업을 원활히 하기위한 강도(대략 50kPa)를 만족하였다.

• 대한토목학회논문집
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• 제28권1C호
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• pp.41-51
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• 2008

본 논문은 말뚝 및 기초지반의 강성이 수평재하말뚝의 거동에 미치는 영향을 알아보고자 주문진 표준사와 김해점토를 기초지반으로 수평재하말뚝에 대한 실내실험을 실시하였다. 또한 실험 결과를 바탕으로 영향계수를 정량화 할 수 있는 경험식을 산정하였다. 말뚝과 지반의 강성을 고려하기 위하여 길이가 다른 3개의 알루미늄 모형말뚝을 제작하였으며 이를 사질토와 점성토 지반에 설치한 후 기초지반의 상대밀도(사질토 지반) 및 비배수전단강도(점성토 지반)를 변화시켜가며 수평재하 실내실험을 수행하였다. 실험을 통하여 산정된 p-y 곡선의 초기기울기는 사질토와 점성토 지반 모두에서 깊이와 말뚝-지반의 강성에 비례하였으나 점성토 지반의 경우 사질토 지반에 비하여 깊이에 따른 초기기울기의 증가율이 작은 경향을 나타내었다. 또한 극한 지반반력의 경우 모든 지반 조건에서 수평지반반력계수와 유사하게 깊이와 지반강성에 비례하여 증가하였으나 말뚝 강성에 대한 영향은 적게 나타났다. 이와 같은 특성을 고려하여 본 논문에서는 p-y 곡선의 초기기울기 산정 식을 실험결과와 가장 유사한 형태를 지니는 쌍곡선으로 지반 조건에 따라 제시하였으며 제안된 식을 기존의 연구 및 현장재하시험과 비교하여 제안 식의 적용성을 검증하였다.

• 대한토목학회논문집
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• 제26권1D호
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• pp.73-79
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• 2006

본 연구의 목적은 포장의 설계수명과 공용년수를 증대시켜 아스팔트 포장의 유지보수비용을 감소시킬 수 있는 장수명 아스팔트 포장용 고강성 혼합물을 개발하는데 있다. 따라서 본 연구에서는 고강성 아스팔트 바인더를 개발하였으며 다양한 실내 물성시험을 수행하였다. 실내 물성시험 결과 새롭게 개발된 고강성 아스팔트 바인더가 프랑스의 고강성 아스팔트 바인더와 유사하다는 것을 알 수 있었고, 바인더 외에 혼합물의 공용성을 평가하기 위해 기존의 일반아스팔트 혼합물과 새롭게 개발된 고강성 아스팔트 혼합물의 비교 시험을 수행하였다. 공용성 시험 결과 동탄성계수 측정시험에서는 고강성 아스팔트 혼합물이 일반 아스팔트 혼합물보다 강성에 있어 $5^{\circ}C$에서는 10~15%, $15^{\circ}C$에서는 20~25%, $30^{\circ}C$에서는 거의 2배가 증가함을 알 수 있었다. 또한 수분손상시험 및 휠트래킹시험, 피로시험을 수행한 결과 일반 아스팔트 혼합물에 비해 고강성 아스팔트 혼합물의 공용성이 우수한 것으로 평가되었다.

• 생물정신의학
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• 제5권1호
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• pp.83-94
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• 1998

Objectives : Phencyclidine(PCP) or PCP-like substances such as ketamine have been known to rekindle the cognitive dysfunction in schizophrenia. The aims of this study were to identify whether PCP-like substances can produce cognitive deficit in schizophrenia, to discuss relation with aging process, and finally to speculate underlying neurochemical mecha-nisms by various drug responses. Methods : In experiment I, radial maze tests were done in 24 Sprague-Dawley rats for 3 days to get baseline data. Being divided into 4 groups(6 rats respectively) of normal aged, normal adult controls, atropine-treated and ketamine-treated, the radial maze tests were repeated on every week for 6 weeks, and then the rats were sacrificed by intracardiac perfusion with phosphate-buffered 10% formaldehyde solution for histology. The brain specimen was stained with hematoxylin-eosin to count cells in the prefrontal cortex and hippocampus. In experiment II, radial maze tests were done for 48 rats before any drug treatment and only after ketamine administration. Thereafter, haloperidol, bromocriptine, clonidine, nimodipine, tacrine, valproic acid, naloxone and fluoxetine were intramuscularly injected on every other day in addition to ketamine. Radial maze tests were repeated on every week for 6 weeks, and then rats were prepared by the same procedure for histology. Results : 1) Reaction times of radial maze tests of atropine-treated rats were significantly prolonged than those of normal aged(p<0.05) or normal adult controls(p<0.05). Cell numbers of prefrontal cortex & hippocampus in ketamine-treated rats were significantly reduced than those in normal aged (p<0.05) or normal adult controls(p<0.005). 2) Reduced cell numbers by ketamine became significantly raised by tacrine administration in prefrontal cortex & hippocampus(p<0.05), while there were no significant changes on radial maze tests. Cell numbers also tended to be raised by nimodipine, fluoxetine and haloperidol administration. Conclusions : In conclusion, the visuospatial memory disorders in ketamine-induced psychotic rats might be partly asso-ciated with aging process. Furthermore, the responses to the various drugs suggested cholinergic system might have an important role in the neurochemical mechanism of the cognitive dysfunction in ketamine-induced psychosis. Otherwise, calcium metabolism as well as serotonergic and dopaminergic systems seemed to be possibly related.

• Clinical and Experimental Reproductive Medicine
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• 제29권1호
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• pp.57-66
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• 2002

Objective : This study was designed to investigate the interrelationship and clinical usefulness of sperm morphology by strict criteria (SM), acrosome reaction following ionophore challenge test (ARIC) and sperm penetration assay (SPA) using zona-free hamster ova as prognostic factors in in vitro fertilization. Materials and Methods: Semen samples were provided by 83 patients undergoing IVF. We first evaluated the differences between normal fertilization group and poor fertilization group on three andrologic tests. Secondly, we analyzed the relationship between the three andrologic tests and in vitro fertilization on IVF settings. Finally, we evaluated the effectiveness of the three andrologic tests as the prognostic indicators for fertilizing ability. Results: The fertilization rate of all men in the poor fertilization group was less than 30%; but there was no evidence that this poor fertilization was due to oocyte defects. The results of three andrologic tests were significatly higher in normal fertilization group. Fertilization rate (%) in vitro was highly correlated (p<0.001) with % normal sperm by SM, ARIC value (%), and SPA result. By using Receiver-Operator-Characteristic curve (ROC), we evaluated the effectiveness of these three tests. The sensitivity and specificity of SM, ARIC test and SPA in predicting fertilization potential in IVF setting were 76% and 75%, 84% and 90%, and 76% and 95%, respectively. Conclusion: Our data suggest that the three andrologic tests can be reliable tools as prognostic factors of sperm fertilizing ability. Among these test, ARIC test and SPA gave more accurate information on fertilizing capacity. ARIC test was shown to have a predictive value for fertilizing ability comparable to that of SPA that appears to be a simple and cost-effective addition to current andrology laboratory. Combined application of these three tests may give more information on predicting sperm fertilizing capacity.

• International Journal of Oral Biology
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• 제48권2호
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• pp.9-18
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• 2023

The rapid detection of bacteria in the oral cavity, its species identification, and bacterial count determination are important to diagnose oral diseases caused by pathogenic bacteria. The existing clinical microbial diagnosis methods are time-consuming as they involve observing patients' samples under a microscope or culturing and confirming bacteria using polymerase chain reaction (PCR) kits, making the process complex. Therefore, it is required to analyze the development status of substances and systems that can rapidly detect and analyze pathogenic microorganisms in the oral cavity. With research advancements, a close relationship between oral and systemic diseases has been identified, making it crucial to identify the changes in the oral cavity bacterial composition. Additionally, an early and accurate diagnosis is essential for better prognosis in periodontal disease. However, most periodontal disease-causing pathogens are anaerobic bacteria, which are difficult to identify using conventional bacterial culture methods. Further, the existing PCR method takes a long time to detect and involves complicated stages. Therefore, to address these challenges, the concept of point-of-care (PoC) has emerged, leading to the study and implementation of various chair-side test methods. This study aims to investigate the different PoC diagnostic methods introduced thus far for identifying pathogenic microorganisms in the oral cavity. These are classified into three categories: 1) microbiological tests, 2) microchemical tests, and 3) genetic tests. The microbiological tests are used to determine the presence or absence of representative causative bacteria of periodontal diseases, such as A. actinomycetemcomitans, P. gingivalis, P. intermedia, and T. denticola. However, the quantitative analysis remains impossible, and detecting pathogens other than the specific ones is challenging. The microchemical tests determine the activity of inflammation or disease by measuring the levels of biomarkers present in the oral cavity. Although this diagnostic method is based on increase in the specific biomarkers proportional to inflammation or disease progression in the oral cavity, its commercialization is limited due to low sensitivity and specificity. The genetic tests are based on the concept that differences in disease vulnerability and treatment response are caused by the patient's DNA predisposition. Specifically, the IL-1 gene is used in such tests. PoC diagnostic methods developed to date serve as supplementary diagnostic methods and tools for patient education, in addition to existing diagnostic methods, although they have limitations in diagnosing oral diseases alone. Research on various PoC test methods that can analyze and manage the oral cavity bacterial composition is expected to become more active, aligning with the shift from treatment-oriented to prevention-oriented approaches in healthcare.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제49권3호
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• pp.142-147
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• 2023

Objectives: As medical history before surgery is often based on patient reporting, there is the possibility that patients intentionally hide underlying diseases or that dentists cannot recognize abnormal health states. Therefore, more professional and reliable treatment processes are needed under the Korean dental specialist system. The purpose of this study was to elucidate the necessity of a preoperative blood testing routine prior to office-based surgery under local anesthesia. Patients and Methods: Preoperative blood lab data for 5,022 patients from January 2018 to December 2019 were assembled. Study participants were those who underwent extraction or implant surgery under local anesthesia at Seoul National University Dental Hospital. Preoperative blood tests included complete blood count (CBC), blood chemistry, serum electrolyte, serology, and blood coagulation data. Values outside of the normal range were considered an "abnormality," and the percentage of abnormalities among the total number of patients was calculated. Patients were divided into two groups based on the presence of underlying disease. The rates of abnormalities in the blood tests were compared between groups. Chi-square tests were performed to compare data from the two groups, and P<0.05 was considered statistically significant. Results: The percentages of males and females in the study were 48.0% and 52.0%, respectively. Of all patients, 17.0% (Group B) reported known systemic disease, while 83.0% (Group A) reported no specific medical history. There were significant differences between Groups A and B in CBC, coagulation panel, electrolytes, and chemistry panel (P<0.05). In Group A, the results of blood tests that required a change in procedure were identified even though the proportion was very small. Conclusion: Preoperative blood tests for office-based surgery can detect underlying medical conditions that are difficult to identify from patient history alone and can prevent unexpected sequelae. In addition, such tests can result in a more professional treatment process and build patient confidence in the dentist.

• 한국건설순환자원학회논문집
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• 제8권2호
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• pp.198-203
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• 2020

콘크리트는 초기에 인장강도가 확보되지 못하므로 건조수축과 같은 재료적인 균열이 발생하게 된다. 본 연구에서는 셀룰로오즈 섬유를 0.0 ~ 2.0% 혼입한 콘크리트를 대상으로 공기량, 슬럼프와 같은 작업성을 평가하였으며, 재령에 따른 압축 및 인장강도를 평가하였다. 혼입률이 증가할수록 1.0kg/㎥ 수준에서는 공기량 및 슬럼프에서 저하를 확인할 수 없었으며, 이러한 작업성은 2시간까지 유효하게 작용하였다. 강도 평가에서는 혼입률이 증가할수록 인장 및 압축강도가 개선되었으며, 압축강도의 경우 7 ~ 9%수준으로, 인장강도에서는 7 ~ 22% 수준으로 증가하였다. 인장강도에서 증가율이 상대적으로 크게 평가되었는데, 이러한 효과는 균열저항성에 크게 도움을 주리라 판단된다. 본 연구를 통하여 2분간의 혼입 시간, 셀룰로오즈 섬유 1.0kg/㎥의 혼입률 수준이면 120분간 작업성에 큰 영향이 없으리라 평가된다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 학회창립 10주년 기념 1999년도 가을 학술발표회 논문집
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• pp.115-118
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• 1999

Tensile behavior of polypropylene fiber reinforced concrete due to restrained shrinkage has been investigated experimentally by ring and beam tests. Parameters include types of concrete, water-cement ratio, volume fraction of fiber and steel ratio. Results show that little influence of the addition of polypropylene(Vf=0.1%) has been observed as expected and results from other researches.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2001년도 춘계학술대회
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• pp.311-317
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• 2001

The notched Charpy and Izod impact tests are the most prevalent techniques used to characterize the effects of high impulse loads on ploymeric materials. An analysis method for rubber toughened PVC is suggested to evaluate critical strain energy release rates(Gc) from the Charpy impact energy measurements. An Instrumented Charpy Impact tester was used to extract ancillary information concerning fracture properties in addition to total fracture properties and maximum critical loads. The stress intensity factor Kd was computed for varying amounts of rubber contents from the obtained maximum critical loads and also toughening effects were investigated as well.