• Journal of Life Science
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• v.18 no.6
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• pp.891-896
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• 2008

The function of mast cells as effector cells in allergy has been extensively studied. Mast cells activated through high affinity IgE-receptor ($Fc{\varepsilon}RI$) release diverse mediators, and lead to smooth muscle constriction, vasodilation, increase of vascular permeability, leukocyte recruitment and activation, mucus secretion, and tissue proliferation and remodeling. However, various other immunological and non-immunological signals can lead to the activation of mast cells. In resent years, mast cells have been identified to be involved in a complex range of immune functions. Mast cells can be important as key players in the regulation of innate as well as adapted immune responses, and may influence the development of allergy, autoimmune disorder and peripheral tolerance. This review summarizes the recent advances in the understanding of effector functions of mast cells in immune responses.

• Journal of Institute of Control, Robotics and Systems
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• v.7 no.7
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• pp.605-613
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• 2001

In this paper, we design a robust adaptive controller for a nonlinear system with uncertainties to be rejected via disturbance adaptation law. The nonlinear system considered has unknown nonlinear functions being influenced by external disturbance. The upper bound of unknown nonlinear functions at each time is estimated by using a disturbance adaptation law. The estimated nonlinear functions are used to design a stabilizing function a control input. Tuning function is used to estimates unknown system parameter without overparametrization. A set-point regulation error converges to a residual set close to zero asymptotically. The effectiveness of the proposed controller is investigated by computer simulation.

• Proceedings of the IEEK Conference
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• 2002.07c
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• pp.1428-1431
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• 2002

It is general opinion that the future mobile multimedia networks will use different standards and a prospective solution to this problem will be software defined radio (SDR) techniques. SDR provides the flexibility to support multiple air interfaces and signal processing functions at the same time. Especially, digital signal processors and FPGAs are widely used for implementation of these adaptive and flexible functions of a baseband modem for SDR applications. Also, it is known that the modulation schemes of OCQPSK (Orthogonal Complex QPSK) and HPSK (Hybrid PSK) are used for IMT-2000 services of cdma2000 and WCDMA, respectively. Thus, in this paper, we design and implement an OCQPSK / HPSK modem using a DSP chip of Texas Instrument's TMS320C6701. One modulation scheme is operated by adaptive selection between the two schemes and 5 physical traffic channels differentiated by orthogonal codes are implemented in one DSP chip and each channel has 1Mbps data rates and 8Mcps chip rates.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.48 no.8
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• pp.417-425
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• 1999

This paper presents an effective control scheme with the voltage-fed half-bridge series resonant inverter for induction heating system, which is based upon a load-adaptive tuned frequency tracking control strategy using PLL(Phase Locked Loop) and its peripheral control circuits. The proposed control strategy ensures a stable operation characteristics of overall inverter system and ZVS(Zero Voltage Switching) irrespective of sensitive load parameter variations, specially in the non-magnetic materials as well as power regulation. The detail operation principle and the characteristics of inverter system with the proposed control scheme are described and its validity is verified by the simulation and the experimental results for a prototype induction cooking system rated at 1.2kW.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1716-1717
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• 2007

In this paper, a second order fuzzy sliding mode control that combines with a adaptive self-regulating technique is proposed for a nonlinear system with unknown dynamics. The chattering effect that is a representative disadvantage of the sliding mode control is avoided by using the second order sliding mode control instead of the first order sliding mode control. The proposed sub-controller is composed of the equivalent control that is approximated by an online rule regulation sheme and the hitting control that is used to constrain the states of the sub-system to maintain on the sub-sliding surface and used to guarantee the system robustness. Simulation results are presented to show the effectiveness of the proposed controller

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.41.3-41
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• 2001

In this paper, we present a decentralized adaptive neural net(NN) controller for the transient stability and voltage regulation of a multimachine power system. First, an adaptively input-output linearizing controller using NN is designed to eliminate the nonlinearities and interactions between generators. Then, a robust control term which bounds terminal voltage to a neighborhood of the operating point within the desired value is introduced using only local information. In addition, we consider input saturation which exists in the SCR amplifier and prove that the stability of the overall closed-loop system is maintained regardless of the input saturation. The design procedure is tested on a two machine infinite bus power system.

• IMMUNE NETWORK
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• v.12 no.3
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• pp.71-83
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• 2012

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion. High resolution microscopy indeed had a great impact in understanding the function and dynamic structure of immunological synapse. Trends of recent research are now moving towards understanding the mechanical part of immune system, expanding our knowledge in mechanosensitivity, force generation, and biophysics of cell-cell interaction. Actin cytoskeleton plays inevitable role in adaptive immune system, allowing it to bear dynamic and precise characteristics at the same time. The regulation of mechanical engine seems very complicated and overlapping, but it enables cells to be very sensitive to external signals such as surface rigidity. In this review, we focus on actin regulators and how immune cells regulate dynamic actin rearrangement process to drive the formation of immunological synapse.

• BMB Reports
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• v.50 no.10
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• pp.496-503
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• 2017

The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.

• IMMUNE NETWORK
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• v.24 no.1
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• pp.2.1-2.24
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• 2024

Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the modulation of a wide range of immune responses. IL-17 serves as a critical defender against bacterial and fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations in its levels can lead to chronic inflammation and autoimmunity. IL-21, on the other hand, bridges the adaptive and innate immune responses, and its imbalance is implicated in autoimmune diseases and cancer, highlighting its important role in both health and disease. Delving into the intricacies of these cytokines not only opens new avenues for understanding the immune system, but also promises innovative advances in the development of therapeutic strategies for numerous diseases. In this review, we will discuss an updated view of the immunobiology and therapeutic potential of IL-17 and IL-21.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.4.1-4.15
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• 2023

Th cells, which orchestrate immune responses to various pathogens, differentiate from naive CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.