• Proceedings of the KIEE Conference
• /
• 2001.07b
• /
• pp.1172-1175
• /
• 2001

Recently, vector control without a speed sensor for an inverter induction motor system has been developed. In this paper describes the vector control system estimates rotor speed based on FMRAS(Flux Model Reference Adaptive System). Because of improving the initial condition and drift problem by pure integrator is eliminated, we can be expected to rapid responsibility of the speed estimation. The stability of speed estimator is proved on the basis of hyperstability theory. Proposed control system used TMS320C31 DSP for high speed processing. The effectiveness of the proposed system is verified by simulation and experimental results. This result shows that the highly characteristic speed estimation and robust character of load regulation.

• 제어로봇시스템학회:학술대회논문집
• /
• 2005.06a
• /
• pp.186-189
• /
• 2005

In a clinical setting, developing a reliable method for the automated drug infusion system would improve a drug therapy under the unexpected and acute changes of hemodynamics. The conventional proportional-integral-derivative (PID) controller might not be able to achieve maximum performance because of the unexpected change of the intra- and inter-patient variability. The fuzzy PID control and the conventional PID control were tested under the unexpected response of mean arterial blood pressure (MAP) to a vasopressor agent during acute hypotension. Compared with the conventional PID control, the fuzzy PID control performed the robust MAP regulation regardless of the unexpected MAP response (average absolute value of the error between target value and actual MAP: 0.98 vs. 2.93 mmHg in twice response of the expected MAP and 2.59 vs. 9.75 mmHg in three-times response of the expected MAP). The result was due to the adaptive change of the proportional gain in PID parameters.

• Proceedings of the KIEE Conference
• /
• 1989.11a
• /
• pp.426-429
• /
• 1989

The robust self-tuning controller is designed which is guaranteed the asymptotic regulation and tracking in the presence of a bounded parameter perturbation. The global stability in the presence of a finite noise and disturbance is ensured. The controller has a error driven structure, and involves the common model of a disturbance and reference input in the internal model. The adaptive system tunes the controller parameters such that the quadratic performance index which involves a weighting factor is optimized.

• Biomedical Science Letters
• /
• v.10 no.4
• /
• pp.435-445
• /
• 2004

The characteristics of the testis and the annual cycle of the seminiferous epithelium of the Miniopterus schreibersi fuliginosus were examined by optical microscopy. The testis weight and diameter of the seminiferous tubules were increased gradually from May to July, and the highest activity was observed in August. The size then decreased rapidly from October. Spermatogenesis began in May, peaked in August, and was suspended from October to April in the following year. Spermatocytogenesis were produced from May to July. Spermiogenesis occurred from August to September. In particular, immature spematogenic cells in the seminiferous tubules were engulfed by the phagocytosis of Sertoli cells in October. From November to April, the seminiferous tubuly contained only Sertoli cells and Ad spermatogonia. Therefore, the periodic changes in the seminiferous epithelium of M. S. fuliginosus suggest that a long hibernation is an adaptive strategy for the preservation of energy and the regulation of the breeding cycle.

• Clinical and Experimental Pediatrics
• /
• v.58 no.7
• /
• pp.239-244
• /
• 2015

The complement system is part of the innate immune response and as such defends against invading pathogens, removes immune complexes and damaged self-cells, aids organ regeneration, confers neuroprotection, and engages with the adaptive immune response via T and B cells. Complement activation can either benefit or harm the host organism; thus, the complement system must maintain a balance between activation on foreign or modified self surfaces and inhibition on intact host cells. Complement regulators are essential for maintaining this balance and are classified as soluble regulators, such as factor H, and membrane-bound regulators. Defective complement regulators can damage the host cell and result in the accumulation of immunological debris. Moreover, defective regulators are associated with several autoimmune diseases such as atypical hemolytic uremic syndrome, dense deposit disease, age-related macular degeneration, and systemic lupus erythematosus. Therefore, understanding the molecular mechanisms by which the complement system is regulated is important for the development of novel therapies for complement-associated diseases.

• 제어로봇시스템학회:학술대회논문집
• /
• 2000.10a
• /
• pp.151-151
• /
• 2000

The objective of this paper is to develop the new robust and adaptive control system against external environments as applying the probabilistic recognition which is one of the inherent properties of immune system, ability of learning and memorization, and regulation theory of immune network to the system under engineering point of view. In this paper, HIA(Humoral Immune Algorithm) PID controller using Neural Network Identifier was proposed to drive the autonomous guided vehicle(AGV) more effectively. To verify the performance of the proposed HIA PID controller, some experiments for the control of steering and speed of that AGV are performed.

• Reproductive and Developmental Biology
• /
• v.34 no.2
• /
• pp.111-115
• /
• 2010

Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. In this study, we analyzed by immunohistochemical methods adaptive mechanisms to excessive erythrocytosis in transgenic (tg) mice expressing dimeric human erythropoietin (dHuEPO) gene. Splenomegaly was observed over 11~21 times in the tg mice. The 2,672 candidate spleen-derived genes were identified through the microarray analysis method, and decreased genes were higher than increased genes in the spleen. The specific proteins in the increased and decreased genes were analyzed by immunohistochemical methods. Our results demonstrate that problems of abnormal splenomegaly would solve in tg mice overexpressing dHuEPO gene.

• Molecules and Cells
• /
• v.20 no.2
• /
• pp.173-182
• /
• 2005

Heat shock protein gp96 is an endoplasmic reticulum chaperone, belonging to the HSP90 family. The function of gp96 as a molecular chaperone was discovered more than 10 years ago, but its importance has been overshadowed by the brilliance of its role in immune responses. It is now clear that gp96 is instrumental in the initiation of both the innate and adaptive immunity. Recently, the roles of gp96 in protein homeostasis, as well as in cell differentiation and development, are beginning to draw more attention due to rapid development in the structural study of HSP90 and some surprising new discoveries from genetic studies of gp96. In this review, we focus on the aspect of gp96 as an ER molecular chaperone in protein maturation, peptide binding and the regulation of its activity.

• IMMUNE NETWORK
• /
• v.15 no.1
• /
• pp.1-8
• /
• 2015

Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell.

• ETRI Journal
• /
• v.41 no.1
• /
• pp.124-132
• /
• 2019

The energy balance (EB) model of a primary side regulation (PSR) fly-back converter in the discontinuous conduction mode (DCM) is discussed in this paper. Based on this EB model, the stability of a PSR fly-back converter in the pulse skipping mode (PSM) is analyzed, and a self-adapting modulation factor control strategy is proposed. Theoretical analysis and simulation results show that by saving an optocoupler and correlative circuits, which are necessary in traditional PSM fly-back converters, the modulation factor tolerance controlled by this method is 1.26% on average, corresponding to the ideal value. Compared with traditional fly-back PSM controllers, the power saved in the sampler/comparator modules is 87% on average for a load range of $1{\Omega}$ to $1k{\Omega}$.