• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.2
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• pp.213-222
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• 2017

Online advertisement has many benefits comparing to offline advertisement but it also has many challenging problems by online ad abuses. Advertisement injection (Ad injection) is one of the threats that surreptitiously inserts advertisements without a permission of site owners. Users are exposed to additional ads and redundant web traffic by injected ads can cause a service quality problem. Moreover, advertisers can have economic loss when injected ads are different from original ones. Although ad injection leads to these problems it has not been fully studied yet. A few ad injection researches are done by online advertising providers such as Google. In this paper, we analyze ad injection activities to Korean major portal, Naver. We classify 6 types of ad injections and describe their characteristics by analyzing 27 downloaders and 199 installed programs.

• Current Research on Agriculture and Life Sciences
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• v.3
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• pp.190-196
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• 1985

In order to know the effects of ginseng on the stress, histochemical and electron microsbopic observations were carried out of the adrenal cortex on the stressed rats. The experiments were carried out as follow : non-stressed after saline injection (S-NS-AD), stressed after saline injection (S-S-AD), non-stressed after ginseng injection (G-NS-AD), stressed after ginseng injection (G-S-AD). Saline and ginseng extract were treated by peritoneal injection for 30 days. The results obtained are summarized as follows : Histologically a number of small lipid droplets are found more in S-S-AD group than in S-NS-AD group, whereas in ginseng treated groups numerous large lipid droplets are found. Histochemically cholesterol and its ester, glycolipid, phospholipid and glycogen are highly found in ginseng-treated groups. On the other hand, glycogen and cholesterol are also observed in S-S-AD group. Electron microscopically a numbers of lipid droplets are observed in S-S-AD, G-NS-AD and G-S-AD group, especially large lipid droplets and moderate glycogen are found in G-NS-AD and G-S-AD group. In ginseng-treated groups and S-S-AD group, dilated SER, extended intercellular space and dense bodies are observed, and the filopodiae are found in G-S-AD group. These data suggest that ginseng was activate the metabolism and synthesis of the adrenal cortical cells on the stress.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.5
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• pp.1049-1058
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• 2017

The rapid evolution of mobile technologies and proliferation of mobile devices have created a new channel for marketing by mobile advertising. As mobile advertising is a close relative to online advertising, it also has similar problems such as advertisement injections (Ad injections). Users are exposed to unwanted advertisements and redundant web traffic by injected ads can cause additional charges of mobile devices. Although mobile ad injection can cause many problems it has been merely studied. In this paper, we analyze ad injection activities by mobile applications that exploit a legitimate application (Naver mobile application). We reverse-engineered 2 mobile applications and find out characteristics of mobile ad injections. We compare mobile ad injections with online ad injections and suggest feasible mitigations.

• Biomolecules & Therapeutics
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• v.8 no.3
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• pp.241-247
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• 2000

The present study was designed to assess the protective effect of a selective thromboxane $A_2$ receptor antagonist, KT2-962 (KT2) and possible mechanisms of adriamycin(AD)-induced nephrotoxicity in rats. The male Wistar rats were given either of AD (7.5 mg/kg, i.v.) alone in the AD-group (n=5) or in KT2+AD- group (n=5) which is a combination of AD and KT2 (30 mg/kg/day, i.p.) for 10 days from 3 days before and 7 days after AD injection. The body weight, 24-hours urine volume, urine protein and urinary N-acetyl-$\beta$-D-glu-cosaminidase (NAG) activity were measured with an interval of 2 days during 1 week. BUN, serum creatinine and creatinine clearance were measured on the 7th day. KT2 has significantly suppressed AD-induced change of body weight, 24-hours urine volume, urine protein and urinary NAG activity in the KT2+AD-group. The change of BUN, serum creatinine and creatinine clearance were significantly inhibited in the B7T2+AD-group. Based on these results, it is concluded that KT2 prevents AD-induced nephrotoxicity and suggests that endogenous thromboxane A2 may play an important role in AD-induced nephrotoxicity in rats.

• BMB Reports
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• v.43 no.12
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• pp.781-788
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• 2010

An often overlooked issue in the field of adenovirus (Ad)-mediated cancer gene therapy is its limited capacity for effective systemic delivery. Although primary tumors can be treated effectively with intralesional injection of conventional Ad vectors, systemic metastasis is difficult to cure. Systemic administration of conventional naked Ads leads to acute accumulation of Ad particles in the liver, induction of neutralizing antibody, short blood circulation half-life, non-specific biodistribution in undesired organs, and low selective accumulation in the target disease site. Versatile strategies involving the modification of viral surfaces with polymers and nanomaterials have been designed for the purpose of maximizing Ad anti-tumor activity and specificity by systemic administration. Integration of viral and non-viral nanomaterials will substantially advance both fields, creating new concepts in gene therapeutics. This review focuses on current advances in the development of smart Ad hybrid nanocomplexes based on various design-based strategies for optimal Ad systemic administration.

• Journal of Veterinary Science
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• v.25 no.3
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• pp.36.1-36.15
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• 2024

Importance: The intravenous administration of adipose tissue-derived mesenchymal stem cells (AdMSCs) in veterinary medicine is an attractive treatment option. On the other hand, it can result in severe complications, including pulmonary thromboembolism (PTE). Objective: The present study assessed the occurrence of PTE after the intravenous infusion of canine AdMSCs (cAdMSCs) into experimental animals. Methods: Five-week-old male BALB/c hairless mice were categorized into groups labeled A to G. In the control group (A), fluorescently stained 2×10⁶ cAdMSCs were diluted in 200 µL of suspension and injected into the tail vein as a single bolus. The remaining groups included the following: group B with 5×10⁶ cells, group C with 3×10⁶ cells, group D with 1×10⁶ cells, group E with 1×10⁶ cells injected twice with a one-day interval, group F with 2×10⁶ cells in 100 µL of suspension, and group G with 2×10⁶ cells in 300 µL of suspension. Results: Group D achieved a 100% survival rate, while none of the subjects in groups B and C survived (p = 0.002). Blood tests revealed a tendency for the D-dimer levels to increase as the cell dose increased (p = 0.006). The platelet count was higher in the low cell concentration groups and lower in the high cell concentration groups (p = 0.028). A histological examination revealed PTE in most deceased subjects (96.30%). Conclusions and Relevance: PTE was verified, and various variables were identified as potential contributing factors, including the cell dose, injection frequency, and suspension volume.

• Journal of Dental Anesthesia and Pain Medicine
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• v.19 no.3
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• pp.143-149
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• 2019

Background: Uncooperative behavior of children due to dental anxiety may interfere with the effective delivery of dental care and compromise the quality of treatment provided. Injection of local anesthesia is one of the most anxiety-inducing stimuli in pediatric dentistry. This study aimed to compare the efficacy of a child-friendly device, having a combined effect of vibration and distraction, with the conventional method of injection on pain, anxiety, and behavior of pediatric patients aged 6-11 years. Methods: This randomized, crossover, split-mouth study included 30 children requiring a bilateral inferior alveolar nerve block. The children were equally divided into two groups: group 1, aged 6-8 and group 2, aged 9-11 years. All children were injected with anesthesia using the conventional and device method in two separate sessions. They were assessed for anxiety by measuring the pulse rate before and during the administration of local anesthesia. Behavior was assessed using Faces, Legs, Activity, Cry, Consolability (FLACC) scale, and the child's experience while receiving anesthesia was assessed using the Wong Bakers Pain Rating Scale. Results: Results showed that the children who received local anesthesia using the device method had a lower mean pulse rate, FLACC scores, and pain rating scores than those who received local anesthesia using the conventional method. Conclusion: The device method was more effective than the conventional method in managing pain, anxiety, and behavior of patients aged 6-11 years. The device is a cost effective, simple, and child-friendly product for administrating local anesthesia in pediatric patients.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.501-509
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• 2022

Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy. Although overexpression of MAPK mRNA in the skin tissue has been shown in the AD model, the roles of each MAPK in AD pathogenesis have rarely been studied. This study examined the effect of NJK14047, an inhibitor of p38 MAPKs, on AD-like skin lesions induced in BALB/c mice by sensitization and challenges with 1-chloro-2,4-dinitrobenzene (CDNB) on dorsal skin and ears, respectively. After induction of AD, NJK14047 (2.5 mg/kg) or dexamethasone (10 mg/kg) was administrated for 3 weeks via intraperitoneal injection. Following its administration, NJK14047 suppressed CDNB-induced AD-like symptoms such as skin hypertrophy and suppressed mast cell infiltration into the skin lesions. It also reduced CDNB-induced increase in T_H2 cytokine (IL-13) and T_H1 cytokines (interferon-γ and IL-12A) levels but did not decrease serum IgE level. Furthermore, NJK14047 blocked CDNB-induced lymph node enlargement. These results suggest that NJK14047, a p38 MAPK inhibitor, might be an optimal therapeutic option with unique modes of action for AD treatment.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.723-726
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• 2001

The design of delivery system is one of the most important subject in injection molding. Delivery system is a channel to flow the polymer melt from the injection molding machine to the mold cavities and affect quality and productivity of the part. The synthesis of delivery system of injection molding has been done empirically, since it requires profound knowledge about the moldability and causal effects on the properties of the part, which are not available to designers through the current CAD systems. A knowledge-based CAD system is constructed by adding the knowledge module to an existing geometric modeler and contains knowledge to permit non-experts ad well as mold design experts to generate the acceptable geometries of gate and runner for injection molded parts.

• Journal of Acupuncture Research
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• v.22 no.5
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• pp.1-10
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• 2005

Objectives : The Present study was carried out to investigate the preventive effect of Anti-diabetic prescription 1(AD-1) on streptozotocin(STZ)-induced diabetic nephropathy. Methods : AD-1 consists of eleven herbs that have an effect on diabetes mellitus. AD-1 was given to rats with the combination of oral administration and herbal-acupuncture stimulation. The experimental animals were divided into 3 groups : normal group of rats, control group of STZ-induced diabetic rats, sample group with AD-1 treatment. Experimental diabetes was induced by the injection of STZ(60mg/kg) to e rat via the peritoneum. The effect of AD-1 on STZ-induced diabetic nephropathy was observed by measuring the serum level of creatinine and BUN. Urine secretion of albumin for 24 hours and urine level of glucose measures too. Anti-oxidative stress of AD-1 administration in living body was estimated by measuring lipid peroxide and GSH content in cortex of kidneys. Results : STZ induced increase of serum creatinine, BUN and albumin secretion were lowered by AD-1 treatment. Conclusion : The AD-1 treatment showed protective effect on rat diabetic nephropathy model, and action mechanism of the effect was thought to be concerned with anti-oxidative stress.