• 국토계획
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• 제53권6호
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• pp.19-38
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• 2018

The purpose of this study is to examine the impacts of neighborhood sports activity facilities on the exercise time and subjective health level using the National Sport Participation Survey data(2013-2015) in Seoul, Korea. We conducted path analysis including exercise time, subjective health level and various environmental factors. From the survey data, we extracted individual's characteristics including subjective health and exercise time. In addition, we calculated physical environment variables of neighborhood units. The results of this study are as follow. First, most of moderating variables such as gender, age, income and job showed expected relationships with exercise time or subjective health level. Second, the perceived level regarding neighborhood sports facilities such as public sports facilities had a strong positive association with exercise time and subjective health level. Third, the area of public sports facility, neighborhood park and the number of schools had positive effects on the exercise time and subjective health level. Lastly, land use mix and the number of intersections showed a positive effects on exercise time. To sum up, the results indicated that public sports facility, neighborhood park and perceived environment on neighborhood sports facility are critical factors of residents' exercise time and subjective health level.

• 한국CDE학회논문집
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• 제6권3호
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• pp.157-168
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• 2001

The description of enterprise activities is the basis fur process improvement and information system building. To describe such activities, it is necessary to model the enterprise activities from the abstraction level to the implementation level in a stepwise and integrated form. For this reason, several modeling approaches have been proposed. However, most of them lacked the stepwise or integration aspects although some of them covered overall levels. This study proposes the hierarchical modeling approach for integrating the enterprise activity model from the abstraction level to the implementation level systematically. It is composed of five modeling levels such as function level, process level, task level, document workflow level, and event flow level. This study discusses the definition and characteristics of each level and compare our modeling frame with other modeling methodologies in case study.

• 대한간호학회지
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• 제29권3호
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• pp.639-655
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• 1999

An explanatory design was employed to identify the relationship of physical, emotional & social readjustment and social support of post hospitalized stroke patients and their caregivers. A convenient sample of 254 patients who given follow-up care at the outpatient department after discharge and 225 caregivers were recruited. Mental Status Questionnaire (MSQ), Social Support Inventory Stroke Survivors (SSISS), Illness intrusiveness(II), Instument Activity of Daily Living(IADL), Center of Epidemilogic Studies-Depression(CES-D), social activity and caregiver burden were used for measurement in this study. Results showed patient's physical level measured by IADL and psychological level measured by depression were high. But social activity was low. Cognitive function, depression & social activity were not significantly different by the posthospitalized period, but IADL was. The source of professional support was mostly the physician at the outpatient department. The family support was found significantly related to patient's depression & social activity and caregiver's subjective burden. Professional support was found significantly related to patient's IADL & depression. Illness intrusiveness as a mediating variable was a sig nificantly predicting power on patient's IADL & depression. The path analysis was used to identify the variables to predict the physical, emotional, and social status of patients. As a result, patient's age, cognitive function, illness intursiveness and professional support significantly predicted the level of IADL ; patient's cognitive function, illness intrusiveness and family support significantly predicted the level of depression ; and patient's age and family support significantly predicted the level of social activity of posthospitalized stroke patients. Based upon these results, the rehabilitation programs to reduce the illness intrusiveness and improve cognitive funtion were recommended for the readjustment of the stroke patients. This model of the readjustment of the posthospitalized stroke patients is recommended as the framework for care of the stroke patients.

• Toxicological Research
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• 제14권4호
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• pp.587-594
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• 1998

In order to understand the mechanism if the regulation of CYP 1A1 gene expression and ethoxyresorufin deethylase (EROD) activity in ex vivo system, we have studied the action of TCDD and 3MC in the isolated perfused female rat liver. CYP1A1 mRNA level and EROD activity were measured in rat liver that was isolated and perfused with various chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3MC), 17$\beta$-estradiol (E$_2$), morin. TCDD or 3MC alone perfusion into female rat liver resulted in increase of CYP 1A1 mRNA level and the magnitude of stimulation was six times higher with TCDD treatment than 3MC treatment. However E$_2$ perfusion into female rat liver showed inhibition of CYP 1A1 mRNA level. When 10$^{-8}$ M E$_2$ was administered concomitantly with either 10$^{-9}$ M TCDD or 10$^{-9}$ M 3MC, stimulated CYP 1A1 mRNA by either TCDD or 3MC was inhibited. Morin was examined for its effects on CYP 1A1 mRNA level and result was similar to that was observed with estrogen. EROD activity was also stimulated with either TCDD or 3MC perfusion, and the magnitude of EROD stiumlation was smaller than that of CYP 1A1 mRNA stimulation in response to TCDD or 3MC perfusion. Unlike CYP1A1 mRNA level, stimulation of EROD activity was greater with 3MC than TCDD. Concomitant perfusion either E$_2$ or morin with TCDD or 3MC inhibited 3MC perfusion or TCDD perfusion stimulated EROD activity. These data suggested that TCDD and 3MC might act diffrently in terms of regulation of CYP 1A1 gene expression in rat liver.

• 한국융합학회논문지
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• 제13권5호
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• pp.237-247
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• 2022

본 연구는 급속한 고령화 시대에서 우리나라의 고령층의 경제활동 수준을 다양한 머신러닝 기법으로 정확히 예측하고자 하였다. 고령층의 경제활동 수준과 기존 연구들은 고령층의 삶의 만족도, 사회보장제도 등과 연관된 인과성 검증을 중심으로 이루어진 데 반해, 본 연구는 다양한 머신러닝 기법으로 고령층의 경제활동 수준을 예측하였으며, 특히 예측조합법을 함께 사용함으로써 예측의 안정성을 도모하였다. 60세 이상의 경제활동참가율, 취업률 등을 종속변수로 하고 가구 특성, 소득, 평균임금 등을 설명변수로 설정하여 서로 다른 특성을 지닌 5가지의 머신러닝 기법과 2가지의 예측조합법을 적용하여 예측결과들을 비교하였다. 분석 결과, 종속변수별, 예측구간별로 예측성능이 높은 머신러닝 기법 및 예측조합법은 상이하였으나, 예측의 안정성 측면에서는 예측조합법이 상대적으로 우수한 것으로 나타났다. 이에 따라, 본 연구는 고령층의 경제활동 수준을 정확히 예측하고 예측의 안정성을 도모하여 정책적 관점에서도 실용성을 제고한다고 볼 수 있다.

• 근관절건강학회지
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• 제22권3호
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• pp.236-244
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• 2015

Purpose: The purpose of this study was to investigate physical activity of elderly women at senior citizen centers and to identify factors influencing physical activity. Methods: The study was conducted from February 22 to April 20, 2013 for 200 elderly women at senior citizen centers in J City. Levels of physical activity, cognitive function, and nutritional status were measured. Results: The total physical activity amount was $2118.94{\pm}2.36$ MET-min. The average cognitive function score was $21.17{\pm}4.63$, and the average nutritional status score was $24.04{\pm}3.37$. There were significant relationships among physical activity, cognitive function, and nutritional status. In addition, there were significant differences of groups of physical activity by levels of cognitive function and nutritional status. Cognitive function, nutritional status, and age were significantly associated with level of physical activity in elderly women. Conclusion: The results showed many older women were doing moderate physical activity. Physical activity was associated with cognitive function and nutritive conditions. Integrated health promotion program needs to be implemented to increase physical activity level, the cognitive function, and nutritive conditions in elderly women.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.885-888
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• 2002

Four diarylheptanoids, (5R)-1,7-bis (3,4-dihydroxyphenyl)-heptane-5-O-$\beta$-D-glucoside (1), (5R)-1,7-bis (3,4-dihydroxyphenyl)-heptane-5-ol (2), oregonin (3), hirsutanonol (4), were isolated from the bark of Alnus hirsuta Turcz and its inhibitory effects on melanogenesis by measuring the melanin level and tyrosinase activity in B16 melanoma cell were examined. Melanin level and tyrosinase activity were reduced to 75 to 85% by addition of diarylheptanoids to incubation medium of the melanoma cell. On the other hand, melanin level and tyrosinase activity were reduced to 13 to 43% by the addition of diarylheptanoids to incubation medium of the melanoma cell treated with melanogenesis stimulator, $\alpha$-MSH and forskolin. These melanogenesis inhibitory effects were significantly different compared with control.

• 한국IT서비스학회지
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• 제10권4호
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• pp.33-46
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• 2011

This research focus on the economic activity as consumer and producer traits of future customers in the convergence age. We assess level of convergence for digital devices and services respectively by questionnaire survey and interview for 14 professions. And then, for evaluating convergence level and usage of digital services of each respondents, we conducted the questionnaire survey for 343 samples. Findings of our research hold that the group who showed higher level of convergence tends to use the socialized digital services more. Convergence generation were heavy users in appstore on smart-phone and wireless game and more participating. In digital service area, facebook/cyworld, twitter, UCC, portal, internet community in digital service. Convergence generation are global network communication, buying decision making activity, actively opinion expression, prosumer attitude, dependency on digital device, experience based purchase behavior, enthusiastic information sharing.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.318-318
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• 1994

Addition of AAF to murine splenocytes culture produced a dose-related suppression of lymphoproliferative response to lipopolysaccharide (LPS). The time course of the suppression showed that a significant inhibition was occured after a 18 hr AAF treatment. Total protein kinase C activity in splenocytes was decreased to 72% of control level after a 18 hr AAF treatment. Phosphorylation of a PKC specific 80 kDa protein was increased by LPS and AAF down-regulated LPS-induced PKC activity. LPS-induced phosphorylation of overall proteins in membrane and cytosolic fraction were also decreased by the treatment of AAF. A significant increase of PKC activity in membrane fraction was noticed within 10 min of AAF treatment compared to LPS alone and then gradually decreased to LPS level in 60 min. Meanwhile, PKC activity in cytosolic fraction was increased slightly in 10 min by the treatment of AAF and then decrease to 80% LPS level in 30 min. These results suggested that suppressive effect of AAF on LPS-induced lymphoproliferative response may be associated with the down-regulation of PKC and other susceptible kinases in spleen cells.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.47-51
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• 2013

Background: Postoperative complications after esophagectomy can lead to considerable patient discomfort and prolonged length of hospital stay. Lack of physical activity can be one of the independent risk factors for postoperative complications because physical activity is closely related to physical function. The objective of this study was to determine whether physical activity among esophageal cancer patients decreases their risk of postoperative complications after esophagectomy. Materials and Methods: We investigated 51 consecutive patients with newly diagnosed resectable esophageal cancer who were scheduled to receive esophagectomy between January 2009 and November 2011. Demographic, clinicopathologic, and treatment information were recorded and physical function was measured. The last 7-days short version of the International Physical Activity Questionnaire was used to assess physical activity before the operation. Stepwise multiple logistic regression analysis was used to determine whether preoperative physical activity is related to the risk of postoperative complications. Results: Male gender [OR 18.6, (95%CIs: 1.2-284.4); P=0.035], 3-field lymph node dissection (OR 9.6, [95%CIs: 1.4-66.6]; P=0.022), low-level physical activity (OR 28.3, [95%CIs: 3.5-227.7]; P=0.002), and preoperative comorbidities [OR 5.9, (95%CIs: 1.1-31.5); P=0.037] were found to be independently associated with postoperative complications. Conclusions: The present study shows that low-level physical activity, preoperative comorbidities, and 3-field lymph node dissection are independent and significant risk factors for postoperative complications after esophagectomy. Although further study is required, maintaining high-level physical activity preoperatively may decrease the risk of postoperative complications.