• KSBB Journal
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• v.24 no.1
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• pp.101-105
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• 2009

Alcohol oxidation activities and optimization of extraction conditions of Rrhus verniciflua Stokes (RVS) extract were evaluated for the development of a functional biomaterial for improving liver function. When alcohol oxidation activities of RVS was analyzed, the Rrhus verniciflua Stokes bark (RVSB) were higher than the Rrhus verniciflua Stokes heartwood (RVSH). Alcohol oxidation activity value of RVSB increased in a concentration-dependent manner. In the comparative analysis between Hovenia dulcis Thunb (HOT) and Alnus japonica Steud (AJS) which was reported as a alcohol oxidation material, alcohol oxidation activity is much higher than the others. The experimental conditions were optimized for alcohol oxidation-active components production from RVSB. The extraction conditions such as temperature, time, pH and particle size were performed. It was recommended to extract the alcohol oxidation-active components from RVSB by hot water (pH 7.0) at $85^{\circ}C$ for 8 hours.

• Journal of Integrative Natural Science
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• v.4 no.4
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• pp.315-322
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• 2011

This study was performed to investigate the current regulatory guidances of safety and efficacy evaluation for the approval of stereoisomeric drugs in Korea and US. According to the regulatory guidelines in major countries (EU, Canada, US), the important categories for the development of stereoisomeric drugs are classified as 1) development of a single enantiomer as a new active substances 2) development of a racemate as a new active substance 3) development of a new single enantiomer from an approved racemate. For this study, domestic regulatory documents for current guidelines of stereoisomeric drugs were investigated. Also four typical stereoisomeric drugs for three categories were chosen to investigate the new drug submission documents of KFDA and FDA for the safety and efficacy evaluation of stereoisomeric drugs. It is expected that these comparative results between KFDA and FDA will be useful for the safety and efficacy for the regulatory approval of stereoisomeric drugs in Korea.

• Journal of Veterinary Clinics
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• v.25 no.5
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• pp.370-378
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• 2008

The aim of this study was to investigate bioactivities of 50% Chitin - hydroxyapatite (Chitin-H) compound and 50% Chitosan - hydroxyapatite (Chitosan-H) compound in canine bone. Ten healthy mongrel dogs (1-5 years old, 1.7 - 6.9 kg) were used in this study. These compounds had been transplanted into bilateral femur separately, and then the changes of femur were observed through the examinations of hemato-biochemical profiles, radiology, and histological profiles for 42 days. After 3 weeks, expanded radiolucent changes were observed in both areas transplanted the compounds. After 6 weeks, the area transplanted the Chitin-H compound did not observe any changes of bony tissue, while the area inserted the Chitosan-H compound was observed changes of increasing bone formation. In histological examination, infiltrations of inflammatory cells and bone absorptions were observed at both transplanted sites. However an increasing of active osteogenesis was observed at the transplanted site with Chitosan-H compound. In conclusion, Chitosan-H compound had an function of active osteogenesis as compared with Chitin-H compound. From this study, it is indicated that Chitosan-H compound would be used in dogs with severe bone defect.

• Journal of Auto-vehicle Safety Association
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• v.10 no.4
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• pp.25-32
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• 2018

Due to the rapid increase in the number of vehicles, the physical and human losses caused by traffic accidents have become serious social problems. In the global trend, there have been active studies conducted on improving safety level of automobile in order to reduce the number of automobile accident. As a result of such research, traffic accidents continue to decline. In the case of South Korea, however, rate of death by automobile accident is 8.5 per 10,000 people and it is a seven rank among the countries in OECD (Organization for Economic Cooperation and Development). This average rate is almost double compared to average automobile accident rate per 10,000 vehicles, of other OECD countries in 2015. Consequently, many studies and policies currently have been conducted and made for increasing safety of pedestrians; however, they are only emphasizing characteristics of pedestrians and drivers. For this reason, this study suggests scenarios for establishment of test standard corresponding with domestic environment and international standard of AEB (Autonomous Emergency Braking) and conducts a real car test by scenarios by setting up a goal with a function for remaining distance after braking and then examine equation by comparing real car tests results and outcome after calculation. This is a theoretical method to predict a relative remaining distance after AEB prior to conducting a real car test for evaluation of safeness of automobile with AEB and it is expected that it solves problem of complication of real car test.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.418-426
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• 2021

This study investigates the perception of radiation safety management in radiation generator manufacturing workers and medical institutions. The basic data obtained is further applied to improve active coping ability and safety levels. The knowledge and attitude practice score of radiation was found to be related to gender, age, marital status, occupation, position, current work period, total work period, radiation related work period, the manual available, defense facility maintenance, number of defense equipment, radiation safety education, special health examination, and recognition of radiation terms. In particular, the knowledge score of radiologists was highest among the radiation-related occupations (<0.05). Radiation safety management requires active defense endeavors to prevent radiation exposure, by both workers of radiation manufacturers and medical institutions. Moreover, institutional devices such as compliance with guidelines, periodic education, facility reinforcement, manual preparation, and special health checkups are required for efficient radiation safety management.

• Journal of Preventive Medicine and Public Health
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• v.47 no.1
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• pp.47-56
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• 2014

Objectives: The purpose of this study was to investigate the current status of and problems with the Safe Community Programs in Gangbuk-gu, one of the 25 districts of the capital city of Korea. Methods: The study subjects were 396 individuals who were involved in Safe Community Programs between 2009 and 2011. We examined the effectiveness and willingness of respondents to participate as a safety leader of the Safe Community Program with a questionnaire. We examined the injury death rates of Gangbuk-gu by using of the death certificate data of Korea's National Statistical Office. Descriptive statistics and chi-squared tests were used. Results: The effectiveness of programs did not differ but active participation differed significantly among subjects (p<0.05). The injury death rate of Gangbuk-gu as a whole increased during the implementation period. However, senior safety, in particular, may be a helpful program for reducing injuries in Gangbuk-gu. Conclusions: This study suggests that the lack of active participation may be a major problem of Safe Community Programs in Gangbuk-gu. Therefore, Safe Community Programs should be expanded to the entire district of Gangbuk-gu and more active participation programs should be developed.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.15 no.3
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• pp.281-299
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• 2017

The inventory management of radionuclides is essential for the safe management of disposal facilities. In this study, we compared the activity of dry active waste predicted using the generated waste data and that measured for the accepted waste in the disposal facility. For very low level waste, the measured activity was higher than the predicted activity for $^{137}CS$, $^{90}Sr$, $^{99}Tc$ and $^{129}I$. In low level waste, the predicted activity was higher than the measured activity for all radionuclides. We also evaluated the variation in the predicted quantity and total activity of each level of dry active waste through a sensitivity analysis on a scaling factor. This result will contribute to the construction of a Safety Case and safe operation of disposal facilities.

• Geotechnical Engineering
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• v.4 no.1
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• pp.7-16
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• 1988

The safety factor has been used widely and uniquely at present to check the safety of the structure . However, probability of failure would be logically attempted to check the reliability of the structure in future Coulomb's theory or Rankine's theory has been applied in practice to retaining earth structure in spite of the fact that the lateral earth pressure, which is the primary factor in the determination of wall structure, depends on the modes of wall movement . This study is concentrated on the two modes of , wall movement (active case rotation about bottom(AB) , active case rotation about top(AT)) of the overturning'failure of vertical wall with horizontal sand backfill . The static active earth pressure is determined by applying each of Coulomb's theory, Dubrova's redistribution theory and Chang's method The earthquake active earth pressure is determined by adding Seed and Whitman's earthquake pressure to the static earth pressure , On the condition that design variables are fixed with each of the above earth pressure, reliability is analyzed using the recently developed method of AFOSM (Advanced First Order Second Moment)

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1027-1028
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• 2008

Most of the urban transit operation company in Korea have a passive surveillance system to monitor the status of the passengers and facilities in the urban transit service area. The surveillance system is based on CCTV, closed circuit television, and several sensors, such as a fire sensor. However, this system has some limitations to prevent and cope with the emergency quickly. So the urban transit operation companies have plans to be change their surveillance system to be active. The active surveillance system has an intelligent function to detect the event predefined by managers automatically. To construct the active surveillance system, there are a standard concept design and a function analysis. In this paper, we propose the classification of the functions of the active surveillance system for urban transit. We divide the functions into five parts, ordinary monitoring, safety monitoring, environment monitoring, administration support, and record management. And we describe the systems related to the every functions to clarify the classified functions.

• Geomechanics and Engineering
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• v.17 no.6
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• pp.515-525
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• 2019

The calculation of active earth pressure behind retaining wall is a typical three-dimensional (3D) problem with spatial effects. With the help of limit analysis, this paper firstly deduces the internal energy dissipation power equations and various external forces power equations of the 3D retaining wall under the nonlinear strength condition, such as to establish the work-energy balance equation. The pseudo-static method is used to consider the effect of earthquake on active earth pressure in horizontal state. The failure mode is a 3D curvilinear cone failure mechanism. For the different width of the retaining wall, the plane strain block is inserted in the symmetric plane. By optimizing all parameters, the maximum value of active earth pressure is calculated. In order to verify the validity of the new expressions obtained by the paper, the solutions are compared with previously published solutions. Agreement shows that the new expressions are effective. The results of different parameters are given in the forms of figures to analysis the influence caused by nonlinear strength parameters.