• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2001.10a
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• pp.75-79
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• 2001

In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research on dynamic characteristics is very deficient. In this paper, the helical spring are fabricated with NiTi SMA wire of high resistivity, The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMA is analyzed. Also, bidirectional actuator was fabricated and experimented for its performance.

• 연구논문집
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• s.23
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• pp.73-80
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• 1993

This study presents an intelligent PID control method based on the fuzzy logic and this method is applied to the active magnetic bearing system. By using an appropriate fuzzy matrix, some changes of values of the three coefficients of the controller are determined during system operation and these lead to the improvement of the transient and steady state behavior of the closed loop system. The presented method is actually a combination of the principles of PID control and fuzzy logic. Since the fuzzy logic using linguistic variables in place of numeric variables has many points of likeness to the human logic, the improvement in performance is notable especially in case of large nonlinearity and uncertainty such as the controller start and the excessive mass unbalance. A set of simulation and experimental results illustrate and considerable improvement in the control performance including small overshoot and small transient currents in magnet coils, while maintaining the overal static and dynamic characteristics near the equilibrium position.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.199-202
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• 2006

The objective of this study is to propose methods of controlling the wake behind a sphere for drag reduction using the suboptimal control theory and surrogate management framework, respectively. The Reynolds numbers considered is 300 at which the base flow is unsteady planar symmetric. Given the cost function defined as the square of the difference between the target pressure (potential-flow pressure) and real flow pressure on the sphere surface, the suboptimal control makes the flow steady axisymmetric and produces drag reduction. Based on the actuation profile from the suboptimal control, the optimal wavy actuation profile is obtained using the surrogate management framework and produces drag reduction.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.309-312
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• 2006

Effective mixing is an important problem in microfluidics for chemical and biomechanical applications. In this study, the influences of the Reynolds number and the oscillating frequency on mixing characteristics of micro-stirrer are studied in a microchannel with single stirrer. The influence of fluid inertial effects in an active mixer is first discussed. It is found that the stirring effects by stirrer oscillation are promptly attenuated at low Reynolds number, which makes greatly difficult the rapid mixing. As the inertial effects are increased, the chaotic advection is generated and then developed. The mixing phase is finally developed some mushroom shaped structure. And the mixing efficiency is also studied as a function of the oscillating frequency. We found that the mixing efficiency does not always increase with higher oscillating frequency of stirrer. Consequently, we found the functional relation between the optimal frequency of a stirrer and the Reynolds number.

• BMB Reports
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• v.35 no.1
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• pp.24-27
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• 2002

Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.10a
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• pp.47-52
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• 2003

In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research on dynamic characteristics is very deficient. In this paper, the helical spring are fabricated with NiTi SMA wire of high resistivity. The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMA is analyzed. Also, bidirectional actuator was fabricated and experimented fir its performance.

• Molecular & Cellular Toxicology
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• v.3 no.1
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• pp.46-52
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• 2007

In the course of novel TLR (Toll like receptor) 9 ligand, we found novel CpG ODN (Oligodeoxynucleotide) was active in augmenting antibody in mice. However, immune mechanism of new CpG ODNs is unclear. To clarify this, we examined immunoadjuvanticity by employing in vitro and in vivo immune profiles. In brief, in vitro treatment of novel CpG ODN upregulated the expression of TNF-$\alpha$, IL-6, and IL-12 mRNA in macrophages as well as that of IFN-$gamma$ mPNA in mouse splenocytes. In parallel, in vivo injection of novel CpG ODN directly activates macrophages and splenocytess, consequently upregulating MHC class II and CD86. Finally, we demonstrated anti-HBs antibody augmentation of novel CpG ODN. Collectively, this data indicates that novel CpG ODN is immunoadjuvant armed with Th1 typed immune machinery.

• Molecules and Cells
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• v.41 no.11
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• pp.933-942
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• 2018

Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often limited by recurring drug resistance. More importantly, not all molecular targets are enzymes or receptors with druggable 'hot spots' that can be directly occupied by active site-directed inhibitors. Recently, a promising new paradigm has been created, in which small-molecule chemicals harness the naturally occurring protein quality control machinery of the ubiquitin-proteasome system to specifically eradicate disease-causing proteins in cells. Such 'chemically induced protein degradation' may provide unprecedented opportunities for targeting proteins that are inherently undruggable, such as structural scaffolds and other non-enzymatic molecules, for therapeutic purposes. This review focuses on surveying recent progress in developing E3-guided proteolysis-targeting chimeras (PROTACs) and small-molecule chemical modulators of deubiquitinating enzymes upstream of or on the proteasome.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.755-758
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• 1997

In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research of dynamic characteristics is very deficient. In this paper, the helical spring is fabricated with NiTi SMA wire of high resistivity The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMA actuator is analyzed.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.04a
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• pp.346-351
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• 2003

In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research on dynamic characteristics is very deficient. In this paper, the helical spring are fabricated with NiTi SMA wire of high resistivity. The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMT is analyzed. Also, bidirectional actuator was fabricated and experimented for its performance