• Bulletin of the Korean Chemical Society
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• v.26 no.6
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• pp.952-958
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• 2005

Angiotensin-converting enzyme (ACE) is known to be primarily responsible for hypertension. Threedimensional quantitative structure-activity relationship (3D-QSAR) models have been constructed using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a series of 28 ACE inhibitors. The availability of ACE crystal structure (1UZF) provided the plausible biological orientation of inhibitors to ACE active site (C-domain). Alignment for CoMFA obtained by docking ligands to 1UZF protein using FlexX program showed better statistical model as compared to superposition of corresponding atoms. The statistical parameters indicate reasonable models for both CoMFA ($q^2$ = 0.530, $r^2$ = 0.998) and CoMSIA ($q^2$ = 0.518, $r^2$ = 0.990). The 3D-QSAR analyses provide valuable information for the design of ACE inhibitors with potent activity towards C-domain of ACE. The group substitutions involving the phenyl ring and carbon chain at the propionyl and sulfonyl moieties of captopril are essential for better activity against ACE.

• Journal of Digital Contents Society
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• v.15 no.5
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• pp.621-630
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• 2014

The purpose of this study is to extract metaphor characteristics of Social Network Service. Social Network Service is different from existing media only available in one-way communication, each individual expands opinion by sharing daily life and opinion directly and interpreting another user's post. This Study premise that the reason of converting from passive reader to active enunciator is the metaphor characteristics of Social Network Service by 'Source Domain' and 'Target Domain'. In addition, this study examines the meaning of structure user's text production and interpreting based triple mimesis of Paul Ricoeur. This study has significance as arguing with existing study on SNS as metonymic media and suggesting metaphor characteristics and meaning of Social Network Service.

• Journal of Home Health Care Nursing
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• v.24 no.2
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• pp.181-188
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• 2017

Purpose: The aim of this study was to compare between performance and requirements of visiting nursing care in long-term care insurance using the OMAHA system. Methods: The subjects were 72 nurses who had worked in a visiting nursing care center in long-term care insurance. Data were collected from December 5, 2016 to January 31, 2017 using self-recorded questionnaires. The collected data were analyzed using descriptive statistics and paired t-tests. Results: Four dimensions of the OMAHA system showed statistically significant differences between performance and requirements of visiting nursing care in long-term care insurance. The requirements of visiting nursing care were higher than was performance on all 40 items of the OMAHA system. The greatest difference was in environmental domain and then the psychosocial domain. Conclusion: Based on the results, we found that the environmental and psychosocial domains were the largest gap areas. Therefore, with the reality of elderly people living alone and the increase in elderly couples, active intervention connected with the community is needed in residential areas. Further, we suggest that the OMAHA system can be utilized as an integrated conceptual framework for developing and enhancing visiting nursing care in long-term care insurance.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.1
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• pp.83-92
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• 2000

Sound intensity method is well known as a visualization technique of sound field or sound propagation in noise control. Sound intensity or energy flux is a vector quantity which describes the amount and the direction of net flow of acoustic energy at a given position. Especially two dimensional sound intensity method is very useful in evaluating periodic characteristics and acoustic propagation mode of noise source. In this paper, we have studied the noise source Identification, acoustic sound field analysis, and characteristics of noise source of rotary compressor and scroll compressor for air conditioner using complex sound intensity method. Also we proposed a now method of time domain analysis which is used in evaluating of position of noise source in rotary and scroll compressor in this paper This paper presents the advantage, simplicity and economical efficiency of this method by analysing the characteristics of noise source with two dimensional complex sound intensity simultaneously.

• The Journal of the Acoustical Society of Korea
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• v.38 no.1
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• pp.96-105
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• 2019

Ocean reverberation is the most limiting factor in designing realistic and real-time system for sonar simulator. The simulation for an ocean reverberation requires a lot of computational loads, so it is hard to embed program and generate real-time signal in the sonar simulator. In this study, we simulate a time-domain bottom reverberation signal based on Harrison's energy-flux bottom reverberation model by applying Doppler effects as ship maneuvering and autoregressive model. Finally, the bottom reverberation signal with realistic characteristics could be generated for the simulation of ONR reverberation modeling workshop-I problem XI and East Sea ocean environments.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.23-32
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• 2023

Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection may cause clinical manifestations of multiple organ damage, including various neurological syndromes. There are currently two oral antiviral drugs-Paxlovid and molnupiravir-that are recognized to treat COVID-19, but there are still no drugs that can specifically fight the challenges of SARS-CoV-2 variants. Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is a multimolecular complex that can sense heterogeneous pathogen-associated molecular patterns associated with neurological disorders. The NLRP3 activation stimulates the production of caspase-1-mediated interleukin (IL)-1β, IL-18, and other cytokines in immune cells. Panax (P.) ginseng is a medicinal plant that has traditionally been widely used to boost immunity and treat various pathological conditions in the nervous system due to its safety and anti-inflammatory/oxidant/viral activities. Several recent reports have indicated that P. ginseng and its active ingredients may regulate NLRP3 inflammasome activation in the nervous system. Therefore, this review article discusses the current knowledge regarding the pathogenesis of neurological disorders related to COVID-19 and NLRP3 inflammasome activation and the possibility of using P. ginseng in a strategy targeting this pathway to treat neurological disorders.

• Development and Reproduction
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• v.27 no.1
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• pp.39-46
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• 2023

Pumilio (Pum) is an RNA-binding protein and translational repressor important to diverse biological processes. In the Drosophila ovary, Pum is expressed in female germline stem cells (GSCs), wherein it acts as an intrinsic stem cell maintenance factor via repressing target mRNAs that are as yet mostly unknown. Pum recognizes the Pum binding sequence (PBS) in the mRNA 3'UTR through its C-terminus Puf domain. Translational repression is mediated through its N-terminal domain, but the molecular mechanism remains largely unknown. We previously showed that Bag-of-marbles, a critical differentiation-promoting factor of female GSCs, physically interacts with the N-terminus of Pum. We further showed that this interaction is critical to Bam inhibition of Pum repressive action in cultured cells, but the physiological relevance was not addressed. Here we design an in vivo GFP translational reporter bearing the PBS in its 3'UTR and show that GFP expression is reduced in cells wherein Pum is known to be active. Furthermore, we demonstrate in pum mutant ovary that this GFP repression requires Pum, and also that the sensor faithfully monitors Pum activity. Finally, we show that forced expression of Bam inhibits Pum-mediated repression, validating that Bam inhibits Pum activity in vivo.

• Ocean Systems Engineering
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• v.13 no.4
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• pp.401-421
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• 2023

Reducing hawser line tensions and dynamic responses to a certain level is of paramount importance as the hawser lines provide important structural linkage between 2 body TLP-TAD system. The objective of this paper is to demonstrate how MR Damper can be utilized to achieve this. Hydrodynamic coefficients and wave forces for two bodies including second-order effects are obtained by 3D diffraction/radiation panel program by potential theory. Then, multi-hull-riser-mooring-hawser fully-coupled time-domain dynamic simulation program is applied to solve the complex two-body system's dynamics with the Magneto-Rheological (MR) Damper modeled on one end of hawser. Since the damping level of MR Damper can be changed by inputting different electric currents, various simulations are conducted for various electric currents. The results show the reductions in maximum hawser tensions with MR Damper even for passive control cases. The results also show that the hawser tensions and MR Damper strokes are affected not only by input electric currents but also by initial mooring design. Further optimization of hawser design with MR Damper can be done by active MR-Damper control with changing electric currents, which is the subject of the next study.

• Korean Journal of Microbiology
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• v.45 no.3
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• pp.239-245
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• 2009

Translation initiation factor eIF1A performs essential functions in various initiation steps including 43S preinitiation complex formation in eukaryotes, and contains a highly conserved oligonucleotide-binding (OB) fold. In our previous study, we discovered that eIF1A possesses RNA annealing activity and forms a stable complex with double-stranded RNA. In this study, we initiated site-directed mutations in eIF1A to find the active sites for these biochemical activities and to investigate whether they are essential functions for yeast cell growth. A truncated protein, eIF1A($\Delta$T), devoid of both N- and C-terminal domains but containing an intact OB-fold exhibited RNA annealing activity. In contrast, all point mutations in OB-fold domain, except R57D, impaired both RNA annealing and dsRNA binding activities, indicating that the intact OB-fold domain is required for both activities. Viabilities of the mutant yeast cells were not correlated with RNA annealing activity but with the in vivo protein stabilities in the case of R57D and K94D.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.88-90
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• 2012

This paper describes a 10-bit 10-MS/s asynchronous successive approximation register (SAR) analog-to-digital converter (ADC) with a rail-to-rail input range. The proposed SAR ADC consists of a capacitor digital-analog converter (DAC), a SAR logic and a comparator. To reduce the frequency of an external clock, the internal clock which is asynchronously generated by the SAR logic and the comparator is used. The time-domain comparator with a offset calibration technique is used to achieve a high resolution. To reduce the power consumption and area, a split capacitor-based differential DAC is used. The designed asynchronous SAR ADC is fabricated by using a 0.18 um CMOS process, and the active area is $420{\times}140{\mu}m^2$. It consumes the power of 0.818 mW with a 1.8 V supply and the FoM is 91.8 fJ/conversion-step.