• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.218-221
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• 1997

In this paper, we designed a myocaldial ischemia model based on L-R dynamic model including hyperkalemia and anoxia. Using the model, we simulated the effects of ionic concentration $[K^+]_o$ and intracellular $[ATP]_i$ on action potential in single cardiac cell. Also we evaluated this model by comparing the simulated results with that of other researches. In luther research, we are going to consider the effect of acidosis quantitatively.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.207-208
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• 1998

Classification of extracellularly recorded action potential into each unit is an important procedure for further analysis of spike trains as point process. We utilize feedforward neural network structures, multilayer perceptron and radial basis function network to implement spike classifier. For the efficient training of classifiers, nonlinear energy operator that can trace the instantaneous frequency as well as the amplitude of the input signal is used. Trained classifiers shows successful operation, up to 90% correct classification was possible under 1.2 of signal-to-noise ratio.

• Molecules and Cells
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• 제38권4호
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• pp.297-303
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• 2015

Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging. If potential treatments are to be developed to treat insulin resistance, then it is important to fully understand insulin signaling and glucose metabolism. While recent large-scale "omics" studies have revealed the acetylome to be comparable in size to the phosphorylome, the acetylation of insulin signaling proteins and its functional relevance to insulin-stimulated glucose transport and glucose metabolism is not fully understood. In this Mini Review we discuss the acetylation status of proteins involved in the insulin signaling pathway and review their potential effect on, and relevance to, insulin action in skeletal muscle.

• Annals of Clinical Neurophysiology
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• 제9권1호
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• pp.39-41
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• 2007

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.58-58
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• 2001

Even though atrial fibrillation is the most prevalent arrhythmia, the mechanism of development is not yet clear. Recently, there has been several reports that the most frequent source of paroxysmal atrial fibrillation is located inside pulmonary vein. Recently we successfully isolated single cardiac myocytes which were inside of pulmonary vein and reported the spontaneous action potential was generated from these cells.(omitted)

• International journal of advanced smart convergence
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• 제7권4호
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• pp.154-160
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• 2018

Sometimes, literature therapy is done by literature question. Participants naturally get the effect of literature therapy depending on when and what questions we ask. This study aims to lead the discussion of Gosijo's literature physiology ignited by the question. Gosijo, the subject of the study, described the depressed present state of the poetic narrator in the first and second line. By the way, poetic narrator asked a question in the first phrase of the last line and led the action potential. And in the second phrase of the last line, the poetic narrator called the code of sadness and the sadness code came. We have plotted this as Emotion Codon. The result of Emotion Codon at this time was that the narrative of Gosijo ignites the literature therapy mechanism through sadness.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.84.2-84.2
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• 2003

The number of patients suffering from atrial fibrillation is increasing and many cardiologists is trying to develop the ideal antiarrhythmic drugs for atrial fibrillation. An ideal antiarrhythmic agent would selectively prolong the action potential duration more in extraordinarily depolarized cardiac myocytes than in normal cells, and show tissue selectivity. Voltage-gated K$\^$+/ (Kv) channels represent a structurally and functionally diverse group of membrane proteins. These channels play an important role in determining the length of the cardiac action potential and are the targets for antiarrhythmic drugs. (omitted)

• Journal of Microbiology and Biotechnology
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• 제33권3호
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• pp.288-298
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• 2023

Host defense peptides are expressed in various immune cells, including phagocytic cells and epithelial cells. These peptides selectively alter innate immune pathways in response to infections by pathogens, such as bacteria, fungi, and viruses, and modify the subsequent adaptive immune environment. Consequently, they play a wide range of roles in both innate and adaptive immune responses. These peptides are of increasing importance due to their broad-spectrum antimicrobial activity and their functions as mediators linking innate and adaptive immune responses. This review focuses on the pleiotropic biological functions and related mechanisms of action of human host defense peptides and discusses their potential clinical applications.

• Biomolecules & Therapeutics
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• 제14권2호
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• pp.110-113
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• 2006

We tested effect of sarcotride A, a bioactive cyclitol derivative from a marine sponge, on membrane potential in C6 glioma cells. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded glioma cells. Sarcotride A increased membrane potential in a concentration-dependent manner. We tested effects of pertussis toxin, U73122, EIPA, and $Na^+-free$ media on sarcotride A-induced increase of membrane potential to investigate involvement of G proteins, phospholipase C, $Na^+/H^+$ exchanger, and $Na^+$ channels. However, we were not able to observe any significant effect of those pharmacological inhibitors, excluding the involvement of the molecules as candidate targets or signaling molecules of sarcotride A-induced increase of membrane potential. Further investigation is necessary to elucidate action mechanism of sarcotride A.

• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.52-56
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• 2021

There is no assurance that malware could only cause virtual damage to computer programs and data as its potential is endless. However, legal provisions were earlier developed to cater to either a physical damage caused by a physical action or a virtual damage caused by a virtual action. When crossovers occur, it becomes quite uncertain as to how viable the current laws are in handling this matter. The author seeks to address the issue from the perspective of the laws of Malaysia.