• Wind and Structures
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• 제14권3호
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• pp.221-238
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• 2011

The estimated response of large-scale engineering structures to severe wind loads is prone to modelling uncertainties that can only ultimately be assessed by full-scale testing. To this end ambient vibration data from full-scale monitoring of the historic Clifton Suspension Bridge has been analysed using a combination of a frequency domain system identification method and a more elaborate stochastic identification technique. There is evidence of incipient coupling action between the first vertical and torsional modes in strong winds, providing unique full-scale data and making this an interesting case study. Flutter derivative estimation, which has rarely previously been attempted on full-scale data, was performed to provide deeper insight into the bridge aerodynamic behaviour, identifying trends towards flutter at higher wind speeds. It is shown that, as for other early suspension bridges with bluff cross-sections, single-degree-of-freedom flutter could potentially occur at wind speeds somewhat below requirements for modern designs. The analysis also demonstrates the viability of system identification techniques for extracting valuable results from full-scale data.

• 한국신뢰성학회지:신뢰성응용연구
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• 제8권3호
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• pp.113-124
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• 2008

In reliability engineering, failure reporting, analysis, and corrective action system (FRACAS) is an useful tool for effective failure reporting and related operations. FRACAS is generally mainly focused on implementation of its closed-loop process, but also includes various related information which has to be effectively managed such as failure types, failure modes, failure mechanisms, and corrective actions. In this study, we adopt and utilize the concept of process knowledge, and create it through abstraction of FRACAS information. At each step of closed-loop process, the necessary type of knowledge, priority and usability are clearly defined. This study also suggests corresponding management tools such as business process management system, knowledge management system, and their key elements and functions to deal with process knowledge. A prototype system using simple closed-loop process with its process knowledge is presented to demonstrate the feasibility of the proposed work.

• 한국철도학회논문집
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• 제9권6호
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• pp.739-745
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• 2006

The role of maintenance in railway is going to be extended to improve the reliability of railway system in the aspect of Asset management gradually. In this paper, the meaning of reliability and safety in RCM which has been applied in order to improve the efficiency of maintenance is deduced. And the analysis task of reliability and safely which has been recommended in railway standards such as EN50126 and IEC62278 is reviewed in the aspect of RCM. Finally, the several ways are proposed to apply RCM to railway system through the comparison between the RCM procedure and the analysis procedure for the reliability and safety in railway standards. Hereafter, if the analysis of reliability and safety is performed with the concept of RCM in the beginning of railway business, it will be more efficient to improve the reliability and manage the railway asset.

• 한국식품영양과학회지
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• 제25권3호
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• pp.539-549
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• 1996

Large bowel cancer correlates tightly to dietary factors such as dietary fiber and fat. Dietary fiber prevents the large bowel cancer in different modes of action which depend upon physicochemical and fermentable properties. Water-soluble fiber is fermented easily by intestinal microbes producing short chain fatty acids ; in contrast, water-insoluble fiber occurs effectively more rapid transit time due to greater bulk of gut content, though it is unfermentable. Not only short chain fatty acid is utilized in the proximal and distal colon as primary energy source, but also it lowers pH in the colon to normalize cellular differentiation and helps to stimulate peri staltic movement by acting as an osmotic laxative. In particular, butyric acid may also regulate gene expression and cell growth, though it is an important respiratory fuel for the colonocyte. Since dietary fiber and non-digestible oligosaccharides are the major source of butyric acid, this provides a possible link between dietary fiber and oligosaccharide and prevention of large bowel cancer. But, as with many links between dietary fiber and large bowel cancer, a direct casual association has not been established. In addition, RDA of dietary fiber which is 20~25g/day for adult Japanese, appears to be reasonable for the defecation once daily and the prevention of large bowel cancer.

• Toxicological Research
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• 제33권3호
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• pp.173-182
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• 2017

In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs) as well as grouping (category formation) allowing for read-across. A challenging area for in silico modelling is the prediction of chronic toxicity and the No Observed (Adverse) Effect Level (NO(A)EL) in particular. A proposed solution to the prediction of chronic toxicity is to consider organ level effects, as opposed to modelling the NO(A)EL itself. This review has focussed on the use of structural alerts to identify potential liver toxicants. In silico profilers, or groups of structural alerts, have been developed based on mechanisms of action and informed by current knowledge of Adverse Outcome Pathways. These profilers are robust and can be coded computationally to allow for prediction. However, they do not cover all mechanisms or modes of liver toxicity and recommendations for the improvement of these approaches are given.

• The Plant Pathology Journal
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• 제32권2호
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• pp.157-161
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• 2016

Gamma irradiation was evaluated for its in vitro and in vivo antibacterial activity against a postharvest bacterial pathogen, Erwinia carotovora subsp. carotovora (Ecc). Gamma irradiation in a bacteria cell suspension resulted in a dramatic reduction of the viable counts as well as an increase in the amounts of DNA and protein released from the cells. Gamma irradiation showed complete inactivation of Ecc, especially at a dose of 0.6 kGy. In addition, scanning electron microscopy of irradiated cells revealed severe damage on the surface of most bacterial cells. Along with the morphological changes of cells by gamma irradiation, it also affected the membrane integrity in a dose-dependent manner. The mechanisms by which the gamma irradiation decreased the bacterial soft rot can be directly associated with the disruption of the cell membrane of the bacterial pathogen, along with DNA fragmentation, results in dose-dependent cell inactivation. These findings suggest that gamma irradiation has potential as an antibacterial approach to reduce the severity of the soft rot of paprika.

• Biomolecules & Therapeutics
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• 제23권5호
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• pp.414-420
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• 2015

Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the exact anti-inflammatory mechanism of fisetin is not understood. In this study, the pharmacological action modes of fisetin in lipopolysaccharide (LPS)-stimulated macrophage-like cells were elucidated by using immunoblotting analysis, kinase assays, and an overexpression strategy. Fisetin diminished the release of nitric oxide (NO) and reduced the mRNA levels of inducible NO synthase (iNOS), tumor necrosis factor (TNF)-${\alpha}$, and cyclooxygenase (COX)-2 in LPS-stimulated RAW264.7 cells without displaying cytotoxicity. This compound also blocked the nuclear translocation of p65/nuclear factor (NF)-${\kappa}B$. In agreement, the upstream phosphorylation events for NF-${\kappa}B$ activation, composed of Src, Syk, and I${\kappa}B{\alpha}$, were also reduced by fisetin. The phospho-Src level, triggered by overexpression of wild-type Src, was also inhibited by fisetin. Therefore, these results strongly suggest that fisetin can be considered a bioactive immunomodulatory compound with anti-inflammatory properties through suppression of Src and Syk activities.

• Nuclear Engineering and Technology
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• 제47권3호
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• pp.227-239
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• 2015

The thermal, mechanical, and neutronic performance of the metal alloy fast reactor fuel design complements the safety advantages of the liquid metal cooling and the pool-type primary system. Together, these features provide large safety margins in both normal operating modes and for a wide range of postulated accidents. In particular, they maximize the measures of safety associated with inherent reactor response to unprotected, doublefault accidents, and to minimize risk to the public and plant investment. High thermal conductivity and high gap conductance play the most significant role in safety advantages of the metallic fuel, resulting in a flatter radial temperature profile within the pin and much lower normal operation and transient temperatures in comparison to oxide fuel. Despite the big difference in melting point, both oxide and metal fuels have a relatively similar margin to melting during postulated accidents. When the metal fuel cladding fails, it typically occurs below the coolant boiling point and the damaged fuel pins remain coolable. Metal fuel is compatible with sodium coolant, eliminating the potential of energetic fuel-coolant reactions and flow blockages. All these, and the low retained heat leading to a longer grace period for operator action, are significant contributing factors to the inherently benign response of metallic fuel to postulated accidents. This paper summarizes the past analytical and experimental results obtained in past sodium-cooled fast reactor safety programs in the United States, and presents an overview of fuel safety performance as observed in laboratory and in-pile tests.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(1)
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• pp.264-270
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• 1998

This research broadens the prime concern of nuclear power plant operations from safe performance to both economic and safe performance. First emergency diesel generator is identified as one of main contributors for the lost plant availability through the review of plants forced outage records. The framework of an integrated architecture for performing modern on-line condition for operational availability improvement is configured in this work. For the development of the comprehensive sensor networks for complex target systems, an integrated methodology incorporating a structural hierarchy, a functional hierarchy, and a fault-system matrix is formulated. The second part of our research is development of intelligent diagnosis and maintenance advisory system, which employs Bayesian Belief networks (BBNs) as a high level reasoning tool incorporating inherent uncertainty use in probabilistic inference. Our prototype diagnosis algorithms are represented explicitly through topological symbols and links between them in a causal direction. As new evidence from sensor network development is entered into the model especially, our advisory of system provides operational advice concerning both availability and safety, so that the operator is able to determine the likely modes, diagnose the system state, locate root causes, and take the most advantageous action. Thereby, this advice improves operational availability

• 대한조선학회지
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• 제20권1호
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• pp.21-27
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• 1983

The mode superposition method(MSM) for the forced transverse vibration analysis of structures subject to Timoshenko beam analogy, which had originally been developed by Ormondroyd and McGoldrick, is reviewed to formulate it in more general form taking account of rotary inertia, dampings in separate terms of internal and external ones, and simultaneous action of exciting forces and moments. To investigate some general features of the method in practical utilizations, resonant maximum amplitudes of 4 high speed ships under concentrated sinusoidal excitation at the stern are calculated by both MSM and the finite difference method(FDM). For the FDM the hulls are discretized into 40 equal segments, and in utilization of MSM contributions of the first six modes are summed up to obtain responses up to the six-nodes resonant mode. The numerical results show that MSM gives slightly higher values, $4{\sim}10%$, than those by FDM. Since there is always uncertainty in the damping estimation of actual systems, influences of the damping magnitude on resonant amplitudes and a practical method to estimate modal damping coefficients are discussed.