• Journal of Pharmaceutical Investigation
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• v.37 no.3
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• pp.131-135
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• 2007

A previous report recently demonstrated that ultrasound-induced hyperthermia (USHT:0.4 watts (W)/$cm^2$ at $41^{\circ}C$) could increase cellular uptake of P-glycoprotein (P-gp) substrates in P-gp expressing cancer cell lines. Since P-gp plays a major role in limiting drug permeability in the multi-drug resistant (MDR) cells, studies were conducted to elucidate the mechanism of USHT on cellular accumulation of P-gp and non-P-gp substrate in MDR cells. To accomplish this aim, we studied the effects of USHT on the accumulation of P-gp substrate, R123 and non-P-gp substrate, antipyrine in MDR cells. We demonstrated that USHT increased permeability of hydrophobic molecules (R123 and $[^{14}C]$-antipyrine). The enhanced permeability is reversible and size-dependent as USHT produces a much larger effect on cellular accumulation of $[^{14}C]$-antipyrine (MW 188) than that of R123 (MW 380.8). These results suggest that USHT could affect MDR cells more sensitive than BBMECs. Also, the present results point to the potential use of USHT to increase cellular uptake of P-gp recognized substrates, mainly anti-cancer agents into cancer cells.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1880-1884
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• 2007

The Natural Resource Conservation Service Curve Number(NRCS-CN) method is one of the widely used methods for computation of runoff from a basin. However, NRCS-CN method has weak point in that the spatial land use distribution characteristics are ignored by using area weighted CN value. This study developed a program which can estimate runoff by considering spatial distribution of CN and flow accumulation at the outlet of the watershed by appling Moglen's method. Comparisons between the results from NRCS-CN method and this study showed good agreement with measured data of experimental watersheds. The developed program predicted lower runoff than the conventional NRCS-CN method. As a conclusion, this study proposes a new design direction which can simulate real runoff phenomena. And the developed program could be applied into runoff minimization design for a basin development.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2005.10a
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• pp.91-96
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• 2005

This study was performed for the research on the method for reducing non-point pollutant with the gabion which was made of gravel-packed plastic frame, and for the characterization of gabion adsorbing pollutant. The result showed that the concentrations of suspended solid in turbid water were reduced to $77.7{\sim}84.7%$ when the water was flowing through the gabion. The uniformity coefficients on the grain size accumulation curves of the adsorbed pollutant were larger on the large grain size gabion than those on the small grain size gabion, and the coefficients of curvature were smaller on the large grain size gabion than those of the small grain size gabion. The adsorption rates were dependent on the grain size of packed gravel. The rates were smaller on inlet and outlet than those on middle place on the series of gabion.

• Korean Management Science Review
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• v.23 no.1
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• pp.87-113
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• 2006

This paper describes a comprehensive approach to examine how technological innovation contributes to the renewal of the firm's competences through its dynamic and reciprocal relationship with R&D and product commercialization. Three theories of technology and innovation (R&D and technological knowledge concept, product-process concept, technological interdependence concept) are used to relate technology and innovation to strategic management. Based on those theories, this paper attempts to identify dynamic relationship between product innovation and process innovation by system dynamics, by investigating the aspect of the dynamic changes of the closed feedback circulation structure in which R&D investments drive technological knowledge accumulation, and such knowledge accumulation actualizes product innovation and process innovation, subsequently resulting in the increase of productivity, customer satisfaction, profit generation, and re-investment on R&D from the created profits. This provides the ability to assess the advantages and disadvantages of different technological innovation strategies and commitments, and the opportunity to explore equilibrium point and suggest a generalized technological innovation model under different industry environment parameters and time-strategies.

• Korean Journal of Organic Agriculture
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• v.8 no.2
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• pp.53-77
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• 2000

This paper aims to point out the problems and solutions of soil fertility enhancement in Korean organic farming which does not harmonize with internationally recognized standard of organic agriculture such as Basic Standard of IFOAM, EU regulations, and guidelines of FAO/WHO codex alimentarius. The necessity of rotation, legume, green manure to enhance the soil fertility or organic farming system was discussed, and the reasons why salt accumulation including nitrate and phosphate in the rooted soil profiles was frequently occurred in Korean organic farmer's field also discussed. Soil testing for correct handling of organic fertilization was introduced to void the salt accumulation just applying the huge amount of organic fertilizer year to year to reach a maximum crop yield. In the conclusion it was suggested for Korean organic agriculture to make an effort to coincide it's regulation with internationally recognized standards for organic farming.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.10
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• pp.1865-1867
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• 2007

We propse a novel corner detection algorithm for locating 2D Data Matrix barcode in an image. The proposed method accumulates weight for each cross point defined by every combination of edge points in the image, and detects the corner point of the barcode L-pattern by determining the location of the highest accumulated weight. By designing the weight considering the connectivity of two lines around the cross point, we were able to detect the corner of L-pattern even for the cases that the lines of L-patterns are short. In the experiments, the proposed method showed improved performance compared with the conventional Hough transform based method in terms of detectability and computation time.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.4 no.4
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• pp.35-42
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• 1981

This paper grasped the labor productivity actual condition by the standard of per unit working hour and production about the main products of our country's industrial the main materials and could understand the average of our country's labor productivity as compared this with the labor productivity actual condition of Japan. As the point at issue of analitical result. 1. Low a matter of thinking about productivity. 2. Have a lot of difficult problem in an industrial part. 3. Have the point at issue on technical development and accumulation. 4. Have the point at issue on management. As a countermeasure about these. 1. must convert the way of use of industrial policy. 2. must make a housing development and special serialization of a small and medium enterprise. 3. must establish an organic technical development system. 4. must grope the policy of management rationalization.

• Water Engineering Research
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• v.7 no.1
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• pp.1-8
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• 2006

Recently, the population growth and agricultural development are rapidly undergoing in the South-West Texas. The junction of three river basins such as Lavaca river basin, Colorado-Lavaca Coastal basin and Lavaca-Guadalupe Coastal basin, are interesting for non-point and point source pollutant modeling: Especially, the 2 basins are an intensively agricultural region (Colorado-Lavaca Coastal/Lavaca-Guadalupe Coastal basins) and several cities are rapidly extended. In case of the Lavaca river basin, there are many range land. Several habitat types wide-spread over three relatively larger basins and five wastewater discharge regions are located in there. There are different hazardous substances which have been released. Total nutrient loads are composed of land surface load and river load as Non-point source and discharge from wastewater facilities as point source. In 3 basins region, where point and non-point sources of poll Jtion may be a big concern, because increasing fertilizers and pesticides use and population cause. This project objective seeks to how to assess and control the accumulation of non-point and point source and discuss the main impacts of agriculture and environmental concern as non-point source with water quality related to pesticides, fertilizer, and nutrients and as point source with wasterwater discharge from cities. The GIS technique has been developed to aid in the point and non-point source analysis of impacts to natural resource within watershed. This project shows the losses in $kg/km^2/year$ of BOD (Biological Oxygen Demand), TN (Total Nitrogen) and TP (Total Phosphorus) in the runoff from the surface of 3 basins. In the next paper, sediment contamination will show how to evaluate in Estuarine habitats of these downstream.

• 사회경제평론
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• no.38
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• pp.9-49
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• 2012

Our luck is brute if we cannot choose or control it and, thus, we are not responsible for it. Our luck is optional if we can choose or control it and, thus, we are responsible for it. Egalitarian justice at least demands brute luck be fully neutralized. If, however, brute luck is not fully neutralized and possibly accumulated, what will happen to the Gini coefficients as a measure of inequality due to brute luck? By simulating brute luck under various combinations of the rate of accumulation and the level of, what I call, leximin-redistribution, I obtain the Gini coefficients for the distribution of the accumulated and, then, redistributed brute luck. The level of the leximin-redistribution determines the negative or positive relation between the rate of accumulation and the Gini coefficient. The minimum leximin-redistribution level that generates the negative relation between the rate of accumulation and the Gini coefficient, depends on the characteristics of the starting-point distribution of brute luck. The sooner the leximin-redistribution is ushered in, the lower the minimum level becomes. The so-called 'Growth First Redistribution Later' policy may hurt victims of brute bad luck.

• Korean Journal of Environmental Agriculture
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• v.29 no.4
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• pp.343-347
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• 2010

Heavy application of fertilizer and manure in excess from the optimum requirement for crop growth can increase phosphorus (P) accumulation and P release potential in soils. In this study, the relationship between soil test P and 0.01M $CaCl_2$ extractable P was analysed to evaluate the P release potential of agricultural soils under different land-use. The paddy, upland, plastic film house(PFH) soils were sampled from Tongyoung and Changnyeong, and Daegok areas in Gyeongnam province, respectively. With respect to the P accumulation, available P contents in upland and PFH soils were 619 and 796 mg $P_2O_5$/kg, respectively indicating that different land-use types can greatly impact soil P accumulation. As soil available P was increased in the paddy soil, the content of 0.01M $CaCl_2$ extractable P also linearly increased without change point. Comparatively, P threshold were detected at 520 mg $P_2O_5$/kg in both upland and PFH soils, indicating that P release potential were higher in these land-use systems. For reducing P release from agricultural soils, management of optimum P content is needed in soils possessing high P release potential. Further, the change point value, if it is to be used as an environmental indicator, requires more detailed investigation to cover a wide range of soil characteristics.