• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.1
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• pp.26-32
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• 2013

Boesenbergia pandurata (Roxb.) Schltr. has been reported to possess anti-oxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of Boesenbergia pandurata extract (BPE) in a high-fat diet (HFD)-induced obese mice model. C57BL/6J mice were fed with either the high-fat diet or a 0.5% BPE-supplemented HFD for 8 weeks. The BPE-containing HFD significantly reduced body weight gain and the accumulation of visceral fat mass in mice model without altering the amount of food intake. Moreover, mice fed with BPE-containing HFD had lower concentrations of lipids in their blood, lower hepatic lipid accumulation, and lower serum leptin levels compared with the HFD-fed mice. RT-PCR analysis showed that the expression levels of peroxisome proliferators-activated receptor ${\gamma}2$ ($PPAR{\gamma}2$) and CCAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$) genes in the epididymal fat tissue of mice fed the BPE-containing HFD increased 1.16- and 1.30-fold, respectively, compared to mice fed HFD only. In conclusion, BPE attenuated visceral fat accumulation and improved dyslipidemia in a mice model with HFD-induced obesity.

• Journal of Environmental Science International
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• v.16 no.12
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• pp.1369-1382
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• 2007

To find proper water quality management strategy for oxygen consumption organic matters in Jinhae bay, the physical process and net supply/decomposition in terms of COD was estimated by three-dimensional eco-hydrodynamic modeling. The estimation results of physical process in terms of COD showed that transportation of COD was dominant in loading area from land to sea, while accumulation of COD was dominant in $middle{\sim}bottom$ level. In case of surface level, the net supply rate of COD was $0{\sim}60\;mg/m^2/day$. The net decomposition rate of COD was $0{\sim}-0.05\;mg/m^2/day$($-5{\sim}-10$ m, in depth) to 2 level, and $-0.05{\sim}-0.20\;mg/m^2/day(10m{\sim})$ to bottom level. These results indicate that the biological decomposition and physical accumulation of COD are occurred for the most part of Jinhae Bay bottom. The variation of net supply or net decomposition rate of COD as reducing land based input loading is also remarkable. Therefore, it is important to consider both allochthonous and autochthonous oxygen demanding organic matters to improve the water quality of Jinhae Bay.

• Nutrition Research and Practice
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• v.12 no.2
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• pp.110-117
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• 2018

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD. MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model. Animals were divided into three groups (n = 7): normal diet group (ND), WD group, and WD plus 1% EAF group. RESULTS: EAF reduced OA-stimulated lipid accumulation in HepG2 cells in the absence of cellular cytotoxicity and significantly blocked transcriptional activation of sterol regulatory element-binding protein 1 and fatty acid synthase genes. Subsequently, we investigated these effects in vivo in mice fed either ND or WD in the presence or absence of EAF supplementation. In comparison to the ND controls, the WD-fed mice exhibited increases in body weight, liver weight, epididymal fat weight, and accumulation of fat in hepatocytes, and these effects were significantly attenuated by EAF supplementation. CONCLUSIONS: Allium fistulosum attenuates the development of NAFLD, and EAF elicits anti-lipogenic activity in liver. Therefore, EAF represents a promising candidate for use in the development of novel therapeutic drugs or drug combinations for the prevention and treatment of NAFLD.

• BMB Reports
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• v.56 no.9
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• pp.520-525
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• 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis could contribute to AD-related cognitive impairment. Adult subventricular zone (SVZ) neurogenesis, which occurs in the lateral ventricles, plays a crucial role in structural plasticity and neural circuit maintenance. Alterations in adult SVZ neurogenesis are early events in AD, and impaired adult neurogenesis is influenced by the accumulation of intracellular Aβ. Although Aβ-overexpressing transgenic 5XFAD mice are an AD animal model well representative of Aβ-related pathologies in the brain, the characterization of altered adult SVZ neurogenesis following AD progression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesis changes with AD progression in 2-, 4-, 8-, and 11-monthold male 5XFAD mice. We first investigated the Aβ accumulation in the SVZ using the 4G8 antibody. We observed intracellular Aβ accumulation in the SVZ of 2-month-old 5XFAD mice. In addition, 5XFAD mice exhibited significantly increased Aβ deposition in the SVZ with age. Next, we performed a histological analysis to investigate changes in various phases of adult neurogenesis, such as quiescence, proliferation, and differentiation, in SVZ. Compared to age-matched wild-type (WT) mice, quiescent neural stem cells were reduced in 5XFAD mice from 2-11 months of age. Moreover, proliferative neural stem cells were decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in 5XFAD mice from 2-11 months of age. Intriguingly, we found that adult SVZ neurogenesis was reduced with aging in healthy mice. Taken together, our results revealed that impairment of adult SVZ neurogenesis appears with aging or AD progression.

• Magazine of the Korean Society of Agricultural Engineers
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• v.38 no.5
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• pp.47-54
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• 1996

본 연구에서는 지표면유출과 중간유출의 수문학적과정을 함께 모의발생 시키는 합성 유역모델이 제시되었다. 본 모델은 디지털지형모델과 상호 연결되도록 하였으며 지형이 복잡한 지역에서도 유출이 시간과 공간적으로 누가계산되어 이 분야의 조사연구에 필요한 정보를 제공할 수 있다. 본모델을 이용 유역의 불투수층 위에 분포해있는 토양의 중간계층과 토양수분의 계산 및 침투/용탈의 과정을 모의 발생시킬 수 있다.

• Electrical & Electronic Materials
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• v.11 no.10
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• pp.24-31
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• 1998

Interfacial effect in polymetric composites have been studied extensively. This report deals mainly with the effects of interfacial space charge and interface structure. A model for the dynamic process of interfacial space charge accumulation is proposed. The new model might interpret some interface phenomena which is difficult to be explained in terms of traditional Maxwell-Wagner theory. An interface structure is also presented, by which the importance of surface treatment of glass Fiber for improving the properties of FRP could be well understood.

• Journal of the military operations research society of Korea
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• v.9 no.1
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• pp.15-28
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• 1983

In sequential capital allocation processes, the information on the future availability (flexibility) of invested funds provides a decision maker with additional insight into the characteristics of alternatives. The investment decision with consideration of flexibility and profitability results in more wealth accumulation than the decision without considering flexibility does in sequential investment processes. To utilize the information on the flexibility under certainty, the PV/FI decision model is developed.

• Journal of Korea Technology Innovation Society
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• v.2 no.1
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• pp.1-15
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• 1999

This study aims at integrating the sociological study of technology and the economic study of technological learning. It is argued that the sociological approaches of innovation have some strong points in criticizing technological determinism, but have some weak points in explaining how the knowledge base for innovation is accumulated. On the contrary, the economic approaches of innovation have strong points in explaining technology accumulation, but ignore socio-political process of innovation. This study suggests the model which integrates the socio-political process and technological loaming process.

• Journal of the Korea Concrete Institute
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• v.13 no.5
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• pp.415-422
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• 2001

The present paper focuses on the development of a realistic analysis model for the deformation calculation of reinforced concrete beams subjected to fatigue loadings. The proposed model considers the effect of cyclic creep, which arises from the repeated loading, to calculate the deformation of reinforced concrete beams. A comprehensive experimental program has been set up to identify the deformation accumulation of reinforced concrete beams under repeated loadings. The major test variables were the concrete compressive strength and the magnitude of fatigue loads. The model was calibrated from the present test results. The proposed model allows more realistic analysis of reinforced concrete beams under fatigue loads, especially deformation accumulation of such beams.

• Preventive Nutrition and Food Science
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• v.3 no.4
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• pp.362-367
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• 1998

Thyroid hormone(T3) stimulates hepatic lipogenesis by increasing expression of genes, indluding acetyl-CoA carboxylase and fatty acid synthase. S14 protein, which is thougth to be involved in lipid metabolism , appears to respond in parallel . Effect of T3 on lipogenesis in white and brown adipose tissue are less clear, and may be complicated by indirect effects of the hormone. We developed an adipocytes system where the indirect effects of thyroid hormone are abolished and direct effects of T3 on lipogenesis could be tested. Fat accumulation was mesured by Oil-Red O staining. Insulin clearly enhanced fat accumulation by 2-fold . Isobutylemethylxanthie(IBMX) apeared to inhibit insulin -stimulated fat accumulation. Dexamethasone increased insulin-stimulatedfat accumulation about 1.3-fold. confluent adipocytes were cultured in serum-free medium or medium containing 10% fetal calf serum or 10% fetal calf serum stripped of thyroid hormone and lipogenesis, assessed by the incorporation of 3H2O , was measured. Medium without serum or supplemented with T3-depleted serum did not amplify the stimulatory effect of T3 on lipogenesis compared to medium containing 10% fetal calf seru. Dexamethasone alone led to a decrease inlopogenesis of about 50 % in white adipocytes and 25% in brown adipocytes. However, dexamethasone amplified the lipogenic respnse to T3 by about 30% in whit eadipocytes and 60% in brown adipocytes. T3(1$\mu$M) stimulated lipogenesis and acetyl-CoA carboxylase and fatty acid syntase mRNA levels up to 2 -fold in both types of adipocytes. It seems that these adipocytes systems are as useful model to study the effects of hormones on lipogenic gene expression as well as lipogenesis.