• Journal of Life Science
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• v.31 no.9
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• pp.849-855
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• 2021

Recently, as nanotechnology has been introduced and used in various fields, the development of new drugs has been accelerating. Nanoparticles have maintained blood drug concentration for extended periods of time with a single administration of the drug. The drug can then be selectively released only at the pathological site, thereby reducing side effects to other non-pathological sites. In addition, nanoparticles can be modified for selective target sites delivery for other specific diseases, with polymers being widely used in the manufacture of these nanoparticles. Poly (D,L-lactic-co-glycolic acid ) (PLGA) is one of the most extensively developed biodegradable polymers. PLGA is widely used in drug delivery for a variety of applications. It has also been approved by the FDA as a drug delivery system and is widely applied in controlled release formulations, such as in gene therapy treatments. PLGA nanoparticles have been developed as delivery systems with high efficiency to specific cell types by using passive and active targeting methods. After the development of a drug delivery system using PLGA nanoparticles, the drug is selectively delivered to the target site, and the effective blood concentration for extended periods of time is optimized according to the disease. In this review paper, we focus on ways to improve cell-specific treatment outcomes by examining the development of astrocyte selective nanoparticles based on PLGA nanomaterials for gene therapy.

• Journal of Technology Innovation
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• v.29 no.4
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• pp.1-30
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• 2021

Due to the recent development of system semiconductors, technical innovation for the electric devices of the automobile industry is rapidly progressing. In particular, the electric device of automobiles is accelerating technology development competition among automobile parts makers, and the development cycle is also changing rapidly. Due to these changes, the importance of strategic planning for R&D is further strengthened. Due to the paradigm shift in the automobile industry, the Product-Technical Roadmap (P/TRM), one of the R&D strategies, analyzes technology forecasting, technology level evaluation, and technology acquisition method (Make/Collaborate/Buy) at the planning stage. The product-technical roadmap is a tool that identifies customer needs of products and technologies, selects technologies and sets development directions. However, most companies are developing the product-technical roadmap through a qualitative method that mainly relies on the technical papers, patent analysis, and expert Delphi method. In this study, empirical research was conducted through simulations that can supplement and strengthen the product-technical roadmap centered on the automobile industry by fusing Gartner's hype cycle, cumulative moving average-based data preprocessing, and deep learning (LSTM) time series analysis techniques. The empirical study presented in this paper can be used not only in the automobile industry but also in other manufacturing fields in general. In addition, from the corporate point of view, it is considered that it will become a foundation for moving forward as a leading company by providing products to the market in a timely manner through a more accurate product-technical roadmap, breaking away from the roadmap preparation method that has relied on qualitative methods.

• Informatization Policy
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• v.26 no.2
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• pp.24-45
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• 2019

This paper analyzes the size of direct and indirect impact of the information and communication technology(ICT) producing sector to the Korean economic growth We first divide the entire economy into the ICT producing sector and the ICT using sector, and estimate the contributions to the economic growth by each sector. We also try to answer the question on what the possible causes of the ICT producing sector's contribution are to growth. In oder to find the answer, we focus on the change in the relative prices of ICT products produced in the ICT producing sector and examine the long-term relations among the relative prices of ICT products, the ratio of ICT products used in the ICT using sector as an intermediate input, and the output of the entire economy. We find that the overall economic growth has been weakened but the ICT sector's contribution to the growth has increased. Specifically, the indirect contribution of the ICT producing sector, through the ICT using sector, to economic growth was greater than the direct contribution of the ICT producing sector itself. We also find a stable, long-term negative relation between the relative prices of ICT products produced in the ICT producing sector and the ratio of ICT products as an intermediate input in the ICT using sector. In addition, the decrease in the relative prices of ICT products produced in the ICT producing sector increases the use of ICT products in the ICT using sector and the output of the entire economy. These findings can be interpreted that the price decrease in the ICT products improves the production efficiency in other sectors and helps directly and indirectly, accelerating growth of the entire economy.

• Journal of Climate Change Research
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• v.4 no.1
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• pp.41-49
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• 2013

Recent findings have revealed that black carbon is one of the substantial materials affecting climate change along with greenhouse gases. Usually, black carbon is generated by incomplete combustion of biomass and deposited on snow and ice surface, resulting in increasing adsorption of radiant energy and accelerating ice melting. However, it is still questionable what the emission characteristics of black carbons from biomass combustion is. We investigated the emission characteristics of black carbon generated from a wood stove in this study. We found that the emission of black carbon was highly dependent upon combustion temperature and the amount of combustion air supplied. The emission factors were 1.01 g-BC/kg-Oak for fireplace wood burning under incomplete combustion, 0.37 g-BC/kg-Oak for fireplace wood burning under complete combustion and 0.29 g-BC/kg-Oak for small wood-stove burning.

• Journal of Digital Convergence
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• v.16 no.12
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• pp.257-266
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• 2018

The implication of this study is that the development and market participation of the next generation eco - friendly vehicles is accelerating, and consumers 'interest is increasing. Also, the product attributes of environment - friendly vehicles and the government's policy support for the next generation eco - friendly vehicles. The purpose of this study is to investigate the effect of purchasing behavior of eco-friendly vehicles on the product attributes of eco-friendly vehicles. Economic, image, functionality, and service convenience have positive effects on consumers' purchase intention. As a result of examining the moderating effect of the government support policy between the product attributes of environment - friendly vehicles and the purchase intentions of environment - friendly vehicles, the government or municipal government has no control effect such as vehicle price subsidy, vehicle tax subsidy, Carbon tax support to prevent emissions was found to have a moderating effect of supporting 10,000 won per ton, even if 5,000 won per ton was supported. This suggests that consumers who prefer to buy eco-friendly vehicles are more likely to have environmental factors.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.12
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• pp.1056-1069
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• 2018

In order to promote the commercial space activities of the private sector, the Trump Administration announced the commercial space regulatory reforms by issuing the Space Policy Directive-2 (SPD-2) on May 24, 2018, followed by the SPD-3 dealing with a separate issue of the space traffic management on June 18. Both executive orders, based on the recommendations prepared by the National Space Council (NSC) reconstituted in June 2017 and signed by the President, involve regulatory reform policy related to launch services, commercial remote sensing, establishment of one-stop shop office in Commerce Department, radio frequency spectrum, export control, and space traffic management, providing a strong guidance to the Federal Government. The commercial space regulatory reform policy can be seen in broader terms of the National Security Strategy earlier announced on Dec. 18, 2017, and as such, it pursues the economic growth of the U.S. and the national security as well. The U.S. law and policy prioritizing its national interests by promoting commercial space activities may lead to concerns and debate on the potential breach of the provisions of the Outer Space Treaty. Hence, it is worth noting the legal implications as derived from the U.S. space policy and domestic legislation, thereby accelerating international discussion to build on international norms as appropriate to the pr ogress of space technology and space commercialization.

• Journal of Conservation Science
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• v.34 no.6
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• pp.459-470
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• 2018

Cellulose nitrates were used for folklore artifacts(ornamental beads and pipes in hatstrings, frames of eyeglasses, ornamental eyeglass cases, headband ornaments, and jeogori buttons) between the 19th and 20th centuries; however, they are susceptible to cracking, crazing, embrittlement, and crumbling due to deterioration. To consolidate and adhere deteriorated cellulose nitrate folklore artifacts, water-soluble acrylic emulsion adhesives were investigated. For consolidation, Plextol D 498, which has the lowest viscosity in low concentrations, was used. In adhesive films whose glass transition temperature(Tg) is lower than room temperature, the tensile stress and modulus decreased and the strain increased; therefore, the flexibility was high. The Plextol D 498 and Plextol D 498 and Dispersion K 52 films maintained their adhesiveness and flexibility after artificial-sunlight-accelerated ageing, and Plextol D 498 and Dispersion K 52 films hardly caused yellowing. Plextol D 498 was the most stable for accelerating ageing. A low concentration of Plextol D 498 emulsion resulted in the best permeability on the surface of cellulose nitrate, compared with other acrylic emulsions. To prevent ornamental hatstrings from cracking, crazing, embrittlement, and crumbling, a Plextol D 498 emulsion was used. After applying low concentrations(1%, 3%) of the emulsion to consolidate the fragments and high concentration to adhere the fragments, the ornamental hatstrings were protected from crumbling by deterioration, and their fragments were well-adhered. To preserve it from deterioration by oxygen and humidity, the treated ornament was sealed with an oxygen-barrier film using a low-humidity oxygen scavenger.

• The Journal of the Korea Contents Association
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• v.19 no.2
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• pp.409-423
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• 2019

The purposes of this study was to confirm the current issues of workforce policy of dental auxiliary personnel in Korea. The literature review and data collection were conducted in terms of the auxiliary personnel supply, regional distribution, legal works, working environment. Despite the rapid increase in the number of dental hygienists, the number of active dental hygienists is less than half of the total, and the dental clinics still experience the shortage. Considering the dental hygienist's work, the available dental auxiliary personnel for the dental assistance is limited. The proportion of dental hygienists is concentrated in large cities, and the ratio of dental clinics composed of only dental hygienists is high. Thus, it is essential to look for a plan to solve the disparity. The criterion for judging the legality of the works is ambiguous because a large portion of dental hygienist's work is not specified in the Medical Technicians Act. The job life is also shortened, and occupational profession and satisfaction are lowered. Thus, job burnout is accelerating. The difference between the legal works and the practiced works of dental hygienist and the conflict between the personnel might be due to the lack of utilization plans for the dental personnel at the government level. Therefore, the government should establish the roles of dental hygienist in accordance with the demands of the dental health service, institutionalize the necessary policies accordingly, and make efforts to establish plans to improve the relevant laws and utilize the manpower appropriately.

• Korean Journal of Heritage: History & Science
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• v.46 no.3
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• pp.150-171
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• 2013

The most important part of conservation treatment of murals is to preserve them against the risk of a damage by injecting fixative into them when the painting loses its cohesion or powderization of pigments occurred due to occurrence of cracks inside the painting layer. However, studies on the stability of fixative used for painting layers of murals are still insufficient. This study manufactured a mural as a specimen and colored it with four kinds of pigments including oyster shell white, cinnabar, malachite and red clay and applied four kinds of fixative, including, Paraloid $B-72^{(R)}$, Caparol-$binder^{(R)}$, glue and Hydoxypropyl $cellulose^{(R)}$. artificially generated environmental changes in temperature, humidity and ultraviolet rays which may occur after the completion of conservation treatment. Then the changes in physical properties were observed in multifaceted ways such as color stability, contact angle, brilliance, adhesive strength and surface. As a result, this study found that ultraviolet rays and hot?humid environment have a large impact on color stability causing changes in brightness and chroma of all painting layers where the fixative were applied, except for oyster shell white and are considered the main factors of decomposition by accelerating the aging process of fixatives applied. In comparison to the synthetic resins that were also tested in this study, the traditional glue showed satisfactory results in terms of color stability and influence preservation and the hydrophile property. As it showed exceptionally outstanding adhesive strength in all painting layers in the aspect of adhesive strength, it is considered to be highly stabile for the fixation treatment of painting layers of mural.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.80-91
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• 2019

Korean society is now in the 2017 system. The zeitgeist is now hoping to move into a society where the right to pursue happiness centered on democracy, human rights, and peace is recognized, and to the era of the fourth industrial revolution. The paradigm shifts in the education arena began before the start of this socio-political system. The educational autonomy centered on the progressive education superintendent is accelerating the influx of alternative education, which is part of the civic education movement, through public school reforms. It can be seen that not only the progressive camp but also the conservative government emphasized educational policies such as the liberal semester system, which was gradually adopted by the government. For education that is appropriate for a rapidly changing society, it is necessary to discuss about educational grand-discourse that can alternate current public education. Although it does not mean only one discourse, it is a necessary process to systematically consider alternate education of public education and to suggest the direction for future education. In this regard, this study aims to introduce the discourse that can produce critical consciousness and creativity that emphasize the praxis and practice through critical pedagogy and bricolage.