• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1687-1698
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• 2021

This study is to produce multiple layers of liposomes in a supercritical state and encapsulates active ingredients in order to stably encapsulate thermodynamically unstable active ingredients. In order to form a liposome in a supercritical state, a mixed surfactant development including vegetable-derived hydrogenated phosphatidyl choline and their delivative, hydrogenated sucrose distearate was synthesized as high purity. It describes a manufacturing method of injecting liquid carbon dioxide into a reactor to create a supercritical state and stirring to produce a giant liposome, and adding and loading genistein and quercetin. The HLB of the mixed lipid complex (SC-Lipid Complex) was 12.50, and multiple layers of liposome vesicles were formed even at very low concentrations. This surfactant had a specific odor with a pale yellow flake, the specific gravity was 0.972, and the acid value was 0.12, indicating that it was synthesized with high purity. As a result of the emulsifying capacity experiment using 20 wt% capric/capric triglyceride and triethylhexanoin using SC-Lipid Complex, it was found to have 96.2% emulsifying power. SC LIPOSOME GENISTEIN was confirmed that a multi-layer liposome vesicle was formed through a transmission electron microscope (Cryo-TEM) for the supercritical liposome encapsulated with genistein. The primary liposome particle size in which genistein was encapsulated was 253.9 nm, and the secondary capsule size was 18.2 ㎛. Using genistein as the standard substance, the encapsulation efficiency of supercritical liposomes was 99.5%, and general liposomes were found to have an efficiency of 93.6%. In addition, the antioxidant activity experiment in which quercetin was sealed was confirmed by the DPPH method, and it was found that the supercritical liposome significantly maintained excellent antioxidant activity. In this study, thermodynamically unstable raw materials were sealed into liposomes without organic solvents in a supercritical state. Based on these results, it is expected that it can be applied to various forms such as highly functional skincare cosmetics, makeup cosmetics, and scalp protection cosmetics.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.893-905
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• 2020

This study is a study on solubilization and emulsifying power of tocopheryl acetate using vegetable surfactants. High purity polyglyceryl-10 isostearate and polyglyceryl-10 oleate were mixed to synthesize a vegetable surfactant with excellent solubilizing power and emulsifying power. The mixed raw material was named Solubil EWG-1100. The appearance of this raw material was a pale yellowish paste with a specific smell, specific gravity of 1.12, and acid value of 0.085. The HLB value of this surfactant was calculated by the Griffin's equation with an average value of 15.17. The behavior of this surfactant to solubilize tocopheryl acetate was mechanically verified. The performance of solubilization was evaluated by a method of visual evaluation and was measured by a transmittance rate at 650 nm using a UV spectrophotometer. As a result, in the formulation using 3% ethanol as a co-solvent, the concentration of surfactant was required to solubilize tocopheryl acetate was required about 5 times of natural surfactant. In the formulation without ethanol as a co-solvent, the concentration of surfactant was required to solubilize tocopheryl acetate required about 7 times of natural surfactant. In addition, the concentration of surfactant required to make an emulsifivation 10 % of tocopheryl acetate was 1 wt% of Solubil EWG-1100, and the emulsified particle size was 3.5 mm in cream formula. In order to obtain stable and fine emulsified particles, it was found that as the concentration of tocopheryl acetate increased, the concentration of Solubil EWG-1100 also was to increase. As a result of testing the solubilizing power of the surfactant according to the pH various change, it showed stable solubilizing power in the acidic region of pH=3.2, the neutral region of pH=7.0, and the alkaline region of pH=11.8. As application, based on these results, it is expected that it can be widely applied to the cosmetics field that develops skin care prescriptions, sensitive skin products, and heavy dry skin products.

• Herbal Formula Science
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• v.16 no.1
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• pp.147-168
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• 2008

HYTE (Hyeonggaeyeongyotang Extract), a polyherbal formula has been used as folk medicine, 28days repeat oral dose toxicity was tested in SD rats according to KFDA Guideline[2005-60]. Methods : In this study, mortality, clinical signs, body weight and gains, food and water consumption, ophthalmologic observation, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathological observations were conducted during 28days of dosing periods. Results: 1. No HYTE treatment-related mortalities and clinical signs were detected in all dosing levels tested in male and female rats during the whole experimental periods. 2. No HYTE treatment-related changes on body weight, gains and food consumption were detected in all dosing levels tested in male and female rats during the whole experimental periods except for 2000mg/kg-dosing female groups in which significantly increase of body weight, gains, food and water consumption were detected compared to that of vehicle control in some points. 3. No HYTE treatment-related changes on ophthalmologic examination were detected in all dosing levels tested in male and female rats. 4. No HYTE treatment-related changes on urinalysis were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing female groups in which, significantly increase of urine volume and related decrease on the urine specific gravity were detected as secondary effects of increase on the water consumptions not HYTE treatment-related toxicological signs. 5. No HYTE treatment-related changes on hematology were detected in all dosing levels tested in male and female rats except for increases in the total WBC count and lymphocytes of 2000mg/kg-dosing male and female groups with decrease of large unstained cells as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. 6. No HYTE treatment-related changes on serum biochemistry were detected in all dosing levels tested in male and female rats. 7. No HYTE treatment-related changes on gross findings, organ weight and histopathology were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing male and female groups in which, spleen and thymus organ weights, hypertrophy at gross observation and hyperpalsia of lymphoid cells and follicles at histopathological observation in spleen and thymus were detected as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. Conclusions : Based on these results, the NOAEL and MTD of HYTE in SD rats were considered as over 2000mg/kg, respectively at 28days repeat oral dose toxicity test because most of these findings were considered as results of pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs or secondary effects.

• Journal of the Korean Geotechnical Society
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• v.30 no.5
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• pp.47-54
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• 2014

Although shear wave velocity ($V_s$) is an important design factor in seismic design, the measurement is not usually made in typical field investigation due to time and economic limitations. In the present study, an investigation was made to predict sand $V_s$ based on the standard penetration test (SPT) results by using artificial neural network (ANN) model. A total of 650 dataset composed of SPT-N value ($N_{60}$), water content, fine content, specific gravity for input data and $V_s$ for output data was used to build and train the ANN model. The sensitivity analysis was then performed for the trained ANN to examine the effect of the input variables on the $V_s$. Also, the ANN model was compared with seven existing empirical models on the performance. The sensitivity analysis results revealed that the effect of the SPT-N value on $V_s$ is significantly greater compared to other input variables. Also, when compared with the empirical models using Nash-Sutcliffe Model Efficiency Coefficient (NSE) and Root Mean Square Error (RMSE), the ANN model was found to exhibit the highest prediction capability.

• International Commerce and Information Review
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• v.14 no.3
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• pp.159-183
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• 2012

Promoted in places like Korea, the central government and the local governments that can provide information on which to base investment policy to attract foreign direct mutation-specific gravity model (Shift-Share Model) In this study, the decrease of foreign direct investment performance using factors looked up in the industry. The sample period of 2009, 2010, 2011 nationwide (metropolitan and non-metropolitan separated) of foreign direct investment performance for Industry Standard Industrial Classification (Division) was conducted. Factors to look at the results of the National Growth Effect(NS), the industrial structure effect (IM), local allocation effect(RS) to decrease foreign direct investment in 2010 and 2011 non-metropolitan, metropolitan national growth effect(RS) is negative(-) has a value. Because it appears to be the aftermath of the global recession, the impact on the domestic economy Metropolitan area and the Industrial Mix Effect(IM) to the development of education, culture, business, and transportation, etc. in the development of service industries than in non-metropolitan valid environment. In the sector of services (food accommodation, business services, entertainment), We did it, was able to find the function. However, the Regional Share Effect(RS) be competitive in the manufacturing sector in metropolitan areas in the metal and chemical sectors have been identified. These results seems to enhance the competitiveness of the region, such as the metropolitan area's excellent workforce. Shift-Share analysis technique based on competitive factors of the region, to find the failure has limitations.

• Journal of the Korea Concrete Institute
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• v.23 no.5
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• pp.551-558
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• 2011

The effect of the maximum aggregate size and substitution rate of natural sand on the mechanical properties of concrete is evaluated using 15 lightweight aggregate concrete mixes. For mechanical properties of concrete, compressive strength increase with respect to age, tensile resistance, elastic modulus, rupture modulus, and stress-strain relationship were measured. The experimental data were compared with the design equations specified in ACI 318-08, EC2, and/or CEB-FIP code provisions and empirical equations proposed by Slate et al., Yang et al., and Wang et al. The test results showed that compressive strength of lightweight concrete decreased with increase in maximum aggregate size and amount of lightweight fine aggregates. The parameters to predict the compressive strength development could be empirically formulated as a function of specific gravity of coarse aggregates and substitution rate of natural sand. The measured rupture modulus and tensile strength of concrete were commonly less than the prediction values obtained from code provisions or empirical equations, which can be attributed to the tensile resistance of lightweight aggregate concrete being significantly affected by its density as well as compressive strength.

• The Korean Journal of Food And Nutrition
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• v.25 no.4
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• pp.922-929
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• 2012

This study was performed in order to investigate the quality characteristics of sponge cake made with Laminaria japonia powder. To evaluate the physical and sensory analysis, Laminaria japonia powder was added to wheat flour in various ratio (3, 5, 7, 9%, w/w). The specific gravity and loss rate increased with the addition of Laminaria japonia powder. The crude protein and ash levels in the sponge cakes increased linearly with the addition of 0~9 g of Laminaria japonia powder/100 g of wheat flour. For the crumb color values, lightness (L) and yellowness (b) decreased with the addition of Laminaria japonia powder, whereas redness (a) significantly increased (P<0.05). In the texture analysis, the hardness, gumminess and chewiness were increased; however, the cohesiveness and resilience were reduced by the addition of Laminaria japonia powder. When the sensory characteristics were evaluated, 5% Laminaria japonia sponge cake showed the highest sensory properties, except for color. Therefore, the results suggested that 5% Laminaria japonia sponge cake could be helpful in improving the physical quality as well as the taste.

• Korean Journal of Food Science and Technology
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• v.9 no.4
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• pp.284-290
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• 1977

The lipid components, fatty acid compositions, physical and chemical characteristics of crude oil in Amorpha fruticosa seed were determined and proximate compositions of it were also analyzed. The results were summarized as follow: 1) The proximate composition showed moistrue to be 10.14%, crude protein to be 21.77%, crude fats to be 12.73%, carbohydrates to be 51.75% and crude ash to be 3.61%. 2) Specific gravity, refractive index, smoke point and titer of the crude oil were $0.925\;(15/15^{\circ}C)$, $1,477(15^{\circ}C)$, $175^{\circ}C$ and $14.8^{\circ}C$, respectively. 3) Iodine, saponification, acid, ester value and unsaponifiable content of the crude oil were 144, 182, 2.9, 179 and 5.17%, respectively. 4) Lipid components were separated by TLC and quantitatively determined by TLC scanner to give 75% triglycerides, 14% esterified sterols, 3.08% phospholipids, 4.4% free sterols and 3.77% free fatty acids. 5) Fatty acid compositions were quantitatively determined by GLC to give 76.21% linoleic acid, 9.92% palmitic acid, and 5.07% stearic acid as the main components, oleic, linolenic, palmitoleic and arachidic acid were presented in small quantities.

• Journal of the Korean Wood Science and Technology
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• v.10 no.3
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• pp.180-188
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• 1982

This study was carried out to make hardboard fire retardants and to examine the properties of the hard-board treated with them. The fire retardant treatment was achieved by surface impregnation of water soluble retardant chemicals into the forming mat with 55 percent of moisture content. followed by the hot pressing process. Ammonium monophosphate, ammonium diphosphate, sodium borate, and boric acid were used as the fire retardants. Fire retardant test was carried out by using the differential thermal analysis thermogram. The results are summarized as follows: 1. Fire retardant-treated hardboard showed higher values of the specific gravity. water absoption, and flexural strength than those of untreated hardboard. Especially, the treatment of ammonium monophosphate gave the best results in the flexural strength, and a 10 gr/$ft^2$ loading of the fire retardant compound of ammonium monophoshate, ammonium diphosphate, and sodium borate drew the best flexural strength value among the three different experimental loadings of 10, 20 and 30 gr/$ft^2$. 2. There were no definite differences in moisture content between the fire retardant-treated hardboard and the untreated hardboard. 3. The fire retardant compound of ammonium monophosphate, ammonium diphosphate, and sodium borate resulted in the best fire retardancy, and its fire retardancy was increased in proportion to the increase of loading.

• Journal of the Korean Wood Science and Technology
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• v.15 no.3
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• pp.56-67
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• 1987

Plywoods used for construction as a decorative interior material are inflammable and can make fire accidents, causing destruction of human life and property. Therefore, it is indeed required to make fire-retardant treated plywood. In this study, 3.7mm yellow meranti plywoods were soaked in 18% boric acid solutions and tap water by hot-cold bath for 1/2, 2/2, 4/2, 6/2 hours and redrying of treated plywoods was carried out by press drying at the platen temperature of 110, 130, 160, $180^{\circ}C$ and then it was conducted to investigate solution absorption, drying rates, dynamic young's modulus. specific gravity and fire-retardant factors such as burning point, flame spread length. flame exhausted time, back side carbonized area and weight loss by treating time, treating solutions and platen temperature. The results are as follows; 1. When plywood was impregnated with the hot bath temperature of $70^{\circ}C$ for 1. 2, 4, 6 hours and the cold bath temperature of $15^{\circ}C$ for 2 hours respectively, retentions of boric acid were 1.565, l.597, 1.643, 1.709kg/$(30cm)^3$ and all of them exceeded the minimum retention [1.125kg/$(30cm)^3$] even in the shortest treatment. 2. In hot-cold bath method for 1/2 hours, the drying rates of treated plywood remarkably increased with the extension of platen temperature of 110, 130, 160, $180^{\circ}C$ and the values of boric acid treated plywood were 5.900, 10.196, 45.42, 54.958m.c%/min and the values of water treated plywood were 6.014, 12.373, 46.520, 55.730m.c%/min and drying rates of water treated plywood were faster than those of boric acid treated plywood. 3. The values of boric acid treated plywoods in dynamic young's modulus were widely higher than those of water treated plywoods. And it can be observed that there were highly significant differences for treating time between dynamic young's modulus, and the values of boric acid plywoods increased with the extension of treating time but on the contrary water treated plywoods were decreased values with prolonged time 4. It was observed that there were highly significant differences for platen temperature between dynamic young's modulus. When the values of water treated plywoods in dyna nic young's modulus were abruptly decreased according to the rise of platen temperature. boric acid treated plywoods showed rather increased values at $160^{\circ}C$ of platen temperature. And in 2- way interactions, there were also highly significant for dynamic young's modulus between treating time x treating solutions and platen temperature x treating solutions. 5. Correlation coefficients of fire-retardant factors were shown in table 5. It could be recognized that there were close correlations between the treating solutions and burning point, flame spread length, back side carbonized area, flame exhausted time and weight loss, but there was no correlation between fire-retardant factors and treating time and platen temperature. 6. From table 6, it can be observed that there were highly significant differences for burning point, flame spread length, flame exhausted time, back side carbonized area, weight loss between treating solutions. And in 2-way interactions, there were highly significant for burning point, flame spread length, weight loss between treating time $\times$ treating solutions.