• Corrosion Science and Technology
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• 제22권1호
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• pp.36-43
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• 2023

Single-crystal Ni-rich NCM is a material that has drawn attention in the field of lithium-ion batteries due to its high energy density and long cycle life. In this study, we investigated the properties of single-crystal NCM 811 and its potential for use in lithium-ion batteries. High-quality single crystals of NCM 811 were successfully synthesized by crystal growth via a flux method. The single-crystal nature of the samples was confirmed through detailed characterization techniques, such as scanning electron microscopy and x-ray diffraction with Rietveld refinement. The crystal structure and electrochemical performances of the single-crystal NCM 811 were analyzed and compared to its poly-crystal counterpart. The results indicated that single-crystal NCM 811 had electrochemical performance and thermal stability superior to poly-crystalline NCM 811, making it a suitable candidate for high-performance batteries. The findings of this study contribute to a better understanding of the characteristics and potential of single-crystal NCM 811 for lithium-ion batteries.

• 한국어병학회지
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• 제34권2호
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• pp.177-184
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• 2021

Vaccines based on single-cycle viruses that are replication-incompetent due to knockout of replication-related structural gene(s) are more immunogenic than inactivated or subunit vaccines and can be used as delivery vehicles for foreign antigens without concerns on the reverting to virulent forms. The aim of this study was to develop a delivery vehicle for nervous necrosis virus (NNV)-like particles (VLPs) using G gene deleted single-cycle VHSV (rVHSV-𝚫G). Recombinant single-cycle VHSVs carrying NNV capsid protein gene between N and P gene of rVHSV-𝚫G genome (rVHSV-𝚫G-NNV_Cap) were rescued by reverse genetic technology. The successful expression of NNV capsid protein in cells infected with rVHSV-𝚫G-NNV_Cap was demonstrated by Western blot analysis, and the production of NNV VLPs in infected cells was confirmed using an electron microscopy. The results suggest that single-cycle VHSVs can be used as a safe delivery vehicle for NNV VLPs, and can be extended to other pathogens for the development of prophylactic vaccines.

• 대한기계학회논문집A
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• 제33권4호
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• pp.296-309
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• 2009

Thick-walled cylinder with high pressure have had wide application in the armament industry. In the thick-walled cylinder, fatigue crack is generated at inner radius and developed toward the outer radius. To prevent generation of fatigue crack, the autofrettage process had been used. The compressive residual stress induced by the autofrettage process extends loading pressure and fatigue life of the thick-walled cylinder. In this study, the residual stress of single and compound cylinder by the autofrettage process was evaluated. The analytical compressive residual stress of single cylinder was good agreement with experimental result at inner radius. The analysis on the residual stress of compound cylinder was conducted. The compressive residual stress at inner radius was increased with the overstrain level. And fatigue life of the compound cylinder with initial crack was evaluated. The considered initial crack shape was straight and semi-elliptical. The fatigue life was extended with the overstrain level. The fatigue life of the compound cylinder with semi-elliptical crack was longer than straight crack. The suitable way to extend fatigue life of the compound cylinder was proposed.

• Journal of Veterinary Science
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• 제21권1호
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• pp.9.1-9.15
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• 2020

Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most important regenerative seed cells. Recently, differentiation of human PSCs into functional tissues and cells in vitro has been widely reported. However, although porcine reports are rare they are quite essential, as the pig is an important animal model for the in vitro generation of human organs. In this study, we reprogramed porcine embryonic fibroblasts into porcine iPSCs (piPSCs), and differentiated them into cluster of differentiation 31 (CD31)-positive endothelial cells (ECs) (piPSC-derived ECs, piPS-ECs) using an optimized single-layer culture method. During differentiation, we observed that a combination of GSK3β inhibitor (CHIR99021) and bone morphogenetic protein 4 (BMP4) promoted mesodermal differentiation, resulting in higher proportions of CD31-positive cells than those from separate CHIR99021 or BMP4 treatment. Importantly, the piPS-ECs showed comparable morphological and functional properties to immortalized porcine aortic ECs, which are capable of taking up low-density lipoprotein and forming network structures on Matrigel. Our study, which is the first trial on a species other than human and mouse, has provided an optimized single-layer culture method for obtaining ECs from porcine PSCs. Our approach can be beneficial when evaluating autologous EC transplantation in pig models.

• 한국아동복지학
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• 제55호
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• pp.113-141
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• 2016

본 연구는 부모-자녀관계와 학교생활 행복의 관계에서 자녀의 대인관계와 정신건강이 매개역할을 하는지, 이러한 구조모형 속에서 한부모 자녀와 양부모 자녀는 차이가 있는지를 분석하고자 한다. 이를 위해 본 연구에서는 한국교육개발원의 한국교육종단연구 2013 자료(2차년)를 사용하였다. 분석 대상은 초등학교 6학년 6,643명(한부모 756명, 양부모 5,887명)이다. 연구방법은 AMOS 18.0을 이용한 구조방정식 분석을 통한 다집단 분석을 실시하였으며, 매개효과를 분석하기 위하여 Sobel test를 실시하였다. 본 연구의 분석결과는 다음과 같다. 첫째, 한부모 자녀는 양부모 자녀보다 대인관계, 정신건강, 학교생활 행복 모두에서 유의하게 낮은 수준인 것으로 나타났다. 둘째, 부모-자녀관계와 학교생활 행복의 관계에서 대인관계와 정신건강은 매개역할을 하는 것으로 나타났다. 셋째, 총효과를 통해 아동의 학교생활 행복에 가장 많은 영향을 미치는 변수를 살펴본 결과 대인관계인 것으로 나타났다. 넷째, 한부모 여부에 따른 다집단 분석결과 연구모형에서 유의미한 차이가 나타나지 않았다.

• 한국식품영양학회지
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• 제29권5호
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• pp.808-817
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• 2016

In this study, we investigated the effects of pre-soaking in salt and sugar solution prior to air drying at $50^{\circ}C$ on the characteristics of dried apples. Pre-soaking solutions included single solutions of salt 2% and sugar 2%; and combined solutions of salt 2%+sugar 2% and salt 2%+sugar 5%, respectively. The effects of pre-soaking condition and drying were evaluated in terms of moisture content (MC), water activity, color, antioxidant activity determined by DPPH radical scavenging activity, shear force, microbial contents, and sensory evaluation of apple slices. The control sample without pre-soaking showed the most rapid drying rate; in addition, the single solutions showed higher MC and water activity after drying time of 120 min, as compared to combined solutions. In all samples, MC and water activity showed high correlation coefficients of 0.91 to 0.97; whereas, shear force was negatively correlated with MC and water activity. The single solution of salt 2% showed decrease in change of color, including L, a, and b values, and the number of aerobic bacteria during drying. In addition, highest antioxidant activity and values of sensory preferences were observed in the dried apple pre-soaked in single solution of salt 2%.

• Clinical and Experimental Reproductive Medicine
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• 제38권1호
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• pp.6-9
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• 2011

Objective: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. Methods: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. Results: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. Conclusion: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.

• Genomics & Informatics
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• 제11권3호
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• pp.135-141
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• 2013

Gene set analysis is a powerful tool for interpreting a genome-wide association study result and is gaining popularity these days. Comparison of the gene sets obtained for a variety of traits measured from a single genetic epidemiology dataset may give insights into the biological mechanisms underlying these traits. Based on the previously published single nucleotide polymorphism (SNP) genotype data on 8,842 individuals enrolled in the Korea Association Resource project, we performed a series of systematic genome-wide association analyses for 49 quantitative traits of basic epidemiological, anthropometric, or blood chemistry parameters. Each analysis result was subjected to subsequent gene set analyses based on Gene Ontology (GO) terms using gene set analysis software, GSA-SNP, identifying a set of GO terms significantly associated to each trait ($p_{corr}$ < 0.05). Pairwise comparison of the traits in terms of the semantic similarity in their GO sets revealed surprising cases where phenotypically uncorrelated traits showed high similarity in terms of biological pathways. For example, the pH level was related to 7 other traits that showed low phenotypic correlations with it. A literature survey implies that these traits may be regulated partly by common pathways that involve neuronal or nerve systems.

• 한국압력기기공학회 논문집
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• 제10권1호
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• pp.64-69
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• 2014

Gr. 91 steel is used for the major structural components of Generation-IV reactor systems, such as a very high temperature reactor(VHTR) and sodium-cooled fast reactor(SFR). Since these structures are designed for up to 60 years at elevated temperatures, the prediction of long-term creep life is important for a design application of Gr. 91 steel. In this study, a number of creep rupture data were collected through world-wide literature surveys, and using these data, the long-term creep life was predicted in terms of three methods: the single-C method in Larson-Miller(L-M) parameter, multi-C constant method in the L-M parameter, and a modified method("sinh" equation) in the L-M parameter. The results of the creep-life prediction were compared using the standard deviation of error value, respectively. Modified method proposed by the "sinh" equation revealed better agreement in creep life prediction than the single-C L-M method.

• 가족자원경영과 정책
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• 제18권1호
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• pp.115-140
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• 2014

In light of today's socioeconomic scenario, life management skills, especially economic life management skills are essential. This study focuses on a household account book as a tool for economic education. This study aims to assess the characteristics of household economic management in terms of the effect of keeping a household account book on Japanese in their 20s to 30s in a single-family household. It also compares the awareness of the change in economic life behavior between before and after keeping a household account book. Moreover, it analyzes the determinants of continuity in keeping a household account book. This Study used data obtained from an Internet survey of household account books by the Institute for Research on Household Economics in Japan. The study sample consist of 1,255 Japanese in their 20s to 30s who kept household account records for a month as well as preliminary and post-survey information about these people. The results were as follows. First, the average annual income of the subjects was at most 3,000,000 yen; their level of financial assets was at most 1,000,000 yen, their economic life behavior became future-oriented after practice of keep a household account book in that they established a budget and savings plan. Second, keeping a household account book had a positive effect on the people that they have budget and spending plans for the next year. Finally, factors that affected the continuity in keeping a household account book included the experience of keeping one from before.