• 대한안과학회지
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• 제54권9호
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• pp.1445-1451
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• 2013

목적: 당뇨병유두병증에서 유리체강내 베바시주맙 주입술 후 망막신경섬유층 두께 변화를 장기간 측정한 2예를 보고하고자 한다. 증례요약: 36세 당뇨환자가 우안 시력저하(20/200)로 내원하였고 안저검사상 양안 시신경유두부종이 관찰되었다. 스펙트럼영역 빛간섭단층촬영기로 측정한 우안의 망막신경섬유층 두께 $278{\mu}m$로 증가 소견, 시야검사상 우안 코쪽에 국소적인 협착을 보였다. 우안 베바시주맙 주입술을 하였고 3주 후 두께는 $135{\mu}m$로 감소했으며 시력도 20/25로 호전되었으나, 좌안 시력저하(20/32)와 망막신경섬유층 두께가 $207{\mu}m$로 증가하였다. 좌안 베바시주맙 주입술을 하였고, 3주 후 두께는 $147{\mu}m$로 감소했고 시력도 20/20으로 호전되었다. 이 후 점차적으로 양안 망막신경섬유층 두께는 감소하였고, 1년 후 검사에서 우안 $87{\mu}m$, 좌안 $109{\mu}m$였다. 57세 당뇨환자가 우안 시력저하(20/200)로 내원하였고 우안의 시신경유두부종과 망막신경섬유층의 두께가 $252{\mu}m$로 증가된 소견 및 시야검사상 맹점확대를 보였다. 우안 베바시주맙 주입술 3주 후 두께는 $136{\mu}m$로 감소했고 시력은 20/70으로 호전되었으며, 3개월 후 $104{\mu}m$, 6개월에는 $83{\mu}m$로 감소했다. 결론: 본 증례에서 유리체강내 베바시주맙 주입술 후 3주내 시력의 상승과 스펙트럼영역 빛간섭단층촬영기를 통한 1년간 평균 망막신경섬유층 두께의 감소를 확인할 수 있었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1797-1802
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• 2005

In this study, we were developed an accuracy of the proposed two dimensional statical inclinometer what used a position sensitive detector(PSD) by an error analysis. The inclinometer consists of a laser source, a mass, an optic-fiber, and a PSD. The gravity direction on a base platform of the inclinometer is changed by an unknown inclination angle. And a laser spot is moved from the origin to another position of a PSD following a variation of an optical path by the gravity. These processes enable the inclinometer to estimate the inclination angle from distance information of the moving spot. A design methodology on the basis of a sensitivity analysis was applied to improve the measurement performance such as a full measuring range and a resolution. But it still has error factors, so we analyze the uncertainty of the inclinometer to evaluate the systematic errors from alignments, assembly error and so on. The experimental performance evaluation about the design objectives as a measuring range and a resolution was performed. And the validity and the feasibility of the design process were certified by an experimental process. Systematic errors eliminated to improve the accuracy of the inclinometer by the corrected measuring model from the calibration process between the inclination angle and the PSD position instead of the nominal measuring model. The ANOVA(analysis of variance) confirmed the effect of eliminating the systematic errors in the inclinometer. From these methodologies, the proposed inclinometer was able to measure with a high resolution(35.14sec) and a wide range(from $-15^{\circ}\;to\;15^{\circ}$

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 22-24 Oct. 1991
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• pp.1796-1800
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• 1991

Picture Archiving and Communication Systems(PACS) provide an integration of digital imaging information in a hospital, which encompasses various imaging equipment, viewing workstations, database archive systems, and a high speed fiber optic network. One of the most important requirements for integration is the standardization of communication protocols to connect devices from different vendors. Since 1985, the ACR-NEMA standard provides a hardware interface, a set of software commands, and a consistent set of data formats for point-to-point interconnection of medical equipment. However, it has been shown to be inadequate for PACS networking environments, because of its point-to-point nature and its inflexibility to allow other services and protocols in the future. Based on previous experience of PACS developments in The University of Arizona, a new communication protocol for PACS networks has been suggested to the ACR-NEMA Working Group VI. The defined PACS protocol is intended to facilitate the development of PACS's capable of interfacing with other hospital information systems. Also, it is intended to allow the creation of diagnostic information data bases which can be interrogated by a variety of distributed devices. A particularly important goal is to support communications in a multivendor environment. The new protocol specifications are defined primarily as a combination of the International Organization for Standardization / Open Systems Interconnection (ISO/OSI) protocols and the data format portion of ACR-NEMA standard. This paper addresses the specification and implementation of the proposed PACS protocol into network node. The protocol specification, which covers Presentation, Session, Transport, and Network layers, is summarized briefly. The implementation has natural extentions to Global PACS environments. The protocol implementation is discussed based on our implementation efforts in the UNIX Operating System Environment. At the same time, results of performance evaluation are presented to demonstrate the implementation of defined protocol. The testing of performance analysis is performed on the PACS prototype node.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2004년도 학술대회지
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• pp.198-203
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• 2004

This paper describes a real-time control architecture for DUSAUV (Dual Use Semi-Autonomous Underwater Vehicle), which has been developed at Korea Research Institute of Ships & Ocean Engineering (KRISO), KORDI, for being a test-bed oj development of technologies for underwater navigation and manipulator operation. DUSAUV has three built-in computers, seven thrusters for 6 degree of freedom motion control, one 4-function electric manipulator, one pan/tilt unit for camera, one ballasting motor, built-in power source, and various sensors such as IMU, DVL, sonar, and so on. A supervisor control system for GUI and manipulator operation is mounted on the surface vessel and communicates with vehicle through a fiber optic link. Furthermore, QNX, one of real-time operating system, is ported on the built-in control and navigation computers of vehicle for real-time control purpose, while MicroSoft OS product is ported on the supervisor system for GUI programming convenience. A hierarchical control architecture which consist of three layers (application layer, real-time layer, and physical layer) has been developed for efficient control system of above complex underwater robotic system. The experimental results with implementation of the layered control architecture for various motion control of DUSAUV in a basin of KRISO is also provided.

• 전기학회논문지
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• 제58권1호
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• pp.147-154
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• 2009

This paper presents a grating~integrated SPR (Surface Plasmon Resonance) sensor chip for simple and inexpensive biomolecule detection. The grating-integrated SPR sensor chip has two sensing channels having a nano grating for SPR coupling. An external mirror is used for multi channel SPR sensing. The present sensor chip replaces bulky and expensive optical components, such as fiber-optic switches or special shaped prisms, resulting in a simple and inexpensive wavelength modulated multi-channel SPR sensing system. We fabricate a SPR sensor chip integrated with 835 nm-pitch gratings by a micromolding technique to reduce the fabrication cost. In the experimental characterization, the refractive index sensitivity of each sensing channel is measured as $321.8{\pm}8.1nm$/RI and $514.3{\pm}8.lnm$/RI, respectively. 0.5uM of the target biomolecule (streptavidin) was detected by a $1.13{\pm}0.16nm$ shift of the SPR dip in the 10%-biotinylated sample channel, while the SPR dip in the reference channel for environmental perturbation monitoring remained at the same position. From the experimental results, multi-channel biomolecule detection capability of the present grating-integrated SPR sensor chip has been verified. On the basis of the preliminary experiments, we successfully measured the binding reaction rate for the $2\;nM{\sim}200\;nM$ monoclonal-antibiotin, thus verifying biomolecule concentration detectability of the present SPR sensor chip. The binding reaction rates measured from the present SPR sensor chip agredd well with those from a commercialized SPR sensor.

• Current Optics and Photonics
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• 제1권2호
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• pp.132-137
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• 2017

To investigate the usefulness of optical coherence tomography (OCT) for imaging lymphedema, we directly compared it to other histological methods in a mouse model of lymphedema. We performed detailed imaging of the lymphedema lesion on a mouse tail. We imaged the mouse tail in vivo with OCT and created histopathological samples. We constructed a spectrometer-based OCT system using a fiber-optic Michelson interferometer. The light was directed to 50:50 couplers that split the light into reference and sample arms. Backscattered light from a reference mirror and the sample produced an interference fringe. An OCT image of the lymphedema model revealed an inflammatory reaction of the skin that was accompanied by edema, leading to an increase in the light attenuation in the dermal and subcutaneous layers. Similar to OCT image findings, histological biopsy showed an inflammatory response that involved edema, increased neutrophils in epidermis and subdermis, and lymphatic microvascular dilatation. Furthermore, the lymphedema model showed an increase in thickness of the dermis in both diagnostic studies. In the mouse tail model of lymphedema, OCT imaging showed very similar results to other histological examinations. OCT provides a quick and useful diagnostic imaging technique for lymphedema and is a valuable addition or complement to other noninvasive imaging tools.

• 한국광학회지
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• 제33권6호
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• pp.317-323
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• 2022

본 논문에서는 투명한 물질의 두께를 측정하기 위한 방법으로 기하 위상 렌즈 기반의 색공초점 센서를 개발하고, 성능 개선을 위한 보정 방법을 제시한다. 일반적인 색공초점 센서의 복잡한 설계로 인한 한계를 극복하기 위해, 기하 위상 렌즈를 이용하여 전체 시스템의 크기를 줄이고, 시스템 오차를 보상하기 위한 파장 첨두 위치 추출 방법과 계통 오차 제거 방법을 설명한다. 색공초점 센서를 이용하여 투명한 물질의 두께를 측정하기 위한 이론을 설명하고, 이를 사파이어 및 BK7 물질의 두께를 측정함으로써 실험적으로 검증한다. 색공초점 센서를 이용한 두께 측정 방법은 기존의 간섭계 및 공초점 센서의 방법들에 비해 측정 속도가 빠르고, 분산 등에 의한 두께 측정 영역 제한이 없기 때문에 많은 응용이 가능하다.

• 한국임상수의학회지
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• 제16권2호
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• pp.300-308
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• 1999

Arthroscopy is a valuable diagnostic and operative tool in equine and human orthopedics. The arthroscope is a difficult instrument to use and requires patience, practice, and persistence in order to obtain good results. This technique was found to be less traumatic than arthrotomy, invasiveness, rapid recovery and the feasibility of surgically correcting many arthropathies. The use of the arthroscope in the dog provides a new dimension in the study and diagnosis of joint derangements. The purpose of this report is to introduce the use of the arthroscope in the dog-more specifically, in the stifle of the dog. A diameter 2.7 mm fore-oblique viewing arthroscope, cold light source, video and video printer are used. With the fore-oblique viewing type it is possible to view directly as well as slightly to the side and the range of viewing can be increased by rotating the arthroscope around the object The scope is connected with a cold light source by means of a fiber-optic light guide. The stifle joint was flexed to 20~30$^{\circ}$. The joint were lavaged with lactated Ringer's solution during arthroscopic examination. Arthroscopy of the stifle was performed prior to arthrotomy in 1 dead dog and 4 healthy dogs, and other 3 dogs was performed only arthroscopic examination. In this study only the conventional approaches were used and in most cases it was possible to view all the intra-articular structures via the lateral infrapatellar approach. In the stifle joint, endoscopic observation was performed to find lateral femoral condyle, patella, medial femoral condyle, trochlear groove, tibia, fat, cranial cruciate ligament, caudal cruciate ligament lateral meniscus, tendon of long digital extensor muscle, medial meniscus, and medial collateral ligament Post-arthroscopic examination, the lameness had disappeared within 12~24 hours. Pain and swelling in the stifle joint had disappeared within 24~36 hours. Post-arthroscopic secondary infection was never encountered in the dogs. In conclusion, arthroscopic insertion technique in canine stifle joint using a diameter 2.7 mm 30$^{\circ}$ arthroscope was established and arthroscopical views of all anatomical structures in the normal stilfe joint were obtained through lateral infrapatellar portal.

• Transactions on Electrical and Electronic Materials
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• 제13권6호
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• pp.310-316
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• 2012

A new method for early caries diagnosis was proposed and tested through a home-made optical examination system that used quantitative light fluorescence (QLF) and digital imaging fiber optic transillumination (FOTI) (DIFOTI), with light sources across a wide spectral range, from 350 nm to 1,000 nm. The front-illuminated infrared light scattering image (FIR) showed similar diagnostic abilities to that of DIFOTI. The FIR method was invented based on the observation that caries lesions lose the high transmittance and low scattering properties of benign enamel tissue. There are various methods for the early diagnosis of caries, such as visual examination, exploration, X-ray radiography, QLF, FOTI, and infrared fluorescence (diagnodent). Among them, methods based on optical properties are regarded as having the most potential. A comparative study was performed between the FOTI, QLF, diagnodent, optical coherence tomography, and FIR scattering image methods, using 20 extracted teeth samples with early caries. A scale of lesion measurement based on optical image contrast was proposed. The statistical analysis showed a significant correlation between the DIFOTI and FIR methods (r = 0.35, p < 0.05). However, the QLF and diagnodent methods showed little association with FIR images, as they have different detection principles as compared with FIR. Tomographic images obtained by OCT, using 1,330 nm super luminescent LED as a gold standard of tooth structure, verified that the FOTI and FIR results correctly represented the lack of homogeneity in dental tissue. The newly proposed FIR method attained similar diagnostic results to those of FOTI, but with an easier approach.

• 한국정보통신학회논문지
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• 제4권1호
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• pp.17-25
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• 2000

ATM PON은 수동 광 분배망에서 ATM셀을 전송하는 가입자망으로서 다양한 형태의 가입자를 하나의 통합된 플랫폼에서 처리할 수 있기 때문에 차세대 엑세스망의 해법으로 간주된다. 본 논문에서는 ATM PON이 가지고 있는 장점과 그것이 동작하기 위한 핵심적인 프로토콜을 살펴본다. 그 중에서도 ranging은 시스템에서 시분할 다중화 액세스를 가능하게 하는 가장 중요한 프로토콜이다. 이 프로토콜의 문제점은 ranging 셀이 도착하는 시간구간, 즉 윈도우가 너무 길다는 것이다. 이 기간 동안 상향으로 가입자 트래픽을 전달할 수 없으므로, 서비스 품질이 저하될 가능성이 매우 높다. 이 논문에서는 광케이블의 길이를 어느 정도의 오차를 갖고 알고 있을 때 윈도우 길이를 최소화하는 방안을 제시한다. 제시된 알고리즘을 사용할 경우, 광케이블의 길이가 1 Km 변이를 가질 때 기존 방법에 비해 윈도우 길이가 7 %에 지나지 않는 성능 향상을 얻을 수 있다.