• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.89-99
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• 2020

Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners has allowed for using deep learning in the analysis of tissue images because many whole slide images (WSIs) are accessible to researchers. In the present study, we investigated the possibility of a deep learning-based, fully automated, computer-aided diagnosis system with WSIs from a stomach adenocarcinoma dataset. Three different convolutional neural network architectures were tested to determine the better architecture for tissue classifier. Each network was trained to classify small tissue patches into normal or tumor. Based on the patch-level classification, tumor probability heatmaps can be overlaid on tissue images. We observed three different tissue patterns, including clear normal, clear tumor and ambiguous cases. We suggest that longer inspection time can be assigned to ambiguous cases compared to clear normal cases, increasing the accuracy and efficiency of histopathologic diagnosis by pre-evaluating the status of the WSIs. When the classifier was tested with completely different WSI dataset, the performance was not optimal because of the different tissue preparation quality. By including a small amount of data from the new dataset for training, the performance for the new dataset was much enhanced. These results indicated that WSI dataset should include tissues prepared from many different preparation conditions to construct a generalized tissue classifier. Thus, multi-national/multi-center dataset should be built for the application of deep learning in the real world medical practice.

• Journal of The Korea Institute of Healthcare Architecture
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• v.15 no.2
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• pp.59-66
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• 2009

The purpose of this study is to define the concept of sustainability, to understand the traditional belief system, to comprehend user-focused healing environment, to understand the current status of Korean Hospitals, to analyze the selected case studies, and to point the way toward enhanced architectural solutions for healing environment in hospitals. The research results indicate that the design of healthcare facilities with healing effects depend on the considerations of 5 senses of patients. In other words, the sustainable design approach to create a healthy healing environment is very important, and architects must be aware of diverse sensory needs of the patients. In addition, the following factors affection healthcare facilities must be considered to create healing environment for users: - "Emphasis on sustainable Design" for harmony among nature, man, and building. - Creation of user Focused Healing Environment reflecting the suers' senses. - Search for New Hospital Forms through various design experiments to create the most suitable healing environment. - "Perception of Paradigm Shift" form a focus on sickness-oriented to wellness-oriented healthcare facility design. - "Awareness of Creating User-Friendly Environment" covering the entire age group form youth to elderly.

• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.2
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• pp.17-28
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• 2010

The considerable increase of the elderly with dementia is expected annually and when we think about the family members' and the patients' suffering, it could be painful. Above all things, it imposes heavy economic burdens on the family members that have patients who suffer from diseases of age like dementia or paralysis that caring them at home and also, it is not desirable for those old people in point of physical or environmental circumstances for medical care. Thus, it is needed urgently that the expansion of specified facilities and improvement of services for these old people. Under this present condition, it is the special feature that the subject of research is people/facilities that offer services, not the elderly with dementia-the main user of those facilities. This proposal aims to make a study of expansion and improvement the old people's welfare facilities by using remodeled closed Small and Midium Hospitals which are the bad effect of economic growth. Also, it can save money with re-using abolished buildings which is property of the nation and protect environment too. In this study, We examine the present conditions of old people's welfare institution, and research a factor of remodeling for welfare facilities. Then we will verify remodeling-possibility which is concrete and working by using the product of this study.

• Annual Conference of KIPS
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• 2021.11a
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• pp.805-807
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• 2021

In-hospital cardiac arrest is a significant problem for medical systems. Although the traditional early warning systems have been widely applied, they still contain many drawbacks, such as the high false warning rate and low sensitivity. This paper proposed a strategy that involves a deep learning approach based on a novel interpretable deep tabular data learning architecture, named TabNet, for the Rapid Response System. This study has been processed and validated on a dataset collected from two hospitals of Chonnam National University, Korea, in over 10 years. The learning metrics used for the experiment are the area under the receiver operating characteristic curve score (AUROC) and the area under the precision-recall curve score (AUPRC). The experiment on a large real-time dataset shows that our method improves compared to other machine learning-based approaches.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2765-2769
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• 2013

Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

• Korean Institute of Interior Design Journal
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• v.18 no.5
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• pp.191-199
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• 2009

Recently general hospitals in Korea are focusing on healing environment which care for patients on the side of spirit and psychology without medical treatment. For the reason, architects are planning a public space on a large scale in which can be held cultural performances and artistic events. Those of social activities can be effective healing environment according to the "Anthroposophical medicine" studied by Rudolf Steiner. To the patient, Social healing environment is relation with normal life and back to the life. The case of a large-scale public space on hospital in foreign country shows the effect of healing environment through social community. So it is valuated as a social healing environment and community space. Even though the large-scale public space has been being increased in our circumstance, there is no evaluation of use on it. So there is no idea how people are satisfied with public space to stay and form a concourse by themselves. The purpose of this study is to find out the desire of people, who use the large-scale public space by analysis of observation research and interview in the general hospitals. And finally this study suggests the factors which can realize social healing environment on the planning of public space in hospital architecture.

• Journal of Biomedical Engineering Research
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• v.26 no.2
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• pp.65-71
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• 2005

The main obstacles for adopting a mobile health information system to existing hospital information system are the redundancy of clinical data and the additional workload for implementing the new system. To obtain a seamless communication and to reduce the workload of implementation, an easy and simple implementation strategy is required. We propose a mobile clinical information system (MobileMed) which is specially designed for the easy implementation. The key elements of MobileMed are a smart interface, an HL7 message server, a central clinical database (CCDB), and a web server. The smart interface module transfers the key information to the HL7 message server as new clinical tests data is recorded in the existing laboratory information system. The HL7 message server generates the HL7 messages and sends them to the CCDS. As a central database the CCDS collects the HL7 messages and presents them to the various mobile devices such as PDA. Through this study we might conclude that the architecture for the mobile system will be efficient for real-time data communication, and the specially designed interface will be an easy tool for implementing the mobile clinical information system.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.33 no.12
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• pp.19-28
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• 2017

The purpose of this study is to propose a design methodology to build temporary isolation rooms when infectious diseases suddenly occur in a certain region, such as the case of MERS-Cov in South Korea in 2015. Although most big hospitals usually have isolation rooms, they are expensive and dangerous to run such facilities on normal and typical days. To deal with these problems in this research, shipping containers are chosen as devices used to build the temporary isolation rooms near the original hospital. To do so, firstly, a prototype for the temporary isolation room was designed with the three part modules. The first part is for the medical team; the second part including the isolation rooms is for patients; the third part is for medical selection rooms to test the specimens. Secondly, the plan was compared with the MERS-Cov infection control guidelines. Finally this prototype is applied into the Yong-in Yon-sei severance hospital and then evaluated through a CFD simulation using STAR-CCM+(ver.9.06) for checking infectious bacterium movement in this prototype. The result showed that the prototype is effectively safe for patients tested as negative, patients waiting to be tested, and the medical team.

• Journal of The Korea Institute of Healthcare Architecture
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• v.18 no.2
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• pp.77-84
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• 2012

This study is to understand the architectural types and characteristics of the medical facilities during ancient period. The study is based on the research of the medical and architectural history. The medical or healthcare facilities are influenced by their social, cultural and conceptual idea, especially how they think about 'disease', 'cure' and the 'medicine'. As the results of the examination of this study can be summarized as followings. Firstly, Ancient medical facilities are classified into four types according to the ideas of 'disease' and 'cure' ; 1) God oriented facility 2) health welfare facility 3) treatment oriented facility 4) practice & educational facility. Secondly, there are three typical types of the spatial characteristics what modern hospitals have ; 1) nursing ward 2) treatment ward 3) hostel or hospice. And they are all assembled around the courtyard in common. Thirdly, their architectures are not 'designed' but 'derived' plan by reasonable other building types, and transformed by medical function. Fourthly, a consideration of the surrounding circumstances is the most important point to make the medical health facilities during ancient period.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.54 no.5
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• pp.315-323
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• 2005

The recent development of embodiment technology of the medical images makes most medical institutions introduce PACS in haste. However, while many older HIS and PACS systems are not yet capable of some of the integration, several new systems are moving rapidly in that direction. Typical PACS system architecture begins with the HIS since this is where the correct patient demographic information and in many cases the orders originate. So, PACS developed convenience of users and to satisfy user's demand because of financial limitations and administrator-oriented considerations in the process of development. Therefore, we have developed a CDA (Clinical Document Architecture) based PACS with HIS, by which we can search and refer to the patient's medical images and information with few restrictions of time and space for diagnosis and treatment. Target model of this research limited to 135 of hospital have 200 beds. We'll make more effort to develop the application which insures the better quality and information of medical images. Medical Image History manages the patient's image files and various medical informations like film chart in connection with time. This trial will contribute to the reduction of the financial loss caused by unnecessary devices and improve the quality in the medical services. The demand on the development of the program which refers to the medical data quickly and keeps them stable will be continued by the medical institute. This will satisfy the client's demand and improve the service to the patients in that the program will be modified from the standpoint of the users.