• Journal of The Korean Digital Architecture Interior Association
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• v.6 no.2
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• pp.55-63
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• 2006

The purpose of this study is to analyze the problems in assumption of the distinguished behaviors of hospitalized dementia patients- which can be easily emerged and recognized in senile dementia patients and their distinctive behavior characters in different physical environment per person. Furthermore, it is to suggest a fundamental data to improve physical environment of the different facilities and the design guidelines for reconstruction in terms of the new and therapeutic function of the dementia specialized department. For planning on the dementia specialized hospital, considerablely, security and safety, comfortableness, personal identification of the facility, emotional stability and the proper stimulation for the patients are emphasized according to the research on the frequent and major issues of the patients from their own dwelling place.

• Journal of The Korea Institute of Healthcare Architecture
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• v.13 no.1
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• pp.7-15
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• 2007

The medicine is used for diagnosis, treatment or prevention of disease and consequently has an important influence upon human life and health. Its effectiveness and safety must be guaranteed. In order to achieve the facility that meets GMP, KFDA has provided standards for quality assurance of the manufacture, examination and tests of medical supplies. The result of this study were as follows : the GMP facilities are divided into work, lab/test and storage spaces, and the systematic corridor. The clean rooms are mainly installed in work and lab/test spaces, and maintain class 10,000 in average. The individual space for the procedures that requires class 100 is not provided as a separate division. Instead, they are performed in the clean bench of the laboratory.

• Journal of The Korea Institute of Healthcare Architecture
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• v.6 no.10
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• pp.59-65
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• 2000

Wards are the biggest part in hospital buildings and the flow of medical personnels and materials is an important factor in the ward design. The evaluation method of the wards and is esscential for the optimum design considering function, environment, patient psychology, etc. This study attempts to classify ward pattern and analyse architectural characteristics, survey the wards in Korea. The purpose of this study is to get the design guideline of the wards To achieve this goal, ward type by using corridor form were introduced and then each type was systematically analyzed. A evaluation method are developed from studied factors and are applied to existing wards to check the reliability.

• Journal of The Korea Institute of Healthcare Architecture
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• v.10 no.2
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• pp.39-49
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• 2004

With its rapid modernization and unparalleled speed of aging, South Korea faces the need for dramatic increase in its supply of nursing homes. Among the spacial components of nursing homes, residential units are considered as an essential part because the older person in nursing homes usually spend most of their time in residential units and the nursing homes are mainly composed of various residential units. It is necessary, therefore, to prepare a guideline for the plan of residential units in order to design the healthy and efficient nursing homes. This paper has first identified the concept of residential unit and analyzed 66 cases in the 62 nursing homes from 4 countries. And 4 nursing homes in Korea have been surveyed for the in-depth study. On the basis of this analysis, architectural prototypes of residential units have been proposed and the architectural characteristics of them have been compared analytically.

• Korean Institute of Interior Design Journal
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• v.15 no.5 s.58
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• pp.193-201
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• 2006

In according as the social action of women is active, the average life span is longer than male, not only woman's social position is higher, but also the construction of the more professional woman special hospital Is increased. In occasion to the recent woman special hospital, give medical treatment about pediatrics and the breast surgery as well, and the sphere is increasing as compose the variety network, from the health medical center to check the woman's physical to the postpartum care center. The trend of the lobby is arranged the more service area as the concept of the woman hospital is changed, the sphere is increasing. Accordingly, this study research and analyze the service zone and design elements on the focus the lobby of the internal woman special hospital, have an intention of guideline about the interior design of the after woman hospital. As the subject of study, selected the hospital that lobby serves to show the identity of total space, and the woman special hospital that is introduced to the relation journal with architecture or interior design, is opened after 2000 years, below the 100 bed. As the study method, understand the composition of lobby space through floor analysis, examination by the visit, analyzed the arrangement constituent, the design trend. The direction of lobby space mentioned in the study result is that secure the publicness, guarantee the privacy zone, and is important that the adequate arrangement of commercial space contribute to client's mental stability, desire that inflected as the more positive communication place.

• International Journal of Stem Cells
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• v.15 no.4
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• pp.347-358
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• 2022

Background and Objectives: The search for a suitable alternative for urethral defect is a challenge in the field of urethral tissue engineering. Induced pluripotent stem cells (iPSCs) possess multipotential for differentiation. The in vitro derivation of urothelial cells from mouse-iPSCs (miPSCs) has thus far not been reported. The purpose of this study was to establish an efficient and robust differentiation protocol for the differentiation of miPSCs into urothelial cells. Methods and Results: Our protocol made the visualization of differentiation processes of a 2-step approach possible. We firstly induced miPSCs into posterior definitive endoderm (DE) with glycogen synthase kinase-3𝛽 (GSK3𝛽) inhibitor and Activin A. We investigated the optimal conditions for DE differentiation with GSK3𝛽 inhibitor treatment by varying the treatment time and concentration. Differentiation into urothelial cells, was directed with all-trans retinoic acid (ATRA) and recombinant mouse fibroblast growth factor-10 (FGF-10). Specific markers expressed at each stage of differentiation were validated by flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR) assay, immunofluorescence staining, and western blotting Assay. The miPSC-derived urothelial cells were successfully in expressed urothelial cell marker genes, proteins, and normal microscopic architecture. Conclusions: We built a model of directed differentiation of miPSCs into urothelial cells, which may provide the evidence for a regenerative potential of miPSCs in preclinical animal studies.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.3
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• pp.15-23
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• 2019

Purpose: As the medical laboratories in general hospitals have made an efforts on quality management and employee health, they recognized the need of design guideline for clinical laboratory. As laboratories are prohibited to patients, their environments are becoming more congested and deteriorated as time goes by. So, this study investigates the current status of facility and equipment of laboratory medicine focusing on less than three hundred patient bed hospitals, and searches the improving matters. Methods: Questionnaires to technologist captains and field surveys to medical laboratories in korean hospitals have been conducted for the data collection. 18 answers have been analysed statistically by MS Excel program. Results: The result of this study can be summarized into followings. Clinical laboratory functions are all hematology, clinical chemistry, immunology, transfusion and urine microscopy, and except for three including microbiology for infection and bio safety level. Average man power of lab are 12.3 man including lab director and captain. Patient bed number, space area and total specimen numbers are not correlated with each other, but specimen numbers and employee number are correlated with. Work space distances are usually good, but exit distances are not adequate for escape owing to obstacles. Specimen delivery system by courier, test method by automatic analyzer, access floor for exposed plumbing and electricities are more practical. Open lab layed out in the center and lab support layed peripheral in space diagram. Lab space configuration by SD method showed that lab support area and employee support area are dissatisfied. Implications: Specialized hospital and yearly total specimen numbers are related to the space area and organization for laboratory planning and design.

• Journal of The Korea Institute of Healthcare Architecture
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• v.30 no.3
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• pp.17-24
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• 2024

Purpose: The medical care for children in Korea is needed more than previous time as the situation changed. However, there is a few useful research for the planning of the children's specialized public medical center. This study has been started to provide basic information for the planning of Korean children's specialized public medical center. Methods: Research and architectural documentation with field surveys to 5 of 14 children's specialized public medical center, data have been analyzed for characteristics of children's medical care. Results: The result of this study can be summarized into three points. The first one is that children's medical care can be categorized independent and integrated type according to connection with main hospital. Independent type has vertical or horizontal form from spatial composition. The second one is that spatial composition are allocated by typical service, outpatient, central, and inpatient ward zones. The outpatient zone has horizontal/vertical type, central zone has concentrated/separated type by spatial and treatment situation of medical center. The third one is that children's hospital school is the specific program and healing environment for children. Implications: It is necessary to make typical model for national wide medical care for children in Korea.

• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.210-214
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• 2011

Background and Objectives : Narrow Band Imaging(NBI) is a novel optical technique that enhances the visualization of superficial microvascular architecture which is commonly increased and founded as an irregular shape in a neoplastic lesion. The aim of this study is the evaluation of the usefulness of NBI in the diagnosis of Head and Neck Cancer. Subjects and Methods : From December 2009 to January 2011, 31 consecutive patients who were diagnosed with head and neck malignancy were enrolled in this prospective study. The malignant findings of NBI were demarcated brownish lesion or increased intraepithelial papillary capillary loops(IPCLs) with or without irregularity. Results : There were 29 cases(93.5%) of well demarcated brownish lesion, 26 cases(83.9%) of increased IPCLs and 4 cases(12.9%) of satellite lesions. Diagnostic accuracy of endoscopic examination was increased from 83.9% to 93.5%, when NBI was applied to the conventional endoscopy(p>0.05). Conclusion : NBI is a powerful and safe screening test, which can be performed in out patient clinic without any supplementary procedure.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.373-376
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• 2015

Background: EVA1A (eva-1 homolog A) is a novel gene that regulates programmed cell death through autophagy and apoptosis. Our objective was to investigate the expression profiles and potential role of EVA1A in normal and neoplastic human pancreatic tissues. Materials and Methods: The expression pattern of EVA1A in normal pancreatic tissue was examined by indirect immunofluorescence and confocal microscopy. Protein levels in paraffin-embedded specimens from normal and diseased pancreatic and matched non-tumor tissues were evaluated by immunohistochemistry. Results: EVA1A colocalized with glucagon but not with insulin, demonstrating production in islet alpha cells. Itwas strongly expressed in chronic pancreatitis, moderately or weakly expressed in the plasma membrane and cytoplasm in pancreatic acinar cell carcinoma, and absent in normal pancreatic acinar cells. Although the tissue architecture was deformed, EVA1A was absent in the alpha cells of pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms, mucinous cystadenomas, solid papillary tumors and pancreatic neuroendocrine tumors. Conclusions: EVA1A protein is specifically expressed in islet alpha cells, suggesting it may play an important role in regulating alpha-cell function. The ectopic expression of EVA1A in pancreatic neoplasms may contribute to their pathogenesis and warrants further investigation.