• 한국안전학회지
• /
• 제30권3호
• /
• pp.1-6
• /
• 2015

Self-piercing riveting (SPR) is receiving more recognition as a possible and effective solution for joining automotive body panels and structures, particularly for aluminum parts and dissimilar parts. In this study, static strength and fatigue tests were conducted using coach-peel and cross-tension specimens with Al-5052 plates for evaluation of fatigue strength of the SPR joints. For the static experiment results, the fracture modes are classified into pull-out fracture due to influence of plastic deformation of joining area. During the fatigue tests for the coach-peel and cross-tension specimens with Al-5052, interface failure mode occurred on the top substrate close to the rivet head in the most cycle region. There were relationship between applied load amplitude $P_{amp}$ and life time of cycle N, $P_{amp}=715.5{\times}N^{-0.166}$ and $P_{amp}=1967.3{\times}N^{-0.162}$ were for the coach-peel and cross- tension specimens, respectively. The finite element analysis results for specimens were adopted for the parameters of fatigue lifetime prediction. The relation between SWT fatigue parameter and number of cycles was found to be $SWT=192.8N_f^{-0.44}$.

• 센서학회지
• /
• 제30권5호
• /
• pp.326-330
• /
• 2021

Reactions between gold (Au) surface plasmon resonance (SPR) chips and bovine serum albumin (BSA) dissolved in solutions of different pH were investigated. The charge on the BSA depends on the pH of the solution in which it is dissolved. Thus, dissolving BSA in different pH solutions resulted in different charges of BSA. Among the BSA dissolved in solutions with pH 4.01, 7.4, and 10.01, the SPR response was the highest for BSA dissolved in the solution of pH 4.01. To eliminate the response variation owing to the difference in the refractive indices of the solutions, phosphate buffered saline (PBS) was injected into the system after the reaction of BSA with the Au SPR chip had happened. In this case too, the BSA dissolved in the solution with pH 4.01 exhibited the highest response. This may be attributed to the non-uniform distribution of ionic patches on the BSA, which can induce electrostatic attraction to the surface even though BSA has a positive charge at pH 4.01, and the absolute values of the net charge of BSA at pH 4.01 and 7.4 were very close.

• 대한후두음성언어의학회지
• /
• 제29권2호
• /
• pp.79-82
• /
• 2018

Background and Objectives : Laryngeal contact granuloma is benign inflammatory disease induced by excessive mechanical contact of larynx such as endotracheal intubation, voice abuse, laryngeal microsurgery as well as laryngopharygeal reflux. Because it is caused by various risk factors, multiple treatment modalities are required. The purpose of study is to evaluate treatment effect of topical steroid through nasal cavity in contact granuloma. Materials and Method : Fifty-two patients were enrolled in this study with exception of intubation granuloma. Patients were classified with four groups (Proton pump inhibitor (PPI), Nasal steroid spray (SPR), PPI+SPR, Observation) according to treatment modality. Results : Patients who treated with PPI (Odds ratio 2.45, p=0.03) and combination of PPI and SPR (Odds ratio 2.88, p<0.01) had significantly better response than patients who not treated with medical therapy. Conclusion : Combination therapy of nasal steroid spray and PPI is effective for contact granuloma of larynx and considered as a treatment of choice rather than PPI only treatment.

• 한국항공우주학회지
• /
• 제48권8호
• /
• pp.597-609
• /
• 2020

동축 로터 시스템은 기존의 헬리콥터뿐만 아니라 드론, PAV, 차세대 고속 회전익기 및 화성탐사용 헬리콥터에 적용되는 등, 활용 분야가 점점 넓어지고 있다. 로터 시스템의 성능 연구는 기존 연구에서 동축 로터를 대상으로도 여러 차례 수행되었으나, 로터 블레이드의 변형에 대한 연구는 주로 단일 로터 시스템만을 대상으로 진행되었다. 하지만 동축 로터 시스템에서는 주변에서 발생하는 유동이 복잡하며, 두 로터의 간격이 로터 시스템 전체의 성능에 주요한 영향을 주므로 블레이드의 변형 연구가 더욱 중요하다. 이에 본 연구에서는 최신식 고속 영상촬영 기법 중 하나인 SPR(Stereo Pattern Recognition) 기법을 사용해 동축 로터 블레이드의 변형 측정에 대한 실험적 연구를 수행하였다. 본 연구에는 한국항공우주연구원에서 개발한 축소 동축 로터 시험장치가 사용되었으며, 로터 블레이드의 변형과 성능의 연관성을 고찰하기 위해 동축 로터 시스템의 성능시험이 선행되었다. 해당 시스템의 로터 블레이드 변형을 SPR 기법으로 측정한 결과는 사전에 진행된 성능시험 결과와 함께 본 논문에 제시되었다.

• Interaction and multiscale mechanics
• /
• 제2권3호
• /
• pp.277-293
• /
• 2009

The Enriched Free Mesh Method (EFMM) is a patch-wise procedure in which both a displacement field on an element and a stress/strain field on a cluster of elements connected to a node can be defined. On the other hand, the Superconvergent Patch Recovery (SPR) is known to be an efficient post-processing procedure of the finite element method to estimate the error norm at a node. In this paper, we discuss the relationship between solutions of the EFMM and those of the SPR through several convergence studies. In addition, in order to solve the demerit of the smoothing effect on the fracture mechanics fields, we implement a singular stress field to a local patch in the EFMM, and its effectiveness is investigated.

• 한국전자파학회논문지
• /
• 제13권8호
• /
• pp.790-796
• /
• 2002

우리나라에는 역사적으로 아름답고 소중한 목조 건축물들이 문화재로 보존되고 있다. 그러나 목조 건축물들은 오랜 세월동안 풍화작용, 병충해 등과 같은 거친 환경조건에 노출되어 있다. 이러한 원인으로 인하여 건축물에 구조적 결함을 야기하기도 한다. 따라서 사전에 목조 건축물을 진단할 수 있는 방법이 필요하다. 본 논문에서는 목조 건축물의 비파괴 검사에 표면하부 탐사 레이더의 적용 가능성을 3차원 유한차분 시간영역 모의계산과 실제 측정을 통하여 조사하였다.

• BMB Reports
• /
• 제43권9호
• /
• pp.593-598
• /
• 2010

Tetrahydrobiopterin ($BH_4$) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine and serotonin as well as the release of glutamate. Deficiencies in $BH_4$ levels and reduced activities of $BH_4$-associated enzymes have been recently reported in patients with schizophrenia. Accordingly, it is possible that abnormalities in the biochemical cascades regulated by $BH_4$ may alter DA, 5-HT and Glu neurotransmission, and consequently contribute to the pathophysiology of different neuropsychiatric diseases including schizophrenia. The development of a novel strain of mutant mice that is deficient in $BH_4$ by knocking out the expression of a functional sepiapterin reductase gene (spr -/-) has added new insights into the potential role of $BH_4$ in the pathophysiology and improved treatment of schizophrenia.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제9권2호
• /
• pp.143-146
• /
• 2004

A surface plasmon resonance (SPR) imaging system was constructed and used to detect the hexahistidine-ubiquitin-tagged human parathyroid hormone fragment (His$\sub$6/-Ub-hPTHF(1-34)) expressed in Escherichia coli. The hexahistidine-specific antibody was immobilized on a thin gold film coated with ProLinker$\^$TM/ B, a novel calixcrown derivative with a bifunctional coupling property that permits efficient immobilizaton of capture proteins on solid matrices. The soluble and insoluble fractions of an E. coli cell lysate were spotted onto the antibody-coated gold chip, which was then washed with buffer (pH 7.4) solution and dried. SPR imaging measurements were carried out to detect the expressed His$\sub$6/-Ub-hPTHF(1-34). There was no discernible protein image in the uninduced cell lysate, indicating that non-specific binding of contaminant proteins did not occur on the gold chip surface. It is expected that the approach used here to detect affinity-tagged recombinant proteins using an SPR imaging technique could be used as a powerful tool for the analyses of a number of proteins in a high-throughput mode.

• 한국안전학회지
• /
• 제30권4호
• /
• pp.1-7
• /
• 2015

Self-piercing riveting (SPR) process is gaining popularity due to its many advantages. The SPR does not require a pre-drilled hole and has capability to join a wide range of similar or dissimilar materials and combinations of materials. This study investigated the fatigue strength of self-piercing rivet joint with aluminum alloy (Al-5052) and steel (SPCC) sheets. Static and fatigue tests on tensile-shear specimens were conducted. From the static strength aspect, the optimal punching force for the specimen with upper SPCC (U.S) sheet and lower aluminum alloy(L.A) sheets was 34 kN. During static test the specimens fractured in pull-out fracture mode due to influence of plastic deformation of joining area. There was a relationship between applied load amplitude $P_{amp}$ and number of cycles N ; $P_{amp}=19588N_f^{-0.211}$ and $P_{amp}=4885N_f^{-0.083}$ for U.S-L.A and U.A-L.S specimens, respectively. U.A-L.S fatigue specimens failed due to fretting crack initiation around the rivet neck between upper and lower sheets.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2003년도 생물공학의 동향(XII)
• /
• pp.635-638
• /
• 2003

For the acute assessment on biological toxicity of wastewater, surface plasmon resonance(SPR) based cell viability detection was performed using gold surface-confined cell as a result of adhesion-modifying chemicals. Escherichia coli O157:H7 (E. coli O157:H7) was investigated after exposure to EDTA. Cells were immobilized on gold coated slide glass for SPR analysis by the method of cross-linking carboxyl group on the bacterial surface with amine group of poly-L-lysine that had been coupled to the gold surface modified by a self-assembled monolayer of 11-mercaptounde canoic acid (11-(MUA)). Reflective intensity of each flow step was changed with respect to confect of ethylenediaminetetraacetic acid (EDTA) disodium salt and phosphate-buffered saline (PBS) solution. The proposed detection technique can be used for biological toxicity test.